Target Engagement in Biology and Drug Discovery

Overview

Course Overview

Small molecules play an important role in biological research and drug discovery. Demonstrating target engagement by a small molecule is essential to understand its mechanism of action. This course will give a solid practical and theoretical grounding in evaluating how a small molecule interacts with its biological target in cells or in vitro and its role in drug discovery. 

Audience

This course is aimed at pre and post doctoral and established researchers developing/using small molecules in drug discovery or for the elucidation of biological questions.

Modules/Resources

• Cellular Thermal Shift Assay (CETSA)
• Bioluminescence Resonance Energy Transfer (BRET)
• PROTAC: targeted protein degradation
• Computational methods for target identification

Speakers

Speakers and Trainers

Benedict-Tilman Berger

Goethe University Frankfurt

Germany

Erik Bonke

Promega

Germany

Caroline End

Promega

Germany

William Farnaby

University of Dundee

UK

Eugene Gbekor

EMBL Heidelberg

Germany

Britta Jehle

EMBL Heidelberg

Germany

Stefan Kubicek

CeMM

Austria

Andrew Leach

EMBL-EBI

UK

Kerstin Putzker

EMBL Heidelberg

Germany

Matthew Robers

Promega

USA

Anna Rutkowska

GSK

Germany

Mikhail Savitski

EMBL Heidelberg,

Germany

Peter Sehr

EMBL Heidelberg

Germany

Scientific Organisers

Joe Lewis

EMBL Heidelberg

Germany

Friedrich Reinhard

GSK

Germany

Course Organisers

Lea Hohmann

EMBL Heidelberg

Germany

Programme