Yasmine Belkaid
remote speaker
National Institute of Allergy and Infectious Diseases (NIH)
USA
EMBO | EMBL Symposium
This conference will take place at EMBL Heidelberg, with the option to attend virtually.
Human microbiota – the collection of microbes living in and on our body – have a significant impact on human health and well-being. They have been associated with numerous diseases, yet we are still far from understanding their role in the context of lifestyle and genetics. Various initiatives are underway around the world to survey the human microbiota at several body sites, characterise them, understand their interactions with the human hosts, elucidate their role in diseases, and design possible therapeutic or dietary interventions. There is a new wave of studies mining the human microbiota for health-relevant bioactive compounds, for characterising specific microbial strains and for cataloguing the human microbiota from all across the globe. This conference will provide plentiful opportunities for researchers to learn about and to connect to important developments in studying the human microbiota. The return of this established meeting will bring together the community for a timely, in-person symposium picking up on developments across the field since the last edition in 2018.
For 2023, sessions will focus on the human microbiome across biological time and in nutrition and drugs, host-microbe interactions, integrative approaches in microbiome research and methodological advances in microbiome analysis. The final session will look to the future of microbiome research and translation.
“This meeting was in my top 3 of best meetings ever that I attended. The atmosphere was very lively, with lots of good discussions with diverse scientists. The topic, microbiome research, was covered extremely well. I am looking forward to attending the next time this meeting is taking place!”
– Peter van Baarlen, Wageningen University, the Netherlands.
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Please see EMBL’s COVID-19 safety recommendations if attending the on-site event.
remote speaker
National Institute of Allergy and Infectious Diseases (NIH)
USA
Wageningen University
The Netherlands
Spanish National Research Council
Spain
Luxembourg Institute of Health
Luxembourg
Keio University School of Medicine
Japan
Harvard University
USA
University of California, San Diego
USA
University of Antwerp
Belgium
Max Planck Institute for Biology
Germany
University of Tübingen
Germany
University of Michigan
USA
Stanford University
USA
Weizmann Institute of Science
Israel
Saint-Antoine Hospital
France
Queensland University of Technology
Australia
University of Luxembourg
Luxembourg
The Hebrew University of Jerusalem
Israel
University of Groningen
The Netherlands
University of Copenhagen
Denmark
Stanford University
USA
EMBL Heidelberg
Germany
EMBL Heidelberg
Germany
EMBL Heidelberg
Germany
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Time (Europe/Berlin) | Speaker |
---|---|
11:15 – 13:00 | Registration and light refreshments |
11:45 – 12:45 | Pre-conference workshop “Robust and versatile ultra-high-throughput single-microbe genome sequencing” by Atrandi Biosciences (registration required) |
13:00 – 13:30 | Opening remarks and lightning talks by Scientific Organisers |
Session 1: Methodological advances in microbiome analysis Session chair: Manimozhiyan Arumugam | |
13:30- 14:00 | A pipeline for developing novel therapeutics from the human microbiome Gene Tyson – Queensland University of Technology, Australia |
14:00 – 14:15 | Ex vivo cultivation model of the complex human gut microbiota for investigating modulation approaches and spatial interactions Annelies Geirnaert – ETH Zurich, Food Biotechnology, Switzerland Not available on demand |
14:15- 14:30 | Detecting Natural Selection in the Human Microbiota Sur Herrera Paredes – Universidad Nacional Autónoma de México, Mexico |
14:30- 15:00 | Systems ecology of the human expobiome Paul Wilmes – University of Luxembourg, Luxembourg |
15:00 – 15:30 | Coffee break and meet the speakers |
15:30 – 15:45 | Identification of eukaryotic symbionts and diet as bycatch in human gut microbiome data Oleksandr Maistrenko – Royal Netherlands Institute for Sea Research, Netherlands |
15:45- 16: | Kinetic modeling and in vitro fermentation reveal how gut microbiota impacts bioactivation and bioavailability of phytoestrogens Maja Stevanoska – ETH Zurich, Switzerland Not available on demand |
16:00- 16:30 | Ultra-fast, reference-free genomics algorithm discover novel genomic regulation in the microbial world Julia Salzman – Stanford University, USA (Remote speaker) |
16:30 – 17:00 | The Isala project and the vaginal microbiome Sarah Lebeer – University of Antwerp, Belgium |
17:00 – 18:30 | Global Grants for Gut Health symposium 17:00 – 17:05 Welcome and Introductory Remarks Ami Bhatt – Stanford University, USA 17:05 – 17:30 Bile Acid Conjugation as a New Mechanism of Host-Microbiome Crosstalk Robert Quinn – Michigan State University, USA 17:30 – 17:55 Using genomics to decode infant dietary diversity and microbiome maturation Lawrence David – Duke University, USA 17:55 – 18:20 Gut microbiome metabolites and growth in children at risk of malnutrition Evans Mudibo – Wageningen University / KEMRI-Wellcome Trust Research Programme 18:20 – 18:25 Concluding Remarks Ami Bhatt – Stanford University, USA |
18:30 – 20:00 | Dinner in EMBL Canteen |
20:00 – 21:00 | After dinner drinks and speed networking (optional, 20:00-20:30) |
Time (Europe/Berlin) | Speaker |
---|---|
Session 2: The human microbiome across biological age Session chair: Peer Bork | |
09:30 – 10:00 | Maternal-infant microbiota: Factors shaping microbial transfer, assembly and evolution Maria Carmen Collado – Spanish National Research Council (CSIC), Spain |
10:00 – 10:15 | Longitudinal culturing of the developing human microbiome reveals temporal and spatial differentiation between distal body sites Sara Di Simone – Hudson Institute of Medical Research, Australia |
10:15 – 10:30 | Tracking the transmission of the gut microbiome: a one health perspective Mireia Valles-Colomer – Pompeu Fabra University, Spain |
10:30 – 11:00 | Coffee break and meet the speakers |
11:00 – 11:30 | Toward the development of defined microbial therapeutics Kenya Honda – Keio University School of Medicine, Japan Not available on demand |
11:30 – 11:45 | Gut metagenomic profiling of 1,800 African women reveals novel microbial diversity and associations with cardiometabolic health Jakob Wirbel – Stanford University, USA |
11:45 – 12:00 | Unsaturated long-chain fatty acids differentially modulate growth of vaginal Lactobacillus species Meilin Zhu – MIT, USA Not available on demand |
12:00 – 12:30 | Longitudinal Variability of Bifidobacterium Species in the Infant Gut is Independent of Maternal Milk HMO Composition Moran Yassour – The Hebrew University of Jerusalem, Israel Not available on demand |
12:30 – 14:00 | Lunch |
Session 3: The human microbiome’s response to nutrition and drugs Session chair: Ami Bhatt | |
14:00 – 14:30 | The consequences of drugging the gut microbiome – from the individual microbe to the host Lisa Maier – University of Tübingen, Germany Not available on demand |
14:30 – 14:45 | Baseline gut microbiome predicts the efficacy of randomized oral antihypertensives in patients with essential hypertension Lianmin Chen – Nanjing Medical University, China |
14:45 – 15:00 | Emergence of community behaviors in the gut microbiota upon drug treatment Sarela Garcia-Santamarina – ITQB NOVA, Portugal |
15:00 – 15:30 | Coffee break and meet the speakers |
15:30 – 16:00 | Dietary fiber and mucin degrading bacteria in inflammatory bowel disease Eric Martens – University of Michigan, USA |
16:00- 16:15 | Investigating microbial dark matter unveils a consistent gut metagenomic biomarker for response to immune checkpoint blockade across diverse cohorts Chan Yeong Kim – EMBL Heidelberg, Germany |
16:15 – 16:30 | Immunotherapy and microbiome – unique set of taxa and genes associated with antibiotics use Giacomo Vitali – INRAE, France |
16:30 – 17:00 | Gut Microbial Synthetic communities to study how microbial ecologic networks collaboratively ferment glycans from diet and mucin Clara Belzer – Wageningen University, The Netherlands |
17:00 – 18:30 | Poster session 1 (odd numbers) with beer and snacks Please see the poster overview here. |
Free evening |
Time (Europe/Berlin) | Speaker |
---|---|
Session 4: Host-microbe interactions Session chair: Nicola Segata | |
09:30 – 10:00 | Silent flagellins, or how the gut immune system turns a blind eye Ruth Ley – Max Planck Institute for Biology, Germany |
10:00 – 10:15 | Bacterial DNA inversions and functional plasticity during inflammation and encounter with bacteriophages Shaqed Carasso – Technion – Israel Institute of Technology, Israel |
10:15 – 10:30 | Host-Microbiome Interactions between Lesional Skin Microbiome and Genomic Profiles in Psoriasis Susceptibility Loci Predisposes to Psoriasis Vulgaris in Indian Patients Souvik Mukherjee – National Institute of Biomedical Genomics, India |
10:30 – 11:00 | Coffee break and meet the speakers |
11:00 – 11:30 | Leveraging diet to engineer the gut microbiome Mahesh Desai – Luxembourg Institute of Health, Luxembourg Not available on demand |
11:30 – 11:45 | A role for the gut microbiome in determining the rate of progression of amyotrophic lateral sclerosis Maria Emilia Panzetta – Duke University, USA |
11:45 – 12:00 | Extravesicles secreted by human gut GABA-producing Bacteroides sp.: a possible shuttle mechanism for neuroactive metabolites Basit Yousuf – University of Ottawa, Canada |
12:00 – 12:30 | Talk title tbc Yasmine Belkaid – National Institute of Allergy and Infectious Diseases (NIH) – remote speaker |
12:30 – 14:00 | Lunch and Meet the editors |
Session 5: Integrative approaches in microbiome research Session chair: Maria Carmen Collado | |
14:00 – 14:30 | Microbiome multi-omics and the Human Microbiome Bioactives Resource Curtis Huttenhower – Harvard University, USA |
14:30 – 14:45 | Microbial sub-species diversity and its interactions with host physiology Liron Zahavi and Saar Shoer – Weizmann Institute of Science, Israel |
14:45 – 15:00 | Multi-view integration of microbiome data for predicting host disease Efrat Muller – Tel Aviv University, Israel |
15:00 – 15:30 | Coffee break and meet the speakers |
15:30- 16:00 | Development of gut microbiome and virome during the first year of life Alexandra Zhernakova – University of Groningen, The Netherlands |
16:00 – 16:15 | Gut microbial genetic architecture of human health Yue Zhang and Doaming Wang – University Medical Center Groningen, The Netherlands Not available on demand |
16:15 – 16:30 | Exploration of >1000 human gut viromes and matched metagenomes discovers phages with unexpected integration potential and broad host range Lore Van Espen – KU Leuven, Belgium |
16:30 – 17:00 | Personalized medicine based on deep human phenotyping Eran Segal – Weizmann Institute of Science, Israel |
17:00- 18:30 | Poster session 2 (even numbers) with beer and snacks Please see the poster overview here. |
18:30 – 00:00 | Conference dinner at Heidelberg Castle with band (limited seating, first come first served) |
Time (Europe/Berlin) | Speaker |
---|---|
Session 6: Future outlook for microbiome research and translation Session chair: Moran Yassour | |
09:30 – 10:00 | High throughput approaches for integrated microbiome and metabolome studies Rob Knight – University of California, San Diego, USA |
10:00 – 10:15 | Unraveling the complex interplay between the human gut microbiome, diet, and cardiometabolic health from the ZOE PREDICT studies Francesco Asnicar – University of Trento, Italy |
10:15 – 10:30 | Revealing the reservoir and spread of antimicrobial resistance in the human gut microbiota using the controlled human infection model Irina Chelysheva – University of Oxford, United Kingdom |
10:30 – 11:00 | Coffee Break and Meet the speakers |
11:00 – 11:30 | Host-microbiome tryptophan metabolism in IBD Harry Sokol – Saint-Antoine Hospital, France |
11:30 – 11:45 | Fecal metabolic dysbiosis is associated with 30-day mortality of patients on the medical intensive care unit Alexander de Porto – University of Chicago, USA |
11:45 – 12:00 | Harnessing gut microbiota for risk assessment and therapeutics of NAFLD Yueqiong Ni – Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI), Germany (Remote speaker) |
12:00 – 12:15 | Key metabolic interactions define microbiota response to nutrient changes Remy Young – Hudson Institute of Medical Research, Australia |
12:15 – 12:30 | Discovery and development of anaerobic microbial choline metabolism inhibitors that target novel proteins beyond the choline utilization gene cluster Amelia Woo – Harvard University, USA Not available on demand |
12:30 – 12:45 | Closing Remarks and Poster Prize |
12:45 – 13:15 | Packed Lunch and departure |
13:15 | Buses to downtown Heidelberg and 1 bus to Frankfurt airport (terminal 1 (30 EUR), tickets may be purchased on-site) |
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Where is the nearest Covid test centre? | Wo ist das nächste Covid-Testzentrum? |
Hello | Hallo |
Goodbye | Auf Wiedersehen |
Good morning | Guten Morgen |
Good afternoon | Guten Tag |
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Please speak more slowly | Können Sie bitte langsamer sprechen |
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Where is the nearest COVID-19 test centre? | Wo ist das nächste COVID-19 Testzentrum? |
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Silver sponsor
Bronze sponsors
Session sponsor
Event sponsor
Media partners
Disease Models & Mechanisms, The Company of Biologists Journal
EMBO Molecular Medicine, an EMBO Press journal
FEBS Journal, a FEBS Press journal
FEBS Letters, a FEBS Press journal
FEBS Open Bio, a FEBS Press journal
International Union of Biochemistry and Molecular Biology
Open Biology, a Royal Society journal
Bio Essays, a Wiley Online Library
Advanced Biology, a Wiley Online Library
Sponsorship opportunities
We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.de for further information on sponsoring possibilities.
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For on-site participants only.
This industry webinar will be hosted by our sponsor Atrandi Biosciences prior to the EMBO | EMBL Symposium: The human microbiome
on Wednesday 20 September 2023, 11:45 – 12:45
Participation in this workshop is free of charge for registered on-site conference attendees. The number of available places is limited (first come, first served).
All registered conference attendees will receive an email with a registration link.
ABSTRACT
Robust and versatile ultra-high-throughput single-microbe genome sequencing
by Linas Pupelis, Justyna Mazul
Atrandi Biosciences
Whole-genome and targeted sequencing open a window to understanding the function of unculturable microorganisms. On one hand, metagenomic sequencing is attractive for its straightforward sequencing library preparation from bulk environmental samples but only offers limited resolution into individual species. On the other hand, single-microbe sequencing offers true single-clone resolution but can only meaningfully address the high biological diversity expected in environmental samples if performed on thousands of individual cells in parallel. To satisfy the need to study such large numbers of single-microbes per sample, well- and droplet-based approaches keep evolving in parallel to provide single-cell compartmentalization required during sequencing library preparation. However, these approaches suffer from a fundamental trade-off between throughput and versatility. Being individually addressable, microwells enable multi-step processing but are not scalable. Droplets offer a throughput of up to a million cells per experiment but only allow a limited number of processing steps to be performed. The later limitation is severely felt when it comes to microbial research, as harsh conditions typically required for lysis are incompatible with downstream nucleic acid barcoding steps. Our Semi-Permeable Capsule (SPC) technology combines the throughput of droplets with the versatility of wells by enabling a virtually unlimited number of processing steps on genetic material from millions of individual microbes in parallel. We demonstrate the use of SPCs for barcoding >100,000 individual microbial genomes to obtain single-microbe whole genome sequencing data of unprecedented quality.
Date: 20 - 23 Sep 2023
Location: EMBL Heidelberg and Virtual
Venue: EMBL Advanced Training Centre
Deadline(s):
Abstract submission: Closed
Registration (On-site): Closed
Registration (Virtual): Closed
Organisers:
Contact: Lea Hohmann