Publications – Diz-Muñoz Group

PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance.

Baghdadi MB, Houtekamer RM, Perrin L, Rao-Bhatia A, Whelen M, Decker L, Bergert M, Pérez-Gonzàlez C, Bouras R, Gropplero G, Loe AKH, Afkhami-Poostchi A, Chen X, Huang X, Descroix S, Wrana JL, Diz-Muñoz A, Gloerich M, Ayyaz A, Matic Vignjevic D, Kim TH

Science (New York, N.Y.), 2024

doi:10.1126/science.adj7615.

Ezrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics.

Verdys P, Rey Barroso J, Girel A, Vermeil J, Bergert M, Sanchez T, Métais A, Mangeat T, Bellard E, Bigot C, Astarie-Dequeker C, Labrousse A, Girard JP, Maridonneau-Parini I, Vérollet C, Lagarrigue F, Diz-Muñoz A, Heuvingh J, Piel M, du Roure O, Le Cabec V, Carréno S, Poincloux R

The EMBO journal, 2024

doi:10.1038/s44318-024-00173-7.

Caging of membrane-to-cortex attachment proteins can trigger cellular symmetry breaking.

Dar S, Moreno RT, Palaia I, Gopalan AB, Sun ZG, Strauss L, Sprenger RR, Belmonte JM, Foster SK, Murrell M, Ejsing CS, Šarić A, Leptin M, Diz-Muñoz A

bioRxiv, 2024

doi:10.1101/2024.10.14.618153.

Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay.

Mihlan M, Wissmann S, Gavrilov A, Kaltenbach L, Britz M, Franke K, Hummel B, Imle A, Suzuki R, Stecher M, Glaser KM, Lorentz A, Carmeliet P, Yokomizo T, Hilgendorf I, Sawarkar R, Diz-Muñoz A, Buescher JM, Mittler G, Maurer M, Krause K, Babina M, Erpenbeck L, Frank M, Rambold AS, Lämmermann T

Cell, 2024

doi:10.1016/j.cell.2024.07.014.

Lipotype acquisition during neural development is not recapitulated in stem cell-derived neurons.

Gopalan AB, van Uden L, Sprenger RR, Fernandez-Novel Marx N, Bogetofte H, Neveu PA, Meyer M, Noh KM, Diz-Muñoz A, Ejsing CS

Life science alliance, 2024

doi:10.26508/lsa.202402622.

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells.

Conti S, Venturini V, Cañellas-Socias A, Cortina C, Abenza JF, Stephan-Otto Attolini C, Middendorp Guerra E, Xu CK, Li JH, Rossetti L, Stassi G, Roca-Cusachs P, Diz-Muñoz A, Ruprecht V, Guck J, Batlle E, Labernadie A, Trepat X

Nature communications, 2024

doi:10.1038/s41467-024-47227-2.

Author correction: Pulsed stimulated Brillouin microscopy enables high-sensitivity mechanical imaging of live and fragile biological specimens.

Yang F, Bevilacqua C, Hambura S, Neves A, Gopalan A, Watanabe K, Govendir M, Bernabeu M, Ellenberg J, Diz-Muñoz A, Köhler S, Rapti G, Jechlinger M, Prevedel R

Nature methods, 2024

doi: 10.1038/s41592-024-02259-w.

Pulsed stimulated Brillouin microscopy enables high-sensitivity mechanical imaging of live and fragile biological specimens.

Yang F, Bevilacqua C, Hambura S, Neves A, Gopalan A, Watanabe K, Govendir M, Bernabeu M, Ellenberg J, Diz-Muñoz A, Köhler S, Rapti G, Jechlinger M, Prevedel R

Nature methods, 2023

doi:10.1038/s41592-023-02054-z.

Sensing their plasma membrane curvature allows migrating cells to circumvent obstacles.

Sitarska E, Almeida SD, Beckwith MS, Stopp J, Czuchnowski J, Siggel M, Roessner R, Tschanz A, Ejsing C, Schwab Y, Kosinski J, Sixt M, Kreshuk A, Erzberger A, Diz-Muñoz A

Nature communications, 2023

doi:10.1038/s41467-023-41173-1.

High-resolution line-scan Brillouin microscopy for live imaging of mechanical properties during embryo development.

Bevilacqua C, Gomez JM, Fiuza UM, Chan CJ, Wang L, Hambura S, Eguren M, Ellenberg J, Diz-Muñoz A, Leptin M, Prevedel R

Nature methods, 2023

doi:10.1038/s41592-023-01822-1.

Order from chaos: how mechanics shape epithelia and promote self-organization.

Vicente FN, Diz-Muñoz A

Current Opinion in Systems Biology, 2023

doi:10.1016/j.coisb.2023.100446.

The distance between the plasma membrane and the actomyosin cortex acts as a nanogate to control cell surface mechanics.

Lembo S, Strauss L, Cheng D, Vermeil J, Siggel M, Toro-Nahuelpan M, Chan CJ, Kosinski J, Piel M, Roure OD, Heuvingh J, Mahamid J, Diz-Muñoz A

bioRxiv, 2023

doi:10.1101/2023.01.31.526409.

Convolutional networks for supervised mining of molecular patterns within cellular context.

de Teresa-Trueba I, Goetz SK, Mattausch A, Stojanovska F, Zimmerli CE, Toro-Nahuelpan M, Cheng DWC, Tollervey F, Pape C, Beck M, Diz-Muñoz A, Kreshuk A, Mahamid J, Zaugg JB

Nature methods, 2023

doi:10.1038/s41592-022-01746-2.

Quantification of apparent membrane tension and membrane-to-cortex attachment in animal cells using atomic force microscopy-based force spectroscopy.

Bergert M, Diz-Muñoz A

Methods in molecular biology (Clifton, N.J.), 2023

doi:10.1007/978-1-0716-2851-5_3.

Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord.

Sánchez-Iranzo H, Halavatyi A, Diz-Muñoz A

eLife, 2022

doi:10.7554/elife.75429.

Self-generated gradients steer collective migration on viscoelastic collagen networks.

Clark AG, Maitra A, Jacques C, Bergert M, Pérez-González C, Simon A, Lederer L, Diz-Muñoz A, Trepat X, Voituriez R, Vignjevic DM

Nature materials, 2022

doi:10.1038/s41563-022-01259-5.

Understanding the interplay of membrane trafficking, cell surface mechanics, and stem cell differentiation.

Li JH, Trivedi V, Diz-Muñoz A

Seminars in cell & developmental biology, 2022

doi:10.1016/j.semcdb.2022.05.010.

A mechano-osmotic feedback couples cell volume to the rate of cell deformation.

Venkova L, Vishen AS, Lembo S, Srivastava N, Duchamp B, Ruppel A, Williart A, Vassilopoulos S, Deslys A, Garcia Arcos JM, Diz-Muñoz A, Balland M, Joanny JF, Cuvelier D, Sens P, Piel M

eLife, 2022

doi:10.7554/eLife.72381.

Load adaptation by endocytic actin networks.

Kaplan C, Kenny SJ, Chen X, Schöneberg J, Sitarska E, Diz-Muñoz A, Akamatsu M, Xu K, Drubin DG

Molecular biology of the cell, 2022

doi:10.1091/mbc.E21-11-0589.

Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse.

Leithner A, Altenburger LM, Hauschild R, Assen FP, Rottner K, Stradal TEB, Diz-Muñoz A, Stein JV, Sixt M

The Journal of cell biology, 2021

doi:10.1083/jcb.202006081.

Using migrating cells as probes to illuminate features in live embryonic tissues.

Gross-Thebing S, Truszkowski L, Tenbrinck D, Sánchez-Iranzo H, Camelo C, Westerich KJ, Singh A, Maier P, Prengel J, Lange P, Hüwel J, Gaede F, Sasse R, Vos BE, Betz T, Matis M, Prevedel R, Luschnig S, Diz-Muñoz A, Burger M, Raz E

Science advances, 2020

doi:10.1126/sciadv.abc5546.

Protocol on tissue preparation and measurement of tumor stiffness in primary and metastatic colorectal cancer ssamples with an atomic force microscope.

Shen Y, Schmidt T, Diz-Muñoz A

STAR protocols, 2020

doi:10.1016/j.xpro.2020.100167.

Cell surface mechanics gate embryonic stem cell differentiation.

Bergert M, Lembo S, Sharma S, Russo L, Milovanović D, Gretarsson KH, Börmel M, Neveu PA, Hackett JA, Petsalaki E, Diz-Muñoz A

Cell stem cell, 2020

doi:10.1016/j.stem.2020.10.017.

A 3D Brillouin microscopy dataset of the in-vivo zebrafish eye.

Sánchez-Iranzo H, Bevilacqua C, Diz-Muñoz A, Prevedel R

Data in brief, 2020

doi:10.1016/j.dib.2020.105427.

Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer.

Shen Y, Wang X, Lu J, Salfenmoser M, Wirsik NM, Schleussner N, Imle A, Freire Valls A, Radhakrishnan P, Liang J, Wang G, Muley T, Schneider M, Ruiz de Almodovar C, Diz-Muñoz A, Schmidt T

Cancer cell, 2020

doi:10.1016/j.ccell.2020.05.005.

Pay attention to membrane tension: mechanobiology of the cell surface.

Sitarska E, Diz-Muñoz A

Current opinion in cell biology, 2020

doi:10.1016/j.ceb.2020.04.001.

Cell scientist to watch - Alba Diz-Munoz

Breuer M, Diz-Munoz A

JOURNAL OF CELL SCIENCE, 2020

doi:10.1242/jcs.245373.

Cell confinement reveals a branched-actin independent circuit for neutrophil polarity.

Graziano BR, Town JP, Sitarska E, Nagy TL, Fošnarič M, Penič S, Iglič A, Kralj-Iglič V, Gov NS, Diz-Muñoz A, Weiner OD

PLOS BIOLOGY, 2019

doi:10.1371/journal.pbio.3000457.

In vivo function of the lipid raft protein flotillin-1 during CD8+ T cell-mediated host surveillance.

Ficht X, Ruef N, Stolp B, Samson GPB, Moalli F, Page N, Merkler D, Nichols BJ, Diz-Muñoz A, Legler DF, Niggli V, Stein JV

Journal of immunology (Baltimore, Md. : 1950), 2019

doi:10.4049/jimmunol.1900075.

Brillouin microscopy: an emerging tool for mechanobiology.

Prevedel R, Diz-Muñoz A, Ruocco G, Antonacci G

Nature methods, 2019

doi:10.1038/s41592-019-0543-3.

Hydraulic control of mammalian embryo size and cell fate.

Chan CJ, Costanzo M, Ruiz-Herrero T, Mönke G, Petrie RJ, Bergert M, Diz-Muñoz A, Mahadevan L, Hiiragi T

Nature, 2019

doi:10.1038/s41586-019-1309-x.

Imaging mechanical properties of sub-micron ECM in live zebrafish using Brillouin microscopy.

Bevilacqua C, Sánchez-Iranzo H, Richter D, Diz-Muñoz A, Prevedel R

Biomedical optics express, 2019

doi:10.1364/BOE.10.001420.

The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells.

Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck R, Balmer J, Fiocchi A, Kreutzfeldt M, Merkler D, Iannacone M, Ariga A, Stoffel MH, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV

The Journal of experimental medicine, 2018

doi:10.1084/jem.20170896.