We are happy to share a new collaborative work lead by Jana Aupic and Alessandra Magistrato from the National Research Council of Italy (CNR) in Triest. Molecular dynamics simulations of the complete yeast catalytic spliceosome revealed detailed trajectories of the reagents during the first step of splicing catalysis and shed new light on the role of monovalent potassium ion in stabilising the substrate and promoting productive reaction.

Congratulations to everyone involved!