Lisa Manning
Syracuse University
USA
EMBO | EMBL Symposium
This conference will take place at EMBL Heidelberg, with the option to attend virtually. Proof of COVID-19 vaccination or recovery is required for on-site attendance. Please see EMBL’s COVID-19 safety policy for on-site events.
Environmental mechanics impact the behaviour of cells, which in turn modify their surroundings. These bi-directional cell-tissue interactions have important consequences for gene expression, cell fate and function and give rise to transient and permanent tissue modifications. These processes are key for immunity and homeostasis, but also play a role in pathological processes as they are critical for fibrosis, inflammation and cancer metastasis.
This symposium will focus on the interplay of cells with their environment and will bring together clinicians, cell biologists and material scientists interested in mechanobiology at the molecular, cellular and tissue level to approach its role in human physiology and pathology from different perspectives and scales. We will specifically discuss new technological approaches from the field of material sciences that enable the study of mechanobiology in vivo and in vitro, keeping in mind their potential use in a more applied context.
National University of Singapore
Singapore
EMBL Heidelberg
Germany
Inserm
France
Max Planck Institute for the Science of Light
Germany
Institute of Science and Technology Austria
Austria
Collège de France and Institut de Biologie du Développement de Marseille
France
National University of Singapore
Singapore
Institut Curie
France
University College London
UK
University of Cambridge
UK
Ludwig Maximilian University of Munich
Germany
Institute for Bioengineering of Catalonia and Universitat de Barcelona
Spain
Centre for Genomic Regulation, Barcelona
Spain
The Rockefeller University
USA
University of California, Santa Barbara
USA
Max Planck Institute of Molecular Cell Biology and Genetics
Germany
Intitut Curie
France
Max Planck Institute for Molecular Biomedicine and University of Helsinki
Finland
EMBL Heidelberg
Germany
Institute of Science and Technology
Austria
Friedrich Miescher Institute for Biomedical Research
Switzerland
Institute of Science and Technology Austria
Austria
Institute for Bioengineering of Catalonia
Spain
EMBL Heidelberg
Germany
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Please find the poster listing here.
Time | Speaker |
---|---|
11:30-13:00 | Registration and Lunch |
13:00-13:15 | Opening remarks by scientific organisers |
13:15-14:15 | Keynote Lecture 2: Dynamic coupling of signalling, force generation and tissue remodeling during neural tube closure Ed Munro – University of Chicago, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
14:15-17:15 | Session 1 Session chairs: Alba Diz-Muñoz and Carl-Philipp Heisenberg |
14:15-14:40 | Transducing – and shielding – mechanical signals from integrins to the nucleus Pere Roca-Cusachs – Institute for Bioengineering of Catalonia and Universitat de Barcelona, Spain AVAILABLE ON DEMAND AFTER LIVE STREAM |
14:40-14:55 | Cytoplasmic forces functionally reorganize nuclear condensates in oocytes Adel Al Jord – Collège de France, France AVAILABLE ON DEMAND AFTER LIVE STREAM |
14:55-15:40 | Coffee Break and Meet the speakers with Ed Munro, Pere Roca-Cusachs and Adel Al Jord, Nimesh Chahare |
15:40-16:05 | Physics of living matter: From molecule to embryo Sebastian Streichan – University of California, Santa Barbara, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
16:05-16:20 | Synthetic epithelial morphogenesis through controlled stretching and buckling Nimesh Chahare – Institute for Bioengineering of Catalonia, Spain AVAILABLE ON DEMAND AFTER LIVE STREAM |
16:20-16:45 | Mechanical cell cooperation promotes apoptotic cell clearance in the early embryo Verena Ruprecht – Centre for Genomic Regulation, Spain LIVE STREAM ONLY |
16:45-17:00 | Focal adhesion signalling mainly regulates the mechano-responsive dynamics of Yes-associated protein Windie Hoefs – Francis Crick Institute, UK AVAILABLE ON DEMAND AFTER LIVE STREAM |
17:00-17:15 | Loss of nuclear volume under confinement Alice Williart – Institut Curie, France AVAILABLE ON DEMAND AFTER LIVE STREAM |
17:15-18:15 | Pre-dinner drinks |
18:15-19:45 | Dinner in the Canteen |
19:45-21:30 | After dinner drinks |
Time | Speaker |
---|---|
09:15 – 12:00 | Session 2 Session chairs: Rong Li and Xavier Trepat |
09:15-09:40 | High-throughput mechanical phenotyping for in-vitro diagnostics Jochen Guck – Max Planck Institute for the Science of Light, Germany AVAILABLE ON DEMAND AFTER LIVE STREAM |
09:40-09:55 | Programming multicellular interactions and organization using synthetic cell adhesion molecules Adam Stevens – University of California, San Francisco, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
09:55-10:10 | Topological attractors triggered by cell-cell adhesion properties Bernat Corominas-Murtra – University of Graz, Austria AVAILABLE ON DEMAND AFTER LIVE STREAM |
10:10-10:40 | Coffee Break and Meet the Speakers with Verena Ruprecht, Sebastian Streichan and Nimesh Chahare, Bernat Corominas-Murtra, Windie Hoefs, Raphael Reuten, Alice Williart |
10:40-11:05 | Dynamics and mechanics of cell shape during cellular state changes Ewa Paluch – University of Cambridge, UK AVAILABLE ON DEMAND AFTER LIVE STREAM |
11:05-11:20 | Membrane-to-Cortex Attachment regulates cortical mechanics Leanne Strauss – EMBL Heidelberg, Germany AVAILABLE ON DEMAND AFTER LIVE STREAM |
11:20-11:35 | Mechanochemical rules for membrane-reshaping filaments Billie Meadowcroft – Institute of Science and Technology Austria, Austria AVAILABLE ON DEMAND AFTER LIVE STREAM |
11:35-12:00 | Cephalic furrow in Drosophila – what is it good for? Pavel Tomancak – Max Planck Institute of Molecular Cell Biology and Genetics, Germany AVAILABLE ON DEMAND AFTER LIVE STREAM |
12:00-13:30 | Lunch |
12:30 – 13:30 | Workshop: Presentation of the ERC Funding Schemes Moderator: Nadia El Mjiyad – European Research Council, Belgium Presenters: Danijela Vignjevic, Institue Curie. France Edouard Hannezo, Institute of Science and Technology Austria, Austria LIVE STREAM ONLY |
13:30-16:25 | Session 3 Session chairs: Pere Roca-Cusachs and Anđela Šarić |
13:30-13:55 | Deciphering the role of mechanics in a ‘post-molecular’ conception of vertebrate organogenesis Amy Shyer – The Rockefeller University, USA LIVE STREAM ONLY |
13:55-14:10 | Symmetry breaking in intestinal organoid formation Cornelia Schwayer – Friedrich Miescher Institute for Biomedical Research, Switzerland LIVE STREAM ONLY |
14:10-14:25 | Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance Sirio Dupont – University of Padua, Italy AVAILABLE ON DEMAND AFTER LIVE STREAM |
14:25 – 14:50 | Biochemical, mechanical and geometrical information in morphogenesis Thomas Lecuit – Collège de France and Institut de Biologie du Développement de Marseille, France AVAILABLE ON DEMAND AFTER LIVE STREAM |
14:50-15:35 | Coffee Break and Meet the Speakers with Thomas Lecuit, Ewa Paluch, Amy Shyer, Pavel Tomancak and Sirio Dupont, Billie Meadowcroft, Cornelia Schwayer, Leanne Strauss |
15:35-15:50 | A push-pull mechanism of microtubule-spectrin mechanics controls apical cell shape homeostasis during epithelial folding Yu-Chiun Wang – RIKEN Center for Biosystems Dynamics Research, Japan AVAILABLE ON DEMAND AFTER LIVE STREAM |
15:50-16:05 | Mechanical control of mammalian ovarian folliculogenesis Chii Jou Chan – National University of Singapore, Singapore AVAILABLE ON DEMAND AFTER LIVE STREAM |
16:05-16:30 | Nuclear mechanotransduction: regulation of cell fate and integrity Sara Wickström -Max Planck Institute for Molecular Biomedicine and University of Helsinki, Finland LIVE STREAM ONLY |
16:30-17:00 | Flash talks (2 minutes / 1 slide per talk) 57 – Esther Comellas, #63 – John Robert Davis, #65 – Lucas Dent, #69 – Julia Eckert, #75 – María García, #91 – Cécile Jacques, #95 – Deqing Kong, #113 – Saranne J. Mitchell, #119 – Fabrizio Andrea Pennacchio, #127 – Marta Sampietro, #131 – Jana Sipkova, #145 – Mehmet Can Ucar, #147 – Clementine Villeneuve, #151 – Qiutan Yang |
17:00-19:00 | Poster Session 1 (odd) with beer and snacks |
Free evening |
Time | Speaker |
---|---|
09:15-12:00 | Session 4 Session chairs: Verena Ruprecht and Xavier Trepat |
09:15-09:40 | The impact of chronic osmotic stress on mammalian cell growth and genome stability Rong Li – National University of Singapore, Singapore LIVE STREAM ONLY |
09:40-09:55 | Morphogen gradient orchestrates pattern-preserving morphogenesis via motility-driven (un)jamming Diana Pinheiro – Institute of Science and Technology Austria, Austria LIVE STREAM ONLY |
09:55-10:10 | Metastasis predisposition basement membrane mechanics Raphael Reuten – University of Freiburg, Germany AVAILABLE ON DEMAND AFTER LIVE STREAM |
10:10-10:40 | Coffee Break with Sara Wickström, Rong Li and Yu-Chiun Wang, Chii Jou Chan, Diana Pinheiro, Raphael Reuten |
10:40-11:05 | Mechanical and signalling interactions between microtubules and integrin adhesions Alexander Bershadsky – National University of Singapore, Singapore AVAILABLE ON DEMAND AFTER LIVE STREAM |
11:05-11:20 | Mechanical coupling of supracellular stress amplification and tissue fluidization Stig Ove Bøe – Oslo University Hospital, Norway AVAILABLE ON DEMAND AFTER LIVE STREAM |
11:20-11:35 | Plectin-mediated cytoskeletal crosstalk controls tensional homeostasis and cell cohesion in epithelial sheets Magdalena Prechova – Institute of Molecular Genetics of the Czech Academy of Sciences, Czech Republic AVAILABLE ON DEMAND AFTER LIVE STREAM |
11:35-12:00 | Mechanics of blastocyst morphogenesis Jean-Leon Maitre – Institut Curie, France AVAILABLE ON DEMAND AFTER LIVE STREAM |
12:00-13:30 | Lunch |
13:30-16:25 | Session 5 Session chairs: Thomas Lecuit and Prisca Liberali |
13:30-13:55 | Cancer-associated fibroblasts form contractile capsules that actively compress cancer cells and modulate mechanotransduction Danijela Vignjevic – Institut Curie, France LIVE STREAM ONLY |
13:55-14:10 | Planar-polarized myosin cables enable cell field positioning during Drosophila germband retraction Sudeepa Nandi – Tata Institute of Fundamental Research, India LIVE STREAM ONLY |
14:10-14:25 | Pulling or Pushing? Revisiting the mechanics of C. elegans gonad morphogenesis Priti Agarwal – Tel Aviv University, Israel LIVE STREAM ONLY |
14:25 – 14:50 | Mechanobiology of immune responses Joerg Renkawitz – Ludwig Maximilian University of Munich, Germany AVAILABLE ON DEMAND AFTER LIVE STREAM |
14:50-15:35 | Coffee Break and Meet the Speakers‘ with Alexander Bershadsky, Joerg Renkawitz, Danijela Vignjevic and Priti Agarwal, Sudeepa Nandi, Magdalena Prechova, Stig Ove Bøe |
15:35-15:50 | Contact percolation promotes flocking migration and a pro-inflammatory cytosolic DNA response in epithelial tissues Leonardo Barzaghi – IFOM, the FIRC Institute of Molecular Oncology, Italy AVAILABLE ON DEMAND AFTER LIVE STREAM |
15:50-16:05 | Piezo1 activates non-canonical EGFR signalling Carlos Pardo-Pastor – King’s College London, UK AVAILABLE ON DEMAND AFTER LIVE STREAM |
16:05-16:30 | Theoretical mechanobiology in multicellular systems Anna Erzberger – EMBL Heidelberg, Germany AVAILABLE ON DEMAND AFTER LIVE STREAM |
16:30-17:00 | Flash talks (2 minutes / 1 slide per talk) 48 – Shiri Avivi Kela, #54 – David Brückner, #62 – Sarah D’Annunzio, #82 – Hanna-Maria Häkkinen, #92 – Konstantinos Kalyviotis, #102 – Allison Lewis, #116 – Marianne Montemurro, #128 – Andreas Schoenit, #140 – Jakub Sumbal, #142 – Stéphanie Torrino, #150 – Harry Warner |
17:00-19:00 | Poster Session 2 (even) with beer and snacks |
19:00 – 22:00 | BBQ with live music from Lazy Fur |
Time | Speaker |
---|---|
09:15-12:45 | Session 6 Session chairs: Alba Diz-Muñoz and Pavel Tomancak |
09:15-09:40 | Multiscale interplay between cytoskeletal mechanics, cellular fate and tissue geometry Edouard Hannezo – Institute of Science and Technology Austria, Austria AVAILABLE ON DEMAND AFTER LIVE STREAM |
09:40-09:55 | Morphodynamics of human brain organoid patterning Akanksha Jain – ETH Zürich, Switzerland AVAILABLE ON DEMAND AFTER LIVE STREAM |
09:55-10:20 | Coping with Mechanical Stress: Tissue dynamics during development and repair Yanlan Mao – University College London, UK AVAILABLE ON DEMAND AFTER LIVE STREAM |
10:20-10:50 | Coffee break and Meet the Speakers with Anna Erzberger, Edouard Hannezo, Yanlan Mao and Leonardo Barzaghi, Carlos Pardo-Pastor, Akanksha Jain, Yekaterina Miroshinikova |
10:50-11:15 | Intravascular forces shape tumor metastasis Jacky G. Goetz – Inserm, France LIVE STREAM ONLY |
11:15-11:30 | Nulear deformation modulates stem cell fate by altering chromatin accessibility and gene expression Yekaterina Miroshinikova – NIH, USA LIVE STREAM ONLY |
11:30-11:45 | Spatial coordination between trophoblast migration and embryo growth determines peri-implantation mouse development Vladyslav Bondarenko – EMBL Heidelberg, Germany and Hubrecht Institute, The Netherlands AVAILABLE ON DEMAND AFTER LIVE STREAM |
11:45-12:45 | Keynote lecture 2: Predicting onset and arrest of tissue remodeling in epithelial layers Lisa Manning – Syracuse University, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
12:45 – 13:00 | Closing Remarks and Poster Prize |
13:00 – 13:15 | Packed Lunch and Departure |
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On-site Academia | €700 |
On-site PhD Student | €600 |
On-site Industry | €900 |
Virtual Academia | €175 |
Virtual PhD Student | €125 |
Virtual Industry | €225 |
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Bronze sponsors
Media partners
Development, a The Company of Biologists journal
Disease Models & Mechanisms, The Company of Biologists Journal
Journal of Cell Science, a The Company of Biologists journal
EMBO reports, an EMBO Press journal
Open Biology, a Royal Society journal
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EMBO | EMBL Symposia promote scientific communication and collaboration in the European research area. They provide scientists with a platform to discuss and exchange ideas on forward-looking topics and new developments in the life sciences.
Topics emphasise upcoming developments and the interdisciplinary nature of related fields. Jointly funded and organised by EMBO and EMBL – and complementary to their respective courses, workshops, and conference programmes – the symposia promote scientific communication and collaboration.
All symposia are held in the EMBL Advanced Training Centre (ATC) in Heidelberg, Germany, or virtually.
Date: 15 - 18 May 2022
Location: EMBL Heidelberg and Virtual
Deadline(s):
Abstract submission: Closed
Registration (On-site): Closed
Registration (Virtual): Closed
Organisers:
Contact: Nathalie Sneider