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Science – Page 2 – Galej Group

Galej Group

Structure and function of RNA-protein complexes

The Galej group uses an integrated structural biology approach combined with biochemistry and biophysics to investigate large RNA-protein complexes involved in gene expression.

Category: Science

A new paper on the Integrator complex

Our newest paper describing the structure of the catalytic core of the Integrator complex is online now in Molecular Cell. Integrator complex was discovered more than 15 years ago as a specialised endonuclease responsible for the 3’-end processing of spliceosomal snRNAs. More recent studies…

A new spliceosome assembly intermediate identified

Check out our latest pre-print from the Nagai group identifying a new spliceosome assembly intermediate. The most complete and accurate depiction of the catalytic spliceosome to date; 9 datasets, 12 focused maps, 4 years in making. Fantastic effort by Max Wilkinson and Sebastian Fica.…

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