William M. Bement
University of Wisconsin-Madison,
USA
Overview
The final programme, poster listing, bus schedule and onsite handout (with logistical information) are now available for download.
Ahead of the meeting, speaker Madeline Lancaster shares how curiosity and serendipity culminated
in her pioneering method to grow cerebral organoids.
Symposium Overview
This symposium aims to understand the mechanisms of self-organising properties of multi-cellular systems. One of the defining features of living systems is their capacity to break symmetry and self-organise to form reproducible shapes and patterns. However, the mechanistic understanding of this process remains a challenge as it requires a multi-disciplinary approach. This symposium will bring together those working in distinct disciplines such as cell and developmental biology, tissue biophysics, theoretical modelling, organoids and synthetic biology, and will provide a platform to discuss and identify key approaches and future collaborations.
Session Topics
- Symmetry breaking in cells and tissues
- Collective cell behaviour
- Morphogenesis
- Tissue mechanics
- Pattern formation
- Modelling self-organisation
- Synthetic biology
- Organogenesis and organoids
Who should attend?
Researchers working on both the mechanisms and manipulation of tissue morphogenesis, using in vivo animal models and ex vivo organoid approaches.
Speakers
Speakers and Trainers
Speakers
Gaudenz Danuser
The University of Texas Southwestern Medical Center
USA
Stefano De Renzis
EMBL Heidelberg
Germany
Suzanne Eaton
Max Planck Institute of Molecular Cell Biology and Genetics
Germany
Zev J. Gartner
University of California, San Francisco
USA
Matthew C. Gibson
Stowers Institute for Medical Research
USA
Carl-Philipp Heisenberg
Institute of Science and Technology Austria
Austria
Kinneret Keren
Technion- Israel Institute of Technology
Israel
Madeline Lancaster
MRC Laboratory of Molecular Biology
UK
Thomas L. Lecuit
IBDM, Collège de France
France
Ana-Maria Lennon-Duménil
Institut Curie
France
Rong Li
Johns Hopkins University
USA
Prisca Liberali
Friedrich Miescher Institute for Biomedical Research
Switzerland
L. Mahadevan
Friedrich Miescher Institute for Biomedical Research
Switzerland
Stefano Piccolo
University of Padova
Italy
Petra Schwille
Max Planck Institute of Biochemistry
Germany
Manuel Théry
Hopital Saint-Louis
France
James M. Wells
Cincinnati Children’s Hospital Medical Center
USA
Scientific Organisers
Darren Gilmour
University of Zurich
Switzerland
Takashi Hiiragi
EMBL Heidelberg
Germany
Celeste M. Nelson
Princeton University
USA
Orion Weiner
University of California, San Francisco,
USA
Conference Organisers
Tim Nürnberger
EMBL Heidelberg
Germany
Programme
| Time | Speaker |
|---|---|
| 12.45-14.30 | Arrival / Registration with light refreshments |
| 13.30-14.15 | Industry workshop hosted by Fluidigm in Helix Room A (first come – first served) |
| 14.30-14.45 | Opening remarks |
| 14.45-18.30 | Session 1: Cellular Organisation Chair: Orion Weiner |
| 14.45-15.15 | A template for actin organization at the leading edge Orion Weiner, University of California, San Francisco |
| 15.15-15.30 | Selected talk: Benny Shilo, Weizmann Institute of Science |
| 15.30-15.45 | Selected talk: Inna Averbukh, Weizmann Institute of Science |
| 15.45-16.15 | Dynamics and instabilities of contractile actin networks in artificial cells Kinneret Keren, Technion- Israel Institute of Technology |
| 16.15-17.00 | Coffee Break & Meet the Speakers |
| 17.00-17.30 | EMBO Young Investigator Lecture: Contribution of polarity reversal to the formation of metastases Manuel Théry, Hopital Saint-Louis |
| 17.30-17.45 | Selected talk: Natalie Kirkland, University College London |
| 17.45-18.00 | Selected talk: William Roman, Instituto de Medicina Molecular |
| 18.00-18.30 | Cellular proteostasis during aging through asymmetric cell division and organelle-based clearance Rong Li, Johns Hopkins University |
| 18.30-20.00 | Welcome Dinner |
| Time | Speaker |
|---|---|
| 09.00-12.15 | Session 1 (continued): Cellular Organisation Chair: Orion Weiner |
| 09.00-09.30 | Bring the pain: Response of an excitable embryo to cell damage William M. Bement, University of Wisconsin-Madison |
| 09.30-09.45 | Selected talk: Clemens Cabernard, University of Washington, Seattle |
| 09.45-10.00 | Selected talk: Jérémy Sallé, Jacques Monod Institute (CNRS) |
| 10.00-10.30 | Dendritic Cell Migration: from microfluidics to in vivo imaging Ana-Maria Lennon-Duménil, Institut Curie |
| 10.30-11.15 | Coffee Break |
| 11.15-11.45 | Probing the feedback interactions between cell morphogenesis and signaling Gaudenz Danuser, The University of Texas Southwestern Medical Center |
| 11.45-12.00 | Selected talk: Claudio Franco, Instituto de Medicina Molecular |
| 12.00-12.15 | Selected talk: Alexis Maizel, Heidelberg University |
| 12.15-14.00 | Lunch in ATC Foyer |
| 14.00-17.45 | Session 2: Mechanics Chair: Carl-Philipp Heisenberg |
| 14.00-14.30 | Control and self-organization of cell mechanics during tissue morphogenesis Thomas L. Lecuit, IBDM, Collège de France |
| 14.30-14.45 | Selected talk: Xinyi Yang, Institut Biologie Paris Seine |
| 14.45-15.00 | Selected talk: Stephanie Ellis, The Rockefeller University |
| 15.00-15.30 | To be presented onsite Suzanne Eaton, Max Planck Institute of Molecular Cell Biology and Genetics |
| 15.30-16.15 | Coffee Break & Meet the Speakers |
| 16.15-16.45 | Motifs in morphogenesis L. Mahadevan, Harvard University |
| 16.45-17.00 | Selected talk: Andrew Lawton, Sloan Kettering Institute |
| 17.00-17.15 | Selected talk: Rob Tetley, University College London |
| 17.15-17.45 | Tissue genetics: clonality, heterogeneity, and growth in Drosophila imaginal epithelia Matthew C. Gibson, Stowers Institute for Medical Research |
| 17.45-18.00 | Selected Flash Talks (1 slide / 2 min each): Barriga #55 / DasGupta #63 / He #75 / Imran Alsou #77 / Masselink #85 / Petridou #93 |
| 18.00-19.30 | Poster Session I (odd numbers) with beer and snacks |
| 19.30-21.00 | Dinner |
| 21.00-22.30 | After-dinner drinks in ATC Rooftop Lounge |
| Time | Speaker |
|---|---|
| 09.00-11.45 | Session 3: Synthetic Biology Chair: Stefano De Renzis |
| 09.00-09.30 | Synthetic Morphogenesis in Naive Embryonic Tissues Stefano De Renzis, EMBL Heidelberg |
| 09.30-09.45 | Selected talk: Victoria Deneke, Duke University |
| 09.45-10.00 | Selected talk: Mijo Simunovic, The Rockefeller University |
| 10.00-10.45 | Coffee Break |
| 10.45-11.15 | Tissue Origami: engineering tissue folding by mechanical compaction of the mesenchyme Zev J. Gartner, University of California, San Francisco |
| 11.15-11.30 | Selected talk: Tony Tsai, Harvard Medical School |
| 11.30-11.45 | Selected talk: Rashmi Priya, MPI for Heart and Lung Research |
| 11.45-13.30 | Lunch in ATC Foyer |
| 13.30-14.00 | How membranes template protein self-organization Petra Schwille, Max Planck Institute of Biochemistry |
| 14.00-18.00 | Session 4: Self-organisation Chair: Takashi Hiiragi |
| 14.00-14.30 | From Single Cell To Cell Collective And Back Darren Gilmour, EMBL Heidelberg |
| 14.30-14.45 | Selected talk: Akankshi Munjal, Harvard Medical School |
| 14.45-15.00 | Selected talk: Michel Bagnat, Duke University |
| 15.00-15.30 | Organ size control via the interplay between luminal pressure and cell mechanics Chii Jou Chan, EMBL Heidelberg |
| 15.30-16.15 | Coffee Break & Meet the Speakers |
| 16.15-16.45 | Human Pluripotent stem cell-derived gastrointestinal organoids as new models to study developmental processes in humans James M. Wells, Cincinnati Children’s Hospital Medical Center |
| 16.45-17.00 | Selected talk: Stephanie Höhn, University of Cambridge |
| 17.00-17.15 | Selected talk: Miguel Concha, Universidad de Chile |
| 17.15-17.45 | Self-organization and symmetry breaking of intestinal organoids Prisca Liberali, Friedrich Miescher Institute for Biomedical Research |
| 17.45-18.00 | Selected Flash Talks (1 slide / 2 min each): Bailles #52 / Baumgärtner #56 / Libby #83 / Pour #95 / Schauer #102 / Zinner #121 |
| 18.00-19.30 | Poster Session II (even numbers plus #83 / #95 / #121) with beer and snacks |
| 19.30-21.30 | Conference Dinner |
| 21.30-00.00 | Conference Party with DJ |
| Time | Speaker |
|---|---|
| 09.00-13.00 | Session 5: Modeling Organogenesis and disease Chair: Darren Gilmour |
| 09.00-09.30 | YAP/TAZ in stem cells and tissue regeneration Stefano Piccolo, University of Padova |
| 09.30-09.45 | Selected talk: Francesco Atzeni, University of Zurich |
| 09.45-10.00 | Selected talk: Chengming Chuong, University of Southern California |
| 10.00-10.30 | Studying Human Brain Development and Evolution in Cerebral Organoids Madeline Lancaster, MRC Laboratory of Molecular Biology |
| 10.30-11.15 | Coffee Break & Meet the Speakers |
| 11.15-11.45 | Developing under pressure: physical force as a pacer of morphogenesis Celeste M. Nelson, Princeton University |
| 11.45-12.00 | Selected talk: Francis Corson, CNRS / Ecole Normale Supérieure |
| 12.00-12.15 | Selected talk: Etienne Loiseau, CNRS |
| 12.15-12.45 | Ooplasmic segregation in zebrafish Carl-Philipp Heisenberg, Institute of Science and Technology Austria |
| 12.45-13.00 | Closing remarks |
| 13.00-13.35 | Packed lunch |
| 13.35 | Bus departures |
Date: 11 - 14 Mar 2018
Location: EMBL Heidelberg