Nobutaka Hirokawa
The University of Tokyo
Japan
EMBO | EMBL Symposium
This conference will take place at EMBL Heidelberg, with the option to attend virtually.
Transport alert: storm damage is affecting some rail routes in southern Germany. Please check your journey on the website of the German rail operator, Deutsche Bahn if travelling by train.
This symposium, initiated in 2010, has taken place every second year since and brings together early-career and established researchers from all over the world who are interested in microtubule biology and its impact on human health and disease.
The microtubule cytoskeleton is essential for a wide variety of cellular functions, such as chromosome segregation, directed vesicle and organelle transport, cell motility, and cell polarity. Impaired microtubule function can lead to human diseases including cancer and neurodegenerative disorders, where microtubules serve as important therapeutic targets. In recent years, interdisciplinary approaches embracing cell biology, genetics, molecular biology, biochemistry, biophysics, structural biology, and mathematical modelling have made a tremendous impact on microtubule research.
The progressive diversification of the microtubule field creates the need for this strong meeting that unifies the community and brings together researchers from different disciplines interested in microtubule research. As per the now well-established format, the 2024 edition of the symposium will feature inspirational keynote and landmark lectures, a large number of short talk opportunities selected from the submitted abstracts, lively poster sessions, and activities for networking.
“Wonderful meeting that integrates the latest biophysics and cell biology. An opportunity for extended discussion with emerging leaders of the field.” – Tim Mitchson, Harvard Medical School, USA
“Great meeting that gathers a wonderful community in very fruitful discussions and networking. A must repeat!!!” – Ana Pimenta-Marques, University Nova de Lisboa, Portugal
“This conference provided a space for stimulating scientific discussions and constructive feedback! A great community to be a part of.” – Veronica Farmer, Vanderbilt University, USA
Utrecht University
The Netherlands
University of Colorado Boulder
USA
Columbia University
USA
MRC Laboratory of Molecular Biology
UK
LADIA
France
Institut Jacques Monod
France
Institut de la Vision
France
Stanford University
USA
University of Geneva
Switzerland
Institute for Research and Innovation in Health (i3S)
Portugal
Instituto de Medicina Molecular João Lobo Antunes
Portugal
University of Geneva
Switzerland
University of Cambridge
UK
National Tsing Hua University
Taiwan
MRC Laboratory of Molecular Biology
UK
Tohoku University
Japan
Max Planck Institute for Infection Biology
Germany
University of Virginia
USA
Max Planck Institute for Multidisciplinary Sciences
Germany
National Institute of Genetics
Japan
Institut Curie
France
Vanderbilt University
USA
Yale University
USA
Institut Curie
France
Dresden University of Technology
Germany
Tohoku University
Japan
Course and Conference Team Lead
EMBL Heidelberg
Germany
Are you on social media? Post using #EESMicrotubules and don’t forget to tag @EMBLEvents
Time (Europe/Berlin) | Speaker |
12:30 – 14:00 | Registration and light refreshments |
14:00 – 14:10 | Opening remarks |
14:10 – 15:55 | Session 1: Patterning of microtubule arrays Chair: Luke Rice – University of Texas, USA |
14:10 – 14:35 | The role of cytoskeleton in nuclear positioning and membrane remodeling during muscle formation Edgar Gomes – Instituto de Medicina Molecular João Lobo Antunes, Portugal |
14:35 – 14:50 | Step-wise assembly of axonemes visualised by cryo-electron tomography of the ciliary tip Helen Foster – Human Technopole, Italy |
14:50 – 15:15 | Regulation of microtubule function in ischaemic heart failure Xuan li – University of Cambridge, UK |
15:15 – 15:30 | Tubulin glutamylation patterns are central to axon guidance via selective tuning of microtubule-severing enzymes Coralie Fassier – Sorbonne Université, France |
15:30 – 15:55 | Precise control of microtubule structure and intracellular trafficking in living cells and behaving animals Yu-Chun Lin – National Tsing Hua University, Taiwan |
15:55 – 16:25 | Coffee Break and Meet the speakers |
16:25 – 17:55 | Session 2: Emerging topics 1 Chair: Susanne Bechstedt – McGill University, Canada |
16:25 – 16:40 | Native structures of tubulin-rich polymers from human parasite Toxoplasma gondii Rui Zhang – Washington University, USA |
16:40 – 16:55 | Robust cytoplasmic partitioning by solving an intrinsic cytoskeletal instability Melissa Rinaldin – Technische Universität Dresden, Germany |
16:55 – 17:10 | Torque generation by mitotic motors in microtubule overlaps Stefan Diez – Technische Universität Dresden, Germany |
17:10 – 17:25 | Molecular interplay between HURP and Kif18A in the regulation of the mitotic spindle Juan Manuel Perez Bertoldi – University of California, Berkeley, USA |
17:25 – 17:40 | Tubulin Code: Generating recognition patterns to selectively direct Microtubule-Associated Proteins Arya Krisnan – Institut Curie, France Not available on demand |
17:40 – 17:55 | Doublecortin and paclitaxel compete for control of microtubule lattice expansion and compaction Gary Brouhard – McGill University, Canada |
17:55 – 20:00 | Dinner in Canteen |
20:00 – 22:00 | After dinner drinks & poster preview |
Time (Europe/Berlin) | Speaker |
09:00 – 09:45 | Landmark Lecture: Microtubule plus-end tracking proteins: 25 years of cellular fireworks Anna Akhmanova – Utrecht University, The Netherlands |
09:45 – 10:15 | Coffee Break |
10:15 – 12:00 | Session 3: Microtubule motors and their regulation Chair: Zdenek Lansky – Institute of Biotechnology, Czech Academy of Sciences, Czech Republic |
10:15 – 10:40 | Animating microtubules by combining scientific drawing and programming Renaud Chabrier – Independent author, artist, and researcher |
10:40 – 10:55 | Stepping in two directions: mechanisms that govern the bidirectional motility of mitotic kinesin motors Leah Gheber – Ben-Gurion University of the Negev, Israel |
10:55 – 11:20 | A novel adaptor for cytoplasmic dynein 1 regulates ER sheet organization Reto Gassman – University of Porto, Portugal |
11:20 – 11:45 | Activation of monomeric kinesins Shinsuke Niwa – Tohoku University, Japan |
11:45 – 12:00 | Cryo-EM studies of cooperation between dynein/dynactin and kinesin-1 Sami Chaaban – MRC Laboratory of Molecular Biology, UK |
12:00 – 13:45 | Lunch & meet the speakers |
13:45 – 14:45 | Session 4: Emerging Topics 2 Chair: Laura Schaedel – Saarland University, Germany |
13:45 – 14:00 | Microtubule and centrin networks enable ultrastructural plasticity in planktonic eukaryotes Gautam Dey – EMBL Heidelberg, Germany |
14:00 – 14:15 | Cryo-ET reveals actin filaments within platelet microtubules Chisato Tsuji – University of Bristol, UK |
14:15 – 14:30 | Investigating microtubule nucleation apparatus in plant cells Masayoshi Nakamura – Nagoya University, Japan |
14:30 – 14:45 | Expanding the tubulin code through TTLL11 polyglutamylase activity Jana Nedvedová – Institute of Biotechnology of the Czech Academy of Sciences, Czech Republic |
14:45 – 15:15 | Flash talks session 1 #67 Subham Biswas #91 Takahiro Deguchi #97 Marcos Fariña-Mosquera #123 Carla Jaramillo #139 Thibault Legal #151 Eleonora Messuti #153 Aniruddha Mitra #161 Shweta Nandakumar #171 Yannes Popp #179 Mariana Romeiro Motta #197 Sarah Steffens #199 Bhagyanath Suresh #205 Emma van Grinsven #213 Yucheng Ye #217 Guoli Zhao |
15:15 – 15:45 | Coffee Break and Meet the speakers |
15:45 – 18:30 | Poster Session 1 (odd numbers) with beer and snacks |
18:30 – 20:00 | Dinner in EMBL Canteen |
20:00 – 20:45 | Keynote #1 The kinesin superfamily molecular motors and intracellular transport: from regulation of brain functions and development to related diseases Nobutaka Hirokawa – The University of Tokyo, Japan |
20:45 – 22:30 | Networking drinks |
Time (Europe/Berlin) | Speaker |
09:00 – 10:45 | Session 5: Microtubule Biophysics Chair: Francois Nedelec – University of Cambridge, UK |
09:00 – 09:25 | Diverse cytomotive actins and tubulins share a polymerisation switch mechanism conferring robust dynamics Jan Löwe – MRC Laboratory of Molecular Biology, UK |
09:25 – 09:50 | CLASPs stabilize the pre-catastrophe intermediate state between microtubule growth and shrinkage Marija Zanic – Vanderbilt University, USA |
09:50 – 10:15 | Towards a Complete Mechanochemical Cycle of Dynein-1 by High-Resolution Cryo-EM Jack Zhang – Yale University, USA **this talk is virtual** |
10:15 – 10:30 | Visualization of GTP hydrolysis in microtubules Tomohiro Shima – University of Tokyo, Japan |
10:30 – 10:45 | Non-averaging structural analysis of microtubules using cryo-ET Hanjin Liu – University of Tokyo, Japan |
10:45 – 11:15 | Coffee Break and Meet the speakers |
11:15 – 13:00 | Session 6: Microtubules in neurons Chair: Andreas Prokop – The University of Manchester, UK |
11:15 – 11:40 | Zebrafish as a model for the study of in vivo axonal transport in neurons and related disorders Fillipo Del Bene – Institut de la Vision, France Not available on demand |
11:40 – 11:55 | Mechanotransduction control of axonal microtubule distribution Shaul Yogev – Yale School of Medicine, USA |
11:55-12:20 | Of Axons and Microtubules: Tales from the Tubulin Code Francesca Bartolini – Columbia University, USA |
12:20 – 12:35 | In vitro reconstitution of microtubule doublets by MAP6d1 Dharshini Gopal – Université Grenoble, France |
12:35 – 13:00 | Asymmetric microtubule nucleation from the Golgi in neurons Paul Conduit- Institut Jacques Monod, France |
13:00 – 14:15 | Lunch |
14:15 – 15:00 | Landmark Lecture #2 Microtubules as tracks and engines: how scientific ideas emerge and evolve Richard McIntosh – University of Colorado Boulder, USA |
15:00 – 15:20 | Flash talks session 2 #66 Anika Binder #78 Po-Pang Chen #86 Sabina Colombo #96 Juan Estevez- Gallego #128 Daria Khuntsariya #130 Alison Kickuth #140 Miguel Leung #146 Francesca Maci #168 Gera Pavlova #198 Simone Steilberg |
15:20 – 15:50 | Coffee Break and Meet the speakers |
15:50 – 16:40 | Roundtable discussion: Gamma-Tubulin Complexes Anna Akhmanova – Utrecht University, The Netherlands Paul Conduit- Institut Jacques Monod, France Kuo-Chiang Hsia – Institute of Molecular Biology, Taiwan Tarun Kapoor – The Rockefeller University, USA Jens Luders – Institute for Research in Biomedicine, Spain Thomas Surrey – Centre for Genomic Regulation, Spain |
16:40 – 19:00 | Poster Session 2 (even numbers) with beer and snacks |
19:00 – 00:00 | BBQ and conference party |
Time (Europe/Berlin | Speaker |
09:30 – 11:15 | Session 7: Tubul-ins and outs Chair: Jawdat Al-Bassam – University of California, Davis, USA |
09:30 – 09:55 | The TRiCky business of folding tubulin Judith Frydman – Stanford University, USA Not available on demand |
09:55 – 10:10 | Ancestrally conserved methyl marks regulating neuronal function “written” on microtubules by the histone methyltransferase NSD3/MES-4 Edward Pietryk – Baylor College of Medicine, USA |
10:10 – 10:35 | Autoregulated control of tubulin mRNA stability Ivana Gasic – University of Geneva, Switzerland Not available on demand |
10:35 – 10:50 | Unveiling the tubulin code readers required for directed cell migration Marin Barisic – Danish Cancer Institute, Denmark |
10:50 – 11:15 | Opportunities & challenges: Studying microtubules form ectotherms Simone Reber – Max Planck Institute for Infection Biology, Germany Not available on demand |
11:15 – 11:45 | Coffee Break and Meet the speakers |
11:45 – 13:00 | Session 8: Microtubule-based control of cell architecture Chair: Isabelle Arnal – Grenoble Institute of Neuroscience, France |
11:45 – 12:10 | The archaeal origins of the eukaryotic cytoskeleton Buzz Baum – MRC Laboratory of Molecular Biology, UK Not available on demand |
12:10 – 12:35 | Unveiling centriole architecture assembly using expansion microscopy Virginie Hamel – University of Geneva, Switzerland Not available on demand |
12:35 – 13:00 | Examining the material properties of the spindle apparatus in cell-free Xenopus egg extracts Yuta Shimamoto – National Institute of Genetics, Japan |
13:00 – 14:30 | Lunch |
14:30 – 16:15 | Session 9: Microtubules in cell division Chair: Rytis Prekeris – University of Colorado, USA |
14:30 – 14:55 | Chimeras of Kinesin-6 and Kinesin-14 reveal domain functions and properties that lead to aneuploidy in fission yeast Phong Tran – Institut Curie,France |
14:55 – 15:10 | Uncovering the molecular mechanism of central spindle symmetry breaking during asymmetric cell division with synthetic biology Lara Krüger – MRC Laboratory of Molecular Biology, UK |
15:10 – 15:35 | Using 3D large scale electron tomography to study force generation in the mitotic spindlee Stefanie Redemann – University of Virginia, USA |
15:35 – 15:50 | Midzone spindles reorganisation from metaphase-to-anaphase in vitro Wei Ming Lim – Centre for Genomic Regulation, Spain |
15:50 – 16:15 | New insights into spindle assembly and aneuploidy in oocytes Melina Schuh – Max Planck Institute for Multidisciplinary Sciences, Germany Not available on demand |
16:15 – 16:30 | Poster prizes |
16:30 – 16:45 | Closing remarks |
On-site registration fees include admission, conference materials, meals and coffee breaks. Participants are expected to book and pay their own accommodation and travel expenses.
Virtual registration fees include access to all of the talks (live streamed and on-demand) and the facility to submit questions.
On-site Academia | €725 |
On-site PhD Student | €625 |
On-site Industry | €925 |
On-site Journal Editors* | €300 |
Virtual Academia | €225 |
Virtual PhD Student | €175 |
Virtual Industry | €275 |
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On-site participants
You may apply for financial assistance when submitting your abstract. In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.
Virtual participants
If you are attending virtually, you can apply for financial assistance in the submission portal by the abstract deadline. Read the instructions on how to apply for financial assistance. Only submissions for financial assistance will be accepted. Presentation abstracts cannot be submitted here and will be declined.
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View our list of external funding opportunities and information on attending a conference as an event reporter.
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The hotels below have rooms on hold for participants until Wednesday 8 May 2024, in some cases at special rates. Please email the hotel directly, quoting the booking code EES24-07 to confirm the exact price of the room.
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Hello | Hallo |
Goodbye | Auf Wiedersehen (formal) Tschüss (informal) |
Good morning | Guten Morgen |
Good afternoon | Guten Tag |
Good evening | Guten Abend |
Good night | Gute Nacht |
I’m sorry | Es tut mir leid |
Excuse me… | Entschuldigen Sie |
How are you? | Wie gehts? |
I’m fine thanks. And you? | Mir geht es gut , danke. Und Dir/Ihnen? |
What is your name | Wie heißen Sie? (formal) Wie heißt du? (informal) |
My name is.. | Ich heiße.. |
Do you speak English | Sprechen Sie englisch? |
I don’t understand | Ich verstehe nicht |
Please speak more slowly | Können Sie bitte langsamer sprechen |
Thank you | Dankeschön |
Where is the toilet? | Wo ist die Toilette? |
Please call me a taxi | Bitte rufen Sie mir ein Taxi |
How do I get to….? | Wie komme ich zum/zur…..? |
A beer/two beers please | Ein Bier/zwei Bier bitte |
A glass of red/white wine please | Ein Glas Rot/Weißwein bitte |
The menu, please | Die Speisekarte, bitte |
Is there a local speciality? | Gibt es eine Spezialität aus dieser Gegend? |
I’m vegetarian | Ich bin Vegetarier |
It was delicious | Es war hervorragend |
The bill, please | Die Rechnung, bitte |
I have a headache | Ich habe Kopfschmerzen |
I have a sore throat | Ich habe Halsschmerzen |
My stomach hurts | Ich habe Magenschmerzen |
I’m allergic to | Ich bin allergisch gegen |
I need a doctor who speaks English. | Ich brauche einen Arzt, der englisch spricht. |
Please note that only on-site participants are able to submit abstracts and participate in the poster sessions.
We are using an event platform for this conference. More information about the platform will be shared ahead of the conference.
Additional information can be found in our Code of Conduct.
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Please find additional information including FAQs, terms and conditions, COVID-19 safety policy and travelling to EMBL on our Information for participants page.
COVID-19 information for on-site events at EMBL Heidelberg can be found in our COVID-19 FAQs.
EMBO | EMBL Symposia promote scientific communication and collaboration in the European research area. They provide scientists with a platform to discuss and exchange ideas on forward-looking topics and new developments in the life sciences.
Topics emphasise upcoming developments and the interdisciplinary nature of related fields. Jointly funded and organised by EMBO and EMBL – and complementary to their respective courses, workshops, and conference programmes – the symposia promote scientific communication and collaboration.
All symposia are held in the EMBL Advanced Training Centre (ATC) in Heidelberg, Germany, or virtually.
Media partners
EMBO Reports, an EMBO Press journal
International Union of Biochemistry and Molecular Biology
Journal of Cell Science, The Company of Biologists Journal
Medinformatics, a Bon View Publishing journal
Open Biology, a Royal Society journal
Sponsorship opportunities
We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.de for further information.
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Date: 5 - 8 Jun 2024
Location: EMBL Heidelberg and Virtual
Venue: EMBL Advanced Training Centre
Deadline(s):
Abstract submission: Closed
Registration (On-site): Closed
Registration (Virtual): Closed
Organisers:
Contact: Christopher Stocks