Defining and defeating metastasis

Time	Speaker
12:00 – 13:30	Registration and Lunch
13:30 – 13:45	Opening remarks by scientific organisers
13:45 – 14:30	Keynote lecture: Microenvironmental Regulation of Metastasis Johanna Joyce – University of Lausanne, Ludwig Institute for Cancer Research, Switzerland
	Session 1 Chair: Eduard Batlle – Institute for Research in Biomedicine, Spain
14:30 – 15:00	Dormancy and outbreak of metastasis initiating cells Joan Massagué – Memorial Sloan Kettering Cancer Center, USA
15:00 – 15:15	Zeb1 expression in CAFs promotes distant metastasis in PDAC Isabell Armstark – Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
15:15 – 15:30	Identification of regulators of CRC metastasis via in vitro and in vivo CRISPR screens in an organoid-based CRC mouse model M. Andres Blanco – University of Pennsylvania, USA AVAILABLE ON DEMAND AFTER LIVE STREAM
15:30 – 16:15	Coffee break and meet the speakers in ATC Foyer
16:15 – 16:45	Biology and Vulnerabilities of Circulating Tumor Cells Nicola Aceto – ETH Zürich, Switzerland AVAILABLE ON DEMAND AFTER LIVE STREAM
16:45 – 17:00	Eosinophils and adaptive immune cells cooperate to enhance response to immune checkpoint blockade in breast cancer Olga Blomberg – Netherlands Cancer Institute, The Netherlands
17:00 – 17:15	Cell viscoelasticity orchestrates intravascular and early steps of metastasis Valentin Gensbittel – INSERM U1109, CRBS, Tumor Biomechanics, Université de Strasbourg, France AVAILABLE ON DEMAND AFTER LIVE STREAM
17:15 – 17:45	Modelling metastasis in the lungs and liver Erik Sahai – The Francis Crick Institute, UK
17:45 – 18:15	Pre-dinner drinks
18:15 – 19:45	Dinner in Canteen
19:45 – 21:00	Social event: Science Pub Quiz
19:45- 21:30	After Dinner Drinks in the ATC Foyer

Time	Speaker
	Session 2 Chair: Erik Sahai – The Francis Crick Institute, UK
09:00 – 09:30	Characterizing the metastatic seeding clone in lung cancer evolution Nicholas McGranahan – University College London, UK
09:30 – 09:45	Quiescence-inducing 3D-engineered matrix uncovers drug protective signaling pathway of dormant cancer cells Amaia Cipitria – Biodonostia Health Research Institute, Spain
09:45 – 10:00	Reactivation of embryonic programs in tissue damage and cancer Hassan Fazilaty – University of Zurich, Switzerland AVAILABLE ON DEMAND AFTER LIVE STREAM
10:00 – 10:15	The NALCN channel regulates metastasis and non-malignant cell dissemination Eric Rahrmann – University of Cambridge, UK AVAILABLE ON DEMAND AFTER LIVE STREAM
10:15 – 10:45	Coffee break and meet the speakers in ATC Foyer
10:45 – 11:00	Mitochondrial RNA modifications: from metabolism to metastasis Sylvain Delaunay – German Cancer Research Center (DKFZ), Germany AVAILABLE ON DEMAND AFTER LIVE STREAM
11:00 – 11:15	PAK2 dependency of mesenchymal colorectal cancer cells can be exploited to prevent tumour growth and metastasis Patricia Gomez Barila – Amsterdam UMC, The Netherlands AVAILABLE ON DEMAND AFTER LIVE STREAM
11:15 – 11:45	Cellular strategies and molecular mechanisms driving breast cancer metastasis Andrew Ewald – Johns Hopkins University School of Medicine, USA AVAILABLE ON DEMAND AFTER LIVE STREAM
11:45 – 12:00	Flash talks (2 minutes / 1 slide per talk) #51 Natasja Costermans – #59 Kathrin Fuchs – #73 Maria Peiris Pages – #81 Saba Sameri
12:00 – 13:30	Lunch
12:30 – 13:30	Panel discussion session: Publishing science – new challenges, new opportunities Panelist: Andrew Ewald – Johns Hopkins University School of Medicine, USA Daniel Klimmeck – The EMBO Journal, Germany Joan Massagué – Memorial Sloan Kettering Cancer Center, USA Lise Roth – EMBO Molecular Medicine, Germany
13:30 – 15:00	Poster Session 1 (odd numbers)
15:00 – 15:45	Coffee break and meet the speakers in ATC Foyer
	Session 3 Chair: Adrienne Boire – Memorial Sloan Kettering Cancer Center, USA
15:45 – 16:15	Tumor-environment interactions during pancreatic cancer metastasis Scott Lowe – Memorial Sloan Kettering Cancer Center, USA AVAILABLE ON DEMAND AFTER LIVE STREAM
16:15 – 16:45	Cell migration and invasion in the pancreatic cancer microenvironment Laura Machesky – Cancer Research UK Beatson Institute, UK AVAILABLE ON DEMAND AFTER LIVE STREAM
16:45 – 17:00	Vascular aging limits metastasis Ashik Ahmed Abdul Pari – German Cancer Research Center (DKFZ), Germany
17:00 – 17:30	Role of Air Pollution in Lung Cancer Initiation: Revisiting Tumour Promoters Charles Swanton – The Francis Crick Institute, UK
17:30	Free evening

Time	Speaker
	Session 4 Chair: Thomas Brabletz – Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
09:00 – 09:30	NoStem cells, immune evasion and metastasis in colorectal cancer Eduard Batlle – Institute for Research in Biomedicine, Spain
09:30 – 09:45	Liver colonization by colorectal cancer metastases requires YAP-controlled plasticity at the micrometastatic stage Maria C. Heinz – University Medical Center Utrecht, The Netherlands AVAILABLE ON DEMAND AFTER LIVE STREAM
09:45 – 10:00	Atrx loss induces a hybrid-EMT phenotype, tumour invasion and metastasis Kevin Myant – Edinburgh University, United Kingdom AVAILABLE ON DEMAND AFTER LIVE STREAM
10:00 – 10:30	Towards rational combination therapies: Understanding tumor evolution during therapy response and resistance Anna Obenauf – Research Institute of Molecular Pathology (IMP), Austria
10:30 – 11:00	Coffee break and meet the speakers in ATC Foyer
11:00 – 11:15	The Curated Cancer Cell Atlas enables a comprehensive characterisation of the transcriptomic processes underlying metastasis Michael Tyler – Weizmann Institute of Science, Israel AVAILABLE ON DEMAND AFTER LIVE STREAM
11:15 – 11:30	The expression of L1CAM in metastasis-initiating cells of lung adenocarcinoma Park Jin Suk – Memorial Sloan Kettering Cancer Center, United States of America
11:30 – 12:00	Rewiring brain response to metastasis into a source of therapeutic resistance Manuel Valiente – Spanish National Cancer Research Center (CNIO) AVAILABLE ON DEMAND AFTER LIVE STREAM
12:00 – 13:30	Lunch
	Session 5 Chair: Frederic J. de Sauvage – Genentech, USA
13:30 – 14:00	Chromosomal instability as a driver of cancer metastasis Samuel F Bakhoum – Memorial Sloan Kettering Cancer Center, USA AVAILABLE ON DEMAND AFTER LIVE STREAM
14:00 – 14:15	Metastatic niche-derived angiocrine Wnt ligands exploit susceptible methylation states to instruct tumour dormancy Moritz Jakab – German Cancer Research Center, Germany AVAILABLE ON DEMAND AFTER LIVE STREAM
14:15 – 14:30	Distinct Contributions of Partial and Full EMT to Breast Cancer Malignancy Nami Sugiyama (Matsuda) – University of Basel, Switzerland AVAILABLE ON DEMAND AFTER LIVE STREAM
14:30 – 15:00	Genetic and spatial properties of metastasising populations Samra Turajlic – The Francis Crick Institute, UK AVAILABLE ON DEMAND AFTER LIVE STREAM
15:00 – 15:45	Coffee break and meet the speakers in ATC Foyer
15:45 – 16:00	Transcription factor NKX2-1 drives serine/glycine synthesis addiction in cancer Elien Heylen – KU Leuven, Belgium AVAILABLE ON DEMAND AFTER LIVE STREAM
16:00 – 16:15	Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells Naël Osmani – INSERM U1109, CRBS, Tumor Biomechanics, Université de Strasbourg, France AVAILABLE ON DEMAND AFTER LIVE STREAM
16:15 – 16:30	Recording metastatic lineage histories at single-cell resolution Kamen Simeonov – University of Pennsylvania, United States of America
16:30 – 17:00	Cellular plasticity in cancer: driving force and therapeutic target Thomas Brabletz – Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany AVAILABLE ON DEMAND AFTER LIVE STREAM
17:00 – 17:15	Flash talks (2 minutes / 1 slide per talk) #42 Petr Benes – #46 Amani Bouzidi – #48 Michael Brügger – #56 Louise Dutton – #82 Michela Serresi
17:15 – 19:15	Poster Session 2 (even numbers)
19:15 – 21:45	BBQ & Live Music (Lazy Fur)

Time	Speaker
	Session 6 Chair: Laura Machesky – Cancer Research UK Beatson Institute, UK
09:00 – 09:30	Metastatic cancer cells outcompete for scarce metabolic resources in the leptomeninges Adrienne Boire – Memorial Sloan Kettering Cancer Center, USA AVAILABLE ON DEMAND AFTER LIVE STREAM
09:30 – 09:45	The H3K36 demethylase KDM2A is a multifunctional regulator of non-small cell lung cancer metastasis Carolyn Kravitz – Yale University, USA AVAILABLE ON DEMAND AFTER LIVE STREAM
09:45 – 10:00	Novel metabolic vulnerabilities in cancer metastasis Alpaslan Tasdogan – University Hospital Essen, Germany
10:00 – 10:15	Stromal Oncostatin M cytokine signalling promotes breast cancer progression and metastasis by reprogramming the tumour microenvironment María Muñoz Caffarel – Biodonostia Health Research Institute, Spain AVAILABLE ON DEMAND AFTER LIVE STREAM
10:15 – 10:45	Coffee break and meet the speakers in ATC Foyer
10:45 – 11:15	Insights into cancer metastasis from the PEACE study Mariam Jamal Hanjani – UCL London, UK
11:15 – 12:00	Keynote lecture: Targeting stem cells and the Wnt pathway in colorectal cancer Frederic J. de Sauvage – Genentech, USA
12:00 – 12:15	Closing remarks and Poster prize
12:15 – 12:45	Packed lunch and Departure

Financial assistance

Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants. Availability is limited to participants attending on-site events in Heidelberg and will be indicated during the abstract or motivation letter submission process.

Your place in the meeting is only confirmed by paying the registration fee, which is mandatory even when receiving a fee waiver.

Registration fee waiver

The fee waiver will cover the registration sum that you have paid to attend the course or conference.

Travel grant

The travel grant will cover the cost of travel (airfare, train, bus, taxi, accommodation, visa, and/or registration fees*) and is provided up to specified caps which are normally as follows:

– up to €400 for participants travelling to an EMBL Course, EMBL Conference or EMBO|EMBL Symposium from within Europe.
– up to €1000 for participants travelling to an EMBL Course, EMBL Conference or EMBO|EMBL Symposium from outside Europe.
– up to €500 for any participant travelling to an EMBO Practical Course or EMBO Workshop.
– up to €1000 for any participant working in Chile, India, Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop.

*Registration fees are only covered for EMBO Practical Courses or EMBO Workshops

The organisers may reduce the grant cap to accommodate more participants. Recipients will be notified of their travel cap amount when they are informed of the outcome of their application. Original receipts must be provided with your signature for all costs incurred within two months of completion of travel. Scanned copies cannot be accepted.

Application

You may apply for financial assistance when submitting your abstract for conferences. In your application, you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.

Selection

The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process. Results will be announced approximately 6-8 weeks before the event start date, however for some events this may be delayed. Selection results do not impact your admission to the meeting. Selection is based on your current work or study location, the reasons for needing financial support and the impact this event will have on your career.

Reimbursement

Costs will be reimbursed after the meeting only once a reimbursement form and original receipts (from travel costs) have been received.

Further details

See our list of external funding opportunities and information on attending a conference as an event reporter.

For further information about financial assistance please refer to the FAQ page.

Accommodation is not included in the conference registration fee.

As further changes in our events are possible due to COVID-19, you should book flights, trains and hotels with flexible options and favourable cancellation conditions.

The hotels below have rooms on hold for participants until Wednesday 18 May 2022, in some cases at special rates. Please quote the booking code EES22-07 and confirm the exact price of the room with the hotel directly.

Hotel Anlage	Hotel ibis Heidelberg	Premier Inn Heidelberg City
Hotel Bayrischer Hof	ISG Hotel	Staycity Aparthotel Heidelberg
B&B Hotel	Leonardo Hotel Heidelberg City Centre	Steffi’s Hostel Heidelberg
Exzellenz Hotel & Boarding House	Hotel Monpti	Hotel Vier Jahreszeiten Heidelberg
Hotel Holländer Hof

Conference shuttle buses

Conference shuttle buses are free of charge for participants, and depart from designated bus stops near the hotels to EMBL and back, mornings and evenings.

The bus stops for this conference are:

Download the bus schedule

• StayCity Hotel (close to B&B Hotel and Main Train Station)
• Heidelberg HBF (EMBL bus stop)
• Premier, Kurfürsten-Anlage 23
• Leonardo Hotel (Bergheimer Str.)
• Neckarmünzplatz
• Peterskirche
• ISG Hotel

View Conference shuttle bus stops and hotels in a larger map. Please note that not every bus stop will be used for every event.

Further details

Address: EMBL, Meyerhofstraße 1, 69117 Heidelberg, Germany. For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue. For information about accommodation and local transportation please refer to the FAQ page.

Catering

All meals and coffee breaks are included in the registration fee. Our catering staff will prepare a wide variety of vegetarian meals, meat and fish dishes, soups, pasta, fresh fruit and vegetables, as well as a variety of desserts.

Please wear your badge at all times when serving yourself.

No food or drinks are allowed in the auditorium.

Charging lockers

There are lockers available next to the stairs leading down into the Auditorium. You will find some of those equipped with sockets to charge your smartphone/tablet etc.

Electricity and charging station

In most places the electricity is 220 volts AC (50 cycles). An adaptor and a plug that fits the German socket may be needed for your appliances/laptop (i.e. American, Japanese, etc.). A USB charging station for electronic devices is available at the registration desk.

EMBL merchandise

EMBL Merchandise is available on Mon – Thu (9 am – 12 pm). If you are interested in purchasing an EMBL souvenir (products presented in the glass display in the registration area), please ask at the registration desk for more information.

Health and safety notes

Please read EMBL’s COVID-19 terms and conditions for events.
Do not smoke in any EMBL building.
Eating and drinking is prohibited in the Auditorium and all laboratories.
Do not enter any restricted areas or the laboratories unless instructed to do so.

If first aid is required …

• The first aid room is located next to the ATC Registration Desk (room 10- 205).
• Dial the Emergency number 222 from any EMBL internal phone only.
• Where is the accident? What happened? How many injured?
• Emergency number 06221-387 7821 from mobile phones.
• Please report all accidents to the conference officer at the registration desk.

In case of fire …

• Press the nearest fire alarm button or the Emergency number 222 from any internal phone.
• A loud fire alarm will go off if an evacuation is required. On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points
• Do not use the lifts.

Beyond first aid…

Please remember to bring your own medication, if needed, to the conference. Note that the next pharmacy is a 4-minute drive from the EMBL, but for many medications you will be required to see a doctor to get a prescription.

Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg. In any case, the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary.

Internet

Wi-Fi is available everywhere on the premises (no password required), just log on to ATC-Guest. The eduroam network (secure, world-wide roaming access service developed for the international research and education community) is also available.

Lost and found

‘’Lost and Found’’ are kept at the registration desk until the end of the conference.

Luggage

There are lockers available on-site to store your luggage, which require a 2 EURO coin to operate. There is another luggage room on level E0, which is free to use but remains unlocked during the conference.

Nursing room

There is a nursing room available in the ATC Rooftop Lounge on level A29.

Photography

During the conference an EMBL Photographer may be taking photographs. If you would not like to appear in these, please inform the photographer or a member of the Course and Conference Office.

Printing

We can help printing your boarding passes/train ticket. Please send it to events@embl.de and collect your print-outs at the registration desk.

Room for prayer, yoga and meditation

There is a room for prayer, mediation and yoga located on level E0 behind the Auditorium. Please be respectful of other participants using the room.

Sightseeing

A variety of activities in Heidelberg can be found on this website: www.heidelberg-marketing.com

Travel to and from the venue

During the event we provide conference shuttle busses to and from EMBL. In addition, there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time. Information on the conference shuttle busses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page.

Useful German expressions

English	German
Hello	Hallo
Goodbye	Auf Wiedersehen
Good morning	Guten Morgen
Good afternoon	Guten Tag
Good evening	Guten Abend
Good night	Gute Nacht
I’m sorry	Tut mir leid
Excuse me…	Entschuldigen Sie
How are you?	Wie geht’s?
I’m fine thanks. And you?	Mir geht es gut , danke, und dir/Ihnen?
What is your name	Wie heisst du? Wie heissen Sie?
My name is	Ich heisse
Do you speak English	Sprechen Sie Englisch?
I don’t understand	Ich verstehe nicht
Please speak more slowly	Können Sie bitte langsamer sprechen
Thank you	Danke schön
Where is the toilet?	Wo ist die Toilette?
Please call me a taxi	Bitte rufen Sie mir ein Taxi
How do I get to….?	Wie komme ich zum/zur…..?
A beer/two beers, please	Ein Bier/zwei Bier bitte
A glass of red/white wine please	Ein Glas Rot/Weisswein bitte
The menu, please	Die Speisekarte, bitte
Is there a local speciality?	Gibt es eine Spezialität aus dieser Gegend?
I’m Vegetarian	Ich bin Vegetarier
It was delicious	Es war hervorragend
The bill, please	Die Rechnung, bitte
I have a headache	Ich habe Kopfschmerzen
I have a sore throat	Ich habe Halsschmerzen
My stomach hurts	Ich habe Magenschmerzen
I’m allergic to	Ich bin allergisch gegen
I need a doctor who speaks English	Gibt es einen Arzt, der Englisch spricht?

What’s included?

• Access to all the livestreamed talks
• Video library of the recorded talks during and after the event
• Facility to submit questions

Please note that only on-site participants are able to submit abstracts and participate in the poster sessions.

Event platform

We are using an event platform for this conference. More information about the platform will be shared ahead of the conference.

Guidelines

• Do not broadcast the conference to unregistered participants.
• You are encouraged to tweet and post about the event. Tweet unless the speaker specifically says otherwise, but be mindful of unpublished data. 
• Please do not capture, transmit or redistribute data presented at the meeting.

Additional information can be found in our Code of Conduct.

Health and well-being

It is important to stay healthy and move around, especially when you are attending an event virtually. We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event.

How to ask questions

Please use the Q&A function in the event platform.

If you have any other questions, you can go to the Help Desk in the event platform. Click on ‘more’ on the top menu and click Help Desk. 

Time zone

The programme is planned based on the Europe/Berlin time zone, unless otherwise stated. Please take your time zone into consideration when planning your attendance.

Please find additional information including FAQs, terms and conditions, COVID-19 safety policy and travelling to EMBL on our Information for Participants page.

COVID-19 information for onsite events at EMBL Heidelberg can be found in our COVID-19 FAQs.