4-Anilinoquinazoline derivatives as the first potent NOD1-RIPK2 signaling pathway inhibitors at the nanomolar range.

Barczyk A, Six P, Rivoal M, Devos C, Dezitter X, Cornu-Choi MJ, Huard K, Pellegrini E, Cusack S, Dubuquoy L, Millet R, Leleu-Chavain N

Journal of medicinal chemistry, 2024

doi:10.1021/acs.jmedchem.4c01713.

The molecular dissection of TRIM25's RNA-binding mechanism provides key insights into its antiviral activity.

Álvarez L, Haubrich K, Iselin L, Gillioz L, Ruscica V, Lapouge K, Augsten S, Huppertz I, Choudhury NR, Simon B, Masiewicz P, Lethier M, Cusack S, Rittinger K, Gabel F, Leitner A, Michlewski G, Hentze MW, Allain FHT, Castello A, Hennig J

Nature communications, 2024

doi:10.1038/s41467-024-52918-x.

The RNA receptor RIG-I binding synthetic oligodeoxynucleotide promotes pneumonia survival.

Wang Y, Kulkarni VV, Pantaleón García J, Longmire MK, Lethier M, Cusack S, Evans SE

JCI insight, 2024

doi:10.1172/jci.insight.180584.

Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.

Arragain B, Krischuns T, Pelosse M, Drncova P, Blackledge M, Naffakh N, Cusack S

Nature communications, 2024

doi:10.1038/s41467-024-51007-3.

Structural snapshots of phenuivirus cap-snatching and transcription.

Williams HM, Thorkelsson SR, Vogel D, Busch C, Milewski M, Cusack S, Grünewald K, Quemin ERJ, Rosenthal M

Nucleic acids research, 2024

doi:10.1093/nar/gkae330.

The RBPome of influenza A virus NP-mRNA reveals a role for TDP-43 in viral replication.

Dupont M, Krischuns T, Gianetto QG, Paisant S, Bonazza S, Brault JB, Douché T, Arragain B, Florez-Prada A, Perez-Perri JI, Hentze MW, Cusack S, Matondo M, Isel C, Courtney DG, Naffakh N

Nucleic acids research, 2024

doi:10.1093/nar/gkae291.

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.

Krischuns T, Arragain B, Isel C, Paisant S, Budt M, Wolff T, Cusack S, Naffakh N

Nature communications, 2024

doi:10.1038/s41467-024-45205-2.

Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.

Arragain B, Pelosse M, Thompson A, Cusack S

Nature communications, 2023

doi:10.1038/s41467-023-44044-x.

Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface.

Lethier M, Huard K, Hons M, Favier A, Brutscher B, Boeri Erba E, Abbott DW, Cusack S, Pellegrini E

Life science alliance, 2023

doi:10.26508/lsa.202201784.

Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptation.

Camacho-Zarco AR, Yu L, Krischuns T, Dedeoglu S, Maurin D, Bouvignies G, Crépin T, Ruigrok RWH, Cusack S, Naffakh N, Blackledge M

Journal of the American Chemical Society, 2023

doi:10.1021/jacs.3c06965.

Structural and functional characterization of the Sin Nombre virus L protein.

Meier K, Thorkelsson SR, Durieux Trouilleton Q, Vogel D, Yu D, Kosinski J, Cusack S, Malet H, Grünewald K, Quemin ERJ, Rosenthal M

PLoS pathogens, 2023

doi:10.1371/journal.ppat.1011533.

Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.

Williams HM, Thorkelsson SR, Vogel D, Milewski M, Busch C, Cusack S, Grünewald K, Quemin ERJ, Rosenthal M

Nucleic acids research, 2023

doi:10.1093/nar/gkac1249.

The mechanism of genome replication and transcription in bunyaviruses.

Malet H, Williams HM, Cusack S, Rosenthal M

PLoS pathogens, 2023

doi:10.1371/journal.ppat.1011060.

Adenosine-dependent activation mechanism of prodrugs targeting an aminoacyl-tRNA synthetase.

Hoffmann G, Le Gorrec M, Mestdach E, Cusack S, Salmon L, Jensen MR, Palencia A

Journal of the American Chemical Society, 2023

doi:10.1021/jacs.2c04808.

Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.

Kouba T, Dubankova A, Drncova P, Donati E, Vidossich P, Speranzini V, Pflug A, Huchting J, Meier C, De Vivo M, Cusack S

Cell reports, 2022

doi:10.1016/j.celrep.2022.111901.

Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex.

Foucher AE, Touat-Todeschini L, Juarez-Martinez AB, Rakitch A, Laroussi H, Karczewski C, Acajjaoui S, Soler-López M, Cusack S, Mackereth CD, Verdel A, Kadlec J

Nature communications, 2022

doi:10.1038/s41467-022-32542-3.

Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.

Krischuns T, Isel C, Drncova P, Lukarska M, Pflug A, Paisant S, Navratil V, Cusack S, Naffakh N

PLoS pathogens, 2022

doi:10.1371/journal.ppat.1010328.

Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.

Arragain B, Durieux Trouilleton Q, Baudin F, Provaznik J, Azevedo N, Cusack S, Schoehn G, Malet H

Nature communications, 2022

doi:10.1038/s41467-022-28428-z.

Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.

Kouba T, Vogel D, Thorkelsson SR, Quemin ERJ, Williams HM, Milewski M, Busch C, Günther S, Grünewald K, Rosenthal M, Cusack S

Nature communications, 2021

doi:10.1038/s41467-021-27305-5.

Influenza virus RNA-dependent RNA polymerase and the host transcriptional apparatus.

Krischuns T, Lukarska M, Naffakh N, Cusack S

Annual review of biochemistry, 2021

doi:10.1146/annurev-biochem-072820-100645.

NCBP3 positively impacts mRNA biogenesis.

Dou Y, Barbosa I, Jiang H, Iasillo C, Molloy KR, Schulze WM, Cusack S, Schmid M, Le Hir H, LaCava J, Jensen TH

Nucleic acids research, 2020

doi:10.1093/nar/gkaa744.

Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.

Arragain B, Effantin G, Gerlach P, Reguera J, Schoehn G, Cusack S, Malet H

Nature communications, 2020

doi:10.1038/s41467-020-17349-4.

Structure and function of influenza polymerase.

Wandzik JM, Kouba T, Cusack S

Cold Spring Harbor perspectives in medicine, 2020

doi:10.1101/cshperspect.a038372.

Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein.

Vogel D, Thorkelsson SR, Quemin ERJ, Meier K, Kouba T, Gogrefe N, Busch C, Reindl S, Günther S, Cusack S, Grünewald K, Rosenthal M

Nucleic acids research, 2020

doi:10.1093/nar/gkaa253.

A structure-based model for the complete transcription cycle of influenza polymerase.

Wandzik JM, Kouba T, Karuppasamy M, Pflug A, Drncova P, Provaznik J, Azevedo N, Cusack S

Cell, 2020

doi:10.1016/j.cell.2020.03.061.

Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.

Liu RJ, Long T, Li H, Zhao J, Li J, Wang M, Palencia A, Lin J, Cusack S, Wang ED

Nucleic acids research, 2020

doi:10.1093/nar/gkaa189.

The cap-snatching mechanism of bunyaviruses.

Olschewski S, Cusack S, Rosenthal M

Trends in microbiology, 2020

doi:10.1016/j.tim.2019.12.006.

Structural snapshots of actively transcribing influenza polymerase.

Kouba T, Drncová P, Cusack S

Nature structural & molecular biology, 2019

doi:10.1038/s41594-019-0232-z.

RIP2 filament formation is required for NOD2 dependent NF-κB signalling.

Pellegrini E, Desfosses A, Wallmann A, Schulze WM, Rehbein K, Mas P, Signor L, Gaudon S, Zenkeviciute G, Hons M, Malet H, Gutsche I, Sachse C, Schoehn G, Oschkinat H, Cusack S

Nature communications, 2018

doi:10.1038/s41467-018-06451-3.

iNEXT: a European facility network to stimulate translational structural biology.

iNEXT Consortium

FEBS letters, 2018

doi:10.1002/1873-3468.13062.

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.

Omoto S, Speranzini V, Hashimoto T, Noshi T, Yamaguchi H, Kawai M, Kawaguchi K, Uehara T, Shishido T, Naito A, Cusack S

Scientific reports, 2018

doi:10.1038/s41598-018-27890-4.

Author Correction: Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.

Schulze WM, Stein F, Rettel M, Nanao M, Cusack S

Nature communications, 2018

doi:10.1038/s41467-018-04643-5.

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.

Koliopoulos MG, Lethier M, van der Veen AG, Haubrich K, Hennig J, Kowalinski E, Stevens RV, Martin SR, Reis E Sousa C, Cusack S, Rittinger K

Nature communications, 2018

doi:10.1038/s41467-018-04214-8.

Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.

Schulze WM, Stein F, Rettel M, Nanao M, Cusack S

Nature communications, 2018

doi:10.1038/s41467-018-04142-7.

Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.

Pflug A, Gaudon S, Resa-Infante P, Lethier M, Reich S, Schulze WM, Cusack S

Nucleic acids research, 2017

doi:10.1093/nar/gkx1210.

Kinetic origin of substrate specificity in post-transfer editing by leucyl-tRNA synthetase.

Dulic M, Cvetesic N, Zivkovic I, Palencia A, Cusack S, Bertosa B, Gruic-Sovulj I

Journal of molecular biology, 2017

doi:10.1016/j.jmb.2017.10.024.

Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.

Schulze WM, Cusack S

Nature communications, 2017

doi:10.1038/s41467-017-01402-w.

Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.

Pellegrini E, Signor L, Singh S, Boeri Erba E, Cusack S

PloS one, 2017

doi:10.1371/journal.pone.0177161.

Structural insights into reptarenavirus cap-snatching machinery.

Rosenthal M, Gogrefe N, Vogel D, Reguera J, Rauschenberger B, Cusack S, Günther S, Reindl S

PLoS pathogens, 2017

doi:10.1371/journal.ppat.1006400.

Structural insights into RNA synthesis by the influenza virus transcription-replication machine.

Pflug A, Lukarska M, Resa-Infante P, Reich S, Cusack S

Virus research, 2017

doi:10.1016/j.virusres.2017.01.013.

An in vitro fluorescence based study of initiation of RNA synthesis by influenza B polymerase.

Reich S, Guilligay D, Cusack S

Nucleic acids research, 2017

doi:10.1093/nar/gkx043.

Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis.

Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA

EMBO molecular medicine, 2017

doi:10.15252/emmm.201607370.

Structural basis of an essential interaction between influenza polymerase and Pol II CTD.

Lukarska M, Fournier G, Pflug A, Resa-Infante P, Reich S, Naffakh N, Cusack S

Nature, 2016

doi:10.1038/nature20594.

Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.

Chopra S, Palencia A, Virus C, Schulwitz S, Temple BR, Cusack S, Reader J

Nature communications, 2016

doi:10.1038/ncomms12928.

Anti-malarial benzoxaboroles target P. falciparum leucyl-tRNA synthetase.

Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ

Antimicrobial agents and chemotherapy, 2016

doi:10.1128/AAC.00820-16.

Cryptosporidium and Toxoplasma parasites are inhibited by a benzoxaborole targeting leucyl-tRNA synthetase.

Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S

Antimicrobial agents and chemotherapy, 2016

doi:10.1128/AAC.00873-16.

Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.

Reguera J, Gerlach P, Rosenthal M, Gaudon S, Coscia F, Günther S, Cusack S

PLoS pathogens, 2016

doi:10.1371/journal.ppat.1005636.

Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5.

Swale C, Monod A, Tengo L, Labaronne A, Garzoni F, Bourhis JM, Cusack S, Schoehn G, Berger I, Ruigrok RW, Crépin T

Scientific reports, 2016

doi:10.1038/srep24727.

Aminoacetylation Reaction Catalyzed by Leucyl-tRNA Synthetase Operates via a Self-Assisted Mechanism Using a Conserved Residue and the Aminoacyl Substrate

Aleksandrov A, Palencia A, Cusack S, Field M

JOURNAL OF PHYSICAL CHEMISTRY B, 2016

doi:10.1021/acs.jpcb.6b02387.

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.

Uchikawa E, Lethier M, Malet H, Brunel J, Gerlier D, Cusack S

Molecular cell, 2016

doi:10.1016/j.molcel.2016.04.021.

Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells.

Avilov S, Magnus J, Cusack S, Naffakh N

PloS one, 2016

doi:10.1371/journal.pone.0149986.

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.

Thierry E, Guilligay D, Kosinski J, Bock T, Gaudon S, Round A, Pflug A, Hengrung N, El Omari K, Baudin F, Hart DJ, Beck M, Cusack S

Molecular cell, 2015

doi:10.1016/j.molcel.2015.11.016.

Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases.

Reguera J, Gerlach P, Cusack S

Current opinion in structural biology, 2016

doi:10.1016/j.sbi.2016.01.002.

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.

Hengrung N, El Omari K, Serna Martin I, Vreede FT, Cusack S, Rambo RP, Vonrhein C, Bricogne G, Stuart DI, Grimes JM, Fodor E

Nature, 2015

doi:10.1038/nature15525.

Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism.

Zhao H, Palencia A, Seiradake E, Ghaemi Z, Cusack S, Luthey-Schulten Z, Martinis S

ACS chemical biology, 2015

doi:10.1021/acschembio.5b00291.

An RNA Hybridization Assay for Screening Influenza A Virus Polymerase Inhibitors Using the Entire Ribonucleoprotein Complex.

Roch FF, Hinterkörner G, Menke J, Tang GQ, Cusack S, Butzendobler B, Buschmann H, Datta K, Wolkerstorfer A

Assay and drug development technologies, 2015

doi:10.1089/adt.2015.668.

Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5

Louber J, Brunel J, Uchikawa E, Cusack S, Gerlier D

BMC BIOLOGY, 2015

doi:10.1186/s12915-015-0166-9.

Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter.

Gerlach P, Malet H, Cusack S, Reguera J

Cell, 2015

doi:10.1016/j.cell.2015.05.006.

Structure of influenza A polymerase bound to the viral RNA promoter.

Pflug A, Guilligay D, Reich S, Cusack S

Nature, 2014

doi:10.1038/nature14008.

Structural insight into cap-snatching and RNA synthesis by influenza polymerase.

Reich S, Guilligay D, Pflug A, Malet H, Berger I, Crépin T, Hart D, Lunardi T, Nanao M, Ruigrok RW, Cusack S

Nature, 2014

doi:10.1038/nature14009.

Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation.

Bousset L, Mary C, Brooks MA, Scherrer A, Strub K, Cusack S

RNA (New York, N.Y.), 2014

doi:10.1261/rna.047209.114.

RIG-I Self-Oligomerization Is Either Dispensable or Very Transient for Signal Transduction

Louber J, Kowalinski E, Bloyet LM, Brunel J, Cusack S, Gerlier D

PloS one, 2014

doi:10.1371/journal.pone.0108770.

RNA clamping by vasa assembles a piRNA amplifier complex on transposon transcripts.

Xiol J, Spinelli P, Laussmann MA, Homolka D, Yang Z, Cora E, Couté Y, Conn S, Kadlec J, Sachidanandam R, Kaksonen M, Cusack S, Ephrussi A, Pillai RS

Cell, 2014

doi:10.1016/j.cell.2014.05.018.

The physiological target for LeuRS translational quality control is norvaline

Cvetesic N, Palencia A, Halasz I, Cusack S, Gruic-Sovulj I

The EMBO journal, 2014

doi:10.15252/embj.201488199.

Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex

Dias J, Van Nguyen N, Georgiev P, Gaub A, Brettschneider J, Cusack S, Kadlec J, Akhtar A

Genes & development, 2014

doi:10.1101/gad.240200.114.

Segmented negative strand RNA virus nucleoprotein structure

Reguera J, Cusack S, Kolakofsky D

Current opinion in virology, 2014

doi:10.1016/j.coviro.2014.01.003.

Crystal structure of vaccinia virus mRNA capping enzyme provides insights into the mechanism and evolution of the capping apparatus

Kyrieleis OJ, Chang J, de la Peña M, Shuman S, Cusack S

Structure (London, England : 1993), 2014

doi:10.1016/j.str.2013.12.014.

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2

Clerici M, Deniaud A, Boehm V, Gehring NH, Schaffitzel C, Cusack S

Nucleic acids research, 2013

doi:10.1093/nar/gkt1197.

Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains

Guilligay D, Kadlec J, Crépin T, Lunardi T, Bouvier D, Kochs G, Ruigrok RW, Cusack S

PloS one, 2014

doi:10.1371/journal.pone.0084973.

CBC-ARS2 stimulates 3'-end maturation of multiple RNA families and favors cap-proximal processing

Hallais M, Pontvianne F, Andersen PR, Clerici M, Lener D, Benbahouche Nel H, Gostan T, Vandermoere F, Robert MC, Cusack S, Verheggen C, Jensen TH, Bertrand E

Nature structural & molecular biology, 2013

doi:10.1038/nsmb.2720.

New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain

Pautus S, Sehr P, Lewis J, Fortuné A, Wolkerstorfer A, Szolar O, Guilligay D, Lunardi T, Décout JL, Cusack S

Journal of medicinal chemistry, 2013

doi:10.1021/jm401369y.

Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9

Wu H, Mathioudakis N, Diagouraga B, Dong A, Dombrovski L, Baudat F, Cusack S, de Massy B, Kadlec J

Cell reports, 2013

doi:10.1016/j.celrep.2013.08.035.

Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage

Datta K, Wolkerstorfer A, Szolar OH, Cusack S, Klumpp K

Nucleic acids research, 2013

doi:10.1093/nar/gkt603.

Systems to establish bunyavirus genome replication in the absence of transcription

Klemm C, Reguera J, Cusack S, Zielecki F, Kochs G, Weber F

Journal of virology, 2013

doi:10.1128/jvi.00371-13.

Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein

Reguera J, Malet H, Weber F, Cusack S

Proceedings of the National Academy of Sciences of the United States of America, 2013

doi:10.1073/pnas.1302298110.

Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria

Hernandez V, Crépin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ

Antimicrobial agents and chemotherapy, 2013

doi:10.1128/aac.02058-12.

Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens

Li L, Palencia A, Lukk T, Li Z, Luthey-Schulten ZA, Cusack S, Martinis SA, Boniecki MT

Proceedings of the National Academy of Sciences of the United States of America, 2013

doi:10.1073/pnas.1218374110.

Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase

Chopra S, Palencia A, Virus C, Tripathy A, Temple BR, Velazquez-Campoy A, Cusack S, Reader JS

Nature communications, 2013

doi:10.1038/ncomms2421.

Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein

Avilov SV, Moisy D, Naffakh N, Cusack S

Vaccine, 2012

doi:10.1016/j.vaccine.2012.09.077.

A structure-based model of RIG-I activation

Kolakofsky D, Kowalinski E, Cusack S

RNA (New York, N.Y.), 2012

doi:10.1261/rna.035949.112.

Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila

Hallacli E, Lipp M, Georgiev P, Spielman C, Cusack S, Akhtar A, Kadlec J

Molecular cell, 2012

doi:10.1016/j.molcel.2012.09.014.

The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors

Mathioudakis N, Palencia A, Kadlec J, Round A, Tripsianes K, Sattler M, Pillai RS, Cusack S

RNA (New York, N.Y.), 2012

doi:10.1261/rna.034181.112.

Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase

Palencia A, Crépin T, Vu MT, Lincecum TL Jr, Martinis SA, Cusack S

Nature structural & molecular biology, 2012

doi:10.1038/nsmb.2317.

Replication-competent influenza A virus that encodes a split-green fluorescent protein-tagged PB2 polymerase subunit allows live-cell imaging of the virus life cycle

Avilov SV, Moisy D, Munier S, Schraidt O, Naffakh N, Cusack S

Journal of virology, 2012

doi:10.1128/jvi.05820-11.

[RIG-I: a viral RNA detector molecular switch]

Kowalinski E, Louber J, Gerlier D, Cusack S

Medecine sciences : M/S, 2012

doi:10.1051/medsci/2012282006.

Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase

Kowalinski E, Zubieta C, Wolkerstorfer A, Szolar OH, Ruigrok RW, Cusack S

PLoS pathogens, 2012

doi:10.1371/journal.ppat.1002831.

The structural basis for the integrity of adenovirus Ad3 dodecahedron

Szolajska E, Burmeister WP, Zochowska M, Nerlo B, Andreev I, Schoehn G, Andrieu JP, Fender P, Naskalska A, Zubieta C, Cusack S, Chroboczek J

PloS one, 2012

doi:10.1371/journal.pone.0046075.

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, Grigorov B, Gerlier D, Cusack S

Cell, 2011

doi:10.1016/j.cell.2011.09.039.

Investigating a macromolecular complex: the toolkit of methods

Perrakis A, Musacchio A, Cusack S, Petosa C

Journal of structural biology, 2011

doi:10.1016/j.jsb.2011.05.014.

Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1

Kadlec J, Hallacli E, Lipp M, Holz H, Sanchez-Weatherby J, Cusack S, Akhtar A

Nature structural & molecular biology, 2011

doi:10.1038/nsmb.1960.

A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase

Crepin T, Peterson F, Haertlein M, Jensen D, Wang C, Cusack S, Kron M

Journal of molecular biology, 2011

doi:10.1016/j.jmb.2010.11.049.

Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms

Boivin S, Cusack S, Ruigrok RW, Hart DJ

The Journal of biological chemistry, 2010

doi:10.1074/jbc.r110.117531.

Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit

Crépin T, Dias A, Palencia A, Swale C, Cusack S, Ruigrok RW

Journal of virology, 2010

doi:10.1128/jvi.00995-10.

Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX

Mourão A, Varrot A, Mackereth CD, Cusack S, Sattler M

RNA (New York, N.Y.), 2010

doi:10.1261/rna.2009910.

Nuclear import and assembly of influenza A virus RNA polymerase studied in live cells by fluorescence cross-correlation spectroscopy

Huet S, Avilov SV, Ferbitz L, Daigle N, Cusack S, Ellenberg J

Journal of virology, 2010

doi:10.1128/jvi.01533-09.

Towards an atomic resolution understanding of the influenza virus replication machinery

Ruigrok RW, Crépin T, Hart DJ, Cusack S

Current opinion in structural biology, 2010

doi:10.1016/j.sbi.2009.12.007.

Avancées dans l'étude structurale et la compréhension moléculaire du mécanisme de transcription du virus de la grippe [Advances in the structural study and molecular comprehension of the transcription mechanism of influenza virus]

Chenavas S, Guilligay D, Cusack S, Hart DJ, Ruigrok RWH, Crépin T

Virologie, 2010

doi:10.1684/vir.2010.0328.

Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription

Reguera J, Weber F, Cusack S

PLoS pathogens, 2010

doi:10.1371/journal.ppat.1001101.

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S

The EMBO journal, 2009

doi:10.1038/emboj.2009.175.

Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles

Seiradake E, Mao W, Hernandez V, Baker SJ, Plattner JJ, Alley MR, Cusack S

Journal of molecular biology, 2009

doi:10.1016/j.jmb.2009.04.073.

Structure and functional relevance of the Slit2 homodimerization domain

Seiradake E, von Philipsborn AC, Henry M, Fritz M, Lortat-Jacob H, Jamin M, Hemrika W, Bastmeyer M, Cusack S, McCarthy AA

EMBO reports, 2009

doi:10.1038/embor.2009.95.

Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis

Johansson S, Nilsson E, Qian W, Guilligay D, Crepin T, Cusack S, Arnberg N, Elofsson M

Journal of medicinal chemistry, 2009

doi:10.1021/jm801609s.

Structure of SRP14 from the Schizosaccharomyces pombe signal recognition particle

Brooks MA, Ravelli RB, McCarthy AA, Strub K, Cusack S

Acta crystallographica. Section D, Biological crystallography, 2009

doi:10.1107/s0907444909005484.

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Dias A, Bouvier D, Crépin T, McCarthy AA, Hart DJ, Baudin F, Cusack S, Ruigrok RW

Nature, 2009

doi:10.1038/nature07745.

[New strategy for targeting influenza virus replication]

Dias A, Bouvier D, Cusack S, Ruigrok RW, Crépin T

Medecine sciences : M/S, 2009

doi:10.1051/medsci/2009254352.

The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution

Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S, Kremer EJ

PLoS pathogens, 2009

doi:10.1371/journal.ppat.1000277.

Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex

Worch R, Jankowska-Anyszka M, Niedzwiecka A, Stepinski J, Mazza C, Darzynkiewicz E, Cusack S, Stolarski R

Journal of molecular biology, 2009

doi:10.1016/j.jmb.2008.10.092.

Structure of the C-terminal head domain of the fowl adenovirus type 1 short fibre

El Bakkouri M, Seiradake E, Cusack S, Ruigrok RW, Schoehn G

Virology, 2008

doi:10.1016/j.virol.2008.05.011.

The structural basis for cap binding by influenza virus polymerase subunit PB2

Guilligay D, Tarendeau F, Resa-Infante P, Coloma R, Crepin T, Sehr P, Lewis J, Ruigrok RW, Ortin J, Hart DJ, Cusack S

Nature structural & molecular biology, 2008

doi:10.1038/nsmb.1421.

Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit

Tarendeau F, Crepin T, Guilligay D, Ruigrok RW, Cusack S, Hart DJ

PLoS pathogens, 2008

doi:10.1371/journal.ppat.1000136.

[Trap the product to specifically inhibit the enzyme]

Crépin T, Cusack S

Medecine sciences : M/S, 2007

doi:10.1051/medsci/200723121087.

Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl-transferase

De la Peña M, Kyrieleis OJ, Cusack S

The EMBO journal, 2007

doi:10.1038/sj.emboj.7601912.

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3

Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA

Acta crystallographica. Section D, Biological crystallography, 2007

doi:10.1107/s0907444907035470.

Structural insights into the Slit-Robo complex

Morlot C, Thielens NM, Ravelli RB, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA

Proceedings of the National Academy of Sciences of the United States of America, 2007

doi:10.1073/pnas.0705310104.

Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human roundabout 1 (Robo1)

Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA

Acta crystallographica. Section F, Structural biology and crystallization communications, 2007

doi:10.1107/S1744309107033027.

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

Rock FL, Mao W, Yaremchuk A, Tukalo M, Crépin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, Alley MR

Science (New York, N.Y.), 2007

doi:10.1126/science.1142189.

A methodology and an instrument for the temperature-controlled optimization of crystal growth

Budayova-Spano M, Dauvergne F, Audiffren M, Bactivelane T, Cusack S

Acta crystallographica. Section D, Biological crystallography, 2007

doi:10.1107/s0907444906054230.

Structure of dimeric SecA, the Escherichia coli preprotein translocase motor

Papanikolau Y, Papadovasilaki M, Ravelli RB, McCarthy AA, Cusack S, Economou A, Petratos K

Journal of molecular biology, 2007

doi:10.1016/j.jmb.2006.12.049.

Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit

Tarendeau F, Boudet J, Guilligay D, Mas PJ, Bougault CM, Boulo S, Baudin F, Ruigrok RW, Daigle N, Ellenberg J, Cusack S, Simorre JP, Hart DJ

Nature structural & molecular biology, 2007

doi:10.1038/nsmb1212.

Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK

Manon F, Favier A, Núñez G, Simorre JP, Cusack S

Journal of molecular biology, 2007

doi:10.1016/j.jmb.2006.09.067.

Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer

Torreira E, Schoehn G, Fernández Y, Jorba N, Ruigrok RW, Cusack S, Ortín J, Llorca O

Nucleic acids research, 2007

doi:10.1093/nar/gkm336.

Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor

Seiradake E, Lortat-Jacob H, Billet O, Kremer EJ, Cusack S

The Journal of biological chemistry, 2006

doi:10.1074/jbc.m605316200.

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value

Banci L, Bertini I, Cusack S, de Jong RN, Heinemann U, Jones EY, Kozielski F, Maskos K, Messerschmidt A, Owens R, Perrakis A, Poterszman A, Schneider G, Siebold C, Silman I, Sixma T, Stewart-Jones G, Sussman JL, Thierry JC, Moras D

Acta crystallographica. Section D, Biological crystallography, 2006

doi:10.1107/s0907444906029350.

High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput gene-to-structure pipeline

Beteva A, Cipriani F, Cusack S, Delageniere S, Gabadinho J, Gordon EJ, Guijarro M, Hall DR, Larsen S, Launer L, Lavault CB, Leonard GA, Mairs T, McCarthy A, McCarthy J, Meyer J, Mitchell E, Monaco S, Nurizzo D, Pernot P, Pieritz R, Ravelli RG, Rey V, Shepard W, Spruce D, Stuart DI, Svensson O, Theveneau P, Thibault X, Turkenburg J, Walsh M, McSweeney SM

Acta crystallographica. Section D, Biological crystallography, 2006

doi:10.1107/s0907444906032859.

Automation of sample mounting for macromolecular crystallography

Cipriani F, Felisaz F, Launer L, Aksoy JS, Caserotto H, Cusack S, Dallery M, di-Chiaro F, Guijarro M, Huet J, Larsen S, Lentini M, McCarthy J, McSweeney S, Ravelli R, Renier M, Taffut C, Thompson A, Leonard GA, Walsh MA

Acta crystallographica. Section D, Biological crystallography, 2006

doi:10.1107/s0907444906030587.

Structures of two bacterial prolyl-tRNA synthetases with and without a cis-editing domain

Crepin T, Yaremchuk A, Tukalo M, Cusack S

Structure (London, England : 1993), 2006

doi:10.1016/j.str.2006.08.007.

Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1

Kadlec J, Guilligay D, Ravelli RB, Cusack S

RNA (New York, N.Y.), 2006

doi:10.1261/rna.177606.

Structural genomics of the Epstein-Barr virus

Tarbouriech N, Buisson M, Géoui T, Daenke S, Cusack S, Burmeister WP

Acta crystallographica. Section D, Biological crystallography, 2006

doi:10.1107/s0907444906030034.

Structural and biochemical characterization of a human adenovirus 2/12 penton base chimera

Zubieta C, Blanchoin L, Cusack S

The FEBS journal, 2006

doi:10.1111/j.1742-4658.2006.05430.x.

Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change

Sukuru SC, Crepin T, Milev Y, Marsh LC, Hill JB, Anderson RJ, Morris JC, Rohatgi A, O'Mahony G, Grøtli M, Danel F, Page MG, Härtlein M, Cusack S, Kron MA, Kuhn LA

Journal of computer-aided molecular design, 2006

doi:10.1007/s10822-006-9043-5.

Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC)

Balatsos NA, Nilsson P, Mazza C, Cusack S, Virtanen A

The Journal of biological chemistry, 2006

doi:10.1074/jbc.m508590200.

Contributions of conformational flexibility to Brugia malayi asparaginyl-tRNA synthetase specificity for inhibitors identified by structure-based screening

Sukuru SCK, Crepin T, Morris JC, Grotli M, Danel F, Page MGP, Haertlein M, Cusack S, Kron MA, Kuhn LA

Abstracts of papers of the American Chemical Society, 2006

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Crystal structure of enteric adenovirus serotype 41 short fiber head

Seiradake E, Cusack S

Journal of virology, 2005

doi:10.1128/jvi.79.22.14088-14094.2005.

The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation

Tukalo M, Yaremchuk A, Fukunaga R, Yokoyama S, Cusack S

Nature structural & molecular biology, 2005

doi:10.1038/nsmb986.

The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases

Tarbouriech N, Buisson M, Seigneurin JM, Cusack S, Burmeister WP

Structure (London, England : 1993), 2005

doi:10.1016/j.str.2005.06.009.

Specificity of recognition of mRNA 5' cap by human nuclear cap-binding complex

Worch R, Niedzwiecka A, Stepinski J, Mazza C, Jankowska-Anyszka M, Darzynkiewicz E, Cusack S, Stolarski R

RNA (New York, N.Y.), 2005

doi:10.1261/rna.2850705.

X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids

Backe PH, Messias AC, Ravelli RB, Sattler M, Cusack S

Structure (London, England : 1993), 2005

doi:10.1016/j.str.2005.04.008.

Adenovirus complex structures

Cusack S

Current opinion in structural biology, 2005

doi:10.1016/j.sbi.2005.03.004.

Prolyl-tRNA synthetase

Musier-Forsyth K, Burke B, Cusack, S

2005

doi:.

Seryl-tRNA Synthetases

Weygand-Durasevic I, Cusack S

2005

doi:.

Significance of the first transcribed nucleoside of capped RNA for ligand-induced folding of the cap-binding complex

Worch R, Niedzwiecka A, Stepinski J, Jankowska-Anyszka M, Mazza C, Darzynkiewicz E, Cusack S, Stolarski R

Journal of physics. Condensed matter : an Institute of Physics journal, 2005

doi:.

Novel way of capping mRNA trimer and studies of its interaction with human nuclear cap-binding complex

Worch R, Stepinski J, Niedzwiecka A, Jankowska-Anyszka M, Mazza C, Cusack S, Stolarski R, Darzynkiewicz E

Nucleosides, nucleotides & nucleic acids, 2005

doi:10.1081/ncn-200061898.

The structure of the human adenovirus 2 penton

Zubieta C, Schoehn G, Chroboczek J, Cusack S

Molecular cell, 2005

doi:10.1016/j.molcel.2004.11.041.

Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites

Burmeister WP, Guilligay D, Cusack S, Wadell G, Arnberg N

Journal of virology, 2004

doi:10.1128/jvi.78.14.7727-7736.2004.

Crystallization, microPIXE and preliminary crystallographic analysis of the complex between the third KH domain of hnRNP K and single-stranded DNA

Backe PH, Ravelli RB, Garman E, Cusack S

Acta crystallographica. Section D, Biological crystallography, 2004

doi:10.1107/s0907444904002628.

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3

Kadlec J, Izaurralde E, Cusack S

Nature structural & molecular biology, 2004

doi:10.1038/nsmb741.

Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain

Huck L, Scherrer A, Terzi L, Johnson AE, Bernstein HD, Cusack S, Weichenrieder O, Strub K

Nucleic acids research, 2004

doi:10.1093/nar/gkh837.

Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion

Kobayashi T, Nureki O, Ishitani R, Yaremchuk A, Tukalo M, Cusack S, Sakamoto K, Yokoyama S

Nature structural biology, 2003

doi:10.1038/nsb934.

Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase

Lincecum TL Jr, Tukalo M, Yaremchuk A, Mursinna RS, Williams AM, Sproat BS, Van Den Eynde W, Link A, Van Calenbergh S, Grøtli M, Martinis SA, Cusack S

Molecular cell, 2003

doi:10.1016/s1097-2765(03)00098-4.

Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering

Mazza C, Segref A, Mattaj IW, Cusack S

Acta crystallographica. Section D, Biological crystallography, 2002

doi:10.1107/s0907444902015445.

Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex

Mazza C, Segref A, Mattaj IW, Cusack S

The EMBO journal, 2002

doi:10.1093/emboj/cdf538.

Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition

Yaremchuk A, Kriklivyi I, Tukalo M, Cusack S

The EMBO journal, 2002

doi:10.1093/emboj/cdf373.

Crystallization and preliminary X-ray analysis of the Escherichia coli adaptor protein ClpS, free and in complex with the N-terminal domain of ClpA

Zeth K, Dougan DA, Cusack S, Bukau B, Ravelli RB

Acta crystallographica. Section D, Biological crystallography, 2002

doi:10.1107/s0907444902006960.

tRNA-like recognition of group I introns by a tyrosyl-tRNA synthetase

Myers CA, Kuhla B, Cusack S, Lambowitz AM

Proceedings of the National Academy of Sciences of the United States of America, 2002

doi:10.1073/pnas.052596299.

Towards the structure of the mammalian signal recognition particle

Wild K, Weichenrieder O, Strub K, Sinning I, Cusack S

Current opinion in structural biology, 2002

doi:10.1016/s0959-440x(02)00292-0.

Structure, folding and assembly of adenovirus fibers

Mitraki A, Raaij M, Ruigrok R, Cusack S, Hernandez J-F, Luckey M

2001

doi:10.1007/0-306-46890-5_16.

Crystal structure of an early protein-RNA assembly complex of the signal recognition particle

Wild K, Sinning I, Cusack S

Science (New York, N.Y.), 2001

doi:10.1126/science.1063839.

Crystal structure of the human nuclear cap binding complex

Mazza C, Ohno M, Segref A, Mattaj IW, Cusack S

Molecular cell, 2001

doi:10.1016/s1097-2765(01)00299-4.

Structure of the fiber head of Ad3, a non-CAR-binding serotype of adenovirus

Durmort C, Stehlin C, Schoehn G, Mitraki A, Drouet E, Cusack S, Burmeister WP

Virology, 2001

doi:10.1006/viro.2001.0967.

A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase

Yaremchuk A, Tukalo M, Grøtli M, Cusack S

Journal of molecular biology, 2001

doi:10.1006/jmbi.2001.4712.

Hierarchical assembly of the Alu domain of the mammalian signal recognition particle

Weichenrieder O, Stehlin C, Kapp U, Birse DE, Timmins PA, Strub K, Cusack S

RNA (New York, N.Y.), 2001

doi:10.1017/s1355838201010160.

Kinetic analysis of adenovirus fiber binding to its receptor reveals an avidity mechanism for trimeric receptor-ligand interactions

Lortat-Jacob H, Chouin E, Cusack S, van Raaij MJ

The Journal of biological chemistry, 2001

doi:10.1074/jbc.m009304200.

Influence of adenoviral fiber mutations on viral encapsidation, infectivity and in vivo tropism

Leissner P, Legrand V, Schlesinger Y, Hadji DA, van Raaij M, Cusack S, Pavirani A, Mehtali M

Gene therapy, 2001

doi:10.1038/sj.gt.3301343.

Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution

van Raaij MJ, Chouin E, van der Zandt H, Bergelson JM, Cusack S

Structure (London, England : 1993), 2000

doi:10.1016/s0969-2126(00)00528-1.

Structure and assembly of the Alu domain of the mammalian signal recognition particle

Weichenrieder O, Wild K, Strub K, Cusack S

Nature, 2000

doi:10.1038/35041507.

Mutual conformational adaptations in antigen and antibody upon complex formation between an Fab and HIV-1 capsid protein p24

Monaco-Malbet S, Berthet-Colominas C, Novelli A, Battaï N, Piga N, Cheynet V, Mallet F, Cusack S

Structure (London, England : 1993), 2000

doi:10.1016/s0969-2126(00)00507-4.

Crystal structure of a eukaryote/archaeon-like protyl-tRNA synthetase and its complex with tRNAPro(CGG)

Yaremchuk A, Cusack S, Tukalo M

The EMBO journal, 2000

doi:10.1093/emboj/19.17.4745.

The 2 A crystal structure of leucyl-tRNA synthetase and its complex with a leucyl-adenylate analogue

Cusack S, Yaremchuk A, Tukalo M

The EMBO journal, 2000

doi:10.1093/emboj/19.10.2351.

Crystallization and preliminary crystallographic analysis of Thermus thermophilus leucyl-tRNA synthetase and its complexes with leucine and a non-hydrolysable leucyl-adenylate analogue

Yaremchuk A, Cusack S, Gudzera O, Grøtli M, Tukalo M

Acta crystallographica. Section D, Biological crystallography, 2000

doi:10.1107/s0907444900004686.

Crystallization and preliminary X-ray diffraction analysis of Thermus thermophilus prolyl-tRNA synthetase

Yaremchuk A, Cusack S, Tukalo M

Acta crystallographica. Section D, Biological crystallography, 2000

doi:10.1107/s0907444999015498.

Improved crystals of Thermus thermophilus prolyl-tRNA synthetase complexed with cognate tRNA obtained by crystallization from precipitate

Yaremchuk A, Kriklivyi I, Cusack S, Tukalo M

Acta crystallographica. Section D, Biological crystallography, 2000

doi:10.1107/s0907444999015504.

The 2 A structure of helix 6 of the human signal recognition particle RNA

Wild K, Weichenrieder O, Leonard GA, Cusack S

Structure (London, England : 1993), 1999

doi:10.1016/s0969-2126(00)80024-6.

Protein microcrystals and the design of a microdiffractometer: current experience and plans at EMBL and ESRF/ID13

Perrakis A, Cipriani F, Castagna JC, Claustre L, Burghammer M, Riekel C, Cusack S

Acta crystallographica. Section D, Biological crystallography, 1999

doi:10.1107/s0907444999009348.

A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein

van Raaij MJ, Mitraki A, Lavigne G, Cusack S

Nature, 1999

doi:10.1038/44880.

Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution

van Raaij MJ, Louis N, Chroboczek J, Cusack S

Virology, 1999

doi:10.1006/viro.1999.9849.

Head-to-tail dimers and interdomain flexibility revealed by the crystal structure of HIV-1 capsid protein (p24) complexed with a monoclonal antibody Fab

Berthet-Colominas C, Monaco S, Novelli A, Sibaï G, Mallet F, Cusack S

The EMBO journal, 1999

doi:10.1093/emboj/18.5.1124.

RNA-protein complexes

Cusack S

Current opinion in structural biology, 1999

doi:10.1016/s0959-440x(99)80009-8.

Escherichia coli SecA shape and dimensions

Shilton B, Svergun DI, Volkov VV, Koch MH, Cusack S, Economou A

FEBS letters, 1998

doi:10.1016/s0014-5793(98)01141-7.

Small is beautiful: protein micro-crystallography

Cusack S, Belrhali H, Bram A, Burghammer M, Perrakis A, Riekel C

Nature structural biology, 1998

doi:10.1038/1325.

The crystal structure of asparaginyl-tRNA synthetase from Thermus thermophilus and its complexes with ATP and asparaginyl-adenylate: the mechanism of discrimination between asparagine and aspartic acid

Berthet-Colominas C, Seignovert L, Härtlein M, Grotli M, Cusack S, Leberman R

The EMBO journal, 1998

doi:10.1093/emboj/17.10.2947.

tRNA recognition by aminoacyl-tRNA synthetases

Cusack S, Yaremchuk Y, Tukalo M

1998

doi:10.1016/B978-012233210-4/50005-0.

tRNA(Pro) anticodon recognition by Thermus thermophilus prolyl-tRNA synthetase

Cusack S, Yaremchuk A, Krikliviy I, Tukalo M

Structure (London, England : 1993), 1998

doi:10.1016/s0969-2126(98)00011-2.

Identification of a minimal Alu RNA folding domain that specifically binds SRP9/14

Weichenrieder O, Kapp U, Cusack S, Strub K

RNA (New York, N.Y.), 1997

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The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14

Birse DE, Kapp U, Strub K, Cusack S, Aberg A

The EMBO journal, 1997

doi:10.1093/emboj/16.13.3757.

Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase

Aberg A, Yaremchuk A, Tukalo M, Rasmussen B, Cusack S

Biochemistry, 1997

doi:10.1021/bi9618373.

The crystal structures of T. thermophilus lysyl-tRNA synthetase complexed with E. coli tRNA(Lys) and a T. thermophilus tRNA(Lys) transcript: anticodon recognition and conformational changes upon binding of a lysyl-adenylate analogue

Cusack S, Yaremchuk A, Tukalo M

The EMBO journal, 1996

doi:10.1002/j.1460-2075.1996.tb01022.x.

The crystal structure of the ternary complex of T.thermophilus seryl-tRNA synthetase with tRNA(Ser) and a seryl-adenylate analogue reveals a conformational switch in the active site

Cusack S, Yaremchuk A, Tukalo M

The EMBO journal, 1996

doi:10.1002/j.1460-2075.1996.tb00644.x.

The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution

Kawashima T, Berthet-Colominas C, Wulff M, Cusack S, Leberman R

Nature, 1996

doi:10.1038/379511a0.

Crystallization of Thermus thermophilus histidyl-tRNA synthetase and its complex with tRNAHis

Yaremchuk AD, Cusack S, Aberg A, Gudzera O, Kryklivyi I, Tukalo M

Proteins, 1995

doi:10.1002/prot.340220413.

The structural basis for seryl-adenylate and Ap4A synthesis by seryl-tRNA synthetase

Belrhali H, Yaremchuk A, Tukalo M, Berthet-Colominas C, Rasmussen B, Bösecke P, Diat O, Cusack S

Structure (London, England : 1993), 1995

doi:10.1016/s0969-2126(01)00166-6.

Cocrystallization of lysyl-tRNA synthetase from Thermus thermophilus with its cognate tRNAlys and with Escherichia coli tRNAlys

Yaremchuk AD, Krikliviy IA, Cusack S, Tukalo MA

Proteins, 1995

doi:10.1002/prot.340210309.

Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solvent

Baudin F, Bach C, Cusack S, Ruigrok RW

The EMBO journal, 1994

doi:10.1002/j.1460-2075.1994.tb06614.x.

The 2.9 A crystal structure of T. thermophilus seryl-tRNA synthetase complexed with tRNA(Ser)

Biou V, Yaremchuk A, Tukalo M, Cusack S

Science (New York, N.Y.), 1994

doi:10.1126/science.8128220.

A small percentage of influenza virus M1 protein contains zinc but zinc does not influence in vitro M1-RNA interaction

Elster C, Fourest E, Baudin F, Larsen K, Cusack S, Ruigrok RW

The Journal of general virology, 1994

doi:10.1099/0022-1317-75-1-37.

Comparison of structure and sequence of influenza B/Yamagata and B/Beijing neuraminidases shows a conserved "head" but much greater variability in the "stalk" and NB protein

Burmeister WP, Baudin F, Cusack S, Ruigrok RW

Virology, 1993

doi:10.1006/viro.1993.1088.

Adenovirus type 40 virions contain two distinct fibers

Kidd AH, Chroboczek J, Cusack S, Ruigrok RW

Virology, 1993

doi:10.1006/viro.1993.1009.

The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid

Burmeister WP, Ruigrok RW, Cusack S

The EMBO journal, 1992

doi:10.2210/pdb1nsb/pdb.

Dynamic instability of liquidlike motions in a globular protein observed by inelastic neutron scattering

Doster W, Cusack S, Petry W

Physical review letters, 1990

doi:10.1103/physrevlett.65.1080.

Neutron scattering.

Cusack S, Jacrot B, Leberman R, May R, Timmins P, Zaccai G

Nature, 1989

doi:10.1038/339330a0.

Dynamical transition of myoglobin revealed by inelastic neutron scattering

Doster W, Cusack S, Petry W

Nature, 1989

doi:10.1038/337754a0.

Inelastic neutron scattering analysis of picosecond internal protein dynamics. Comparison of harmonic theory with experiment.

Cusack S, Smith J, Finney J, Tidor B, Karplus M

Journal of molecular biology, 1988

doi:10.1016/0022-2836(88)90566-9.

Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid.

Weis W, Brown JH, Cusack S, Paulson JC, Skehel JJ, Wiley DC

Nature, 1988

doi:10.1038/333426a0.

Direct measurement of hydration-related dynamic changes in lysozyme using inelastic neutron scattering spectroscopy.

Smith J, Cusack S, Poole P, Finney J

Journal of biomolecular structure & dynamics, 1987

doi:10.1080/07391102.1987.10507662.

Crystals of seryl-tRNA synthetase from Escherichia coli. Preliminary crystallographic data.

Leberman R, Berthet-Colominas C, Cusack S, Härtlein M

Journal of molecular biology, 1987

doi:10.1016/0022-2836(87)90232-4.

Electron microscopy of the low pH structure of influenza virus haemagglutinin.

Ruigrok RW, Wrigley NG, Calder LJ, Cusack S, Wharton SA, Brown EB, Skehel JJ

The EMBO journal, 1986

doi:10.1002/j.1460-2075.1986.tb04175.x.

Structure and composition of influenza virus. A small-angle neutron scattering study.

Cusack S, Ruigrok RW, Krygsman PC, Mellema JE

Journal of molecular biology, 1985

doi:10.1016/0022-2836(85)90131-7.

Three-dimensional molecular shape determination from a limited number of projections.

Cusack S, Jésior JC

Ultramicroscopy, 1985

doi:10.1016/0304-3991(85)90074-9.

Low resolution structure of the influenza C glycoprotein determined by electron microscopy.

Hewat EA, Cusack S, Ruigrok RW, Verwey C

Journal of molecular biology, 1984

doi:10.1016/0022-2836(84)90473-x.

Variation of longitudinal acoustic velocity at gigahertz frequencies with water content in rat-tail tendon fibers.

Cusack S, Lees S

Biopolymers, 1984

doi:10.1002/bip.360230212.

Neutron scattering studies of virus structure.

Cusack S

Basic life sciences, 1984

doi:.

Inelastic neutron scattering studies of hexokinase in solution.

Engelman DM, Dianoux AJ, Cusack S, Jacrot B

Basic life sciences, 1984

doi:.

Structure of the Top a-t component of alfalfa mosaic virus. A non-icosahedral virion.

Cusack S, Oostergetel GT, Krijgsman PC, Mellema JE

Journal of molecular biology, 1983

doi:10.1016/s0022-2836(83)80350-7.

Solution scattering study on the structure of alfalfa mosaic virus strain VRU.

Oostergetel GT, Mellema JE, Cusack S

Journal of molecular biology, 1983

doi:10.1016/s0022-2836(83)80351-9.

Inelastic neutron scattering analysis of hexokinase dynamics and its modification on binding of glucose.

Jacrot B, Cusack S, Dianoux AJ, Engelman DM

Nature, 1982

doi:10.1038/300084a0.

Structural investigations of influenza B virus.

Mellema JE, Andree PJ, Krygsman PC, Kroon C, Ruigrok RW, Cusack S, Miller A, Zulauf M

Journal of molecular biology, 1981

doi:10.1016/0022-2836(81)90521-0.

Evidence for the absence of swelling of alfalfa mosaic virions.

Oostergetel GT, Krijgsman PC, Mellema JE, Cusack S, Miller A

Virology, 1981

doi:10.1016/0042-6822(81)90489-X.

An investigation of the structure of alfalfa mosaic virus by small-angle neutron scattering.

Cusack S, Miller A, Krijgsman PC, Mellema JE

Journal of molecular biology, 1981

doi:10.1016/0022-2836(81)90543-x.

Determination of the elastic constants of collagen by Brillouin light scattering.

Cusack S, Miller A

Journal of molecular biology, 1979

doi:10.1016/0022-2836(79)90339-5.