The Four-Dimensional Genome – Virtual

Overview

Symposium Overview

We will discuss the principles that govern the three-dimensional folding of the genome in chromosomes and inside the nucleus. Our understanding of how this organisation controls genome function and how it changes over time, both in the context of the cell cycle and in the course of normal development is incomplete. Currently, the study of the spatial organisation of the genome is being revolutionised by new genomics and microscopy techniques. The computational analysis and modelling of such data are delivering new insights into genome structure and function.

This symposium will bring together latest advances in the fields of genomics, microscopy and modelling to foster their integration towards a comprehensive spatial and temporal understanding of the functional four-dimensional organisation of the eukaryotic genome.

Session Topics

• Methods to measure and model chromosomes
• Chromosome compartments
• Chromatin and X chromosomes
• Gene regulation
• New ways to image chromosomes
• Chromosome folding during interphase and mitosis
• Recombining chromosomes
• Chromosome architecture during development

Speakers and Organisers

Keynote Speaker

Jef D. Boeke

NYU Langone Health,

USA

Speakers

Andrew S. Belmont

University of Illinois at Urbana–Champaign,

USA

Sara Cuylen-Häring

EMBL Heidelberg,

Germany

Beat Fierz

École Polytechnique Fédérale de Lausanne,

Switzerland

Hironori Funabiki

The Rockefeller University,

USA

Luca Giorgetti

Friedrich Miescher Institute for Biomedical Research,

Switzerland

Scott N. Keeney

Memorial Sloan Kettering Cancer Center,

USA

Simone Köhler

EMBL Heidelberg,

Germany

Brian McStay

National University of Ireland, Galway,

Ireland

Leonid Mirny

Massachusetts Institute of Technology,

USA

Jennifer E. Phillips-Cremins

University of Pennsylvania,

USA

Kikuë Tachibana

Institute of Molecular Biotechnology

Austria

Kenneth S. Zaret

University of Pennsylvania,

USA

Scientific Organiser

Wendy Bickmore

MRC IGMM, University of Edinburgh,

UK

Jan Ellenberg

EMBL Heidelberg,

Germany

Susan M. Gasser

Friedrich Miescher Institute for Biomedical Research,

Switzerland

Christian Häring

EMBL Heidelberg,

Germany

Bas van Steensel

Netherlands Cancer Institute,

The Netherlands

Conference Organiser

Tim Nürnberger

EMBL Heidelberg

Germany

Programme