From functional genomics to systems biology

Time (Europe/Berlin)	Speaker
12:15 – 13:30	Registration and light refreshments
13:30 – 13:45	Opening remarks by Prisca Liberali and Arnaud Krebs
13:45 – 18:00	Session 1 – From molecules to cells Chairs: Mounia Lagha – The Institute of Molecular Genetics of Montpellier, France and Dan Lu – Harvard Medical School, USA
13:45 – 14:10	High-throughput discovery and systematic sequence characterization of human transcriptional regulators Lacra Bintu – Stanford University, USA
14:10 – 14:30	Deep mutational scanning of entire human protein interaction domain families Guillaume Diss – Friedrich Miescher Institute for Biomedical Research, Switzerland
14:30 – 14:55	Self-organization in intestinal organoids Prisca Liberali – Friedrich Miescher Institute for Biomedical Research, Switzerland
14:55 – 15:15	SPIDR: a novel and highly multiplexed method for mapping RNA-protein interactions to comprehensively study post-transcriptional gene expression regulation Marko Jovanovic – Columbia University, USA
15:15 – 15:40	In-cell interaction networks to understand integrated processes Juri Rappsilber – Technische Universität Berlin, Germany
15:40 – 16:10	Coffee break
16:10 – 16:35	Inspecting roles of 3D chromatin organization in transcription by multiplexed chromatin imaging Marcelo Nollmann – CNRS; INSERM, France
16:35 – 16:55	Uncovering the molecular rules of chromatin module formation Judith Kribelbauer – Swiss Federal Institute of Technology Lausanne, Switzerland
16:55 – 17:15	Genomic context and histone marks define pioneer binding to nucleosomes Luca Mariani – Brigham and Women’s Hospital; Harvard Medical School, USA
17:15 – 17:35	Single-molecule live-cell imaging shows that DNA supercoiling restricts the transcriptional bursting of neighboring eukaryotic genes Tineke Lenstra – Netherlands Cancer Institute; Oncode Institute, The Netherlands
17:35 – 18:00	Analysis of tumor ecosystems by spatial proteomics for precision medicine Bernd Bodenmiller – University of Zurich; ETH Zurich, Switzerland Recording not available
18:00 – 18:30	Available for onsite participants only Panel discussion 1: Understanding genomes – current breakthrough in the field (with pre-dinner drinks at ATC Foyer) Panellists: Lacra Bintu – Stanford University, USA Justin Crocker – EMBL Heidelberg, Germany Mounia Lagha – The Institute of Molecular Genetics of Montpellier, France Zohar Shipony – Ultima Genomics, Israel Moderated by Arnaud Krebs – EMBL Heidelberg, Germany
18:30 – 20:00	Dinner (EMBL canteen)
20:00 – 21:30	Social event: pub quiz (EMBL canteen)
21:30 – 22:30	Social event: networking drinks (ATC Rooftop Lounge)

Time (Europe/Berlin)	Speaker
09:00 – 12:10	Session 2 – From molecules to cells (continued) Chairs: Judith Kribelbauer – Swiss Federal Institute of Technology Lausanne, Switzerland and Guillaume Diss – Friedrich Miescher Institute for Biomedical Research, Switzerland
09:00 – 09:25	Biochemical activity is the default DNA state in eukaryotes Carl de Boer – University of British Columbia, Canada
09:25 – 09:45	Dynamic p53 post-translational modifications regulate cellular fates Dan Lu – Harvard Medical School, USA
09:45 – 10:05	Chromatin accessibility is a two-tier process regulated by transcription factor pioneering and enhancer activation Kaelan Brennan – Stowers Institute for Medical Research, USA
10:05 – 10:30	Elucidating mechanisms underlying coupled transcription initiation and 3’ end cleavag Athma Pai – University of Massachusetts Chan Medical School, USA
10:30 – 11:00	Coffee break
11:00 – 11:25	Understanding gene regulation using single molecule genomics Arnaud Krebs – EMBL Heidelberg, Germany
11:25 – 11:45	A race to identify the genes that support neutrophil cell migration Nathan Belliveau – University of Washington; HHMI, USA
11:45 – 12:10	Revealing promoter-enhancer communication mechanisms by high-resolution single-gene imaging Alexandros Pertsinidis – The Sloan Kettering Institute, USA Recording not available
12:10 – 13:45	Lunch
13:45 – 15:45	Poster session 1 (odd numbers) – ATC Helix A Poster listing
15:45 – 18:55	Session 3 – From cells to organs Chairs: Nathan Belliveau – University of Washington; HHMI, USA and Lacra Bintu – Stanford University, USA
15:45 – 16:10	Multimodal perception links cellular state to decision-making in single cells Lucas Pelkmans – University of Zurich, Switzerland
16:10 – 16:30	Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia Lars Velten – Center for Genomic Regulation (CRG), Spain
16:30 – 16:50	CRISPRi screen of schizophrenia risk genes elucidates the role of epigenetic regulators in neurons and progenitors Annique Claringbould – EMBL Heidelberg, Germany
16:50 – 17:15	Gene expression dynamics during the awakening of the zygotic genome Mounia Lagha – The Institute of Molecular Genetics of Montpellier, France Recording not available
17:15 – 17:45	Coffee break
17:45 – 18:10	Finding biology in microscopy images with machine learning Anna Kreshuk – EMBL Heidelberg, Germany
18:10 – 18:30	Barcode-free predictions of cell lineages from single cell transcriptome data Almut Eisele – EPFL, Switzerland Recording not available
18:30 – 18:55	Learning the rules of mRNA processing from massively parallel experiments and machine learning Georg Seelig – University of Washington, USA (Virtual speaker)
18:55 – 20:30	Dinner (EMBL canteen)

Time (Europe/Berlin)	Speaker
09:00 – 12:05	Session 4 – From cells to organs (continued) Chairs: Lars Velten – Center for Genomic Regulation (CRG), Spain and Christine Mayr – Memorial Sloan Kettering Cancer Center, USA
09:00 – 09:25	Sphingolipids control dermal fibroblast heterogeneity Giovanni D’Angelo – Swiss Federal Institute of Technology Lausanne, Switzerland
09:25 – 09:45	Applications of optimal transport theory to single-cell analyses Angela Goncalves – German Cancer Research Center (DKFZ), Germany
09:45 – 10:05	Can we accurately estimate gene regulatory networks from single-cell data? Julio Saez-Rodriguez – University of Heidelberg, Germany
10:05 – 10:35	Coffee break
10:35 – 11:00	Unraveling the tumor microenvironment using multiplexed imaging Leeat Keren – Weizmann Institute of Science, Israel Recording not available
11:00 – 11:20	RANKL-dependent ONECUT2 regulation of Enterocyte and Microfold cell differentiation in the small intestine; a multi-omics study Maria Victoria Luna Velez – Radboud University Nijmegen, The Netherlands
11:20 – 11:40	Laboratory evolution of flies to morphogen dosage via rapid maternal changes reveals predictable outcomes Justin Crocker – EMBL Heidelberg, Germany
11:40 – 12:05	Heterogeneity in tumors: evolving genomes at single-cell resolution Hugo Snippert – University Medical Center Utrecht, The Netherlands
12:05 – 13:30	Lunch Optional: walk/run together (registered participants only)
13:30 – 15:30	Poster session 2 (even numbers) – ATC Helix A Poster listing
15:30 – 18:40	Session 5 – From biological systems to disease Chairs: Frank Albert – University of Minnesota, USA and Athma Pai – University of Massachusetts Chan Medical School, USA
15:30 – 15:55	A high dimensional atlas of phosphorylation-dependent signaling Judit Villen – University of Washington, USA (Virtual speaker)
15:55 – 16:20	Functional proteomics to assess the system-scale nature of metabolism Markus Ralser – Charité Universitätsmedizin Berlin, Germany
16:20 – 16:40	ProteasomeID: quantitative mapping of proteasome interactomes and substrates for in vitro and in vivo studies Alessandro Ori – Leibniz Institute on Aging – Fritz Lipmann Institute, Germany
16:40 – 17:05	Towards a tissue specific and structurally resolved human interactome Pedro Beltrao – EMBL-EBI Hinxton, UK and ETH Zurich, Switzerland
17:05 – 17:35	Coffee break
17:35 – 17:55	Correlated light and electron microscopy volume imaging of organoid cell cultures Edoardo D Imprima – EMBL Heidelberg, Germany Recording not available
17:55 – 18:15	From regulatory landscapes to complex intercellular dependencies using the gastruloid model system Luca Braccioli – The Netherlands Cancer Institute, The Netherlands
18:15 – 18:40	Enabling discovery by in-cell structural biology Julia Mahamid – EMBL Heidelberg, Germany
18:40 – 19:10	Available for onsite participants only Panel discussion 2: From protein identification to function (with pre-dinner drinks at ATC Foyer) Panellists: Pedro Beltrao – EMBL-EBI Hinxton, UK and ETH Zurich, Switzerland Guillaume Diss – Friedrich Miescher Institute for Biomedical Research, Switzerland Marko Jovanovic – Columbia University, USA Rodrigo Villaseñor – Biomedical Center Munich, Germany Moderated by Mikhail Savitski – EMBL Heidelberg, Germany
19:10 – 21:00	Conference dinner (EMBL canteen)
21:00 – 23:00	Social evening with live DJ (ATC Rooftop Lounge)

Time (Europe/Berlin)	Speaker
09:00 – 12:30	Session 6 – From biological systems to disease (continued) Chairs: Pedro Beltrao – EMBL-EBI Hinxton, UK and ETH Zurich, Switzerland and Alessandro Ori – Leibniz Institute on Aging – Fritz Lipmann Institute, Germany
09:00 – 09:25	Deciphering gene regulatory networks and enhancer logic from single-cell multi-omics data Stein Aerts – KU Leuven, Belgium
09:25 – 09:45	Exon-resolution functional genomics uncovers critical protein regions for cellular function Thomas Gonatopoulos Pournatzis – National Cancer Institute; National Institutes of Health, USA Recording not available
09:45 – 10:05	Targeted transcription factor degradation and nascent transcriptomics reveal a new model of core transcriptional regulatory circuitry Maxim Pimkin – Dana-Farber Cancer Institute and Boston Children’s Hospital and Harvard Medical School
10:05 – 10:30	Biophysical proteomics Mikhail Savitski – EMBL Heidelberg, Germany
10:30 – 11:00	Coffee break
11:00 – 11:25	Identification of global and gene-specific regulators of alternative polyadenylation using Perturb-seq Christine Mayr – Memorial Sloan Kettering Cancer Center, USA
11:25 – 11:45	Exploring the vulnerabilities of EGFR-dependent breast cancer cells with single cell lineage-tracing Melania Franchini – University of Naples “Federico II”, Italy
11:45 – 12:05	Genetic variation in ubiquitin system genes creates complex, pathway-specific effects on proteasomal protein degradation Frank Albert – University of Minnesota, USA
12:05 – 12:30	Decoding the central dogma with single molecules Winston Timp – John Hopkins University, USA
12:30 – 12:45	Closing remarks and poster prize announcement
12:45	Packed lunch and departure
13:15	Optional: Shuttle bus to Frankfurt Airport (Terminal 1) Tickets can be purchased on-site during the conference for 25 EUR

Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants. Availability is limited to participants attending on-site events in Heidelberg and will be indicated during the abstract or motivation letter submission process.

Your place in the meeting is only confirmed by paying the registration fee, which is mandatory even when receiving a fee waiver.

Registration fee waiver

The fee waiver will cover the registration sum that you have paid to attend the course or conference.

Travel grant

The travel grant will cover the cost of travel (airfare, train, bus, taxi, accommodation, visa, and/or registration fees*) and is provided up to specified caps which are normally as follows:

– up to €400 for participants travelling to an EMBL Course, EMBL Conference or EMBO|EMBL Symposium from within Europe.
– up to €1000 for participants travelling to an EMBL Course, EMBL Conference or EMBO|EMBL Symposium from outside Europe.
– up to €500 for any participant travelling to an EMBO Practical Course or EMBO Workshop.
– up to €1000 for any participant working in Chile, India, Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop.

*Registration fees are only covered for EMBO Practical Courses or EMBO Workshops

The organisers may reduce the grant cap to accommodate more participants. Recipients will be notified of their travel cap amount when they are informed of the outcome of their application. Original receipts must be provided with your signature for all costs incurred within two months of completion of travel. Scanned copies cannot be accepted.

Childcare grant (EMBO practical courses and workshops only)

For EMBO Practical Course or EMBO Workshop participants with children, there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course or conference. Eligible costs include fees for a baby-sitter or child-care facility, travel costs for a care giver, or travel costs for taking the child to the meeting etc. Please note that priority will be given to early stage researchers. A maximum amount of 500 EUR can be awarded per participant applying for an EMBO Childcare Grant. In order to apply for this grant for EMBO Workshops, you must be registered by the abstract submission deadline.

Application

You may apply for financial assistance when submitting your motivation letter for courses, and abstract for conferences. In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.

Selection

The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process. Results will be announced approximately 6-8 weeks before the event start date, however for some events this may be delayed. Selection results do not impact your admission to the meeting. Selection is based on your current work or study location, the reasons for needing financial support and the impact this event will have on your career.

Reimbursement

Costs will be reimbursed after the meeting only once a reimbursement form and original receipts (from travel costs) have been received.

Further details

View our list of external funding opportunities and information on attending a conference as an event reporter.

For further information about financial assistance please refer to the FAQ page.

Accommodation is not included in the conference registration fee.

As further changes in our events are possible due to COVID-19, you should book flights, trains and hotels with flexible options and favourable cancellation conditions.

The hotels below have rooms on hold for participants until 14 October 2022, in some cases at special rates. Please quote the booking code OMX22-01 and confirm the exact price of the room with the hotel directly.

Hotel Anlage	Hotel ibis Heidelberg	Premier Inn Heidelberg City
Hotel Bayrischer Hof	ISG Hotel	Staycity Aparthotel Heidelberg
B&B Hotel	Leonardo Hotel Heidelberg City Centre	Hotel Vier Jahreszeiten Heidelberg
Exzellenz Hotel	Meininger Heidelberg
Hotel Holländer Hof	Hotel Monpti

Conference shuttle buses

Conference shuttle buses are free of charge for participants, and depart from designated bus stops near the hotels to EMBL and back, mornings and evenings.

Download the conference bus schedule here.

The bus stops for this conference are:

• Staycity Aparthotel (Speyerer Str. 7)
• Kurfürsten-Anlage (opposite Main Train Station)
• Premier Inn Hotel (Kurfürsten-Anlage 23)
• Leonardo Hotel City Centre (Bergheimer Str. 63)
• Neckarmünzplatz (Heidelberg Tourist Information)
• Peterskirche (Bus stop)
• ISG Hotel

View Conference shuttle bus stops and hotels in a larger map. Please note that not every bus stop will be used for every event.

Further details

Address: EMBL, Meyerhofstraße 1, 69117 Heidelberg, Germany. For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue. For information about accommodation and local transportation please refer to the FAQ page.

Catering

All meals and coffee breaks are included in the registration fee. Our catering staff will prepare a wide variety of vegetarian meals, meat and fish dishes, soups, pasta, fresh fruit and vegetables, as well as a variety of desserts.

Please wear your badge at all times when serving yourself.

No food or drinks are allowed in the auditorium.

Charging lockers

There are lockers available next to the stairs leading down into the Auditorium. You will find some of those equipped with sockets to charge your smartphone/tablet etc.

Electricity and charging station

In most places the electricity is 220 volts AC (50 cycles). An adaptor and a plug that fits the German socket may be needed for your appliances/laptop (i.e. American, Japanese, etc.). A USB charging station for electronic devices is available at the registration desk.

EMBL merchandise

EMBL Merchandise is available on Mon – Thu (9 am – 12 pm). If you are interested in purchasing an EMBL souvenir (products presented in the glass display in the registration area), please ask at the registration desk for more information.

Health and safety notes

Please read EMBL’s COVID-19 safety policy for on-site events.
Do not smoke in any EMBL building.
Eating and drinking is prohibited in the Auditorium and all laboratories.
Do not enter any restricted areas or the laboratories unless instructed to do so.

If first aid is required …

• The first aid room is located next to the ATC Registration Desk (room 10- 205).
• Dial the Emergency number 222 from any EMBL internal phone only.
• Where is the accident? What happened? How many injured?
• Emergency number 06221-387 7821 from mobile phones.
• Please report all accidents to the conference officer at the registration desk.

In case of fire …

• Press the nearest fire alarm button or the Emergency number 222 from any internal phone.
• A loud fire alarm will go off if an evacuation is required. On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points
• Do not use the lifts.

Beyond first aid…

Please remember to bring your own medication, if needed, to the conference. Note that the next pharmacy is a 4-minute drive from the EMBL, but for many medications you will be required to see a doctor to get a prescription.

Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg. In any case, the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary.

Internet

Wi-Fi is available everywhere on the premises (no password required), just log on to ATC-Guest. The eduroam network (secure, world-wide roaming access service developed for the international research and education community) is also available.

Lost and found

‘’Lost and Found’’ are kept at the registration desk until the end of the conference.

Luggage

There are lockers available on-site to store your luggage, which require a 2 EURO coin to operate. There is another luggage room on level E0, which is free to use but remains unlocked during the conference.

Nursing room

There is a nursing room available in the ATC Rooftop Lounge on level A29.

Photography

During the conference an EMBL Photographer may be taking photographs. If you would not like to appear in these, please inform the photographer or a member of the Course and Conference Office.

Printing

We can help printing your boarding passes/train ticket. Please send it to events@embl.de and collect your print-outs at the registration desk.

Room for prayer, yoga and meditation

There is a room for prayer, mediation and yoga located on level E0 behind the Auditorium. Please be respectful of other participants using the room.

Sightseeing

A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing.

Travel to and from the venue

During the event we provide conference shuttle buses to and from EMBL. In addition, there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time. Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page.

Useful German expressions

English	German
Hello	Hallo
Goodbye	Auf Wiedersehen
Good morning	Guten Morgen
Good afternoon	Guten Tag
Good evening	Guten Abend
Good night	Gute Nacht
I’m sorry	Tut mir leid
Excuse me…	Entschuldigen Sie
How are you?	Wie geht’s?
I’m fine thanks. And you?	Mir geht es gut , danke, und dir/Ihnen?
What is your name	Wie heisst du? Wie heissen Sie?
My name is	Ich heisse
Do you speak English	Sprechen Sie Englisch?
I don’t understand	Ich verstehe nicht
Please speak more slowly	Können Sie bitte langsamer sprechen
Thank you	Danke schön
Where is the toilet?	Wo ist die Toilette?
Please call me a taxi	Bitte rufen Sie mir ein Taxi
How do I get to….?	Wie komme ich zum/zur…..?
A beer/two beers, please	Ein Bier/zwei Bier bitte
A glass of red/white wine please	Ein Glas Rot/Weisswein bitte
The menu, please	Die Speisekarte, bitte
Is there a local speciality?	Gibt es eine Spezialität aus dieser Gegend?
I’m Vegetarian	Ich bin Vegetarier
It was delicious	Es war hervorragend
The bill, please	Die Rechnung, bitte
I have a headache	Ich habe Kopfschmerzen
I have a sore throat	Ich habe Halsschmerzen
My stomach hurts	Ich habe Magenschmerzen
I’m allergic to	Ich bin allergisch gegen
I need a doctor who speaks English	Gibt es einen Arzt, der Englisch spricht?

What’s included?

• Access to all the livestreamed talks
• Video library of the recorded talks during and after the event
• Facility to submit questions

Please note that only on-site participants are able to submit abstracts and participate in the poster sessions.

Event platform

We are using an event platform for this conference. More information about the platform will be shared ahead of the conference.

Guidelines

• Do not broadcast the conference to unregistered participants.
• You are encouraged to tweet and post about the event. Tweet unless the speaker specifically says otherwise, but be mindful of unpublished data. 
• Please do not capture, transmit or redistribute data presented at the meeting.

Additional information can be found in our Code of Conduct.

Health and well-being

It is important to stay healthy and move around, especially when you are attending an event virtually. We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event.

How to ask questions

Please use the Q&A function in the event platform.

If you have any other questions, you can go to the Help Desk in the event platform. Click on ‘more’ on the top menu and click Help Desk. 

Time zone

The programme is planned based on the Europe/Berlin time zone, unless otherwise stated. Please take your time zone into consideration when planning your attendance.

Please find additional information including FAQs, terms and conditions, COVID-19 safety policy and travelling to EMBL on our Information for Participants page.

COVID-19 information for on-site events at EMBL Heidelberg can be found in our COVID-19 FAQs.