Quantitative biology to molecular mechanisms

Time (Europe/Berlin)	Session
12:00 – 13:30	Registration and light refreshments
13:30 – 13:45	Opening remarks by Scientific Organisers
13:45 – 17:45	Systems to function – Segment 1 Chairs: Mikhail Savitski – EMBL Heidelberg, Germany Arnaud Krebs – EMBL Heidelberg, Germany
13:45 – 14:15	Dynamics and mechanisms of bifunctional transcriptional effectors in human cells Lacramioara Bintu – Stanford University, USA
14:15 – 14:30	Interspecies interactions between the nematode Pristionchus pacificus and bacterial food sources reveal candidate pathways regulating gene expression, behaviour, and survival Marina Athanasouli – Max Planck Institute for Biology Tübingen, Germany
14:30 – 14:45	The genetic architecture of the human SH3 domain interaction network Sebastian Jaaks-Kraatz – Friedrich Miescher Institute for Biomedical Research, Switzerland
14:45 – 15:15	Programming the epigenome to dissect context-dependent chromatin function James Hackett – EMBL Rome, Italy
15:15 – 15:30	Widespread position-dependent transcriptional regulatory sequences in plants Yoav Voichek – Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna BioCenter (VBC) Austria
15:30 – 15:45	Widespread chromatin context-dependencies of DNA double-strand break repair proteins Xabier Vergara – Netherlands Cancer Institute, The Netherlands
15:45 – 16:15	Coffee break and meet the speakers
16:15 – 16:45	Protein (mis)localization in human disease Mikko Taipale – University of Toronto, Canada
16:45 – 17:00	Spatial reconstruction of single-cell enhancer activity in a developing embryo Yad Ghavi-Helm – Ecole Normale Supérieure of Lyon – Institute of Functional Genomics of Lyon (IGFL), France Not available on demand
17:00 – 17:30	Interrogation of subcellular processes through RNA and protein interaction Kathryn Lilley – University of Cambridge, UK virtual speaker
17:30 – 17:45	Mapping Genotype-to-Phenotype Landscapes in Human Cells Abdelghani Mazouzi – Netherlands Cancer Institute, The Netherlands Not available on demand
17:45 – 18:45	Panel discussion: Bridging fields in career and science Moderator: Lacramioara Bintu – Stanford University, USA Panel speakers: Mo Khalil – Boston University, USA Kathryn Lilley – University of Cambridge, UK Mikko Taipale – University of Toronto, Canada Alexander van Oudenaarden – Hubrecht Institute, The Netherlands Xiaowei Zhuang (tbc)- Harvard University, USA
18:45 – 20:15	Dinner in EMBL Canteen
20:15 – 21:15	EMBL Pub Quiz
20:15 – 22:00	After dinner drinks in ATC Rooftop lounge

Time (Europe/Berlin)	Session
09:00 – 12:30	Systems to function – Segment 2 Chairs: Mikko Taipale – University of Toronto, Canada Yad Ghavi-Helm – Ecole Normale Supérieure of Lyon – Institute of Functional Genomics of Lyon (IGFL), France
09:00 – 09:30	Novel sequencing tools to explore translation in individual cells Alexander Van Oudenaarden – Hubrecht Institute, The Netherlands
09:30 – 09:45	A parsimonious mechanism to generate rhythmic gene expression with wide peak phase dispersion Helge Grosshans – Friedrich Miescher Institute for Biomedical Research, Switzerland Not available on demand
09:45 – 10:00	Developmental gene expression patterns driven by synthetic gene regulatory domains Daniel Murad Ibrahim – Berlin Institute of Health / Max Planck Institute for Molecular Genetics, Germany
10:00 – 10:30	Coffee break and meet the speakers
10:30 – 11:00	Building structural and spatial interactomes by cross-linking mass spectrometry Fan Liu – Leibniz Institute FMP Berlin, Germany
11:00 – 11:30	Synthetic reconstitution of complex cellular behavior Mo Khalil – Boston University, USA Not available on demand
11:30 – 11:45	A genetic interaction map for a human cell line Maximilian Billmann – University of Bonn, University Hospital Bonn, Germany Not available on demand
11:45 – 12:00	SPIDR: a multiplexed method for mapping RNA-Protein interactions reveals a mechanism of translational suppression in cellular stress Marko Jovanovic – Columbia University, USA
12:00 – 12:30	Transcription factor exchange enables prolonged transcriptional bursts Tineke Lenstra – Netherlands Cancer Institute, The Netherlands EMBO Young Investigator Lecture
12:30 – 13:15	Hike in the woods
12:30 – 14:00	Lunch
14:00 – 16:00	Systems to molecular mechanism – Segment 1 Chairs: Arnaud Krebs – EMBL Heidelberg, Germany Marko Jovanovic – Columbia University, USA
14:00 – 14:30	Discovering quantitative rules of enhancer-promoter communication with large numbers of artificial regulatory landscapes Luca Giorgetti – FMI Basel, Switzerland
14:30 – 14:45	A phage protein kinase subverts bacterial defense systems through promiscuous phosphorylation Tara Bartolec – EMBL Heidelberg, Germany
14:45 – 15:00	Probing DNA damage sites in living cells reveals novel DNA damage response factors Richard Cardoso da Silva – Utrecht University, The Netherlands Not available on demand
15:00 – 15:15	Functional maps of a genomic locus reveal confinement of an enhancer by its target gene Christine Moene – Netherlands Cancer Institute & Oncode Institute, The Netherlands
15:15 – 15:30	Mechano-transduction via membrane potential for growth control Markus Basan – Harvard Medical School, USA
15:30 – 16:00	Friend or foe: exploring the regulatory role of transposons in early mammalian development Joanna Jachowicz – IMBA Vienna, Austria
16:00 – 16:30	Coffee break
16:00 – 18:00	Poster Session 1 (odd numbers)
18:00 – 19:30	Dinner in EMBL Canteen
19:30 – 21:00	After dinner drinks in ATC Rooftop lounge

Time (Europe/Berlin)	Session
09:00 – 12:45	Systems to molecular mechanism – Segment 2 Chairs: Lacramioara Bintu – Stanford University, USA Celine Vallot – Institut Curie, France
09:00- 09:30	Spatially resolved single-cell genomics & cell atlas of the brain Xiaowei Zhuang – Harvard University, USA Not available on demand
09:30 – 09:45	Mammalian promoters are characterised by low frequency of occupancy and high turnover of RNA polymerase II Kasit Chatsirisupachai – EMBL Heidelberg, Germany
09:45 – 10:00	Chromatin-dependent motif syntax defines differentiation trajectories Sevi Durdu – Friedrich Miescher Institute for Biomedical Research, Germany
10:00- 10:30	Dynamics of microcompartment formation at the mitosis-to-G1 transition Anders Sejr Hansen – MIT Biological Engineering, USA
10:30 – 11:00	Coffee break and meet the speakers
11:00 – 11:30	Parsing human pancreatic cancers to identify localized tumour, stroma, and immune environments Hartland Jackson – Lunenfeld-Tanenbaum Research Institute, Canada Not available on demand
11:30 – 11:45	Scaling laws of human transcriptional activity Jiayin Hong – University of Cambridge, United Kingdom
11:45 – 12:00	Single-molecule chromatin configurations link transcription factor binding to expression in human cells Julia Schaepe – Stanford University, USA
12:00 – 12:30	Using proximity-dependent biotinylation to understand dynamic cell organization Anne Claude Gingras – University of Toronto, Canada
12:30 – 14:15	Lunch
14:15-17:45	Systems to disease – Segment 1 Chairs: Tineke Lenstra – Netherlands Cancer Institute, The Netherlands Anders Sejr Hansen – MIT Biological Engineering, USA
14:15 – 14:45	Single-cell phenoscaping of tumour microenvironment organoids Chris Tape – University College London, UK
14:45 – 15:00	Network-based framework for studying etiology and phenotype diversity in ciliopathies Ellen Aarts – ETH Zurich, Switzerland
15:00 – 15:15	Quantitative analysis of developmental timing in whole embryos Michael Dorrity – EMBL Heidelberg, Germany
15:15 – 15:45	Breast cancer epigenomics at single-cell resolution Celine Vallot – Institut Curie, France
15:45 – 16:15	Coffee break and meet the speakers
16:15 – 18:15	Poster session 2 (even numbers)
18:15 – 20:15	Conference dinner in EMBL Canteen
20:15 – 23:45	Conference party with DJ in Foyer

Time (Europe/Berlin)	Session
09:30 – 12:15	Systems to disease – Segment 2 Chairs: Hartland Jackson – Lunenfeld-Tanenbaum Research Institute, Canada Mikhail Savitski – EMBL Heidelberg, Germany
09:30 – 10:00	Transcriptional condensates in health and disease Denes Hnisz – MPI Molecular Genetics, Germany
10:00 – 10:15	Following transcription complex assembly over time Nils Eickhoff – Netherlands Cancer Institute, The Netherlands
10:15 – 10:30	Automated live-cell single-molecule imaging reveals the molecular dynamics of Sox9 during differentiation and a proliferative state transition in intestinal organoids Nike Walther – University of California, Berkeley, USA Not available on demand
10:30 – 11:00	Coffee break and meet the speakers
11:00- 11:30	Unraveling spatio-temporal regulation of gene expression during the cell cycle through integration of single-cell data and biophysics-informed deep learning Nacho Molina – Institute of Genetics and Molecular and Cellular Biology (IGBMC)​, France
11:30 – 12:00	From proteome variation across single cells to molecular mechanisms Nicolai Slavov – Northeastern University, USA
12:00 – 12:15	Poster prize and closing remarks
12:15 – 13:00	Packed lunch and departure
13:00	Conference shuttle to the Main station and hotels Bus to Frankfurt am Main airport (Terminal 1, tickets are available at the registration desk)

Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants. Availability is limited to participants attending on-site events in Heidelberg and will be indicated during the abstract or motivation letter submission process.

Your place in the meeting is only confirmed by paying the registration fee, which is mandatory even when receiving a fee waiver.

Registration fee waiver

The fee waiver will cover the registration sum that you have paid to attend the course or conference.

Travel grant

The travel grant will cover the cost of travel (airfare, train, bus, taxi, accommodation, visa, and/or registration fees*) and is provided up to specified caps which are normally as follows:

– up to €400 for participants travelling to an EMBL Course, EMBL Conference or EMBO|EMBL Symposium from within Europe.

– up to €1000 for participants travelling to an EMBL Course, EMBL Conference or EMBO|EMBL Symposium from outside Europe.

– up to €500 for any participant travelling to an EMBO Practical Course or EMBO Workshop.

– up to €1000 for any participant working in Chile, India, Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop.

*Registration fees are only covered for EMBO Practical Courses or EMBO Workshops

The organisers may reduce the grant cap to accommodate more participants. Recipients will be notified of their travel cap amount when they are informed of the outcome of their application. Original receipts must be provided with your signature for all costs incurred within two months of completion of travel. Scanned copies cannot be accepted.

Childcare grant (EMBO practical courses and workshops only)

For EMBO Practical Course or EMBO Workshop participants with children, there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course or conference. Eligible costs include fees for a baby-sitter or child-care facility, travel costs for a care giver, or travel costs for taking the child to the meeting etc. Please note that priority will be given to early stage researchers. A maximum amount of 500 EUR can be awarded per participant applying for an EMBO Childcare Grant. In order to apply for this grant for EMBO Workshops, you must be registered by the abstract submission deadline.

Application

You may apply for financial assistance when submitting your motivation letter for courses, and abstract for conferences. In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.

Selection

The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process. Results will be announced approximately 6-8 weeks before the event start date, however for some events this may be delayed. Selection results do not impact your admission to the meeting. Selection is based on your current work or study location, the reasons for needing financial support and the impact this event will have on your career.

Reimbursement

Costs will be reimbursed after the meeting only once a reimbursement form and original receipts (from travel costs) have been received.

Further details

View our list of external funding opportunities and information on attending a conference as an event reporter.

For further information about financial assistance please refer to the FAQ page.

Accommodation is not included in the conference registration fee.

As further changes in our events are possible due to COVID-19, you should book flights, trains and hotels with flexible options and favourable cancellation conditions.

The hotels below have rooms on hold for participants until 18 October 2024, in some cases at special rates. Please quote the booking code OMX24-01 and confirm the exact price of the room with the hotel directly.

Hotel Anlage	Hotel ibis Heidelberg	Hotel Monpti
Hotel Bayrischer Hof	ISG Hotel	Staycity Aparthotel Heidelberg
B&B Hotel	Leonardo Hotel Heidelberg City Centre	Hilton Heidelberg
Exzellenz Hotel	Meininger Heidelberg

Travel information

For travel information, please see here.

If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn ‘Event Ticket’ (called the ‘Veranstaltungsticket’ in German). This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km. You need to provide proof of your event attendance when purchasing the ticket.

For more information in English see here or in German see here.

You can book your ticket here.

Conference shuttle buses

Conference shuttle buses are free of charge for participants, and depart from designated bus stops near the hotels to EMBL and back, mornings and evenings.

Download the conference bus schedule here.

The bus stops for this conference are:

• Staycity Aparthotel (Speyerer Str. 7)
• Kurfürsten-Anlage (opposite Main Train Station)
• Premier Inn Hotel (Kurfürsten-Anlage 23)
• Leonardo Hotel City Centre (Bergheimer Str. 63)
• Neckarmünzplatz (Heidelberg Tourist Information)
• Peterskirche (Bus stop)
• Hans-Böckler-Straße Bus stop (near Rohrbacher Str. 22)
• ISG Hotel

View Conference shuttle bus stops and hotels in a larger map. Please note that not every bus stop will be used for every event.

Further details

Address: EMBL, Meyerhofstraße 1, 69117 Heidelberg, Germany.

For more information about accommodation and travel, please refer to the FAQ page.

Catering

All meals and coffee breaks are included in the registration fee. Our catering staff will prepare a wide variety of vegetarian meals, meat and fish dishes, soups, pasta, fresh fruit and vegetables, as well as a variety of desserts.

Please wear your badge at all times when serving yourself.

No food or drinks are allowed in the auditorium.

Charging lockers

There are lockers available next to the stairs leading down into the Auditorium. You will find some of those equipped with sockets to charge your smartphone/tablet etc.

Electricity and charging station

In most places the electricity is 220 volts AC (50 cycles). An adaptor and a plug that fits the German socket may be needed for your appliances/laptop (i.e. American, Japanese, etc.). A USB charging station for electronic devices is available at the registration desk.

EMBL merchandise

If you are interested in purchasing EMBL merchandise (products presented in the glass display in the registration area), please email the EMBL shop to place an order or get in contact with your Course Organiser.

Kindly note the EMBL shop is only open upon request and all purchases must be made in cash (Euros only).

Health and safety notes

Please read EMBL’s COVID-19 safety policy for on-site events.
Do not smoke in any EMBL building.
Eating and drinking is prohibited in the Auditorium and all laboratories.
Do not enter any restricted areas or the laboratories unless instructed to do so.

If first aid is required …

• The first aid room is located next to the ATC Registration Desk (room 10- 205).
• Dial the Emergency number 222 from any EMBL internal phone only.
• Where is the accident? What happened? How many injured?
• Emergency number 06221-387 7821 from mobile phones.
• Please report all accidents to the conference officer at the registration desk.

In case of fire …

• Press the nearest fire alarm button or the Emergency number 222 from any internal phone.
• A loud fire alarm will go off if an evacuation is required. On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points
• Do not use the lifts.

Beyond first aid…

Please remember to bring your own medication, if needed, to the conference. Note that the next pharmacy is a 4-minute drive from the EMBL, but for many medications you will be required to see a doctor to get a prescription.

Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg. In any case, the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary.

Internet

Wi-Fi is available everywhere on the premises (no password required), just log on to ATC-Guest. The eduroam network (secure, world-wide roaming access service developed for the international research and education community) is also available.

Lost and found

‘’Lost and Found’’ are kept at the registration desk until the end of the conference.

Luggage

There are lockers available on-site to store your luggage, which require a 2 EURO coin to operate. There is another luggage room on level E0, which is free to use but remains unlocked during the conference.

Nursing room

There is a nursing room available in the ATC Rooftop Lounge on level A29.

Photography

During the conference an EMBL Photographer may be taking photographs. If you would not like to appear in these, please inform the photographer or a member of the Course and Conference Office.

Printing

We can help printing your boarding passes/train ticket. Please send it to events@embl.de and collect your print-outs at the registration desk.

Room for prayer, yoga and meditation

There is a room for prayer, mediation and yoga located on level E0 behind the Auditorium. Please be respectful of other participants using the room.

Sightseeing

A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing.

Travel to and from the venue

During the event we provide conference shuttle buses to and from EMBL. In addition, there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time. Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page.

Useful German expressions

English	German
Hello	Hallo
Goodbye	Auf Wiedersehen
Good morning	Guten Morgen
Good afternoon	Guten Tag
Good evening	Guten Abend
Good night	Gute Nacht
I’m sorry	Tut mir leid
Excuse me…	Entschuldigen Sie
How are you?	Wie geht’s?
I’m fine thanks. And you?	Mir geht es gut , danke, und dir/Ihnen?
What is your name	Wie heisst du? Wie heissen Sie?
My name is	Ich heisse
Do you speak English	Sprechen Sie Englisch?
I don’t understand	Ich verstehe nicht
Please speak more slowly	Können Sie bitte langsamer sprechen
Thank you	Danke schön
Where is the toilet?	Wo ist die Toilette?
Please call me a taxi	Bitte rufen Sie mir ein Taxi
How do I get to….?	Wie komme ich zum/zur…..?
A beer/two beers, please	Ein Bier/zwei Bier bitte
A glass of red/white wine please	Ein Glas Rot/Weisswein bitte
The menu, please	Die Speisekarte, bitte
Is there a local speciality?	Gibt es eine Spezialität aus dieser Gegend?
I’m Vegetarian	Ich bin Vegetarier
It was delicious	Es war hervorragend
The bill, please	Die Rechnung, bitte
I have a headache	Ich habe Kopfschmerzen
I have a sore throat	Ich habe Halsschmerzen
My stomach hurts	Ich habe Magenschmerzen
I’m allergic to	Ich bin allergisch gegen
I need a doctor who speaks English	Gibt es einen Arzt, der Englisch spricht?

What’s included?

• Access to all the livestreamed talks
• Video library of the recorded talks during the event and for two weeks afterwards. Please note: at the request of individual speakers, some talks are not recorded.
• Facility to submit questions

Please note that only on-site participants are able to submit abstracts and participate in the poster sessions.

Event platform

We are using an event platform for this conference. More information about the platform will be shared ahead of the conference.

Guidelines

• Do not broadcast the conference to unregistered participants.
• You are encouraged to tweet and post about the event. Tweet unless the speaker specifically says otherwise, but be mindful of unpublished data. 
• Please do not capture, transmit or redistribute data presented at the meeting.

Additional information can be found in our Code of Conduct.

Health and well-being

It is important to stay healthy and move around, especially when you are attending an event virtually. We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event.

How to ask questions

Please use the Q&A function in the event platform.

If you have any other questions, you can go to the Help Desk in the event platform. Click on ‘more’ on the top menu and click Help Desk. 

Time zone

The programme is planned based on the Europe/Berlin time zone, unless otherwise stated. Please take your time zone into consideration when planning your attendance.

Please find additional information including FAQs, terms and conditions, COVID-19 safety policy and travelling to EMBL on our Information for Participants page.

COVID-19 information for on-site events at EMBL Heidelberg can be found in our COVID-19 FAQs.