4 November - 7 November 2025
The mobile genome: genetic and physiological impacts of transposable elements
Deborah Bourc'his, Josefa Gonzalez Perez, Joseph Peters, Julius Brennecke
Description OverviewSpeakersProgrammePractical InformationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Disparaged as selfish DNA for decades it s now clear that transposable elements TEs underlie the remarkably dynamic nature of bacterial plant and animal genomes This conference builds on the highly successful 2021 and 2023 Mobile Genome EMBO workshops and has emerged as the major European venue in this ever growing cross disciplinary research field The 2025 Mobile Genome conference will assemble recognized experts from diverse disciplines e g genomics epigenetics structural biology evolutionary biology and developmental biology as well as the next generation of scientists who will become leaders in the field to discuss the broad impact of TEs on organismal biology A dedicated discussion session focused on technological and conceptual advances will augment the program to provide a forum for cross disciplinary interaction among attendees with the goal of catalyzing collaborative opportunities to address new questions and challenges in TE research This event has been granted the following EMBO sustainability badge Grade 3 of 3 Speakers Keynote speakers Orsolya Barabas University of Geneva Switzerland Speakers Aude Bernheim Institut Pasteur France Emilie Brasset Institute of Genetics Reproduction Development France Edward Chuong University of Colorado USA Ian Henderson University of Cambridge UK George Kassiotis The Francis Crick Institute UK Mia Levine University of Pennsylvania USA Mariusz Nowacki University of Bern Switzerland Leandro Quadrana Institute of Plant Sciences France Irma Querques Max Perutz Labs Austria Helen Rowe Queen Mary University of London UK Mikiko Siomi University of Tokyo Japan Samuel Sternberg Columbia University USA Elly Tanaka Institute of Molecular Biotechnology Austria Cristina Vieira Universit Claude Bernard France Scientific organisers D borah Bourc his Institut Curie France Julius Brennecke Institute of Molecular Biotechnology Austria Josefa Gonz lez Institut Bot nic de Barcelona CSIC Spain Joseph Peters Cornell University USA Event organiser Julia Patricia Nohle Course and Conference Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBOMobileGenome and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Please find the bus shuttle schedule here Day 1 Tuesday 04 November 2025 Time Europe Berlin Speaker12 00 13 30Registration and light refreshments13 30 13 45Opening remarks13 45 14 45Keynote IMechanistic underpinnings of conjugativetransposition of antibiotic resistanceOrsolya Barabas University of Geneva Switzerland14 45 15 15Coffee Break and Meet the speakers15 15 19 00Session 1 Genomics and evolutionChair D borah Bourc his Institut Curie France15 15 15 45TE driven diversification of KRAB ZFP cluster exposes strain specific vulnerabilities in mouse embryosMelania Bruno NICHHD NIH United States of America15 45 16 00Pangenomic analysis of Arabidopsis reveals extensive mutagenic impact of rare transposable elementsPierre Baduel ENS Paris FranceNot available on demand16 00 16 15Giant Starship transposons populate dynamic genomic regions and shape virulence evolution in the fungal genus VerticilliumJulie Noah University of Cologne Germany16 15 16 45Rapid evolution of a multi protein complex under pressure from retrotransposonsMia Levine University of Pennsylvania United States of America16 45 17 15Coffee break and Meet the speakers17 15 17 30Transposable elements support the origin and evolution of 3D genome organizationIana Kim Centre for Genomic Regulation Spain17 30 18 00Cyclical evolution of centromere architecture across 193 eukaryote speciesIan Henderson University ofCambridge United Kingdom18 00 18 15Transposable elements as architects of fungal genomes tracking TE dynamics from decades to a billion yearsTobias Baril University of Neuch tel Switzerland18 15 18 45Leveraging the giant axolotl genome to decipher the origin of the tetrapod limbElly Tanaka Institute of Molecular Biotechnology AustriaNot available on demand18 45 19 00Organisation and dynamics of the giant 88 gbp mistletoe genomeAlexandros Bousios University of Sussex United Kingdom19 00 20 30Dinner in EMBL Canteen20 30 22 00After dinner drinks in ATC Rooftop Lounge Day 2 Wednesday 05 November 2025 Time Europe Berlin Speaker09 00 12 00Session 2 Transposon regulationChair Julius Brennecke Institute of Molecular Biotechnology Austria09 00 09 30The impacts of the dynamic natures of Flamenco cluster on ovarian somatic cellsMikiko Siomi University of Tokyo JapanNot available on demand09 30 09 45The inner nuclear membrane protein Lem2 coordinates transposon silencing and genome stability through LTR specific regulatory networks in fission yeastSigurd Braun Justus Liebig University Giessen Germany09 45 10 15Identification of a locus of epigenetically regulated LINE 1 retroelements that is sensed by the RNA sensor MDA5Helen Rowe Queen Mary Universityof London UK10 15 10 45Coffee Break and Meet the speakers10 45 11 00Charting the m6A ome across retrotransposon mRNAs in mammalsNico Zaghet Institut Curie France11 00 11 15Epigenetic control of transcribed retroelements by the HUSH complex and associated factorsChristopher Douse Lund University Sweden11 15 11 45Germline adenine methylation protects the zygotic genome from DNA lossMariusz Nowacki University of Bern Switzerland11 45 12 00Exploiting natural L1 retrotransposon sequence variation to identify internal features influencing their transcriptional activityLarisa Okorokova IRCAN University C te d Azur France12 00 12 15Flash talk session 1 5 FT 55 Bona 69 Gr nb k 82 Garcia Llagostera 84 Ghosh 89 Johansson12 15 13 40Lunch and Meet the Editors13 40 15 00Poster Session 1 47 92 15 00 17 40Session 2 Transposon regulation continued Chair Julius Brennecke Institute of Molecular Biotechnology Austria15 00 15 30Transposable element silencing in drosophila insights from germline and somatic pathwaysEmilie Brasset Institute of Genetics Reproduction Development France15 30 15 45ChAHP silences SINE retrotransposons by inhibiting TFIIIB recruitmentJakob Schnabl Friedrich Miescher Institute for Biomedical Research Switzerland15 45 16 00Nuclear stress bodies protect Drosophila germ cells from stress induced transposon expressionMadhav Jagannathan ETH Z rich SwitzerlandNot available on demand16 00 16 30Coffee break and Meet the speakers16 30 16 45Novel transposable element derived transcription factors are abundant across animalsIsaac Yellan University of Toronto Canada16 45 17 00Mutations in the MORC2 chromatin regulator cause dysregulation of the repetitive genome during early human neurodevelopmentFereshteh Dorazehi Lund University Sweden17 00 17 25Last minute breakthrough talk Transposable element co option drives transcription factor neofunctionalizationOlga Rosspopoff EPFL Switzerland17 25 17 40Flash talk session 2 5 FT 93 Henriet 99 Igolkina 113 Maiwald 115 Marino 121 Moritoh17 40 19 00Poster Session 2 93 139 19 00 20 30Dinner in EMBL Canteen20 30 22 00After dinner drinks and pub quiz in EMBL Canteen Day 3 Thursday 06 November 2025 Time Europe Berlin Speaker09 00 11 45Session 3 Transposition mechanismsChair Joseph Peters Cornell University United States of America09 00 09 30Mechanistic insights into RNA guided DNA transpositionIrma Querques Max Perutz Labs Austria09 30 09 45De novo engineered guide RNA directed transposition systems address previous issues and reveal features of naturally evolved systemsRichard Schargel Cornell University United States of America09 45 10 00A development specific condensin complex helps the PiggyMac domesticated transposase carry out programmed DNA elimination in Paramecium tetraureliaMireille B termier Institut de Biologie Int grative de la Cellule FranceNot available on demand10 00 10 15Host genes act as traps for de novo piRNA responsesBaptiste Rafanel Institute of Molecular Biotechnology Austria10 15 10 45Coffee break and Meet the speakers10 45 11 00Cis and trans LINE1 R loops distinct mechanisms driving replication stress and fork instabilityPratyashaa Paul IISER Berhampur India11 00 11 15Dissecting regulatory features of LINE 1 ribonucleoprotein biology in mouse zygotesKevin Tse Yale University United States of America Max Planck Institute for Molecular Genetics Germany11 15 11 45Evolution of immunity across domains of lifeAude Bernheim Institut Pasteur France11 45 12 00In cell structural analysis reveals a different maturation process between the Ty3 retrotransposon and the evolutionarily related family of retrovirusesDavide Torre Max Planck Institute for Biochemistry Germany12 00 12 15Flash talk session 3 5 FT 153 Roy 161 Sierra 173 Vendrell Mir 176 Voichek 180 Stefanov12 15 13 40Lunch13 40 15 00Poster Session 3 140 186 15 00 17 40Session 4 Physiological impactChair Josefa Gonz lez Institut Bot nic de Barcelona CSIC Spain15 00 15 30Evolution of functional immune gene isoforms through transposon exonizationEdward Chuong University of Colorado United States of America15 30 15 45Homopolymeric DNA synthesis by an antiviral reverse transcriptaseRimante edaveinyte Columbia University United States of America15 45 16 00RNA sensing induces a sterile interferon response in the placenta that correlates with increased HERV expressionSabine De Lange LUMC Netherlands16 00 16 30Coffee break and Meet the speakers16 30 17 00Epigenetic conflicts and regulatory innovation by transposable elementsLeandro Quadrana Institute of Plant Sciences FranceNot available on demand17 00 17 15A novel role of LTR12C elements in modulating REST mediated transcriptional regulation during HIV 1 infectionMaisha Adiba Leibniz Institute of Virology Germany17 15 17 40Last minute breakthrough talk Transposable elements reshape gene expression in the Drosophila brainChristoph Treiber University of Oxford United Kingdom17 40 18 40Panel discussion on emerging topics in transposon biology18 40 20 00Conference dinner in EMBL canteen20 00 23 00Party with DJ Day 4 Friday 07 November 2025 Time Europe Berlin Speaker09 30 13 30Session 4 Physiological impact continued Chair Josefa Gonz lez Institut Bot nic de Barcelona CSIC Spain09 30 10 00Invasive and adaptive roles of transposableelementsCristina Vieira Universit Claude Bernard France10 00 10 15Epigenetic regulators license post implantation mammalian development by controlling repetitive elementsYusuke Kijima Max Planck Institute for molecular Genetics Germany10 15 10 30In cell structure and snapshots of copia retrotransposons in intact tissue by cryo electron tomographySven Klumpe Research Institute of Molecular Pathology IMP Austria10 30 10 45A retroviral insertion contributed to the divergence of human and chimpanzee brainsJohan Jakobsson Lund University Sweden10 45 11 15Endogenous retroviruses in immunity and cancerGeorge Kassiotis The Francis Crick Institute UKNot available on demand11 15 11 45Coffee break and Meet the speakers11 45 12 00Cancer cell type specific derepression of transposable elements by inhibition of chromatin modifier enzymesDivyesh Patel Norwegian Centre for Molecular Biosciences and Medicine University of Oslo Norway12 00 12 15SA somatically active retrovirus hijacks a nearby genomic regulatory sequence for its own expression and mobilityKasia Siudeja I2BC Universit Paris Saclay France12 15 12 30LINE 1 ORF2p rewires the enhancer landscape and DNA repair programs under p53 deficient conditionsBhavana Tiwari Indian Institute of Science Education and Research Berhampur India12 30 13 00RNA templated antiviral immunity in bacteriaSamuel Sternberg Columbia University United States of America13 00 13 30Closing remarks and Poster prize announcements13 30Packed lunch and departure Shuttle to Frankfurt Airport Friday 7 November 2025 13 45 tickets available at the registration desk Practical Information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 550On site PhD Student 385On site Industry 750On site Journal Editors 300Virtual Academia 200Virtual PhD Student 150Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Julia Patricia Nohle for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 3 October 2025 in some cases at special rates Please email the hotel directly quoting the booking code MGE25 01 to confirm the exact price of the room Hotel AnlageHotel Holl nder Hof Hotel MonptiHotel Bayrischer Hof Hotel ibis HeidelbergPremier Inn Heidelberg City ZentrumB B HotelISG Hotel Staycity Aparthotel HeidelbergThe Heidelberg Exzellenz HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergHilton HeidelbergMeininger HeidelbergHotel Vier Jahreszeiten Heidelberg Please note that as of 1 October 2025 Heidelberg City Council is introducing an overnight stay tax for tourists visiting Heidelberg including work related trips The cost will be 3 50 EUR per night for the first five nights of a consecutive stay and will be added to the hotel s nightly rate Please contact the individual hotel directly if you have any questions Travel information For travel information please see here EMBL Events collaborates with Deutsche Bahn to offer discounted train travel within Germany To take advantage of this offer please contact us at events embl de and we will share the discount link with you Please note that you may need to provide proof of your event attendance when purchasing the ticket and or during your travel Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Please find the bus shuttle schedule here The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn City Zentrum Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel Kurf rsten Anlage 1 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or 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a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an 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HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting 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partners Advanced Biology a Wiley journal Advanced Genetics a Wiley journal BioEssays a Wiley journal ChemBioChem a Wiley journal EMBO Reports an EMBO Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Mobile DNA a BMC Springer Nature journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes 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OverviewSpeakersProgrammePractical InformationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Conference overview Disparaged as “selfish DNA” for decades, it’s now clear that transposable elements (TEs) underlie the remarkably dynamic nature of bacterial, plant, and animal genomes. This conference builds on the highly successful 2021 and 2023 Mobile Genome EMBO workshops and has emerged as the major European venue in this ever-growing cross-disciplinary research field. The 2025 Mobile Genome conference will assemble recognized experts from diverse disciplines (e.g., genomics, epigenetics, structural biology, evolutionary biology, and developmental biology), as well as the next generation of scientists who will become leaders in the field, to discuss the broad impact of TEs on organismal biology. A...
EMBO Workshop
EMBL Heidelberg, Virtual
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