Our members define our research. The Alliance catalyzes scientific development by bringing together experts from both institutions and opening up access to new technologies.

Advances in technology have paved the way for the analysis of disease and health at a global level. The challenge now lies in harnessing the wealth of information to arrive at clinically relevant insights.

With expertise across the fields of genomics, bioinformatics, structural biology & imaging, our researchers are integrating their knowledge, to build on complementary strengths and create new research synergies.

Projects

Genomics

Disentangling gene function & organisation in the microbiome

Cell cycle adaptation to aneuploidy

Mitochondrial thermal proteome profiling for the study of oncometabolites interactome

Personalizing dilated cardiomyopathy

Dissecting NGLY1 deficiency

Mapping the effects of genetic variants from genes to cells to disease

Dissecting molecular mechanisms of epigenetic silencing

Somatic mosaicisms in cancer

Transcription Factor cooperativity atlas

Using scMulti-omics to probe clinical outcomes of child leukemia treatment

Using image-assisted cell sorting to determine the molecular mechanism controlling nuclear size

Cell-type specific chromatin loops & alternative exon usage

Deep Learning-Powered Study of 3D Tissue Structures and Molecular Cues in Breast Cancer Initiation

Deciphering Mechanisms and Rates of Chromosomal Instability in Gastric Cancer

Comprehensive pharmacogenetic analysis using real world data

Genome specialization in dinoflagellates

Co-translational nascent chain modifications and their adaptation to cellular stress

Unlocking the potential of image cell sorting for functional genomics and cell biology

Dissecting gene regulatory networks driving cell type differentiation in a marine annelid

Bioinformatics

Connecting organizational scales from the bottom-up to investigate emergence in embryonic pattern formation

Quantifying tumour evolution and fitness landscapes

Integrative machine learning to decipher genome function

Non-coding RNA annotation

Modern Statistics for Modern Biology

Physiological regulation of metabolism in single cells

Integrative model of human cell signalling

Multiomics characterisation of the regulatory landscape in pulmonary arterial hypertension

Interpretable Machine Learning for Variants in Disease

Imaging and Structural Biology

Integrated Structural Biology

Networks of subcellular compartments and subcellular organization in health and disease

Mechanism of CO₂ fixation reaction by enoyl-CoA carboxylases/reductase

Imaging: from electron, to light and intravital

Watching protein/protein- protein/ligand-interaction dynamics within the mTOR signaling pathway resolved in time and space