Frédéric Chédin
University of California, Davis
USA
EMBO | EMBL Symposium
EMBO and EMBL are committed to sharing research advances and sustaining scientific interaction throughout the coronavirus pandemic. We are delighted to announce that this conference is going virtual and invite you to join us online.
RNA biology is intimately interlinked with DNA metabolism on multiple levels, and the crosstalk between the two nucleic acids involves potential for both conflicts as well as cooperative relationships. On the one hand, gene expression poses a considerable risk for genome maintenance and vice versa. On the other hand, the machineries involved in RNA and DNA transactions are known to cooperate in several important aspects of nuclear biology. This symposium will bring together scientists studying genome maintenance and the DNA damage response with those investigating the biology of transcription and RNA biology in order to discuss these mutual interactions of DNA and RNA metabolism.
University of California, Davis
USA
The Institute of Cancer Research
UK
University of Würzburg
Germany
University of Milan
Italy
University of Geneva
Switzerland
University of Navarre
Spain
The University of Edinburgh
UK
University of Toulouse
France
Vanderbilt University
USA
CNRS – Université de Montpellier
France
University of Texas at Austin
USA
University of Birmingham
UK
University of Massachusetts Medical School
USA
University of Oxford
UK
MRC Laboratory of Molecular Biology
UK
The Francis Crick Institute
UK
Institute of Molecular Biology/ Johannes Gutenberg University of Mainz
Germany
University of Seville
Spain
Institute of Molecular Biology
Germany
Stanford University
USA
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The following times are used in the programme below:
To find out the equivalent time zone in your location, enter Berlin, the CET programme time and your city into the Time Zone Converter.
Time | Speaker |
---|---|
15:00-15:15 (CET) 09:00-09:15 (EDT) | Opening remarks by scientific organisers |
Virtual Session 1: Transcription-associated genomic instability Session chair: Karlene Cimprich | |
15:15-15:40 (CET) 09:15-09:40 (EDT) | Ribonucleotide Excision Repair – Genome Instability, Mutagenesis, and Inflammation Andrew Jackson – The University of Edinburgh, UKAVAILABLE ON DEMAND AFTER LIVE STREAM |
15:40-15:45 (CET) 09:40-09:45 (EDT) | Transition (to setup and switch to the next live talk) |
15:45-16:10 (CET) 09:45-10:10 (EDT) | R-loops in Transcription Coupled DNA Double Strand Break repair Gaëlle Legube – CNRS – University of Toulouse, FranceAVAILABLE ON DEMAND AFTER LIVE STREAM |
16:10-16:15 (CET) 10:10-10:15 (EDT) | Transition (to setup and switch to the next live talk) |
16:15-16:40 (CET) 10:15-10:40 (EDT) | BRCA1, RAD52 and PALB2 promote novel small RNA-driven DNA repairElodie Hatchi – Dana-Farber Cancer Institute, USAAVAILABLE ON DEMAND AFTER LIVE STREAM |
16:40-16:45 (CET) 10:40-10:45 (EDT) | Transition (to setup and switch to the next live talk) |
16:45-17:00 (CET)10:45-11:00 (EDT) | DNA replication timing directly regulates the frequency of oncogenic translocationsRushad Pavri – IMP Vienna, Austria |
17:00-17:05 (CET)11:00-11:05 (EDT | Transition (to setup and switch to the next live talk) |
17:05-17:20 (CET) 11:05-11:20 (EDT) | Rtt101/Cul4 may promote a ribonucleotide excision repair backup pathway in S phase Natalie Schindler – Johannes-Gutenberg University Mainz, Germany |
17:20-17:45 (CET) 11:20-11:45 (EDT) | Break |
17:45-19:15 (CET) 11:45-13:15 (EDT) | Digital poster session 1 |
19:15-19:40 (CET) 13:15-03:40 (EDT) | Toxic R-loops: causes or consequences of DNA replication stress?Philippe Pasero – CNRS – Université de Montpellier, FranceAVAILABLE ON DEMAND AFTER LIVE STREAM |
19:40-19:45 (CET) 13:40-13:45 (EDT) | Transition (to setup and switch to the next live talk) |
19:45-20:10 (CET) 13:45-14:10 (EDT) | Chromatin dynamics, transcriptional homeostasis, and genome stabilityCraig Peterson – University of Massachusetts Medical School, USAAVAILABLE ON DEMAND AFTER LIVE STREAM |
20:10-20:15 (CET) 14:10-14:15 (EDT) | Transition (to setup and switch to the next live talk) |
20:15-20:30 (CET) 14:15-14:30 (EDT) | Chromatin-associated MRN complex protects highly transcribing genes from genomic instability Rosemary Kiernan – French National Centre for Scientific Research, FranceAVAILABLE ON DEMAND AFTER LIVE STREAM |
20:30-20:35 (CET) 14:30-14:35 (EDT) | Transition (to setup and switch to the next live talk) |
20:35-20:50 (CET) 14:35-14:50 (EDT) | Branchpoint translocation by fork remodellers as a general mechanism of R-loop removal Andrew Deans – St Vincent’s Institute of Medical Research, AustraliaAVAILABLE ON DEMAND AFTER LIVE STREAM |
20:50-21:00 (CET) 14:50-15:00 (EDT) | Short break |
21:00-22:00 (CET) 15:00-16:00 (EDT) | Optional: Virtual Speed networking |
End of day 1 – Continued access to digital posters, networking and discussion platforms |
Time | Speaker |
---|---|
Session 2 – Responses to transcription and replication stress Chair: Petra Beli | |
15:00-15:25 (CET) 09:00-09:25 (EDT) | Transcription during DNA damage and heat-shockJesper Svejstrup – The Francis Crick Institute, UKAVAILABLE ON DEMAND AFTER LIVE STREAM |
15:25-15:30 (CET) 09:25-09:30 (EDT) | Transition (to setup and switch to the next live talk) |
15:30-15:55 (CET) 09:30-09:55 (EDT) | Resolution of conflicts of stalling RNA Polymerase with the replication fork by the MYCN oncoprotein Martin Eilers – University of Würzburg, Germany |
15:55-16:00 (CET) 09:55-10:00 (EDT) | Transition (to setup and switch to the next live talk) |
16:00-16:25 (CET) 10:00-10:25 (EDT) | Coordinating chromosome replication with transcription Marco Foiani – University of Milan, Italy |
16:25-16:30 (CET) 10:25-10:30 (EDT) | Break (to setup and switch to the next live talk) |
16:30-16:45 (CET) 10:30-10:45 (EDT) | A novel function of RNase H activities at arrested DNA replication forks in priming fork-resectionCharlotte Audoynaud – Institut Curie / French National Centre for Scientific Research, FranceAVAILABLE ON DEMAND AFTER LIVE STREAM |
16:45-16:50 (CET)10:45-10:50 (EDT) | Transition (to setup and switch to the next live talk) |
16:50-17:05 (CET)10:50-11:05 (EDT) | Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instabilityJurgen Marteijn – Erasmus University Medical Center, The NetherlandsAVAILABLE ON DEMAND AFTER LIVE STREAM |
17:05-17:30 (CET) 11:05-11:30 (EDT) | Short break |
17:30-19:00 (CET) 11:30-13:00 (EDT) | Digital poster session 2 |
19:00-19:25 (CET) 13:00-13:25 (EDT) | SF3B1-targeted Splicing Inhibition Triggers Global Alterations in Transcriptional Dynamics and R-Loop Metabolism Frédéric Chédin – University of California, Davis, USAAVAILABLE ON DEMAND AFTER LIVE STREAM |
19:25-19:30 (CET) 13:25-13:30 (EDT) | Transition (to setup and switch to the next live talk) |
19:30-19:55 (CET) 13:30-13:55 (EDT) | The PBAF chromatin remodelling complex promotes G2/M checkpoint maintenance through regulation of the DREAM complexJessica Downs – The Institute of Cancer Research, UKAVAILABLE ON DEMAND AFTER LIVE STREAM |
19:55-20:00 (CET) 13:55-14:00 (EDT) | Transition (to setup and switch to the next live talk) |
20:00-20:15 (CET) 14:00-14:15 (EDT) | A regulatory phosphosite on Mec1 controls RNAPII and RNAPIII occupancy during replication stressJérôme Poli – Institute of Human Genetics, FranceAVAILABLE ON DEMAND AFTER LIVE STREAM |
20:15-20:20 (CET) 14:15-14:20 (EDT) | Transition (to setup and switch to the next live talk) |
20:20-20:35 (CET) 14:20-14:35 (EDT) | Genome-wide analysis of replication fork progression and stalling by TrAEL-seqJon Houseley – Babraham Institute, UKAVAILABLE ON DEMAND AFTER LIVE STREAM |
20:35-21:00 (CET) 14:35-15:00 (EDT) | Short break |
21:00-21:45 (CES) 15:00-15:45 (EDT) | Optional: Virtual bar mixer |
End of day 2 – Continued access to digital posters, networking and discussion platforms |
Time | Speaker |
---|---|
Session 3 – Interplay between transcription and DNA repair Chair: Georg Stoecklin | |
15:00-15:25 (CET) 09:00-09:25 (EDT) | R-loops act as promoters for antisense transcriptionNicholas Proudfoot – University of Oxford, UK AVAILABLE ON DEMAND AFTER LIVE STREAM |
15:25-15:30 (CET) 09:00-09:30 (EDT) | Transition (to setup and switch to the next live talk) |
15:30-15:55 (CET) 09:30-09:55 (EDT) | R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instabilityPetra Beli – Institute of Molecular Biology, GermanyAVAILABLE ON DEMAND AFTER LIVE STREAM |
15:55-16:00 (CET) 09:55-10:00 (EDT) | Transition (to setup and switch to the next live talk) |
16:00-16:25 (CET) 10:00-10:25 (EDT) | Uncovering noncoding RNA roles in the initiation of chromatin replication Maite Huarte – University of Navarre, Spain |
16:25-16:30 (CET) 10:25-10:30 (EDT) | Transition (to setup and switch to the next live talk) |
16:30-16:45 (CET) 10:30-10:45 (EDT) | Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/MMarco Saponaro – University of Birmingham, UKAVAILABLE ON DEMAND AFTER LIVE STREAM |
16:45-16:50 (CET) 10:45-10:50 (EDT) | Transition (to setup and switch to the next live talk) |
16:50-17:05 (CET) 10:50-11:05 (EDT) | Mediator link between transcription and DNA repair: new insights from the genome-wide location analysis of Rad26 and Rad1-Rad10Julie Soutourina – CEA, FranceAVAILABLE ON DEMAND AFTER LIVE STREAM |
17:05-17:30 (CET) 11:05-11:30 (EDT) | Short break |
17:30-19:00 (CET) 11:30-13:00 (EDT) | Digital poster session 3 |
19:00-19:25 (CET) 13:00-13:25 (EDT) | The CtIP protein and regulation of R-loop processing in human cells Tanya Paull – University of Texas at Austin, USAAVAILABLE ON DEMAND AFTER LIVE STREAM |
19:25-19:30 (CET) 13:25-13:30 (EDT) | Transition (to setup and switch to the next live talk) |
19:30-19:55 (CET) 13:30-13:55 (EDT) | Cytoplasmic hybrids derived from nuclear R-loops activate IRF3 signalingMadzia Crossley – AVAILABLE ON DEMAND AFTER LIVE STREAM |
19:55-20:00 (CET) 13:55-14:00 (EDT) | Transition (to setup and switch to the next live talk) |
20:00-20:15 (CET) 14:00-14:15 (EDT) | Rebuilding of initiation program over large transcribed regions rescues Common Fragile Site instabilityStefano Gnan – Institute Curie, France |
20:15-20:20 (CET) 14:15-14:20 (EDT) | Transition (to setup and switch to the next live talk) |
20:20-20:35 (CET) 14:20-14:35 (EDT) | Dysregulation of R-loop homeostasis in the aging eyeHana Hall – Purdue University, USAAVAILABLE ON DEMAND AFTER LIVE STREAM |
End of day 3 – Continued access to digital posters, networking and discussion platforms |
Time | Speaker |
---|---|
Session 4 – Replication-transcription conflictsSession chair: Andres Aguilera | |
15:00-15:25 (CET) 09:00-09:25 (EDT) | Genome-wide analysis of DNA replication conflictsHelle Ulrich – Institute of Molecular Biology & Johannes Gutenberg University of Mainz, GermanyAVAILABLE ON DEMAND AFTER LIVE STREAM |
15:25-15:30 (CET) 09:25-09:30 (EDT) | Transition (to setup and switch to the next live talk) |
15:30-15:55 (CET) 09:30-09:55 (EDT) | Insights into genome stability and aging from the in vivo firing patterns of DNA replication origins in regenerating mouse liversThanos Halazonetis – University of Geneva, Switzerland |
15:55-16:00 (CET) 09:55-10:00 (EDT) | Transition (to setup and switch to the next live talk) |
16:00-16:25 (CET) 10:00-10:25 (EDT) | The origins of R-Loop formation during replication-transcription conflicts Houra Merrikh – Vanderbilt University, USA |
16:25-16:30 (CET) 10:25-10:30 (EDT) | Transition (to setup and switch to the next live talk) |
16:30-16:45 (CET) 10:30-10:45 (EDT) | Replicon-seq: A new method to study sister replication fork movement and replication/transcription conflictsClemence Claussin – Memorial Sloan Kettering Cancer Center, USA |
16:45-16:50 (CET) 10:45-10:50 (EDT) | Transition (to setup and switch to the next live talk) |
16:50-17:05 (CET) 10:50-11:05 (EDT) | Role of MutSß and MutLß proteins in the restart of R-loop-stalled replication forks in human cellsEsin Isik – University of Zurich, Switzerland |
17:05-17:30 (CET) 11:05-11:30 (EDT) | Short break |
17:30-17:55 (CET) 11:30-11:55 (EDT) | New roles for ATP-dependent chromatin remodelers at transcription-replication conflictsAleix Bayona-Feliu – Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Spain |
17:55-18:00 (CET) 11:55-12:00 (EDT) | Transition (to setup and switch to the next live talk) |
18:00-18:25 (CET) 12:00-12:25 (EDT) | TIAR is essential for G2/M checkpoint activation and retains CDK1 in nuclear G2/M transition granules upon replication stressGeorg Stoecklin – Heidelberg University, GermanyAVAILABLE ON DEMAND AFTER LIVE STREAM |
18:25-18:30 (CET) 12:25-12:30 (EDT) | Transition (to setup and switch to the next live talk) |
18:30-18:55 (CET) 12:30-12:55 (EDT) | Sequences that stall replication Julian Sale – MRC Laboratory of Molecular Biology, UKAVAILABLE ON DEMAND AFTER LIVE STREAM |
18:55-19:00 (CET) 12:55-13:00 (EDT) | Transition (to setup and switch to the next live talk) |
19:00-19:25 (CET) 13:00-13:25 (EDT) | Mechanisms of transcription-replication conflicts in oncogene-induced replication stress Eva Petermann – University of Birmingham, UKAVAILABLE ON DEMAND AFTER LIVE STREAM |
19:25-19:30 (CET) 13:25-13:30 (EDT) | Break (to setup and switch to the next live talk) |
19:30-19:45 (CET) 13:30-13:45 (EDT) | Reconstitution of directional collisions of a eukaryotic replisome with an R-loop reveals multiple replication fork inhibition mechanismsDirk Remus – Sloan Kettering Institute, USAAVAILABLE ON DEMAND AFTER LIVE STREAM |
19:45-19:50 (CET) 13:45-13:50 (EDT) | Transition (to setup and switch to the next live talk) |
19:50-20:05 (CET) 13:50-14:05 (EDT) | The THO and TRAMP complexes prevent transcription-replication conflicts and protect against fragility of expanded CAG repeatsCatherine Freudenreich – Tufts University, USA |
20:05-20:15 (CET) 14:05-14:15 (EDT) | Closing remarks by scientific organizers & poster prize announcements |
Continued access to digital posters, networking and discussion platforms |
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EMBO | EMBL Symposia promote scientific communication and collaboration in the European research area. They provide scientists with a platform to discuss and exchange ideas on forward-looking topics and new developments in the life sciences.
Topics emphasise upcoming developments and the interdisciplinary nature of related fields. Jointly funded and organised by EMBO and EMBL – and complementary to their respective courses, workshops, and conference programmes – the symposia promote scientific communication and collaboration.
All symposia are held in the EMBL Advanced Training Centre (ATC) in Heidelberg, Germany, or virtually.
Date: 9 - 12 Mar 2021
Location: Virtual
Deadline(s):
Abstract submission: Closed
Registration: Closed
Contact: Lea Hohmann