Inflammation-driven NFκB signaling represses Ferroportin transcription in macrophages via HDAC 1 and 3.

Marques O, Horvat NK, Zechner L, Colucci S, Sparla R, Zimmermann S, Neufeldt CJ, Altamura S, Qiu R, Müdder K, Weiss G, Hentze MW, Muckenthaler MU

Blood, 2024

doi:10.1182/blood.2023023417.

The molecular dissection of TRIM25's RNA-binding mechanism provides key insights into its antiviral activity.

Álvarez L, Haubrich K, Iselin L, Gillioz L, Ruscica V, Lapouge K, Augsten S, Huppertz I, Choudhury NR, Simon B, Masiewicz P, Lethier M, Cusack S, Rittinger K, Gabel F, Leitner A, Michlewski G, Hentze MW, Allain FHT, Castello A, Hennig J

Nature communications, 2024

doi:10.1038/s41467-024-52918-x.

The RBPome of influenza A virus NP-mRNA reveals a role for TDP-43 in viral replication.

Dupont M, Krischuns T, Gianetto QG, Paisant S, Bonazza S, Brault JB, Douché T, Arragain B, Florez-Prada A, Perez-Perri JI, Hentze MW, Cusack S, Matondo M, Isel C, Courtney DG, Naffakh N

Nucleic acids research, 2024

doi:10.1093/nar/gkae291.

Superparamagnetic iron oxide nanoparticles reprogram the tumor microenvironment and reduce lung cancer regrowth after crizotinib treatment.

Horvat NK, Chocarro S, Marques O, Bauer TA, Qiu R, Diaz-Jimenez A, Helm B, Chen Y, Sawall S, Sparla R, Su L, Klingmüller U, Barz M, Hentze MW, Sotillo R, Muckenthaler MU

ACS nano, 2024

doi:10.1021/acsnano.3c08335.

Cytosolic RNA binding of the mitochondrial TCA cycle enzyme malate dehydrogenase (MDH2).

Noble M, Chatterjee A, Sekaran T, Schwarzl T, Hentze MW

RNA (New York, N.Y.), 2024

doi:10.1261/rna.079925.123.

Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.

Zhou Y, Ray PS, Zhu J, Stein F, Rettel M, Sekaran T, Sahadevan S, Perez-Perri JI, Roth EK, Myklebost O, Meza-Zepeda LA, von Deimling A, Fu C, Brosig AN, Boye K, Nathrath M, Blattmann C, Lehner B, Hentze MW, Kulozik AE

Nature communications, 2024

doi:10.1038/s41467-024-47031-y.

RNA-binding proteins in cardiovascular biology and disease: the beat goes on.

Völkers M, Preiss T, Hentze MW

Nature reviews. Cardiology, 2024

doi:10.1038/s41569-023-00958-z.

Improved discovery of RNA-binding protein binding sites in eCLIP data using DEWSeq.

Schwarzl T, Sahadevan S, Lang B, Miladi M, Backofen R, Huber W, Hentze MW, Tartaglia GG

Nucleic acids research, 2023

doi:10.1093/nar/gkad998.

RNA-binding proteins regulate post-transcriptional responses to TGF-β to coordinate function and mesenchymal activation of murine endothelial cells.

Wardman R, Keles M, Pachkiv I, Hemanna S, Grein S, Schwarz J, Stein F, Ola R, Dobreva G, Hentze MW, Heineke J

Arteriosclerosis, thrombosis, and vascular biology, 2023

doi:10.1161/atvbaha.123.319925.

Translational control of Ybx1 expression regulates cardiac function in response to pressure overload in vivo.

Varma E, Burghaus J, Schwarzl T, Sekaran T, Gupta P, Górska AA, Hofmann C, Stroh C, Jürgensen L, Kamuf-Schenk V, Li X, Medert R, Leuschner F, Kmietczyk V, Freichel M, Katus HA, Hentze MW, Frey N, Völkers M

Basic research in cardiology, 2023

doi:10.1007/s00395-023-00996-1.

The RNA-binding protein landscapes differ between mammalian organs and cultured cells.

Perez-Perri JI, Ferring-Appel D, Huppertz I, Schwarzl T, Sahadevan S, Stein F, Rettel M, Galy B, Hentze MW

Nature communications, 2023

doi:10.1038/s41467-023-37494-w.

Small non-coding RNA Interactome Capture reveals pervasive, carbon source-dependent tRNA engagement of yeast glycolytic enzymes.

Asencio C, Schwarzl T, Sahadevan S, Hentze MW

RNA (New York, N.Y.), 2022

doi:10.1261/rna.079408.122.

Htseq-clip: a toolset for the preprocessing of eCLIP/iCLIP datasets.

Sahadevan S, Sekaran T, Ashaf N, Fritz M, Hentze MW, Huber W, Schwarzl T

Bioinformatics (Oxford, England), 2022

doi:10.1093/bioinformatics/btac747.

Iron-dependent BMP6 regulation in liver sinusoidal endothelial cells is instructed by hepatocyte-derived secretory signals.

Colucci S, Altamura S, Marques O, Müdder K, Agarvas AR, Hentze MW, Muckenthaler MU

HemaSphere, 2022

doi:10.1097/hs9.0000000000000773.

Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation.

Huppertz I, Perez-Perri JI, Mantas P, Sekaran T, Schwarzl T, Russo F, Ferring-Appel D, Koskova Z, Dimitrova-Paternoga L, Kafkia E, Hennig J, Neveu PA, Patil K, Hentze MW

Molecular cell, 2022

doi:10.1016/j.molcel.2022.05.019.

Vault RNA1-1 riboregulates the autophagic function of p62 by binding to K7/R21 that are critical for p62 oligomerisation.

Büscher M, Horos R, Huppertz I, Haubrich K, Dobrev N, Baudin F, Hennig J, Hentze MW

RNA (New York, N.Y.), 2022

doi:10.1261/rna.079129.122.

Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction.

Muckenthaler L, Marques O, Colucci S, Kunz JB, Fabrowski P, Bast T, Altamura S, Höchsmann B, Schrezenmeier H, Langlotz M, Richter-Pechanska P, Rausch T, Hofmeister-Mielke N, Gunkel N, Hentze MW, Kulozik AE, Muckenthaler MU

Blood, 2021

doi:10.1182/blood.2021013519.

Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.

Powers KT, Stevenson-Jones F, Yadav SKN, Amthor B, Bufton JC, Borucu U, Shen D, Becker JP, Lavysh D, Hentze MW, Kulozik AE, Neu-Yilik G, Schaffitzel C

Nucleic acids research, 2021

doi:10.1093/nar/gkab532.

Core cross-linked polymeric micelles for specific iron delivery: inducing sterile inflammation in macrophages.

Bauer TA, Horvat NK, Marques O, Chocarro S, Mertens C, Colucci S, Schmitt S, Carrella LM, Morsbach S, Koynov K, Fenaroli F, Blümler P, Jung M, Sotillo R, Hentze MW, Muckenthaler MU, Barz M

Advanced healthcare materials, 2021

doi:10.1002/adhm.202100385.

Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes.

Riechert E, Kmietczyk V, Stein F, Schwarzl T, Sekaran T, Jürgensen L, Kamuf-Schenk V, Varma E, Hofmann C, Rettel M, Gür K, Ölschläger J, Kühl F, Martin J, Ramirez-Pedraza M, Fernandez M, Doroudgar S, Méndez R, Katus HA, Hentze MW, Völkers M

Cell reports, 2021

doi:10.1016/j.celrep.2021.109100.

NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes.

Becker JP, Helm D, Rettel M, Stein F, Hernandez-Sanchez A, Urban K, Gebert J, Kloor M, Neu-Yilik G, von Knebel Doeberitz M, Hentze MW, Kulozik AE

iScience, 2021

doi:10.1016/j.isci.2021.102389.

Mechanism of riboregulation of p62 proteinoligomerisation by vault RNA1-1 inselective autophagy.

Büscher M, Horos R, Haubrich K, Dobrev N, Baudin F, Hennig J, Hentze MW

2021

doi:10.1101/2021.04.12.439413.

RNA-binding proteins in human genetic disease.

Gebauer F, Schwarzl T, Valcárcel J, Hentze MW

Nature reviews. Genetics, 2020

doi:10.1038/s41576-020-00302-y.

Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture.

Perez-Perri JI, Noerenberg M, Kamel W, Lenz CE, Mohammed S, Hentze MW, Castello A

Nature protocols, 2020

doi:10.1038/s41596-020-00404-1.

Condensation of Ded1p promotes a translational switch from housekeeping to stress protein production.

Iserman C, Desroches Altamirano C, Jegers C, Friedrich U, Zarin T, Fritsch AW, Mittasch M, Domingues A, Hersemann L, Jahnel M, Richter D, Guenther UP, Hentze MW, Moses AM, Hyman AA, Kreysing M, Kramer G, Alberti S, Franzmann TM

Cell, 2020

doi:10.1016/j.cell.2020.04.009.

Plasticity of nuclear and cytoplasmic stress responses of RNA-binding proteins.

Backlund M, Stein F, Rettel M, Schwarzl T, Perez-Perri JI, Brosig A, Zhou Y, Neu-Yilik G, Hentze MW, Kulozik AE

Nucleic acids research, 2020

doi:10.1093/nar/gkaa256.

'High vault-age': non-coding RNA control of autophagy.

Büscher M, Horos R, Hentze MW

Open biology, 2020

doi:10.1098/rsob.190307.

A genetically encoded diazirine analogue for RNA-protein photocrosslinking.

Dziuba D, Hoffmann JE, Hentze MW, Schultz C

Chembiochem : a European journal of chemical biology, 2019

doi:10.1002/cbic.201900559.

The RNA-binding protein YBX3 controls amino acid levels by regulating SLC mRNA abundance.

Cooke A, Schwarzl T, Huppertz I, Kramer G, Mantas P, Alleaume AM, Huber W, Krijgsveld J, Hentze MW

Cell reports, 2019

doi:10.1016/j.celrep.2019.05.039.

Vault RNA emerges as a regulator of selective autophagy.

Horos R, Büscher M, Sachse C, Hentze MW

Autophagy, 2019

doi:10.1080/15548627.2019.1609861.

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction.

Vinchi F, Porto G, Simmelbauer A, Altamura S, Passos ST, Garbowski M, Silva AMN, Spaich S, Seide SE, Sparla R, Hentze MW, Muckenthaler MU

European heart journal, 2019

doi:10.1093/eurheartj/ehz112.

The small non-coding vault RNA1-1 acts as a riboregulator of autophagy.

Horos R, Büscher M, Kleinendorst R, Alleaume AM, Tarafder AK, Schwarzl T, Dziuba D, Tischer C, Zielonka EM, Adak A, Castello A, Huber W, Sachse C, Hentze MW

Cell, 2019

doi:10.1016/j.cell.2019.01.030.

The human RNA-binding proteome and its dynamics during translational arrest.

Trendel J, Schwarzl T, Horos R, Prakash A, Bateman A, Hentze MW, Krijgsveld J

Cell, 2018

doi:10.1016/j.cell.2018.11.004.

Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture.

Perez-Perri JI, Rogell B, Schwarzl T, Stein F, Zhou Y, Rettel M, Brosig A, Hentze MW

Nature communications, 2018

doi:10.1038/s41467-018-06557-8.

Silica-based solid-phase extraction of cross-linked nucleic acid-bound proteins.

Asencio C, Chatterjee A, Hentze MW

Life science alliance, 2018

doi:10.26508/lsa.201800088.

Elisa Izaurralde 1959-2018.

Hentze MW, Valcárcel J.

2018

doi:10.1038/s41594-018-0081-1.

A brave new world of RNA-binding proteins.

Hentze MW, Castello A, Schwarzl T, Preiss T

Nature reviews. Molecular cell biology, 2018

doi:10.1038/nrm.2017.130.

The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.

Kwon E, Todorova K, Wang J, Horos R, Lee KK, Neel VA, Negri GL, Sorensen PH, Lee SW, Hentze MW, Mandinova A

Nature communications, 2018

doi:10.1038/s41467-018-04092-0.

Identification of RNA-binding domains of RNA-binding proteins in cultured cells on a system-wide scale with RBDmap.

Castello A, Frese CK, Fischer B, Järvelin AI, Horos R, Alleaume AM, Foehr S, Curk T, Krijgsveld J, Hentze MW

Nature protocols, 2017

doi:10.1038/nprot.2017.106.

Characterization of the African swine fever virus decapping enzyme during infection.

Quintas A, Pérez-Núñez D, Sánchez EG, Nogal ML, Hentze MW, Castelló A, Revilla Y

Journal of virology, 2017

doi:10.1128/JVI.00990-17.

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages.

Costa da Silva M, Breckwoldt MO, Vinchi F, Correia MP, Stojanovic A, Thielmann CM, Meister M, Muley T, Warth A, Platten M, Hentze MW, Cerwenka A, Muckenthaler MU

Frontiers in immunology, 2017

doi:10.3389/fimmu.2017.01479.

Dual function of UPF3B in early and late translation termination.

Neu-Yilik G, Raimondeau E, Eliseev B, Yeramala L, Amthor B, Deniaud A, Huard K, Kerschgens K, Hentze MW, Schaffitzel C, Kulozik AE

The EMBO journal, 2017

doi:10.15252/embj.201797079.

Erratum to: Insights into the design and interpretation of iCLIP experiments.

Haberman N, Huppertz I, Attig J, König J, Wang Z, Hauer C, Hentze MW, Kulozik AE, Le Hir H, Curk T, Sibley CR, Zarnack K, Ule J

Genome biology, 2017

doi:10.1186/s13059-017-1294-z.

Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin.

da Silva AR, Neves J, Mleczko-Sanecka K, Tandon A, Sauer SW, Hentze MW, Muckenthaler MU

Journal of molecular medicine (Berlin, Germany), 2017

doi:10.1007/s00109-017-1551-3.

Specific RNP capture with antisense LNA/DNA mixmers.

Rogell BM, Fischer B, Rettel M, Krijgsveld J, Castello A, Hentze MW

RNA (New York, N.Y.), 2017

doi:10.1261/rna.060798.117.

Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure.

Haddad S, Wang Y, Galy B, Korf-Klingebiel M, Hirsch V, Baru AM, Rostami F, Reboll MR, Heineke J, Flögel U, Groos S, Renner A, Toischer K, Zimmermann F, Engeli S, Jordan J, Bauersachs J, Hentze MW, Wollert KC, Kempf T

European heart journal, 2016

doi:10.1093/eurheartj/ehw333.

A Red Carpet for Iron Metabolism.

Muckenthaler MU, Rivella S, Hentze MW, Galy B

Cell, 2017

doi:10.1016/j.cell.2016.12.034.

Insights into the design and interpretation of iCLIP experiments.

Haberman N, Huppertz I, Attig J, König J, Wang Z, Hauer C, Hentze MW, Kulozik AE, Le Hir H, Curk T, Sibley CR, Zarnack K, Ule J

Genome biology, 2017

doi:10.1186/s13059-016-1130-x.

In planta determination of the mRNA-binding proteome of Arabidopsis etiolated seedlings.

Reichel M, Liao Y, Rettel M, Ragan C, Evers M, Alleaume AM, Horos R, Hentze MW, Preiss T, Millar AA

The Plant cell, 2016

doi:10.1105/tpc.16.00562.

Comprehensive Identification of RNA-Binding Domains in Human Cells.

Castello A, Fischer B, Frese CK, Horos R, Alleaume AM, Foehr S, Curk T, Krijgsveld J, Hentze MW

MOLECULAR CELL, 2016

doi:10.1016/j.molcel.2016.06.029.

Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins.

Hauer C, Sieber J, Schwarzl T, Hollerer I, Curk T, Alleaume AM, Hentze MW, Kulozik AE

Cell reports, 2016

doi:10.1016/j.celrep.2016.06.096.

Identification of RNA-binding proteins in macrophages by interactome capture.

Liepelt A, Naarmann-de Vries IS, Simons N, Eichelbaum K, Foehr S, Archer SK, Castello A, Usadel B, Krijgsveld J, Preiss T, Marx G, Hentze MW, Ostareck DH, Ostareck-Lederer A

Molecular & cellular proteomics : MCP, 2016

doi:10.1074/mcp.M115.056564.

The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease

Liao Y, Castello A, Fischer B, Leicht S, Föehr S, Frese C, Ragan C, Kurscheid S, Pagler E, Yang H, Krijgsveld J, Hentze MW, Preiss T

Cell Reports, 2016

doi:10.1016/j.celrep.2016.06.084.

The differential expression of alternatively polyadenylated transcripts is a common stress-induced response mechanism that modulates mammalian mRNA expression in a quantitative and qualitative fashion.

Hollerer I, Curk T, Haase B, Benes V, Hauer C, Neu-Yilik G, Bhuvanagiri M, Hentze MW, Kulozik AE

RNA (New York, N.Y.), 2016

doi:10.1261/rna.055657.115.

Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila.

Sysoev VO, Fischer B, Frese CK, Gupta I, Krijgsveld J, Hentze MW, Castello A, Ephrussi A

Nature communications, 2016

doi:10.1038/ncomms12128.

Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels.

Kovac S, Böser P, Cui Y, Ferring-Appel D, Casarrubea D, Huang L, Fung E, Popp A, Mueller BK, Hentze MW

Haematologica, 2016

doi:10.3324/haematol.2015.140772.

Proteomic analysis reveals branch-specific regulation of the unfolded protein response by nonsense-mediated mRNA decay.

Sieber J, Hauer C, Bhuvanagiri M, Leicht S, Krijgsveld J, Neu-Yilik G, Hentze MW, Kulozik AE

Molecular & cellular proteomics : MCP, 2016

doi:10.1074/mcp.M115.054056.

Mice with hepcidin-resistant ferroportin accumulate iron in the retina.

Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, Galy B, Hentze M, Muckenthaler MU, Dunaief JL

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015

doi:10.1096/fj.15-276758.

IRES unplugged.

Gebauer F, Hentze MW

Science (New York, N.Y.), 2016

doi:10.1126/science.aad8540.

Comprehensive Identification of RNA-Binding Proteins by RNA Interactome Capture.

Castello A, Horos R, Strein C, Fischer B, Eichelbaum K, Steinmetz LM, Krijgsveld J, Hentze MW

Methods in molecular biology (Clifton, N.J.), 2016

doi:10.1007/978-1-4939-3067-8_8.

Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen.

Siegert I, Schödel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski DM, Lang R, Galy B, Hentze MW, Koivunen P, Oefner PJ, Bogdan C, Weiss G, Willam C, Jantsch J

Cell reports, 2015

doi:10.1016/j.celrep.2015.11.005.

FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation.

Popow J, Alleaume AM, Curk T, Schwarzl T, Sauer S, Hentze MW

RNA (New York, N.Y.), 2015

doi:10.1261/rna.052365.115.

The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs.

Beckmann BM, Horos R, Fischer B, Castello A, Eichelbaum K, Alleaume AM, Schwarzl T, Curk T, Foehr S, Huber W, Krijgsveld J, Hentze MW

Nature communications, 2015

doi:10.1038/ncomms10127.

Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins.

Castello A, Hentze MW, Preiss T

Trends in endocrinology and metabolism: TEM, 2015

doi:10.1016/j.tem.2015.09.012.

Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection

Nairz M, Ferring-Appel D, Casarrubea D, Sonnweber T, Viatte L, Schroll A, Haschka D, Fang FC, Hentze MW, Weiss G, Galy B

CELL HOST & MICROBE, 2015

doi:10.1016/j.chom.2015.06.017.

Improved binding site assignment by high-resolution mapping of RNA-protein interactions using iCLIP.

Hauer C, Curk T, Anders S, Schwarzl T, Alleaume AM, Sieber J, Hollerer I, Bhuvanagiri M, Huber W, Hentze MW, Kulozik AE

Nature communications, 2015

doi:10.1038/ncomms8921.

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia.

Guida C, Altamura S, Klein FA, Galy B, Boutros M, Ulmer AJ, Hentze MW, Muckenthaler MU

Blood, 2015

doi:10.1182/blood-2014-08-595256.

Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency.

Martelli A, Schmucker S, Reutenauer L, Mathieu JR, Peyssonnaux C, Karim Z, Puy H, Galy B, Hentze MW, Puccio H

Cell metabolism, 2015

doi:10.1016/j.cmet.2015.01.010.

5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.

Bhuvanagiri M, Lewis J, Putzker K, Becker JP, Leicht S, Krijgsveld J, Batra R, Turnwald B, Jovanovic B, Hauer C, Sieber J, Hentze MW, Kulozik AE

EMBO molecular medicine, 2014

doi:10.15252/emmm.201404461.

Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins.

Kramer K, Sachsenberg T, Beckmann BM, Qamar S, Boon KL, Hentze MW, Kohlbacher O, Urlaub H

Nature methods, 2014

doi:10.1038/nmeth.3092.

Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload

Altamura S, Kessler R, Gröne HJ, Gretz N, Hentze MW, Galy B, Muckenthaler MU

Cell metabolism, 2014

doi:10.1016/j.cmet.2014.07.007.

A versatile assay for RNA-binding proteins in living cells

Strein C, Alleaume AM, Rothbauer U, Hentze MW, Castello A

RNA (New York, N.Y.), 2014

doi:10.1261/rna.043562.113.

Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria

Chung J, Anderson SA, Gwynn B, Deck KM, Chen MJ, Langer NB, Shaw GC, Huston NC, Boyer LF, Datta S, Paradkar PN, Li L, Wei Z, Lambert AJ, Sahr K, Wittig JG, Chen W, Lu W, Galy B, Schlaeger TM, Hentze MW, Ward DM, Kaplan J, Eisenstein RS, Peters LL, Paw BH

The Journal of biological chemistry, 2014

doi:10.1074/jbc.m114.547778.

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.

Mleczko-Sanecka K, Roche F, da Silva AR, Call D, D'Alessio F, Ragab A, Lapinski PE, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro LA, Klingmüller U, King PD, Boutros M, Hentze MW, Muckenthaler MU

Blood, 2014

doi:10.1182/blood-2013-07-515957.

mRNA 3'end processing: A tale of the tail reaches the clinic

Hollerer I, Grund K, Hentze MW, Kulozik AE

EMBO molecular medicine, 2014

doi:10.1002/emmm.201303300.

In Vivo Disruption Of The Hepcidin-Ferroportin Regulatory Circuitry Causes Fatal Systemic and Exocrine Pancreatic Iron Overload

Altamura S, Grone HJ, Kessler R, Galy B, Hentze MW, Muckenthaler MU

BLOOD, 2013

doi:10.1182/blood.V122.21.175.175.

Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond

Danckwardt S, Hentze MW, Kulozik AE

Journal of molecular medicine (Berlin, Germany), 2013

doi:10.1007/s00109-013-1074-5.

The RNA-binding protein repertoire of embryonic stem cells

Kwon SC, Yi H, Eichelbaum K, Föhr S, Fischer B, You KT, Castello A, Krijgsveld J, Hentze MW, Kim VN

Nature structural & molecular biology, 2013

doi:10.1038/nsmb.2638.

Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function

Casarrubea D, Viatte L, Hallas T, Vasanthakumar A, Eisenstein RS, Schümann K, Hentze MW, Galy B

Journal of molecular medicine (Berlin, Germany), 2013

doi:10.1007/s00109-013-1008-2.

Making sense of nonsense

Hentze MW, Izaurralde E

Nature structural & molecular biology, 2013

doi:10.1038/nsmb.2601.

RNA-binding proteins in Mendelian disease

Castello A, Fischer B, Hentze MW, Preiss T

Trends in genetics : TIG, 2013

doi:10.1016/j.tig.2013.01.004.

IRON REGULATORY PROTEINS SECURE EFFICIENT DIETARY IRON INTAKE AND DEFINE A BASAL SET POINT FOR THE REGULATION OF IRON ABSORPTION

Galy B, Ferring-Appel D, Becker C, Gretz N, Grone HJ, Schumann K, Hentze MW

AMERICAN JOURNAL OF HEMATOLOGY, 2013

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IRON REGULATORY PROTEINS MEDIATE MACROPHAGE INNATE IMMUNITY AGAINST SALMONELLA

Nairz M, Ferring-Appel D, Schroll A, Hentze MW, Weiss G, Galy B

AMERICAN JOURNAL OF HEMATOLOGY, 2013

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Circular RNAs: splicing's enigma variations

Hentze MW, Preiss T

The EMBO journal, 2013

doi:10.1038/emboj.2013.53.

System-wide identification of RNA-binding proteins by interactome capture

Castello A, Horos R, Strein C, Fischer B, Eichelbaum K, Steinmetz LM, Krijgsveld J, Hentze MW

Nature protocols, 2013

doi:10.1038/nprot.2013.020.

Iron regulatory proteins control a mucosal block to intestinal iron absorption

Galy B, Ferring-Appel D, Becker C, Gretz N, Gröne HJ, Schümann K, Hentze MW

Cell reports, 2013

doi:10.1016/j.celrep.2013.02.026.

The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption

Anderson SA, Nizzi CP, Chang YI, Deck KM, Schmidt PJ, Galy B, Damnernsawad A, Broman AT, Kendziorski C, Hentze MW, Fleming MD, Zhang J, Eisenstein RS

Cell metabolism, 2013

doi:10.1016/j.cmet.2013.01.007.

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

D'Alessio F, Hentze MW, Muckenthaler MU

Journal of hepatology, 2012

doi:10.1016/j.jhep.2012.06.015.

Automated high-throughput RNAi screening in human cells combined with reporter mRNA transfection to identify novel regulators of translation

Casanova CM, Sehr P, Putzker K, Hentze MW, Neumann B, Duncan KE, Thoma C

PloS one, 2012

doi:10.1371/journal.pone.0045943.

From cis-regulatory elements to complex RNPs and back

Gebauer F, Preiss T, Hentze MW

Cold Spring Harbor perspectives in biology, 2012

doi:10.1101/cshperspect.a012245.

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.

Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW

Cell, 2012

doi:10.1016/j.cell.2012.04.031.

PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding

Moretti F, Kaiser C, Zdanowicz-Specht A, Hentze MW

Nature structural & molecular biology, 2012

doi:10.1038/nsmb.2309.

Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins

Sanchez M, Galy B, Schwanhaeusser B, Blake J, Bähr-Ivacevic T, Benes V, Selbach M, Muckenthaler MU, Hentze MW

Blood, 2011

doi:10.1182/blood-2011-04-343541.

Translational control via protein-regulated upstream open reading frames

Medenbach J, Seiler M, Hentze MW

Cell, 2011

doi:10.1016/j.cell.2011.05.005.

Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon

Neu-Yilik G, Amthor B, Gehring NH, Bahri S, Paidassi H, Hentze MW, Kulozik AE

RNA (New York, N.Y.), 2011

doi:10.1261/rna.2401811.

An efficient factor-depleted mammalian in vitro translation system

Rakotondrafara AM, Hentze MW

Nature protocols, 2011

doi:10.1038/nprot.2011.314.

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

Castoldi M, Vujic Spasic M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU

The Journal of clinical investigation, 2011

doi:10.1172/jci44883.

p38 MAPK controls prothrombin expression by regulated RNA 3' end processing

Danckwardt S, Gantzert AS, Macher-Goeppinger S, Probst HC, Gentzel M, Wilm M, Gröne HJ, Schirmacher P, Hentze MW, Kulozik AE

Molecular cell, 2011

doi:10.1016/j.molcel.2010.12.032.

Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame

Moretti F, Thermann R, Hentze MW

RNA (New York, N.Y.), 2010

doi:10.1261/rna.2384610.

NMD: RNA biology meets human genetic medicine

Bhuvanagiri M, Schlitter AM, Hentze MW, Kulozik AE

The Biochemical journal, 2010

doi:10.1042/bj20100699.

Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway

Cohen LA, Gutierrez L, Weiss A, Leichtmann-Bardoogo Y, Zhang DL, Crooks DR, Sougrat R, Morgenstern A, Galy B, Hentze MW, Lazaro FJ, Rouault TA, Meyron-Holtz EG

Blood, 2010

doi:10.1182/blood-2009-11-253815.

Iron regulatory proteins secure mitochondrial iron sufficiency and function

Galy B, Ferring-Appel D, Sauer SW, Kaden S, Lyoumi S, Puy H, Kölker S, Gröne HJ, Hentze MW

Cell metabolism, 2010

doi:10.1016/j.cmet.2010.06.007.

The REM phase of gene regulation

Hentze MW, Preiss T

Trends in biochemical sciences, 2010

doi:10.1016/j.tibs.2010.05.009.

SIREs: searching for iron-responsive elements

Campillos M, Cases I, Hentze MW, Sanchez M

Nucleic acids research, 2010

doi:10.1093/nar/gkq371.

Two to tango: regulation of Mammalian iron metabolism

Hentze MW, Muckenthaler MU, Galy B, Camaschella C

Cell, 2010

doi:10.1016/j.cell.2010.06.028.

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

Mleczko-Sanecka K, Casanovas G, Ragab A, Breitkopf K, Müller A, Boutros M, Dooley S, Hentze MW, Muckenthaler MU

Blood, 2010

doi:10.1182/blood-2009-09-238105.

Systems analysis of iron metabolism: the network of iron pools and fluxes

Lopes TJ, Luganskaja T, Vujić Spasić M, Hentze MW, Muckenthaler MU, Schümann K, Reich JG

BMC systems biology, 2010

doi:10.1186/1752-0509-4-112.

The role of ABCE1 in eukaryotic posttermination ribosomal recycling

Pisarev AV, Skabkin MA, Pisareva VP, Skabkina OV, Rakotondrafara AM, Hentze MW, Hellen CU, Pestova TV

Molecular cell, 2010

doi:10.1016/j.molcel.2009.12.034.

The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays

Vainshtein Y, Sanchez M, Brazma A, Hentze MW, Dandekar T, Muckenthaler MU

BMC bioinformatics, 2010

doi:10.1186/1471-2105-11-112.

The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA

Duncan KE, Strein C, Hentze MW

Molecular cell, 2009

doi:10.1016/j.molcel.2009.09.042.

In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation

Viatte L, Gröne HJ, Hentze MW, Galy B

Journal of molecular medicine (Berlin, Germany), 2009

doi:10.1007/s00109-009-0494-8.

Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression

Zdanowicz A, Thermann R, Kowalska J, Jemielity J, Duncan K, Preiss T, Darzynkiewicz E, Hentze MW

Molecular cell, 2009

doi:10.1016/j.molcel.2009.09.009.

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S

The EMBO journal, 2009

doi:10.1038/emboj.2009.175.

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD

Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU

Journal of molecular medicine (Berlin, Germany), 2009

doi:10.1007/s00109-009-0447-2.

The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay

Gehring NH, Lamprinaki S, Hentze MW, Kulozik AE

PLoS biology, 2009

doi:10.1371/journal.pbio.1000120.

Disassembly of exon junction complexes by PYM

Gehring NH, Lamprinaki S, Kulozik AE, Hentze MW

Cell, 2009

doi:10.1016/j.cell.2009.02.042.

EMBO Molecular Medicine: Conquering new frontiers

Hentze MW

EMBO molecular medicine, 2009

doi:10.1002/emmm.200900011.

microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells

Beilharz TH, Humphreys DT, Clancy JL, Thermann R, Martin DI, Hentze MW, Preiss T

PloS one, 2009

doi:10.1371/journal.pone.0006783.

Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism

Ferring-Appel D, Hentze MW, Galy B

Blood, 2009

doi:10.1182/blood-2008-05-155093.

Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail

Thoma C, Fraterman S, Gentzel M, Wilm M, Hentze MW

RNA (New York, N.Y.), 2008

doi:10.1261/rna.1043908.

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

Verga Falzacappa MV, Casanovas G, Hentze MW, Muckenthaler MU

Journal of molecular medicine (Berlin, Germany), 2008

doi:10.1007/s00109-008-0313-7.

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

Ivanov PV, Gehring NH, Kunz JB, Hentze MW, Kulozik AE

The EMBO journal, 2008

doi:10.1038/emboj.2008.17.

3' end mRNA processing: molecular mechanisms and implications for health and disease

Danckwardt S, Hentze MW, Kulozik AE

The EMBO journal, 2008

doi:10.1038/sj.emboj.7601932.

Hfe acts in hepatocytes to prevent hemochromatosis

Vujić Spasić M, Kiss J, Herrmann T, Galy B, Martinache S, Stolte J, Gröne HJ, Stremmel W, Hentze MW, Muckenthaler MU

Cell metabolism, 2008

doi:10.1016/j.cmet.2007.11.014.

miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes

Castoldi M, Schmidt S, Benes V, Hentze MW, Muckenthaler MU

Nature protocols, 2008

doi:10.1038/nprot.2008.4.

Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum

Galy B, Ferring-Appel D, Kaden S, Gröne HJ, Hentze MW

Cell metabolism, 2008

doi:10.1016/j.cmet.2007.10.006.

Tethering assays to investigate nonsense-mediated mRNA decay activating proteins

Gehring NH, Hentze MW, Kulozik AE

Methods in enzymology, 2008

doi:10.1016/s0076-6879(08)02623-2.

Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network

Muckenthaler MU, Galy B, Hentze MW

Annual review of nutrition, 2008

doi:10.1146/annurev.nutr.28.061807.155521.

Regulation of iron metabolism in higher eukaryotes: iron-sulfur centers as genetic switches

Pantopoulos K, Hentze MW

2008

doi:10.1002/9783527613700.ch08.

miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes

Castoldi M, Benes V, Hentze MW, Muckenthaler MU

Methods (San Diego, Calif.), 2007

doi:10.1016/j.ymeth.2007.04.009.

Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element?

Percy MJ, Sanchez M, Swierczek S, McMullin MF, Mojica-Henshaw MP, Muckenthaler MU, Prchal JT, Hentze MW

Blood, 2007

doi:10.1182/blood-2007-03-082503.

A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG

Nature structural & molecular biology, 2007

doi:10.1038/nsmb1302.

Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells

Fillebeen C, Muckenthaler M, Andriopoulos B, Bisaillon M, Mounir Z, Hentze MW, Koromilas AE, Pantopoulos K

Journal of hepatology, 2007

doi:10.1016/j.jhep.2007.01.035.

Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals

Danckwardt S, Kaufmann I, Gentzel M, Foerstner KU, Gantzert AS, Gehring NH, Neu-Yilik G, Bork P, Keller W, Wilm M, Hentze MW, Kulozik AE

The EMBO journal, 2007

doi:10.1038/sj.emboj.7601699.

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Thermann R, Hentze MW

Nature, 2007

doi:10.1038/nature05878.

Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

Sanchez M, Galy B, Muckenthaler MU, Hentze MW

Nature structural & molecular biology, 2007

doi:10.1038/nsmb1222.

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe

Vujic Spasic M, Kiss J, Herrmann T, Kessler R, Stolte J, Galy B, Rathkolb B, Wolf E, Stremmel W, Hentze MW, Muckenthaler MU

Blood, 2007

doi:10.1182/blood-2006-07-036186.

Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1

Ludwiczek S, Theurl I, Muckenthaler MU, Jakab M, Mair SM, Theurl M, Kiss J, Paulmichl M, Hentze MW, Ritter M, Weiss G

Nature medicine, 2007

doi:10.1038/nm1542.

Studying translational control in Drosophila cell-free systems

Gebauer F, Hentze MW

Methods in enzymology, 2007

doi:10.1016/s0076-6879(07)29002-0.

Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region

Mihailovich M, Thermann R, Grohovaz F, Hentze MW, Zacchetti D

Nucleic acids research, 2007

doi:10.1093/nar/gkm191.

Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays

Sanchez M, Galy B, Hentze MW, Muckenthaler MU

Nature protocols, 2007

doi:10.1038/nprot.2007.293.

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU

Blood, 2007

doi:10.1182/blood-2006-07-033969.

The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway

Viegas MH, Gehring NH, Breit S, Hentze MW, Kulozik AE

Nucleic acids research, 2007

doi:10.1093/nar/gkm461.

A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay

Boelz S, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE

Biochemical and biophysical research communications, 2006

doi:10.1016/j.bbrc.2006.08.017.

Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse

Galy B, Hölter SM, Klopstock T, Ferring D, Becker L, Kaden S, Wurst W, Gröne HJ, Hentze MW

Nature genetics, 2006

doi:10.1038/ng0906-967.

Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy

Sanchez M, Galy B, Dandekar T, Bengert P, Vainshtein Y, Stolte J, Muckenthaler MU, Hentze MW

The Journal of biological chemistry, 2006

doi:10.1074/jbc.m603876200.

IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice

Corna G, Galy B, Hentze MW, Cairo G

Journal of molecular medicine (Berlin, Germany), 2006

doi:10.1007/s00109-006-0068-y.

Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay

Holbrook JA, Neu-Yilik G, Gehring NH, Kulozik AE, Hentze MW

EMBO reports, 2006

doi:10.1038/sj.embor.7400721.

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation

Kunz JB, Neu-Yilik G, Hentze MW, Kulozik AE, Gehring NH

RNA (New York, N.Y.), 2006

doi:10.1261/rna.12506.

A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA)

Castoldi M, Schmidt S, Benes V, Noerholm M, Kulozik AE, Hentze MW, Muckenthaler MU

RNA (New York, N.Y.), 2006

doi:10.1261/rna.2332406.

The prothrombin 20209 C-->T mutation in Jewish-Moroccan Caucasians: molecular analysis of gain-of-function of 3' end processing

Danckwardt S, Hartmann K, Katz B, Hentze MW, Levy Y, Eichele R, Deutsch V, Kulozik AE, Ben-Tal O

Journal of thrombosis and haemostasis : JTH, 2006

doi:10.1111/j.1538-7836.2006.01885.x.

The molecular circuitry regulating the switch between iron deficiency and overload in mice

Mok H, Mlodnicka AE, Hentze MW, Muckenthaler M, Schumacher A

The Journal of biological chemistry, 2006

doi:10.1074/jbc.m509857200.

Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles.

Chekulaeva M, Hentze MW, Ephrussi A

Cell, 2006

doi:10.1016/j.cell.2006.01.031.

Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation

Duncan K, Grskovic M, Strein C, Beckmann K, Niggeweg R, Abaza I, Gebauer F, Wilm M, Hentze MW

Genes & development, 2006

doi:10.1101/gad.371406.

3' end processing of the prothrombin mRNA in thrombophilia

Danckwardt S, Hartmann K, Gehring NH, Hentze MW, Kulozik AE

Acta haematologica, 2006

doi:10.1159/000090934.

The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD)

Stockklausner C, Breit S, Neu-Yilik G, Echner N, Hentze MW, Kulozik AE, Gehring NH

Nucleic acids research, 2006

doi:10.1093/nar/gkl277.

Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes

Galy B, Ferring D, Hentze MW

Genesis (New York, N.Y. : 2000), 2005

doi:10.1002/gene.20169.

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schümann K, Hentze MW

Blood, 2005

doi:10.1182/blood-2005-04-1365.

Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements

Gehring NH, Kunz JB, Neu-Yilik G, Breit S, Viegas MH, Hentze MW, Kulozik AE

Molecular cell, 2005

doi:10.1016/j.molcel.2005.08.012.

Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation

Hundsdoerfer P, Thoma C, Hentze MW

Proceedings of the National Academy of Sciences of the United States of America, 2005

doi:10.1073/pnas.0506536102.

A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila

Beckmann K, Grskovic M, Gebauer F, Hentze MW

Cell, 2005

doi:10.1016/j.cell.2005.06.011.

Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus

Fillebeen C, Rivas-Estilla AM, Bisaillon M, Ponka P, Muckenthaler M, Hentze MW, Koromilas AE, Pantopoulos K

The Journal of biological chemistry, 2005

doi:10.1074/jbc.m412687200.

Molecular mechanisms of translational control

Gebauer F, Hentze MW

Nature reviews. Molecular cell biology, 2004

doi:10.1038/nrm1488.

Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP

Thoma C, Bergamini G, Galy B, Hundsdoerfer P, Hentze MW

Molecular cell, 2004

doi:10.1016/j.molcel.2004.08.021.

Nonsense-mediated decay approaches the clinic

Holbrook JA, Neu-Yilik G, Hentze MW, Kulozik AE

Nature genetics, 2004

doi:10.1038/ng1403.

The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations

Danckwardt S, Gehring NH, Neu-Yilik G, Hundsdoerfer P, Pforsich M, Frede U, Hentze MW, Kulozik AE

Blood, 2004

doi:10.1182/blood-2003-08-2894.

Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo

Galy B, Ferring D, Benesova M, Benes V, Hentze MW

RNA (New York, N.Y.), 2004

doi:10.1261/rna.7220704.

Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis

Bonnah RA, Muckenthaler MU, Carlson H, Minana B, Enns CA, Hentze MW, So M

Cellular microbiology, 2004

doi:10.1111/j.1462-5822.2004.00376.x.

An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice

Roy CN, Custodio AO, de Graaf J, Schneider S, Akpan I, Montross LK, Sanchez M, Gaudino A, Hentze MW, Andrews NC, Muckenthaler MU

Nature genetics, 2004

doi:10.1038/ng1350.

Balancing acts: molecular control of mammalian iron metabolism

Hentze MW, Muckenthaler MU, Andrews NC

Cell, 2004

doi:10.1016/s0092-8674(04)00343-5.

Rat duodenal IRP1 activity and iron absorption in iron deficiency and after H2O2 perfusion

Schümann K, Brennan K, Weiss M, Pantopoulos K, Hentze MW

European journal of clinical investigation, 2004

doi:10.1111/j.1365-2362.2004.01335.x.

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity

Wang J, Chen G, Muckenthaler M, Galy B, Hentze MW, Pantopoulos K

Molecular and cellular biology, 2004

doi:10.1128/mcb.24.3.954-965.2004.

Using the lambdaN peptide to tether proteins to RNAs

Baron-Benhamou J, Gehring NH, Kulozik AE, Hentze MW

Methods in molecular biology (Clifton, N.J.), 2004

doi:10.1385/1-59259-750-5:135.

Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin

Herrmann T, Muckenthaler M, van der Hoeven F, Brennan K, Gehrke SG, Hubert N, Sergi C, Gröne HJ, Kaiser I, Gosch I, Volkmann M, Riedel HD, Hentze MW, Stewart AF, Stremmel W

Journal of molecular medicine (Berlin, Germany), 2004

doi:10.1007/s00109-003-0508-x.

Molecular analysis of iron overload in beta2-microglobulin-deficient mice

Muckenthaler MU, Rodrigues P, Macedo MG, Minana B, Brennan K, Cardoso EM, Hentze MW, de Sousa M

Blood cells, molecules & diseases, 2004

doi:10.1016/j.bcmd.2004.05.003.

Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife

Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE

Genome biology, 2004

doi:10.1186/gb-2004-5-4-218.

A poly(A) tail-responsive in vitro system for cap- or IRES-driven translation from HeLa cells

Thoma C, Ostareck-Lederer A, Hentze MW

Methods in molecular biology (Clifton, N.J.), 2004

doi:10.1385/1-59259-750-5:171.

Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock

Preiss T, Baron-Benhamou J, Ansorge W, Hentze MW

Nature structural biology, 2003

doi:10.1038/nsb1015.

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, Hachiya T, Hentze MW, Anderson P, Ohno S

Molecular cell, 2003

doi:10.1016/s1097-2765(03)00443-x.

A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA

Grskovic M, Hentze MW, Gebauer F

The EMBO journal, 2003

doi:10.1093/emboj/cdg539.

Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells

Schell T, Köcher T, Wilm M, Seraphin B, Kulozik AE, Hentze MW

The Biochemical journal, 2003

doi:10.1042/bj20021920.

The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast

Baron-Benhamou J, Fortes P, Inada T, Preiss T, Hentze MW

RNA (New York, N.Y.), 2003

doi:10.1261/rna.5100903.

Drosophila sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA

Gebauer F, Grskovic M, Hentze MW

Molecular cell, 2003

doi:10.1016/s1097-2765(03)00176-x.

Relationships and distinctions in iron-regulatory networks responding to interrelated signals

Muckenthaler M, Richter A, Gunkel N, Riedel D, Polycarpou-Schwarz M, Hentze S, Falkenhahn M, Stremmel W, Ansorge W, Hentze MW

Blood, 2003

doi:10.1182/blood-2002-07-2140.

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

Muckenthaler M, Roy CN, Custodio AO, Miñana B, deGraaf J, Montross LK, Andrews NC, Hentze MW

Nature genetics, 2003

doi:10.1038/ng1152.

Y14 and hUpf3b form an NMD-activating complex

Gehring NH, Neu-Yilik G, Schell T, Hentze MW, Kulozik AE

Molecular cell, 2003

doi:10.1016/s1097-2765(03)00142-4.

Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress

Thompson K, Menzies S, Muckenthaler M, Torti FM, Wood T, Torti SV, Hentze MW, Beard J, Connor J

Journal of neuroscience research, 2003

doi:10.1002/jnr.10463.

Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function

Hubert N, Hentze MW

Proceedings of the National Academy of Sciences of the United States of America, 2002

doi:10.1073/pnas.192423399.

Comparison of fluorescent tag DNA labeling methods used for expression analysis by DNA microarrays

Richter A, Schwager C, Hentze S, Ansorge W, Hentze MW, Muckenthaler M

BioTechniques, 2002

doi:10.2144/02333rr05_11834a.

Tolerable upper intakes for dietary iron set by the US Food and Nutrition Board

Schümann K, Borch-Iohnsen B, Hentze MW, Marx JJ

The American journal of clinical nutrition, 2002

doi:10.1093/ajcn/76.3.499.

c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs

Ostareck-Lederer A, Ostareck DH, Cans C, Neubauer G, Bomsztyk K, Superti-Furga G, Hentze MW

Molecular and cellular biology, 2002

doi:10.1128/mcb.22.13.4535-4543.2002.

Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay

Danckwardt S, Neu-Yilik G, Thermann R, Frede U, Hentze MW, Kulozik AE

Blood, 2002

doi:10.1182/blood.v99.5.1811.

The human intronless melanocortin 4-receptor gene is NMD insensitive

Brocke KS, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE

Human molecular genetics, 2002

doi:10.1093/hmg/11.3.331.

Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway

Schell T, Kulozik AE, Hentze MW

Genome biology, 2002

doi:10.1186/gb-2002-3-3-reviews1006.

Iron-dependent regulation of the divalent metal ion transporter

Gunshin H, Allerson CR, Polycarpou-Schwarz M, Rofts A, Rogers JT, Kishi F, Hentze MW, Rouault TA, Andrews NC, Hediger MA

FEBS letters, 2001

doi:10.1016/s0014-5793(01)03189-1.

New ways of initiating translation in eukaryotes.

Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M Jr, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M

Molecular and cellular biology, 2001

doi:10.1128/mcb.21.23.8238-8246.2001.

Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotides

Thoma C, Hasselblatt P, Köck J, Chang SF, Hockenjos B, Will H, Hentze MW, Blum HE, von Weizsäcker F, Offensperger WB

Molecular cell, 2001

doi:10.1016/s1097-2765(01)00364-1.

Fertility facts: male and female germ cell development requires translational control by CPEB

Gebauer F, Hentze MW

Molecular cell, 2001

doi:10.1016/s1097-2765(01)00326-4.

Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia

Gehring NH, Frede U, Neu-Yilik G, Hundsdoerfer P, Vetter B, Hentze MW, Kulozik AE

Nature genetics, 2001

doi:10.1038/ng578.

Protein synthesis. Believe it or not-translation in the nucleus

Hentze MW

Science (New York, N.Y.), 2001

doi:10.1126/science.1063290.

IRP1 activation by extracellular oxidative stress in the perfused rat liver

Mueller S, Pantopoulos K, Hübner CA, Stremmel W, Hentze MW

The Journal of biological chemistry, 2001

doi:10.1074/jbc.m100654200.

Construction of regulatable picornavirus IRESes as a test of current models of the mechanism of internal translation initiation

Pöyry TA, Hentze MW, Jackson RJ

RNA (New York, N.Y.), 2001

doi:10.1017/s1355838201001911.

ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation

Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z

Nature cell biology, 2001

doi:10.1038/35060131.

Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs

Neu-Yilik G, Gehring NH, Thermann R, Frede U, Hentze MW, Kulozik AE

The EMBO journal, 2001

doi:10.1093/emboj/20.3.532.

Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure

De Gregorio E, Baron J, Preiss T, Hentze MW

RNA (New York, N.Y.), 2001

doi:10.1017/s1355838201000577.

Translational control of 15-lipoxygenase and msl-2 mRNAs: single regulators or corepressor assemblies?

Gebauer F, Ostareck DH, Ostareck-Lederer A, Grskovic M, Hentze MW

Cold Spring Harbor symposia on quantitative biology, 2001

doi:10.1101/sqb.2001.66.329.

Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining

Ostareck DH, Ostareck-Lederer A, Shatsky IN, Hentze MW

Cell, 2001

doi:10.1016/s0092-8674(01)00212-4.

Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system

Bergamini G, Preiss T, Hentze MW

RNA (New York, N.Y.), 2000

doi:10.1017/s1355838200001679.

A new era for the RNA world. Conference: RNA 2000

Hentze MW, Izaurralde E, Séraphin B

EMBO reports, 2000

doi:10.1093/embo-reports/kvd100.

The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation

Fortes P, Inada T, Preiss T, Hentze MW, Mattaj IW, Sachs AB

Molecular cell, 2000

doi:10.1016/s1097-2765(00)00020-4.

[Pair of siblings of Italian ethnicity with hyperferritinemia and cataract]

Volkmann M, Schiff JH, Hör M, Hentze MW, Fiehn W, Merkt J

Der Internist, 2000

doi:10.1007/s001080050521.

Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries.

Castagnetti S, Hentze MW, Ephrussi A, Gebauer F

Development (Cambridge, England), 2000

doi:10.1242/dev.127.5.1063.

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, Hediger MA, Hentze MW, Simpson RJ

Molecular cell, 2000

doi:10.1016/s1097-2765(00)80425-6.

Translational Control of Developmental Decisions

Wickens M, Goodwin EB, Kimble J, Strickland S, Hentze MW

2000

doi:.

Nitric oxide, oxygen radicals, and iron metabolism

Pantopoulos K, Hentze MW

2000

doi:.

Translational repression assay procedure: a method to study RNA-protein interactions in yeast

Paraskeva E, Hentze MW

Methods in enzymology, 2000

doi:10.1016/s0076-6879(00)18064-4.

HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells

Riedel HD, Muckenthaler MU, Gehrke SG, Mohr I, Brennan K, Herrmann T, Fitscher BA, Hentze MW, Stremmel W

Blood, 1999

doi:10.1182/blood.V94.11.3915.423k27_3915_3921.

Translational control of dosage compensation in Drosophila by Sex-lethal: cooperative silencing via the 5' and 3' UTRs of msl-2 mRNA is independent of the poly(A) tail

Gebauer F, Corona DF, Preiss T, Becker PB, Hentze MW

The EMBO journal, 1999

doi:10.1093/emboj/18.21.6146.

From factors to mechanisms: translation and translational control in eukaryotes

Preiss T, Hentze MW

Current opinion in genetics & development, 1999

doi:10.1016/s0959-437x(99)00005-2.

Translation driven by an eIF4G core domain in vivo

De Gregorio E, Preiss T, Hentze MW

The EMBO journal, 1999

doi:10.1093/emboj/18.17.4865.

Human cytoplasmic aconitase (Iron regulatory protein 1) is converted into its [3Fe-4S] form by hydrogen peroxide in vitro but is not activated for iron-responsive element binding

Brazzolotto X, Gaillard J, Pantopoulos K, Hentze MW, Moulis JM

The Journal of biological chemistry, 1999

doi:10.1074/jbc.274.31.21625.

Ligand-induced structural alterations in human iron regulatory protein-1 revealed by protein footprinting

Gegout V, Schlegl J, Schläger B, Hentze MW, Reinbolt J, Ehresmann B, Ehresmann C, Romby P

The Journal of biological chemistry, 1999

doi:10.1074/jbc.274.21.15052.

Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress

Gehring NH, Hentze MW, Pantopoulos K

The Journal of biological chemistry, 1999

doi:10.1074/jbc.274.10.6219.

A perfect message: RNA surveillance and nonsense-mediated decay

Hentze MW, Kulozik AE

Cell, 1999

doi:10.1016/s0092-8674(00)80542-5.

Ribosomal pausing and scanning arrest as mechanisms of translational regulation from cap-distal iron-responsive elements

Paraskeva E, Gray NK, Schläger B, Wehr K, Hentze MW

Molecular and cellular biology, 1999

doi:.

Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2

Ostareck-Lederer A, Ostareck DH, Hentze MW

Trends in biochemical sciences, 1998

doi:10.1016/s0968-0004(98)01301-2.

Poly(A)-tail-promoted translation in yeast: implications for translational control

Preiss T, Muckenthaler M, Hentze MW

RNA (New York, N.Y.), 1998

doi:10.1017/s1355838298980669.

IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F

Muckenthaler M, Gray NK, Hentze MW

Molecular cell, 1998

doi:10.1016/s1097-2765(00)80282-8.

Activation of iron regulatory protein-1 by oxidative stress in vitro

Pantopoulos K, Hentze MW

Proceedings of the National Academy of Sciences of the United States of America, 1998

doi:10.1073/pnas.95.18.10559.

Molecular cloning and characterisation of a novel duodenal-specific gene implicated in iron absorption

McKie AT, Wehr K, Simpson RJ, Peters TJ, Hentze MW, Farzaneh F

Biochemical Society transactions, 1998

doi:10.1042/bst026s264.

Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent

De Gregorio E, Preiss T, Hentze MW

RNA (New York, N.Y.), 1998

doi:10.1017/s1355838298980372.

Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans

Muckenthaler M, Gunkel N, Frishman D, Cyrklaff A, Tomancak P, Hentze MW

European journal of biochemistry / FEBS, 1998

doi:10.1046/j.1432-1327.1998.2540230.x.

Binary specification of nonsense codons by splicing and cytoplasmic translation

Thermann R, Neu-Yilik G, Deters A, Frede U, Wehr K, Hagemeier C, Hentze MW, Kulozik AE

The EMBO journal, 1998

doi:10.1093/emboj/17.12.3484.

Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast

Preiss T, Hentze MW

Nature, 1998

doi:10.1038/33192.

The Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA

Gebauer F, Merendino L, Hentze MW, Valcárcel J

RNA (New York, N.Y.), 1998

doi:.

A translational repression assay procedure (TRAP) for RNA-protein interactions in vivo

Paraskeva E, Atzberger A, Hentze MW

Proceedings of the National Academy of Sciences of the United States of America, 1998

doi:10.1073/pnas.95.3.951.

Systematic genomic screening and analysis of mRNA in untranslated regions and mRNA precursors: combining experimental and computational approaches

Dandekar T, Beyer K, Bork P, Kenealy MR, Pantopoulos K, Hentze M, Sonntag-Buck V, Flouriot G, Gannon F, Schreiber S

Bioinformatics (Oxford, England), 1998

doi:10.1093/bioinformatics/14.3.271.

Novel functions for 'nuclear factors' in the cytoplasm: the Sex-lethal paradigm

Gebauer F, Merendino L, Hentze MW, Valcárcel J

Seminars in cell & developmental biology, 1997

doi:10.1006/scdb.1997.0181.

Probing the structure of the regulatory region of human transferrin receptor messenger RNA and its interaction with iron regulatory protein-1

Schlegl J, Gegout V, Schläger B, Hentze MW, Westhof E, Ehresmann C, Ehresmann B, Romby P

RNA (New York, N.Y.), 1997

doi:.

Regulated poly(A) tail shortening in somatic cells mediated by cap-proximal translational repressor proteins and ribosome association

Muckenthaler M, Gunkel N, Stripecke R, Hentze MW

RNA (New York, N.Y.), 1997

doi:.

Starting at the beginning, middle, and end: translation initiation in eukaryotes

Sachs AB, Sarnow P, Hentze MW

Cell, 1997

doi:10.1016/s0092-8674(00)80268-8.

mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end

Ostareck DH, Ostareck-Lederer A, Wilm M, Thiele BJ, Mann M, Hentze MW

Cell, 1997

doi:10.1016/s0092-8674(00)80241-x.

Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress

Pantopoulos K, Mueller S, Atzberger A, Ansorge W, Stremmel W, Hentze MW

The Journal of biological chemistry, 1997

doi:10.1074/jbc.272.15.9802.

eIF4G: a multipurpose ribosome adapter?

Hentze MW

Science (New York, N.Y.), 1997

doi:10.1126/science.275.5299.500.

Mechanisms for posttranscriptional regulation by iron-responsive elements and iron regulatory proteins

Muckenthaler M, Hentze MW

Progress in molecular and subcellular biology, 1997

doi:.

Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13

Weiss G, Bogdan C, Hentze MW

Journal of immunology (Baltimore, Md. : 1950), 1997

doi:.

Iron-sulfur clusters and oxidant stress responses

Hentze MW

Trends in biochemical sciences, 1996

doi:10.1016/0968-0004(96)20019-2.

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

Hentze MW, Kühn LC

Proceedings of the National Academy of Sciences of the United States of America, 1996

doi:10.1073/pnas.93.16.8175.

Conservation of aconitase residues revealed by multiple sequence analysis. Implications for structure/function relationships

Frishman D, Hentze MW

European journal of biochemistry / FEBS, 1996

doi:10.1111/j.1432-1033.1996.0197u.x.

Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways

Pantopoulos K, Weiss G, Hentze MW

Molecular and cellular biology, 1996

doi:.

Iron-sulphur clusters as genetic regulatory switches: the bifunctional iron regulatory protein-1

Paraskeva E, Hentze MW

FEBS letters, 1996

doi:10.1016/0014-5793(96)00574-1.

Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements

Gray NK, Pantopoulos K, Dandekar T, Ackrell BA, Hentze MW

Proceedings of the National Academy of Sciences of the United States of America, 1996

doi:10.1073/pnas.93.10.4925.

Regulated ribosomal frameshifting by an RNA-protein interaction

Kollmus H, Hentze MW, Hauser H

RNA (New York, N.Y.), 1996

doi:.

Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution

Picard V, Renaudie F, Porcher C, Hentze MW, Grandchamp B, Beaumont C

Blood, 1996

doi:.

Translational regulation: versatile mechanisms for metabolic and developmental control.

Hentze MW

Current opinion in cell biology, 1995

doi:10.1016/0955-0674(95)80095-6.

Rapid responses to oxidative stress mediated by iron regulatory protein

Pantopoulos K, Hentze MW

The EMBO journal, 1995

doi:10.1002/j.1460-2075.1995.tb07291.x.

Effect of nitric oxide on expression of transferrin receptor and ferritin and on cellular iron metabolism in K562 human erythroleukemia cells.

Oria R, Sánchez L, Houston T, Hentze MW, Liew FY, Brock JH

Blood, 1995

doi:10.1182/blood.V85.10.2962.bloodjournal85102962.

Differential regulation of two related RNA-binding proteins, iron regulatory protein (IRP) and IRPB.

Pantopoulos K, Gray NK, Hentze MW

RNA (New York, N.Y.), 1995

doi:.

Finding the hairpin in the haystack: searching for RNA motifs.

Dandekar T, Hentze MW

Trends in genetics : TIG, 1995

doi:10.1016/s0168-9525(00)88996-9.

Nuclear degradation of nonsense mutated beta-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of beta-thalassemia?

Kugler W, Enssle J, Hentze MW, Kulozik AE

Nucleic acids research, 1995

doi:10.1093/nar/23.3.413.

Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts

Pantopoulos K, Hentze MW

Proceedings of the National Academy of Sciences of the United States of America, 1995

doi:10.1073/pnas.92.5.1267.

Target-specific arrest of mRNA translation by antisense 2'-O-alkyloligoribonucleotides

Johansson HE, Belsham GJ, Sproat BS, Hentze MW

Nucleic acids research, 1994

doi:10.1093/nar/22.22.4591.

Proteins binding to 5' untranslated region sites: a general mechanism for translational regulation of mRNAs in human and yeast cells.

Stripecke R, Oliveira CC, McCarthy JE, Hentze MW

Molecular and cellular biology, 1994

doi:10.1128/mcb.14.9.5898.

Iron regulates nitric oxide synthase activity by controlling nuclear transcription

Weiss G, Werner-Felmayer G, Werner ER, Grünewald K, Wachter H, Hentze MW

The Journal of experimental medicine, 1994

doi:10.1084/jem.180.3.969.

Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.

Gray NK, Hentze MW

The EMBO journal, 1994

doi:10.1002/j.1460-2075.1994.tb06699.x.

Regulation of protein synthesis by mRNA structure.

Gray NK, Hentze MW

Molecular biology reports, 1994

doi:10.1007/bf00986961.

Enzymes as RNA-binding proteins: a role for (di)nucleotide-binding domains?

Hentze MW

Trends in biochemical sciences, 1994

doi:10.1016/0968-0004(94)90198-8.

Nitric oxide and the post-transcriptional control of cellular iron traffic.

Pantopoulos K, Weiss G, Hentze MW

Trends in cell biology, 1994

doi:10.1016/0962-8924(94)90179-1.

Recombinant iron-regulatory factor functions as an iron-responsive-element-binding protein, a translational repressor and an aconitase. A functional assay for translational repression and direct demonstration of the iron switch

Gray NK, Quick S, Goossen B, Constable A, Hirling H, Kühn LC, Hentze MW

European journal of biochemistry / FEBS, 1993

doi:10.1111/j.1432-1033.1993.tb18420.x.

Translational control by iron-responsive elements.

Hentze MW

Advances in experimental medicine and biology, 1994

doi:.

Iron regulatory factor--the conductor of cellular iron regulation.

Melefors O, Hentze MW

Blood reviews, 1993

doi:10.1016/0268-960x(93)90012-s.

The role of the 5' untranslated region of eukaryotic messenger RNAs in translation and its investigation using antisense technologies.

Pantopoulos K, Johansson HE, Hentze MW

Progress in nucleic acid research and molecular biology, 1994

doi:10.1016/S0079-6603(08)60856-9.

Stimulation of IRE-BP activity of IRF by tetrahydrobiopterin and cytokine dependent induction of nitric oxide synthase.

Weiss G, Goossen B, Doppler W, Fuchs D, Pantopoulos K, Werner-Felmayer G, Grünewald K, Wachter H, Hentze MW

Advances in experimental medicine and biology, 1994

doi:.

Determination of mRNA fate by different RNA polymerase II promoters

Enssle J, Kugler W, Hentze MW, Kulozik AE

Proceedings of the National Academy of Sciences of the United States of America, 1993

doi:10.1073/pnas.90.21.10091.

Translational repression by the human iron-regulatory factor (IRF) in Saccharomyces cerevisiae

Oliveira CC, Goossen B, Zanchin NI, McCarthy JE, Hentze MW, Stripecke R

Nucleic acids research, 1993

doi:10.1093/nar/21.23.5316.

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

Weiss G, Goossen B, Doppler W, Fuchs D, Pantopoulos K, Werner-Felmayer G, Wachter H, Hentze MW

The EMBO journal, 1993

doi:10.1002/j.1460-2075.1993.tb06039.x.

Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells.

Melefors O, Goossen B, Johansson HE, Stripecke R, Gray NK, Hentze MW

The Journal of biological chemistry, 1993

doi:.

Translational regulation by mRNA/protein interactions in eukaryotic cells: ferritin and beyond.

Melefors O, Hentze MW

BioEssays : news and reviews in molecular, cellular and developmental biology, 1993

doi:10.1002/bies.950150203.

Bacteriophage and spliceosomal proteins function as position-dependent cis/trans repressors of mRNA translation in vitro

Stripecke R, Hentze MW

Nucleic acids research, 1992

doi:10.1093/nar/20.21.5555.

Modulation of ferritin H-chain expression in Friend erythroleukemia cells: transcriptional and translational regulation by hemin.

Coccia EM, Profita V, Fiorucci G, Romeo G, Affabris E, Testa U, Hentze MW, Battistini A

Molecular and cellular biology, 1992

doi:10.1128/MCB.12.7.3015.

Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function?

Constable A, Quick S, Gray NK, Hentze MW

Proceedings of the National Academy of Sciences of the United States of America, 1992

doi:10.1073/pnas.89.10.4554.

Position is the critical determinant for function of iron-responsive elements as translational regulators.

Goossen B, Hentze MW

Molecular and cellular biology, 1992

doi:10.1128/MCB.12.5.1959.

Coordination of cellular iron metabolism by post-transcriptional gene regulation.

Kühn LC, Hentze MW

Journal of inorganic biochemistry, 1992

doi:10.1016/0162-0134(92)84064-t.

Determinants and regulation of cytoplasmic mRNA stability in eukaryotic cells.

Hentze MW

Biochimica et biophysica acta, 1991

doi:10.1016/0167-4781(91)90191-n.

Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.

Dandekar T, Stripecke R, Gray NK, Goossen B, Constable A, Johansson HE, Hentze MW

The EMBO journal, 1991

doi:10.1002/j.1460-2075.1991.tb07716.x.

Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase

Hentze MW, Argos P

Nucleic acids research, 1991

doi:10.1093/nar/19.8.1739.

Effect of heparin contained in preparations of small cytoplasmic RNAs on cell-free translation.

Johansson HE, De Groot N, Hochberg AA, Hentze MW

The Journal of biological chemistry, 1991

doi:.

Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo.

Goossen B, Caughman SW, Harford JB, Klausner RD, Hentze MW

The EMBO journal, 1990

doi:10.1002/j.1460-2075.1990.tb07635.x.

Translational regulation of ferritin biosynthesis by iron: a review.

Hentze MW

Current studies in hematology and blood transfusion, 1991

doi:.

Overcoming inhibitions.

Hentze MW

The New biologist, 1990

doi:.

Complex formation between a cytoplasmic protein and the ferritin mRNA regulates translation initiation.

Hentze MW, Goossen B, Caughman SW

Molecular biology reports, 1990

doi:10.1007/bf00360416.

Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements.

Haile DJ, Hentze MW, Rouault TA, Harford JB, Klausner RD

Molecular and cellular biology, 1989

doi:10.1128/MCB.9.11.5055.

Chromosomal localization of nucleic acid-binding proteins by affinity mapping: assignment of the IRE-binding protein gene to human chromosome 9.

Hentze MW, Seuanez HN, O'Brien SJ, Harford JB, Klausner RD

Nucleic acids research, 1989

doi:10.1093/nar/17.15.6103.

The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein.

Rouault TA, Hentze MW, Haile DJ, Harford JB, Klausner RD

Proceedings of the National Academy of Sciences of the United States of America, 1989

doi:10.1073/pnas.86.15.5768.

A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA.

Koeller DM, Casey JL, Hentze MW, Gerhardt EM, Chan LN, Klausner RD, Harford JB

Proceedings of the National Academy of Sciences of the United States of America, 1989

doi:10.1073/pnas.86.10.3574.

Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction.

Hentze MW, Rouault TA, Harford JB, Klausner RD

Science (New York, N.Y.), 1989

doi:10.1126/science.2711187.

The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor.

Caughman SW, Hentze MW, Rouault TA, Harford JB, Klausner RD

The Journal of biological chemistry, 1988

doi:.

A model for the structure and functions of iron-responsive elements.

Hentze MW, Caughman SW, Casey JL, Koeller DM, Rouault TA, Harford JB, Klausner RD

Gene, 1988

doi:10.1016/0378-1119(88)90145-x.

Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA.

Rouault TA, Hentze MW, Caughman SW, Harford JB, Klausner RD

Science (New York, N.Y.), 1988

doi:10.1126/science.3413484.

Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation.

Casey JL, Hentze MW, Koeller DM, Caughman SW, Rouault TA, Klausner RD, Harford JB

Science (New York, N.Y.), 1988

doi:10.1126/science.2452485.

Identification of the iron-responsive element for the translational regulation of human ferritin mRNA.

Hentze MW, Caughman SW, Rouault TA, Barriocanal JG, Dancis A, Harford JB, Klausner RD

Science (New York, N.Y.), 1987

doi:10.1126/science.3685996.

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

Hentze MW, Rouault TA, Caughman SW, Dancis A, Harford JB, Klausner RD

Proceedings of the National Academy of Sciences of the United States of America, 1987

doi:10.1073/pnas.84.19.6730.

Influence of altered transcription on the translational control of human ferritin expression.

Rouault TA, Hentze MW, Dancis A, Caughman W, Harford JB, Klausner RD

Proceedings of the National Academy of Sciences of the United States of America, 1987

doi:10.1073/pnas.84.18.6335.

Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.

Hentze MW, Keim S, Papadopoulos P, O'Brien S, Modi W, Drysdale J, Leonard WJ, Harford JB, Klausner RD

Proceedings of the National Academy of Sciences of the United States of America, 1986

doi:10.1073/pnas.83.19.7226.