Structure and function of RNA-protein complexes
We had a great time at the joint Eustermann-Galej group retreat in Alsace. Two days of intense exchanges, whiteboard presentations and focus group discussions. All that was complemented by great food and an introductory golf session. We are back in Grenoble, inspired to try new experiments!
Check out the latest thematic issue of NSMB focusing on mechanisms of RNA splicing and processing. We are delighted to have our small contribution there!
U5 snRNP is one of the key building blocks of the spliceosome, but how it is assembled and recycled remains unknown. In our new paper published in NSMB, we provide new mechanistic insights into this process. https://www.nature.com/articles/s41594-024-01250-5 We investigated the role of the assembly…
We warmly welcome Sichen, Iskander and Jonas, our latest group members who joined in the past few months. Sichen Su did his PhD in Biochemistry and Molecular Biology at the Fudan University in Shanghai under the supervision of Dr. Jinbiao Ma.He investigated various aspects of RNA metabolism…
We are happy to share a new collaborative work lead by Jana Aupic and Alessandra Magistrato from the National Research Council of Italy (CNR) in Triest. Molecular dynamics simulations of the complete yeast catalytic spliceosome revealed detailed trajectories of the reagents during the first step of…
We are happy to share that our newest collaborative paper on self-damage control and defence system during pathogen infection was just published in Science! Huge congratulations to everyone involved, in particular our collaborators Daniel Fisch and Eva Frickel (https://frickellab.com/) for driving…
A warm welcome to Simonas and Mani, our two newest lab members! Manikandan Parthasarathy did his PhD at the Indian Institute of Science under the supervision of Prof. Mahavir Singh, where he investigated the structure and assembly of type III TA systems from E. coli. He joined EMBL EIPOD-LinC…
Our group was well represented at this year’s RNA Society meeting in Singapore. We presented posters about the Integrator complex (Michal), U2 snRNP (Jonas) and a talk on the tri-snRNP assembly intermediate (Wojtek).It was great to see our two former PhD students, Jonas and Moritz, who keep their…
Jiangfeng Zhao was awarded Marie-Curie postdoctoral fellowship from the European Commission to study the assembly of splicing complexes in mammals. Congratulations!