Solution scattering from biological macromolecules

Overview

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Course overview

Small-angle scattering (SAS) is an analytical technique that provides insights into the conformation of biological macromolecules over various length scales: from small polymers to large assemblies. The macromolecules (including proteins, lipids, and nucleic acids) are measured in solution, so in their quasi-native environment, allowing researchers to probe the effects of different conditions such as pH, salt concentration, and the presence of binding partners. Thus, SAS delivers information beyond the static snapshots obtained with complementary high-resolution methods such as macromolecular crystallography and cryo-electron microscopy.

Recent advances in computational structure predictions such as those from AlphaFold, have further increased the capabilities of SAS for protein science. The computed high-resolution models enable enhanced data interpretation. Furthermore, SAS can easily be used to validate hypotheses derived fromcomputational predictions.

Our primary goal is to provide young scientists with a thorough understanding of SAS methods and itsintegration with complementary structural, computational, and biophysical techniques. Participants will learn to apply SAS to various scientific questions, including macromolecular assemblies, structural transitions, and enzymatic mechanisms. Recent developments in SAS will be highlighted by experts showcasing applications such as SAS studies on the unstructured biology of flexible systems and emerging areas of nanomedicines.

Learning outcomes

Solution small angle scattering (SAS) is emerging as an important tool in the current era of structural biology, applicable to a wide range of scientific research areas. Participants will learn to:

• Take advantage of the simplicity of collecting experimental data to test hypotheses, such as those derived from computer-based models.
• Benefit from the complementary nature of SAS to many other techniques and their combined use in integrative biology.
• Understand how SAS is used to tackle significant scientific problems, gaining information across length scales (from small polymers to large assemblies). This includes exploring the currently poorly understood world of unstructured biology and developing new approaches to address the cellular fate of emerging nanodrug carriers.
• Engage and exchange ideas with global experts while gaining practical experience in incorporating SAS into their research portfolio.

By participating in this program, students will broaden their technical skills and enhance their
ability to conduct innovative research in structural biology and related fields.

What past participants say about the course

“Participating in the EMBL course on “Solution Scattering from Biological Macromolecules” was a delightful experience, with its intimate setting enabling personalized discussions and the well-organized workshop offering ample opportunities for in-depth conversations and data analysis support. Meeting the BioSAXS group was a particular highlight, as their expertise and approachability made the entire experience both educational and enjoyable.” – Jaka Snoj, Department of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia

“At the EMBL course, a distinguished team of experts and beamline scientists provides an invaluable toolbox for SAXS data analysis. From Ab initio to Hybrid models, this comprehensive course offers a unique opportunity for both newcomers to scattering and individuals like myself, who have recently ventured into the study of biomacromolecules through scattering techniques.” – Davide Schirone, Malmö University, Sweden

Sponsors

Sponsorship opportunities

We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.de for further information.

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