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Infection Biology

Characterising pathogen interactions with the host at an atomic, molecular, and tissue level to tackle infection and antimicrobial resistance

Collaborating Institutions and Researchers

Researchers from five institutions are available as collaborators for the Amplifying Funds in Infection Biology

EMBL

Alex Bateman (IBTT)

  • Bacterial cell surface proteins, host-pathogen interactions, deep learning

Maria Bernabeu Aznar (IBTT)

  • Malaria pathogenesis, blood-brain barrier models, vascular inflammation

Sagar Bhogaraju (IBTT)

  • Ubiquitination pathways, bacterial effector proteins, Legionnaires’ disease

Peer Bork (METT)

  • Metagenomics, microbial communities, global microbiomes

Matthieu Boulard (IBTT)

  • Epigenetic gene silencing, adaptive immune response, epigenomic profiling

Matthew Bowler (IBTT)

  • Host reaction to infection, Toxoplasma gondii, inflammatory response

Guy Cochrane (IBTT)

  • Nucleotide sequence data, disease surveillance, vaccine development

Alvaro Hernan Crevenna Escobar (IBTT)

  • Light imaging, host-pathogen interactions, immune response

Gautam Dey (IBTT)

  • Nuclear organisation, malaria parasite, cell cycle network

Robert Finn (METT)

  • Metagenomic data, microbial diversity, genome reconstruction

Maria Marta Garcia Alai (METT)

  • Structural biology, protein-lipid interactions, endocytosis

Nick Goldman (IBTT)

  • Molecular evolution, machine learning, viral genome data

Jan Kosinski (IBTT)

  • Influenza virus, structural biology, pathogen interactions

Eva Kowalinski (IBTT)

  • RNA processing, Trypanosoma parasites, X-ray crystallography and cryo-electron microscopy

Andrew Leach (IBTT)

  • Drug discovery, antimicrobial agents, biological processes

John Lees (IBTT, METT)

  • Pathogen informatics, genomic epidemiology, bioinformatics tools

Julia Mahamid (IBTT)

  • Mycoplasma pneumoniae, RNA viruses, protein synthesis machinery

José Márquez (IBTT)

  • Macromolecular crystallography, therapeutic targets, small-molecule inhibitors

Maria-Jesus Martin (METT)

  • Bioinformatics tools, protein sequence, UniProt database

Simone Mattei (IBTT)

  • Protozoan parasites, cryo-electron tomography, mitochondrial ribosomes

Evangelia Petsalaki (IBTT)

  • Human cell signalling, pathogen interactions, network biology

Julio Saez Rodriguez (METT)

  • Cellular network deregulation, big data integration, disease therapeutics

Mikhail Savitski (METT)

  • Stability proteomics, Thermal Proteome Profiling, drug discovery

Nassos Typas (IBTT, METT)

  • Microbial systems biology, antibiotic resistance, bacterial networks

Jordi van Gestel (METT)

  • Microbial development, predation, mathematical modelling

Flora Vincent (METT)

  • Marine microbial interactions, symbiosis, carbon cycling

Matthias Wilmanns (IBTT)

  • Mycobacterial secretion mechanism, type VII secretion, structural biology

David Yuan (IBTT)

  • Genomic analysis, SARS-CoV-2, quantum computing algorithms

Judith Zaugg (IBTT)

  • Epigenetic variation, immunology, single-cell multiomics

Maria Zimmermann (METT)

  • Gut bacteria, computational modelling, multi-omics data

Michael Zimmermann (METT)

  • Gut microbiome, enzyme-encoding genes, drug metabolism

Institut Pasteur

This list is not restrictive, please check the complete list of researchers here.

Paola Arimondo

  • Epigenetic chemical biology

Giovanna Barba-Spaeth

  • FlavImmunity

Frédéric Barras

  • Stress adaptation and metabolism

Grégory Batt

  • Experimental and computational methods for predictive biology

Sebastian Baumgarten

  • Parasite RNA biology

Aude Bernheim

  • Molecular diversity of microbes

David Bikard

  • Synthetic biology

Sylvain Brisse

  • Biodiversity and epidemiology of bacterial pathogens

Carmen Buchrieser

  • Biology of intracellular bacteria

Pierre Buffet

  • Spleen, parasites and infections

Benoit Chassaing

  • Microbiome-host interactions

Sebastian Duchene

  • Evolutionary dynamics of infectious diseases

Philippe Glaser

  • Ecology and evolution of antibiotics resistance

Lucy Glover

  • Trypanosome molecular biology

Pablo Guardado-Calvo

  • Structural biology of infectious diseases

Didier Guillemot

  • Epidemiology and modelling of antibacterial evasion

Mélanie Hamon

  • Chromatin and infection

Romain Koszul

  • Spatial regulation of genomes

Marc Lecuit

  • Biology of infection

Isabelle Mangeot-Peter

  • Insect-virus interactions

Didier Mazel

  • Bacterial genome plasticity

Hugo Mouquet

  • Humoral immunology

Nicolas Rascovan

  • Microbial paleogenomics

Félix Rey

  • Structural virology

Eduardo Rocha

  • Microbial evolutionary genomics

Anavaj Sakuntabhai

  • Ecology and emergence of arthropod-borne pathogens

Nathalie Sauvonnet

  • Tissue homeostasis

Agathe Subtil

  • Cellular biology of microbial infection

Etienne Simon-Loriere

  • Evolutionary genomics of RNA viruses

Gerald Spaeth

  • Molecular parasitology and signaling

Michael White

  • Infectious disease epidemiology and analytics

Chiara Zurzolo

  • Membrane traffic and pathogenesis

MIMS

Iker Aramburu

  • Illuminating the dark proteome in innate immunity

Ellen Bushell

  • Parasite-host interactions that govern malaria infection and disease

Lars-Anders Carlson

  • Structure and mechanism of viral replication complexes

Laura Carroll

  • Bioinformatic approaches to monitor and combat the spread of bacterial pathogens

André Mateus

  • Mapping protein function in human gut microbiome species using proteomics and systems biology

Ryo Morimoto

  • Immune system evolution; cytidine deaminases in adaptive immunity and genome editing

Björn Schröder

  • Interaction between diet, gut microbiota and mucosal barrier function

Barbara Sixt

  • Cell-autonomous immunity and bacterial evasion strategies

HZI

Yannic Bartsch

  • Fc biology, antibody Fc, Fc effector functions, Fc engineering, monoclonal antibodies, systems Serology

Melanie Brinkmann

  • Innate immunity, herpesviral immune modulation, receptor signalling and trafficking, Type I interferon response, bone morphogenetic proteins, cytokines

Mark Brönstrup

  • Antibacterial and antiviral drug discovery and optimization, antibacterial drug conjugates, PROTACs, mode of action studies through metabolomics, intracellular drug quantification, peptide arrays

Dunja Bruder

  • Influenza, Influenza-pneumococcal co-infection, murine infection models, mucosal immunity, ex vivo immune cell phenotyping (FACS, transcriptional profiling), alveolar type II epithelial cells as targets for and responders to infections, prophylactic and therapeutic interventions (e.g. induction of the antiviral state by targeted stimulation of the interferon system), vaccination (systemic/ mucosal; protein, RNA, defective interfering particles)

Luka Cicin-Sain

  • Pseudovirus neutralisation assay, mutational scanning, virus reverse genetics, SARS-CoV-2, herpesvirus, RSV, Influenza, VSV, vaccine vector development, in vivo animal models, functional T cell assays, live cell imaging, CMV latency, dynamic transcriptomics at single-cell level

Franziska Faber

  • Clostridioides difficile, RNA-based mechanisms of virulence regulation, heterogeneity of virulence processes, microbial interactions, gut organoids

Susanne Häußler

  • Clinical isolates, molecular diagnostics, AMR, genotype-phenotype correlation

Lina Herhaus (starting October 2024)

  • Host-pathogen interactions, autophagy, innate immunity

Jens Hör

  • Phages, bacterial immunity, RNA

Ulrich Kalinke

  • Monoclonal antibodies, human dendritic cells and infection, infection mouse models, neuroinfection

Michael Kolbe

  • Cellular microbiology, bacterial infection, molecular infection mechanisms, Gram-negative pathogens, host pathogen interactions, secretion systems

Martin Korte

  • Viral infection, neuroinflammation, neurodegeneration, memory, brain fog, long COVID

Yang Li

  • Genetic regulation, immune phenotypes, immune responses, infection and vaccination, multi-omics integration, single cell genomics, spatial genomics

Michael Meyer-Hermann

  • Systems immunology, mathematical models, infection dynamics, host-pathogen interaction, adaptive immunity, whole body research.

Josef Penninger

  • Complex organoids, host-pathogen interactions, human tissue engineering, ACE2-molecular decoys, microbial effectomes, lectin applications

Frank Pessler

  • Vaccination strategies, high-risk individuals, biomarker discovery, mass spectrometry, RNA sequencing, therapeutic targets

Thomas Pietschmann

  • Respiratory viruses, hepatitis viruses, RSV, determinants of severe infection, antivirals, vaccines

Emmanuel Saliba

  • Single-cell RNA-seq, spatial transcriptomics, RNA biology, intestinal infection, clinics

Hortense Slevogt

  • Bacterial interaction, immune responses, respiratory microbiome, epithelial models, air-liquid interface, precision cut lung slices

Till Strowig

  • Microbiome, colonisation resistance, MDR enterobacterales, microbiome-based therapeutics, Klebsiella, Segatella/Prevotella

Jörg Vogel

  • RNA biology of bacterial infections

Wellcome Sanger Institute

Stephen Bentley

  • Bacterial respiratory pathogens, vaccine evasion, vaccine design, antibiotic resistance, infection control

Josie Bryant

  • Respiratory microbiome, chronic lung conditions, metagenomics, single-cell transcriptomics, microbiome-host interactions

Ewan Harrison

  • Respiratory viruses, genomic surveillance, metagenomics, antimicrobial resistance, pandemic threats

Trevor Lawley

  • Host-microbiota interactions, gut bacteria, microbiome assembly, pathogen colonisation resistance, immune development

Nicholas Thomson

  • Bacterial genomics, evolution, phylogeography, antimicrobial resistance, diarrhoeal disease, STIs
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