Cellular mechanisms driven by phase separation

Time (Europe/Berlin)	Speaker
12:00 – 14:00	Registration and light refreshments
14:00 – 14:15	Opening remarks
14:15 – 15:15	Keynote lecture: Interphases, Interfaces, and Microphases Rohit Pappu – Washington University in St. Louis, USA
15:15 – 17:30	Session 1: Membraneless compartments in the cell Chair: Sara Cuylen-Häring – EMBL Heidelberg, Germany
15:15 – 15:45	Intracondensate demixing and the onset of disease Tony Hyman – Max Planck Institute of Molecular Cell Biology and Genetics, Germany
15:45 – 16:00	Targeted perturbation of signaling-driven condensates Jurian Schuijers – UMC Utrecht, The Netherlands
16:00 – 16:15	Nucleolus ejects internal components by altering its material properties upon arresting RNA flux Yuki Hayashi – EMBL Heidelberg, Germany Not available on demand
16:15 – 16:30	Specificity of condensate composition regulates transcription Benjamin Sabari – UT Southwestern Medical Center, USA
16:30 – 17:00	Coffee break and meet the speakers
17:00 – 17:30	Identifying condensate-forming proteins regardless of their structural disorder across organisms Agnes Toth-Petroczy – Max Planck Institute of Molecular Cell Biology and Genetics, Germany
17:30 – 18:00	Flash Talk Session 1 #125 Geng-Jen Jang #127 Ramona Jühlen #173 Stefan Niekam #175 Henri Niskanen #187 Aline Reuter #191 Tom Scheidt #201 Alexandra Shelest #203 Min Kyung Shinn #239 Theodore Yang #245 Jason Zhang
18:00 – 19:30	Poster Session 1 (odd numbers)
19:30 – 21:00	Dinner in Canteen
21:00 – 22:00	After dinner drinks in ATC Foyer

Time (Europe/Berlin)	Speaker
09:00 – 11:15	Session 2: Molecular mechanisms of condensate assembly Chair: Alex Holehouse – Washington University School of Medicine, USA
09:00 – 09:30	Modulating DEAD box protein phase transitions with charge and ions Tim Nott – King’s College London, UK
09:30 – 09:45	Surface condensation drives tight junction belt assembly in epithelial tissue sealing Daxiao Sun – Technische Universität Dresden, MPI-CBG, Germany
09:45 – 10:00	Quantifying collective interactions in biomolecular phase separation Hannes Ausserwöger – University of Cambridge, UK
10:00 – 10:30	Coffee break and meet the speakers
10:30 – 10:45	O-GlcNAcylation and poly(ADP-ribosyl)ation of protein IDRs: two case studies in PTM-dependent modulation of biomolecular condensates Michael Nosella – Hospital for Sick Children/University of Toronto, Canada
10:45 – 11:15	Internal Structure of Chromatin Condensates Mike Rosen – The University of Texas Southwestern Medical Center, USA
11:15 – 13:00	Session 3: Protein structure in the condensed state Chair: Janosch Hennig, EMBL Heidelberg, Germany
11:15 – 11:45	Decoding molecular plasticity in the dark proteome Edward Lemke – Johannes Gutenberg University Mainz, Institute of Molecular Biology (IMB), Germany Not available on demand
11:45 – 12:00	A multiscale model of PopZ condensation Keren Lasker – The Scripps Research Institute, USA Not available on demand
12:00 – 12:15	Lightning Condensates: the electrochemical functions of biomolecular condensates Yifan Dai – Washington University in St. Louis, USA Not available on demand
12:15 – 12:30	Structural reorganization underlying yeast cytoplasmic solidification Marie-Christin Spindler – EMBL Heidelberg, Germany
12:30 – 13:00	Complex coacervation of highly charged IDPs Ben Schuler – University of Zurich, Switzerland Not available on demand
13:00 – 14:30	Lunch and meet the editors
14:30 – 16:45	Session 4: Condensates and RNA Chair: Simon Alberti – Technische Universität Dresden, Germany
14:30 – 15:00	Multiphase behavior of the nucleolus throughout the C. elegans life cycle Stephanie Weber – McGill University, Canada
15:00 – 15:15	Germ granule higher-order organization coordinates their different functions Ali Haidar – Institute of Human Genetics IGH – University of Montpellier, France
15:15 – 15:30	Multiscale multiphase condensates buffers mRNA variations to promote robust mRNA:protein stoichiometry Amira Ouertani – Université Côte D’Azur, CNRS, Inserm, iBV, France
15:30 – 16:00	Coffee break and meet the speakers
16:00 – 16:15	Cold-Induced Phase Separation of a Chloroplast RNA binding protein Christian Schmitz-Linneweber – Humboldt University Berlin, Germany
16:15 – 16:30	Biomolecular condensates enable complex cell morphology through localized translation Zachary Geisterfer – Duke University, United States of America
16:30 – 16:45	TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing Tanja Bhuiyan – University of Freiburg, Germany
16:45 – 17:15	Flash talk Session 2 #73 Aritra Chowdhury #86 Nadia Erkamp #104 Marcos Gil-Garcia #116 Clara Hipp #170 Ambuja Navalkar #176 Mihajlo Novakovic #198 Aleksandra Sergeeva #216 Laura Thomas #226 Sören von Bülow #240 Tianjin Yang
17:15 – 18:45	Poster Session 2 (even numbers)
18:45 – 20:30	Dinner in Canteen
20:30 – 22:00	After dinner drinks in ATC Foyer

Time (Europe/Berlin)	Speaker
09:00 – 12:00	Session 5: Condensates in cellular quality control Chair: Dorothee Dormann – Johannes Gutenberg University Mainz, Germany
09:00 – 09:30	SUMO2/3 conjugation of TDP-43 protects against aggregation Serena Carra – University of Modena and Reggio Emilia, Italy
09:30 – 09:45	PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends Nagaraja Chappidi – Technische Universität Dresden, Germany
09:45 – 10:00	TERRA-LSD1 phase separation promotes R-loop formation for telomere maintenance in ALT cancer cells Huaiying Zhang – Carnegie Mellon University, USA
10:00 – 10:30	Coffee break and meet the speakers
10:30 – 11:00	Sequence programmable nucleic acid condensates Ankur Jain – Whitehead Institute for Biomedical Research, USA
11:00 – 11:15	Not just passive: Active PKA inside stress granule regulates their maturation for the timely recovery after stress Sonja Kroschwald – ETH Zurich, Switzerland
11:15 – 11:45	Regulation of stress-induced condensates and their role in cell health Hyun Kate Lee – University of Toronto, Canada
11:45 – 12:00	PDIA6 condensates regulate ER stress signaling Anna Leder – University of Basel, Switzerland
12:00 – 13:30	Lunch
13:30	Free afternoon
14:15 – 15:45	Optional: Guided City Tour of Heidelberg (Registration onsite; limited capacity available) Meeting Point is Neckarmünzplatz

Time (Europe/Berlin)	Speaker
09:30 – 12:00	Session 6: Condensates in gene expression Chair: Sina Wittmann – Institute of Molecular Biology, Germany
09:30 – 10:00	The role of stress-induced nuclear condensates of NELF in organismal physiology Ritwick Sawarkar – University of Cambridge, UK
10:00 – 10:15	Spatially controlled phase separation of MYC proteins as oncogenic principle Martin Eilers – University of Würzburg, Germany Not available on demand
10:15 – 10:30	HP1a mediates chromatin miscibility in vitro; driving spontaneous and reversible heterochromatin compartmentalization Lucy Brennan – University of California, Berkeley, USA
10:30 – 11:00	Coffee break and meet the speakers
11:00 – 11:15	Stress granules reinforce the translation program of the integrated stress response Jarrett Smith – Whitehead Institute, USA
11:15 – 11:45	DEAD-Box ATPases as regulators of RNA-containing membraneless organelles Maria Hondele – University of Basel, Switzerland Not available on demand
11:45 – 12:00	Dissecting the contributions of D/E tracts to setting up nucleolar pH gradients and complexities of complex coacervation Matthew King – Washington University in St. Louis, USA
12:00 – 14:00	Lunch
14:00 – 16:30	Session 7: Emerging technologies Chair: Julia Mahamid – EMBL Heidelberg, Germany
14:00 – 14:30	Molecular mechanisms of protein phase separation Tuomas Knowles – University of Cambridge, UK
14:30 – 14:45	Systematic identification of condensate targets and development of condensate-modifying drugs across therapeutic areas Avinash Patel – Dewpoint Therapeutics, USA
14:45 – 15:00	The phase separation landscape of genome-wide genetic perturbations Meta Heidenreich – Weizmann Institute of Science, Israel
15:00 – 15:15	Short linear motifs as condensation switches Steven Boeynaems – Baylor College of Medicine, USA Not available on demand
15:15 – 15:45	Coffee break and meet the speakers
15:45 – 16:15	Form and function in biomolecular condensation Yongdae Shin – Seoul National University, Korea
16:15 – 16:30	Spatiotemporal control of chromatin-associated condensate nucleation William Jacobs – Princeton University, USA
16:30 – 17:30	Keynote lecture: From physics to biology and back again: How physical understanding of condensate properties can explain biological function and disease processes Tanja Mittag – St. Jude Children’s Hospital, USA
17:30 – 17:45	Feedback Survey Session (Q&A)
17:45 – 18:00	Closing remarks and Poster prize
18:00 – 20:00	Conference Dinner in Canteen
20:00 – 23:00	Conference Party

On-site registration fees include admission, conference materials, meals and coffee breaks. Participants are expected to book and pay their own accommodation and travel expenses.

Virtual registration fees include access to all of the talks (livestreamed and on demand) and facility to submit questions.

On-site Academia	€725
On-site PhD Student	€625
On-site Industry	€925
On-site Journal Editor	€300
Virtual Academia	€225
Virtual PhD Student	€175
Virtual Industry	€275

* Editors from scientific journals are allowed to attend at a reduced rate, but asked to contribute to the conference in return by taking part in ‘meet the editors’ sessions or other planned activities within the programme.

A letter to support your visa application will be issued, on request, once payment of the registration fee is confirmed. We recommend that you book your visa appointment as soon as possible, to avoid any delay with your visa application.

Accredited journalists may be eligible to register for complimentary press registration. Registrants may be required to provide accreditation or equivalent proof of press membership after registration. Please contact Sophie Dutzi for more information. Please note that we do not offer complimentary registrations for editors of scientific journals.

Confirmation and payment

Registration will be on a first come, first served basis. Your place can only be confirmed after payment of the registration fee. If you are added to our waiting list, please consider taking advantage of our offerings to participate virtually.

On-site participants: Types of payments accepted are international bank transfers and credit card payments.

Virtual participants: We are only able to accept card payments. In exceptional cases we can accept bank transfers. Please contact events@embl.de for details.

Abstract submission

Only participants registering to attend the on-site event are eligible to submit an abstract. Abstracts will not be accepted from virtual participants.

After registration you can submit your abstract via a separate link that will be provided in the email confirmation. Alternatively, you can access the link on the confirmation page directly after registering. The same login credentials are used for both processes.

Please note:

Abstract body: The limit of 2000 characters refers to manually typed text and excludes spaces. If an error occurs try using a different web browser (preferably Google Chrome or Mozilla Firefox).

If you copy-paste the text into the form, hidden formatting might still be included which may cause the text to exceed the 2,000 character limit resulting in an error message. We recommend you clear all formatting before pasting in the text.

If you have special symbols in your text, make sure you are using Unicode characters, otherwise these will not be recognised.

Title: The title should not exceed 20 words. Only the first word of the title should start with a capital letter and the rest should be lowercase.

Authors and affiliations: Please fill in the author’s details as requested in the online form. The compulsory fields are: First Name, Last Name, Organisation Name (Affiliation or Company), Country and Email.

Kindly mark only one author in the role of First Author and please don’t forget to indicate who will be the Presenter.

Please enter your co-authors correctly via the system by adding accounts together with their organisation/institute. Do not copy-paste them into the body of the abstract text, as they will not be indexed in the abstract book.

Presentation types: When submitting your abstract, you can apply for an oral or poster presentation. A selection process will take place with the results announced 2-3 weeks after the abstract submission deadline.

For detailed instructions on how to submit a conference abstract, follow the instructions provided in this video.

Please check our FAQs pages for further information on how to submit an abstract.

Financial assistance

Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers, travel grants and childcare grants. 

Your place in the meeting is only confirmed by paying the registration fee, which is mandatory even when receiving a fee waiver.

Registration fee waiver

The fee waiver will cover the registration sum that you have paid to attend the course or conference.

Travel grant

The travel grant will cover the cost of travel to an on-site event (airfare, train, bus, taxi, accommodation, visa, and/or registration fees*) and is provided up to specified caps which are normally as follows:

–up to €400 for participants travelling to an EMBL Conference or EMBO|EMBL Symposium from within Europe.

–up to €1000 for participants travelling to an EMBL Conference or EMBO|EMBL Symposium from outside Europe.

–up to €500 for any participant travelling to an EMBO Workshop.

–up to €1000 for any participant working in Chile, India, Singapore or Taiwan travelling to an EMBO Workshop.

–up to €700 for any participant working in Croatia, Czech Republic, Estonia, Greece, Hungary, Italy, Lithuania, Luxembourg, Poland, Slovenia, and Turkey travelling to an EMBO Workshop.

*Registration fees are only covered for EMBO Workshops

The organisers may reduce the grant cap to accommodate more participants. Recipients will be notified of their travel cap amount when they are informed of the outcome of their application. Original receipts must be provided with your signature for all costs incurred within two months of completion of travel. Scanned copies cannot be accepted.

Childcare grant

There is the possibility to apply for a childcare grant to offset child care costs incurred by participants, speakers and organisers when attending a conference. Eligible costs include (but are not limited to) fees for a baby-sitter or child-care facility and travel costs for a caregiver. Please note that priority will be given to early stage researchers. In order to apply for this grant, you must be registered by the abstract submission deadline. There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants.

Application

On-site participants

You may apply for financial assistance when submitting your abstract. In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.

Virtual participants

If you are attending virtually, you can apply for financial assistance in the submission portal by the abstract deadline. Read the instructions on how to apply for financial assistance. Only submissions for financial assistance will be accepted. Presentation abstracts cannot be submitted here and will be declined. 

In your application you will be asked to summarise your current work,  answer questions regarding why your lab cannot fund your attendance, and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.

Selection

The scientific organisers will select the recipients of all financial assistance during the abstract selection process. Results will be announced approximately 6 – 8 weeks before the event start date, however for some events this may be delayed. Selection results do not impact your admission to the meeting. Selection for registration fee waivers and travel grants is based on scientific merit, your current work or study location, the reasons for needing financial support, and the impact this event will have on your career.

Childcare grants will be allocated in the same timeframe (6-8 weeks before the event start date). Please note that priority will be given to early-stage researchers.

Reimbursement

Costs will be reimbursed after the meeting only once a reimbursement form and original receipts (from travel costs) have been received.

Further details

View our list of external funding opportunities and information on attending a conference as an event reporter.

For further information about financial assistance please refer to the FAQ page.

Accommodation is not included in the conference registration fee.

As further changes in our events are possible, you should book flights, trains and hotels with flexible options and favourable cancellation conditions.

The hotels below have rooms on hold for participants until 16 April 2024, in some cases at special rates. Please email the hotel directly, quoting the booking code EES24-06 to confirm the exact price of the room.

Hotel Anlage	Hilton Heidelberg	Hotel Monpti
B&B Hotel	Hotel Holländer Hof	Premier Inn Heidelberg City
Hotel Bayrischer Hof	Hotel ibis Heidelberg	Hotel Vier Jahreszeiten Heidelberg
Exzellenz Hotel	Leonardo Hotel Heidelberg City Centre

Travel information

For travel information, please see here.

If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn ‘Event Ticket’ (called the ‘Veranstaltungsticket’ in German). This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km. You need to provide proof of your event attendance when purchasing the ticket.

For more information in English see here or in German see here.

You can book your ticket here.

Conference shuttle buses

Conference shuttle buses are free of charge for participants, and depart from designated bus stops near the hotels to EMBL and back, mornings and evenings.

The bus stops for this conference are:

• Hotel Staycity (Speyerer Str. 7)
• Kurfürsten-Anlage (Opposite Main Train Station)
• Hotel Premier (Kurfürsten-Anlage 23)
• Leonardo Hotel Heidelberg City Center (Bergheimer Str. 63)
• Neckarmuenzplatz (Heidelberg Tourist Information)
• Peterskirche (Bus stop)
• ISG Hotel (Im Eichwald 19)

Conference shuttle bus schedule

View Conference shuttle bus stops and hotels in a larger map. Please note that not every bus stop will be used for every event.

Further details

Address: EMBL, Meyerhofstraße 1, 69117 Heidelberg, Germany.

For more information about accommodation and travel, please refer to the FAQ page.

Catering

All meals and coffee breaks are included in the registration fee. Our catering staff will prepare a wide variety of vegetarian meals, meat and fish dishes, soups, pasta, fresh fruit and vegetables, as well as a variety of desserts.

Please wear your badge at all times when serving yourself.

No food or drinks are allowed in the auditorium.

Charging lockers

There are lockers available next to the stairs leading down into the Auditorium. You will find some of those equipped with sockets to charge your smartphone/tablet etc.

Electricity and charging station

In most places the electricity is 220 volts AC (50 cycles). An adaptor and a plug that fits the German socket may be needed for your appliances/laptop (i.e. American, Japanese, etc.). A USB charging station for electronic devices is available at the registration desk.

EMBL merchandise

If you are interested in purchasing EMBL merchandise (products presented in the glass display in the registration area), please email the EMBL shop to place an order or get in contact with your Course Organiser.

Kindly note the EMBL shop is only open upon request and all purchases must be made in cash (Euros only).

Health and safety notes

Please read EMBL’s COVID-19 safety policy for on-site events.
Do not smoke in any EMBL building.
Eating and drinking is prohibited in the Auditorium and all laboratories.
Do not enter any restricted areas or the laboratories unless instructed to do so.

If first aid is required …

• The first aid room is located next to the ATC Registration Desk (room 10- 205).
• Dial the Emergency number 222 from any EMBL internal phone only.
• Where is the accident? What happened? How many injured?
• Emergency number 06221-387 7821 from mobile phones.
• Please report all accidents to the conference officer at the registration desk.

In case of fire …

• Press the nearest fire alarm button or the Emergency number 222 from any internal phone.
• A loud fire alarm will go off if an evacuation is required. On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points
• Do not use the lifts.

Beyond first aid…

Please remember to bring your own medication, if needed, to the conference. Note that the next pharmacy is a 4-minute drive from the EMBL, but for many medications you will be required to see a doctor to get a prescription.

Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg. In any case, the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary.

Internet

Wi-Fi is available on campus using the EMBL-Events network and the event specific password, which will be provided on site. The eduroam network (secure, worldwide roaming access service developed for the international research and education community) is also available.

Lost and found

‘’Lost and Found’’ items are kept at the registration desk until the end of the conference.

Luggage

There are lockers available on-site to store your luggage, which require a 2 EURO coin to operate. There is another luggage room on level E0, which is free to use but remains unlocked during the conference.

Nursing room

There is a nursing room available in the ATC Rooftop Lounge on level A29.

Photography

During the conference, an EMBL Photographer may be taking photos. If you would not like to appear in these, please inform the photographer or a member of the Course and Conference Office.

Printing

We can help to print your boarding pass/train ticket. Please send it to events@embl.de and collect your print-outs at the registration desk.

Room for prayer, yoga and meditation

There is a room for prayer, meditation and yoga located on level E0 behind the Auditorium. Please be respectful of others using the room.

Sightseeing

A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing.

Travel to and from the venue

During the event, we provide conference shuttle buses to and from EMBL. In addition, there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time. Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page.

Useful German expressions

Hello	Hallo
Goodbye	Auf Wiedersehen (formal) Tschüss (informal)
Good morning	Guten Morgen
Good afternoon	Guten Tag
Good evening	Guten Abend
Good night	Gute Nacht
I’m sorry	Es tut mir leid
Excuse me…	Entschuldigen Sie
How are you?	Wie gehts?
I’m fine thanks. And you?	Mir geht es gut , danke. Und Dir/Ihnen?
What is your name	Wie heißen Sie? (formal) Wie heißt du? (informal)
My name is..	Ich heiße..
Do you speak English	Sprechen Sie englisch?
I don’t understand	Ich verstehe nicht
Please speak more slowly	Können Sie bitte langsamer sprechen
Thank you	Dankeschön
Where is the toilet?	Wo ist die Toilette?
Please call me a taxi	Bitte rufen Sie mir ein Taxi
How do I get to….?	Wie komme ich zum/zur…..?
A beer/two beers please	Ein Bier/zwei Bier bitte
A glass of red/white wine please	Ein Glas Rot/Weißwein bitte
The menu, please	Die Speisekarte, bitte
Is there a local speciality?	Gibt es eine Spezialität aus dieser Gegend?
I’m vegetarian	Ich bin Vegetarier
It was delicious	Es war hervorragend
The bill, please	Die Rechnung, bitte
I have a headache	Ich habe Kopfschmerzen
I have a sore throat	Ich habe Halsschmerzen
My stomach hurts	Ich habe Magenschmerzen
I’m allergic to	Ich bin allergisch gegen
I need a doctor who speaks English.	Ich brauche einen Arzt, der englisch spricht.

What’s included?

• Access to all the livestreamed talks
• Video library of the recorded talks during the event and for two weeks afterwards. Please note: at the request of individual speakers, some talks are not recorded.
• Facility to submit questions

Please note that only on-site participants are able to submit abstracts and participate in the poster sessions.

Event platform

We are using an event platform for this conference. More information about the platform will be shared ahead of the conference.

Guidelines

• Do not broadcast the conference to unregistered participants.
• You are encouraged to tweet and post about the event. Tweet unless the speaker specifically says otherwise, but be mindful of unpublished data. 
• Please do not capture, transmit or redistribute data presented at the meeting.

Additional information can be found in our Code of Conduct.

Health and well-being

It is important to stay healthy and move around, especially when you are attending an event virtually. We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event.

How to ask questions

Please use the Q&A function in the event platform.

If you have any other questions, you can go to the Help Desk in the event platform. Click on ‘more’ on the top menu and click Help Desk. 

Time zone

The programme is planned based on the Europe/Berlin time zone, unless otherwise stated. Please take your time zone into consideration when planning your attendance.

COVID-19 information for onsite events at EMBL Heidelberg can be found in our COVID-19 FAQs.