Innate immunity in host-pathogen interactions

Time (Europe/Berlin)	Speaker
11:45 – 13:15	Registration and Lunch
13:15 – 13:30	Opening remarks Felix Randow – MRC Laboratory of Molecular Biology, UK
13:30 – 14:30	Keynote lecture 1 Fanning the Flames: Pyroptosis in Viral and Bacterial Infection Judy Lieberman – Harvard Medical School, USA
14:30 – 18:00	Session 1: Sensing pathogens Session chair: Cyril Zipfel – University of Zurich, Switzerland
14:30 – 15:00	Pyroptosis in antibacterial and antitumor immunity Feng Shao – National Institute of Biological Sciences, China (Virtual speaker) Livestream only
15:00 – 15:15	Structural basis of membrane targeting and coatomer assembly by human GBP1 Tanja Kuhm – Delft University of Technology, The Netherlands
15:15 – 15:30	Mechanism of cGAS-like receptor (cGLR) signaling in animal innate immunity Yao Li – Harvard Medical School / Dana-Farber Cancer Institute, USA Livestream only
15:30 – 16:00	Layers of immunity: Deconstructing the Drosophila effector response Bruno Lemaitre – École Polytechnique Fédérale de Lausanne, Switzerland
16:00 – 16:30	Coffee Break and Meet the speakers
16:30 – 17:00	Biochemical mechanisms of plant NLRs Jijie Chai – Max Planck Institute for Plant Breeding Research, Germany
17:00 – 17:15	The FACT-ETS-1 Antiviral Response (FEAR) Pathway broadly restricts RNA and DNA viruses and is antagonized by poxvirus A51R proteins Don Gammon – UT Southwestern, USA
17:15 – 17:30	A wheat resistosome defines common principles of immune receptor channels Alexander Förderer – Max-Planck Institute for Plant Breeding Research, Germany
17:30 – 18:00	Origin of innate immunity mechanisms in bacterial defense against phages Rotem Sorek – Weizmann Institute of Science, Israel Livestream only
18:00 – 19:00	Pre-dinner drinks and networking
19:00 – 20:30	Dinner

Time (Europe/Berlin)	Speaker
08:15 – 09:00	Meet the journal editors session
09:00 – 12:00	Session 2: The cell biology of infection Session chair: Julie Pfeiffer – University of Texas Southwestern Medical Center, USA
09:00 – 09:30	Molecular mechanisms of innate immunity and inflammatory cell death, PANoptosis Thirumala-Devi Kanneganti – St. Jude Children’s Research Hospital, USA
09:30 – 10:00	How cells defend against invasive bacteria Felix Randow – MRC Laboratory of Molecular Biology, UK
10:00 – 10:15	Transertion is used for bile-mediated localized expression and assembly of Vibrio parahaemolyticus T3SS2 Kim Orth – HHMI-Janelia Research Campus / UT Southwestern, USA
10:15 – 10:30	Gasdermin D-mediated permeabilization of phagolysosomal compartments orchestrates inflammasome activation and pyroptosis Monica Varela – Leiden University, The Netherlands
10:30 – 11:00	Coffee Break and Meet the speakers
11:00 – 11:30	The impact of host innate restriction on the biology of SARS-CoV-2 Variants Wendy Barclay – Imperial College London, UK
11:30 – 12:00	Perception mechanisms and roles of phytocytokines Cyril Zipfel – University of Zurich, Switzerland Livestream only
12:00 – 13:30	Lunch
13:30 – 16:30	Session 3: Fungus-host interactions Session chair: Bernhard Hube – Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Germany
13:30 – 14:00	Fungi on the Brain: How do Microglia Respond to Fungal Invasion? Rebecca Drummond – University of Birmingham, UK
14:00 – 14:15	Innate defenses protect the host against the activities of microbial toxins through short secreted peptides that are not antimicrobial peptides Dominique Ferrandon – Guangzhou Medical University/SFHI, China/Université de Strasbourg UPR9022 du CNRS, France
14:15 – 14:30	Training a pathogen: uncovering the evolutionary mechanisms of host adaptation in a human fungal pathogen Zoe Hilbert – University of Utah, USA
14:30 – 15:00	Education of host immunity through gut fungal commensalism Iliyan Iliev – Weill Cornell Medicine, USA Livestream only
15:00 – 15:30	Coffee Break and Meet the speakers
15:30 – 16:00	Immune Evasion by a Lethal Fungal Pathogen Robin May – University of Birmingham, UK
16:00 – 16:15	Exploiting allelic compatibility in plant paired NLRs to facilitate engineering of new pathogen effector recognition specificities Adam Bentham – John Innes Centre, UK
16:15 – 16:45	Something old and something new: innate regulation of adaptive immunity through Dectin-1 Gordon Brown – University of Exeter, UK Livestream only
16:45 – 17:15	Flash talks ( each 2 minutes) #53 – Bell, Michael #73 – Fischer , Fabian , #97 – Matthew, Liya, #99 – Mills, Kathleen, #101 – Muusse, Timothy, #107 – O’Donovan, Conor John, #115 – Scharte, Felix, #131 – Wein, Tanita, #135 – Zhang, Zhirong
17:15 – 19:15	Poster Session 1 (odd)
	Free evening

Time (Europe/Berlin)	Speaker
09:00 – 12:00	Session 4: Cell-autonomous immunity Session chair: Felix Randow – MRC Laboratory of Molecular Biology, UK
09:00 – 09:30	The Dictyostelium discoideum E3 ubiquitin ligase TrafE coordinates endolysosomal damage response and cell-autonomous immunity to Mycobacterium marinum. Thierry Soldati – University of Geneva, Switzerland Livestream only
09:30 – 10:00	Listeriolysin O induces a phagosome stress response during Listeria monocytogenes growth in spacious vacuoles John Brumell – The Hospital for Sick Children, Canada Livestream only
10:00 – 10:15	Host driven cholesterol modifications provide innate immunity against bacterial and viral pathogens David Heisler – University of Texas Southwestern Medical Center, USA Livestream only
10:15 – 10:30	A type-IV secreted effector from Legionella pneumophila suppresses small RNA-guided gene silencing in human cells to enable disease Justine Toinon – Institut de Biologie de l’École Normale Supérieure, France
10:30 – 11:00	Coffee Break and Meet the speakers
11:00 – 11:30	Cell autonomous defense of the intestinal epithelium by cell death pathways Russell Vance – University of California, Berkeley, USA
11:30 – 12:00	Effector Deployment during Rice Infection by the Blast Fungus Magnaporthe oryzae Nick Talbot – The Sainsbury Laboratory, UK
12:00 – 13:30	Lunch
13:30 – 16:45	Session 5: Pathological consequences of infection and inflammation Session chair: Wendy Barclay – Imperial College London, UK
13:30 – 14:00	Caspase-7 activates ASM to repair gasdermin and perforin pores Ed Miao – Duke University, USA **This talk is now virtual**
14:00 – 14:15	Identification of UBE2L3 & E3 ligases that limit inflammation via mixed ubiquitylation and proteasomal turnover of pro-IL-1β Avinash Shenoy – Imperial College London, UK Livestream only
14:15 – 14:30	A family of Conserved Shigella effectors dampens IFN responses by blocking Calcium signalling Charlotte Odendall – King’s College London, UK
14:30 – 15:00	License to stay: how human cytomegalovirus disrupts, evades and exploits the host Melanie Brinkmann – Helmholtz Centre for Infection Research, Germany
15:00 – 15:30	Coffee Break and Meet the speakers
15:30 – 16:00	Virus infection in the fruit fly disrupts gut homeostasis by modulation of intestinal stem cell proliferation Carla Saleh – Institut Pasteur, France
16:00 – 16:15	Naturally acquired immunity to malaria is characterized by epigenetic reprogramming of innate immune cells Jason Nideffer – Stanford University, USA
16:15 – 16:45	Intravenous BCG promotes protection against SARS-CoV-2 through IFN-γ driven priming of the pulmonary innate compartment Alan Sher – National Institutes of Health, USA
16:45 – 17:15	Flash talks (2 minutes) #60 – Burford, Wesley, #68 – Dumigan, Amy, #88 Kaya, Göksu Gökberk, #98 – Meade, Justin, #106 – Nemegeer, Josephine, #108 – Ofir, Gal, #114 – Rosenberg, Gili, #128 – Van Genechten, Wouter, #130 – Wadhawan, Ashima
17:15 – 19:15	Poster Session 2 (even)
19:15 – 23:00	BBQ & Live Music (Lazy Fur)

Time (Europe/Berlin)	Speaker
09:00 – 13:15	Session 6: Microbiota and pathogen control Session chair: Feng Shao – National Institute of Biological Sciences, China
09:00 – 09:30	Silent recognition of flagellin from human gut commensal bacteria by toll-like receptor 5 Ruth Ley – Max Planck Institute for Developmental Biology, Germany **This talk is now virtual**
09:30 – 10:00	Receptor-like kinase signalling shapes the plant rhizosphere microbiome Cara Haney – University of British Columbia, Canada Livestream only
10:00 – 10:15	Intercrypt Sentinel Macrophages Induce a Tunable Antibacterial NFκB Response in Intestinal Epithelial Cells via TNF Annika Hausmann – University of Copenhagen, Denmark
10:15 – 10:30	Oxygen levels regulate gut microbiota and ILC3 responses Marco Vinolo – Unicamp, Brazil
10:30 – 11:00	Coffee Break and Meet the speakers
11:00 – 11:30	Circadian control of enteric virus infection through rhythmic host innate immune response Julie Pfeiffer – University of Texas Southwestern Medical Center, USA
11:30 – 11:45	An IBD-associated pathobiont collaborates with NSAID to promote inflammation and cell death in the susceptible host via the caspase-8/NLRP3 axis Raminder Singh – University College Cork, Ireland Livestream only
11:45 – 12:15	Innate mucosal defense against Salmonella gut infection Wolf-Dietrich Hardt – ETH Zürich, Switzerland
12:15 – 13:15	Keynote lecture 2 Goblet cell mucus provide the first line of defense Gunnar Hansson – University of Gothenburg, Sweden
13:15 – 13:30	Closing Remarks and Poster Prize
13:30 – 13:45	Packed Lunch and departure

Accommodation is not included in the conference registration fee.

As further changes in our events are possible due to COVID-19, you should book flights, trains and hotels with flexible options and favourable cancellation conditions.

The hotels below have rooms on hold for participants until Thursday 16 June 2022, in some cases at special rates. Please quote the booking code EES22-08 and confirm the exact price of the room with the hotel directly.

Hotel Anlage	Hotel ibis Heidelberg	Premier Inn Heidelberg City
Hotel Bayrischer Hof	ISG Hotel	Staycity Aparthotel Heidelberg
B&B Hotel	Leonardo Hotel Heidelberg City Centre	Steffi’s Hostel Heidelberg
Hotel Holländer Hof	Hotel Monpti	Hotel Vier Jahreszeiten Heidelberg

Conference shuttle buses

Conference shuttle buses are free of charge for participants, and depart from designated bus stops near the hotels to EMBL and back, mornings and evenings.

Download the shuttle timetable here

The bus stops for this conference are:

• StayCity Hotel (close to B&B Hotel and Main Train Station)
• Heidelberg HBF (EMBL Haltestelle/EMBL Bus stop)
• Kurfürsten-Anlage (close to Main Train Station)
• Leonardo Hotel(Bergheimer Str)
• Neckarmünzplatz
• Peterskirche
• Alois Link Platz

View Conference shuttle bus stops and hotels in a larger map. Please note that not every bus stop will be used for every event.

Further details

Address: EMBL, Meyerhofstraße 1, 69117 Heidelberg, Germany. For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue. For information about accommodation and local transportation please refer to the FAQ page.

Catering

All meals and coffee breaks are included in the registration fee. Our catering staff will prepare a wide variety of vegetarian meals, meat and fish dishes, soups, pasta, fresh fruit and vegetables, as well as a variety of desserts.

Please wear your badge at all times when serving yourself.

No food or drinks are allowed in the auditorium.

Charging lockers

There are lockers available next to the stairs leading down into the Auditorium. You will find some of those equipped with sockets to charge your smartphone/tablet etc.

Electricity and charging station

In most places the electricity is 220 volts AC (50 cycles). An adaptor and a plug that fits the German socket may be needed for your appliances/laptop (i.e. American, Japanese, etc.). A USB charging station for electronic devices is available at the registration desk.

EMBL merchandise

EMBL Merchandise is available on Mon – Thu (9 am – 12 pm). If you are interested in purchasing an EMBL souvenir (products presented in the glass display in the registration area), please ask at the registration desk for more information.

Health and safety notes

Please read EMBL’s COVID-19 terms and conditions for events.
Do not smoke in any EMBL building.
Eating and drinking is prohibited in the Auditorium and all laboratories.
Do not enter any restricted areas or the laboratories unless instructed to do so.

If first aid is required …

• The first aid room is located next to the ATC Registration Desk (room 10- 205).
• Dial the Emergency number 222 from any EMBL internal phone only.
• Where is the accident? What happened? How many injured?
• Emergency number 06221-387 7821 from mobile phones.
• Please report all accidents to the conference officer at the registration desk.

In case of fire …

• Press the nearest fire alarm button or the Emergency number 222 from any internal phone.
• A loud fire alarm will go off if an evacuation is required. On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points
• Do not use the lifts.

Beyond first aid…

Please remember to bring your own medication, if needed, to the conference. Note that the next pharmacy is a 4-minute drive from the EMBL, but for many medications you will be required to see a doctor to get a prescription.

Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg. In any case, the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary.

Internet

Wi-Fi is available everywhere on the premises (no password required), just log on to ATC-Guest. The eduroam network (secure, world-wide roaming access service developed for the international research and education community) is also available.

Lost and found

‘’Lost and Found’’ are kept at the registration desk until the end of the conference.

Luggage

There are lockers available on-site to store your luggage, which require a 2 EURO coin to operate. There is another luggage room on level E0, which is free to use but remains unlocked during the conference.

Nursing room

There is a nursing room available in the ATC Rooftop Lounge on level A29.

Photography

During the conference an EMBL Photographer may be taking photographs. If you would not like to appear in these, please inform the photographer or a member of the Course and Conference Office.

Printing

We can help printing your boarding passes/train ticket. Please send it to events@embl.de and collect your print-outs at the registration desk.

Room for prayer, yoga and meditation

There is a room for prayer, mediation and yoga located on level E0 behind the Auditorium. Please be respectful of other participants using the room.

Sightseeing

A variety of activities in Heidelberg can be found on this website: www.heidelberg-marketing.com

Travel to and from the venue

During the event we provide conference shuttle busses to and from EMBL. In addition, there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time. Information on the conference shuttle busses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page.

Useful German expressions

English	German
Hello	Hallo
Goodbye	Auf Wiedersehen
Good morning	Guten Morgen
Good afternoon	Guten Tag
Good evening	Guten Abend
Good night	Gute Nacht
I’m sorry	Tut mir leid
Excuse me…	Entschuldigen Sie
How are you?	Wie geht’s?
I’m fine thanks. And you?	Mir geht es gut , danke, und dir/Ihnen?
What is your name	Wie heisst du? Wie heissen Sie?
My name is	Ich heisse
Do you speak English	Sprechen Sie Englisch?
I don’t understand	Ich verstehe nicht
Please speak more slowly	Können Sie bitte langsamer sprechen
Thank you	Danke schön
Where is the toilet?	Wo ist die Toilette?
Please call me a taxi	Bitte rufen Sie mir ein Taxi
How do I get to….?	Wie komme ich zum/zur…..?
A beer/two beers, please	Ein Bier/zwei Bier bitte
A glass of red/white wine please	Ein Glas Rot/Weisswein bitte
The menu, please	Die Speisekarte, bitte
Is there a local speciality?	Gibt es eine Spezialität aus dieser Gegend?
I’m Vegetarian	Ich bin Vegetarier
It was delicious	Es war hervorragend
The bill, please	Die Rechnung, bitte
I have a headache	Ich habe Kopfschmerzen
I have a sore throat	Ich habe Halsschmerzen
My stomach hurts	Ich habe Magenschmerzen
I’m allergic to	Ich bin allergisch gegen
I need a doctor who speaks English	Gibt es einen Arzt, der Englisch spricht?

What’s included?

• Access to all the livestreamed talks
• Video library of the recorded talks during and after the event
• Facility to submit questions

Please note that only on-site participants are able to submit abstracts and participate in the poster sessions.

Event platform

We are using an event platform for this conference. More information about the platform will be shared ahead of the conference.

Guidelines

• Do not broadcast the conference to unregistered participants.
• You are encouraged to tweet and post about the event. Tweet unless the speaker specifically says otherwise, but be mindful of unpublished data. 
• Please do not capture, transmit or redistribute data presented at the meeting.

Additional information can be found in our Code of Conduct.

Health and well-being

It is important to stay healthy and move around, especially when you are attending an event virtually. We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event.

How to ask questions

Please use the Q&A function in the event platform.

If you have any other questions, you can go to the Help Desk in the event platform. Click on ‘more’ on the top menu and click Help Desk. 

Time zone

The programme is planned based on the Europe/Berlin time zone, unless otherwise stated. Please take your time zone into consideration when planning your attendance.

Please find additional information including FAQs, terms and conditions, COVID-19 safety policy and travelling to EMBL on our Information for Participants page.

COVID-19 information for on-site events at EMBL Heidelberg can be found in our COVID-19 FAQs.