In situ serial crystallography facilitates 96-well plate structural analysis at low symmetry.

Foos N, Florial JB, Eymery M, Sinoir J, Felisaz F, Oscarsson M, Beteva A, Bowler MW, Nurizzo D, Papp G, Soler-Lopez M, Nanao M, Basu S, McCarthy AA

IUCrJ, 2024

doi:10.1107/s2052252524005785.

Targeting the conserved active site of splicing machines with specific and selective small molecule modulators.

Silvestri I, Manigrasso J, Andreani A, Brindani N, Mas C, Reiser JB, Vidossich P, Martino G, McCarthy AA, De Vivo M, Marcia M

Nature communications, 2024

doi:10.1038/s41467-024-48697-0.

Linking the autotaxin-LPA axis to medicinal cannabis and the endocannabinoid system.

Eymery MC, Boumendjel A, McCarthy AA, Hausmann J

International journal of molecular sciences, 2024

doi:10.3390/ijms25063212.

The assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination.

McGregor L, Acajjaoui S, Desfosses A, Saïdi M, Bacia-Verloop M, Schwarz JJ, Juyoux P, von Velsen J, Bowler MW, McCarthy AA, Kandiah E, Gutsche I, Soler-Lopez M

Nature communications, 2023

doi:10.1038/s41467-023-43865-0.

Discovery of potent chromone-based autotaxin inhibitors inspired by cannabinoids.

Eymery MC, Nguyen KA, Basu S, Hausmann J, Tran-Nguyen VK, Seidel HP, Gutierrez L, Boumendjel A, McCarthy AA

European journal of medicinal chemistry, 2023

doi:10.1016/j.ejmech.2023.115944.

Linking medicinal cannabis to autotaxin-lysophosphatidic acid signaling.

Eymery MC, McCarthy AA, Hausmann J

Life science alliance, 2023

doi:10.26508/lsa.202201595.

The crystal structure of the EspB-EspK virulence factor-chaperone complex suggests an additional type VII secretion mechanism in M. tuberculosis.

Gijsbers A, Eymery M, Gao Y, Menart I, Vinciauskaite V, Siliqi D, Peters PJ, McCarthy A, Ravelli RBG

The Journal of biological chemistry, 2022

doi:10.1016/j.jbc.2022.102761.

BioSAXS at European Synchrotron Radiation Facility - Extremely Brilliant Source: BM29 with an upgraded source, detector, robot, sample environment, data collection and analysis software.

Tully MD, Kieffer J, Brennich ME, Cohen Aberdam R, Florial JB, Hutin S, Oscarsson M, Beteva A, Popov A, Moussaoui D, Theveneau P, Papp G, Gigmes J, Cipriani F, McCarthy A, Zubieta C, Mueller-Dieckmann C, Leonard G, Pernot P

Journal of synchrotron radiation, 2023

doi:10.1107/s1600577522011286.

Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract.

Münch J, Engesser M, Schönauer R, Hamm JA, Hartig C, Hantmann E, Akay G, Pehlivan D, Mitani T, Akdemir ZC, Tüysüz B, Shirakawa T, Dateki S, Claus LR, van Eerde AM, Genomics England Research Consortium, Smol T, Devisme L, Franquet H, Attié-Bitach T, Wagner T, Bergmann C, Höhn AK, Shril S, Pollack A, Wegner T, Scott A, Paolucci S, Buchan J, Gabriel GC, Posey JE, Lupski JR, Petit F, McCarthy AA, Pazour GJ, Lo CW, Popp B, Halbritter J

Kidney international, 2022

doi:10.1016/j.kint.2022.01.028.

The absence of the caffeine synthase gene is involved in the naturally decaffeinated status of Coffea humblotiana, a wild species from Comoro archipelago.

Raharimalala N, Rombauts S, McCarthy A, Garavito A, Orozco-Arias S, Bellanger L, Morales-Correa AY, Froger S, Michaux S, Berry V, Metairon S, Fournier C, Lepelley M, Mueller L, Couturon E, Hamon P, Rakotomalala JJ, Descombes P, Guyot R, Crouzillat D

Scientific reports, 2021

doi:10.1038/s41598-021-87419-0.

Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals.

Blum TB, Housset D, Clabbers MTB, van Genderen E, Bacia-Verloop M, Zander U, McCarthy AA, Schoehn G, Ling WL, Abrahams JP

Acta crystallographica. Section D, Structural biology, 2021

doi:10.1107/S2059798320014540.

Attaining atomic resolution from in situ data collection at room temperature using counter-diffusion-based low-cost microchips.

Gavira JA, Rodriguez-Ruiz I, Martinez-Rodriguez S, Basu S, Teychené S, McCarthy AA, Mueller-Dieckman C

Acta crystallographica. Section D, Structural biology, 2020

doi:10.1107/S2059798320008475.

X-ray structure of the human karyopherin RanBP5, an essential factor for influenza polymerase nuclear trafficking.

Swale C, Da Costa B, Sedano L, Garzoni F, McCarthy AA, Berger I, Bieniossek C, Ruigrok RWH, Delmas B, Crépin T

Journal of molecular biology, 2020

doi:10.1016/j.jmb.2020.03.021.

Structure and function of roundabout receptors.

Bisiak F, McCarthy AA

Sub-cellular biochemistry, 2019

doi:10.1007/978-3-030-28151-9_9.

Decapping enzyme NUDT12 partners with BLMH for cytoplasmic surveillance of NAD-capped RNAs.

Wu H, Li L, Chen KM, Homolka D, Gos P, Fleury-Olela F, McCarthy AA, Pillai RS

Cell reports, 2019

doi:10.1016/j.celrep.2019.11.108.

Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.

Ashraf U, Tengo L, Le Corre L, Fournier G, Busca P, McCarthy AA, Rameix-Welti MA, Gravier-Pelletier C, Ruigrok RWH, Jacob Y, Vidalain PO, Pietrancosta N, Crépin T, Naffakh N

Proceedings of the National Academy of Sciences of the United States of America, 2019

doi:10.1073/pnas.1901214116.

Structural principles in Robo activation and auto-inhibition.

Barak R, Yom-Tov G, Guez-Haddad J, Gasri-Plotnitsky L, Maimon R, Cohen-Berkman M, McCarthy AA, Perlson E, Henis-Korenblit S, Isupov MN, Opatowsky Y

Cell, 2019

doi:10.1016/j.cell.2019.02.004.

MXCuBE2: the dawn of MXCuBE Collaboration.

Oscarsson M, Beteva A, Flot D, Gordon E, Guijarro M, Leonard G, McSweeney S, Monaco S, Mueller-Dieckmann C, Nanao M, Nurizzo D, Popov AN, von Stetten D, Svensson O, Rey-Bakaikoa V, Chavas LMG, Chado I, Gourhant P, Gadea L, Legrand P, Isabet T, Sirigu S, Savko M, Thompson A, Shepard W, Nan J, Mueller U, Bolmsten F, Eguiraun M, Milàn-Otero A, Nardella A, Kastner A, Schmuckermaier L, Thunnissen M, Hellmig M, Weiss MS, Gerlach M, Feiler C, Bowler MW, Gobbo A, Papp G, Sinoir J, McCarthy AA, Karpics I, Nikolova M, Bourenkov G, Schneider T, Boer R, Juanhuix J, Cuní G, Andreu J, Paciorek W, Flensburg C, Keller P, Fogh R, de Sanctis D, Bricogne G, Vonrhein C

Journal of synchrotron radiation, 2019

doi:10.1107/S1600577519001267.

CrystalDirect-To-Beam: Opening the shortest path from crystal to data.

Felisaz F, Sinoir J, Papp G, Pica A, Bowler MW, Murphy P, Hoffmann G, Zander U, Lopez-Marrero M, Janocha R, Giraud T, Svensson O, Popov S, Leonard G, Mueller-Dieckmann C, Márquez JA, McCarthy A, Cipriani F

2019

doi:10.1063/1.5084627.

Structural basis for the activation of the deubiquitinase Calypso by the Polycomb protein ASX.

De I, Chittock EC, Grötsch H, Miller TCR, McCarthy AA, Müller CW

Structure (London, England : 1993), 2019

doi:10.1016/j.str.2018.11.013.

Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development.

Mendel M, Chen KM, Homolka D, Gos P, Pandey RR, McCarthy AA, Pillai RS

Molecular cell, 2018

doi:10.1016/j.molcel.2018.08.004.

Calibration of rotation axes for multi-axis goniometers in macromolecular crystallography.

White KI, Bugris V, McCarthy AA, Ravelli RBG, Csankó K, Cassetta A, Brockhauser S

Journal of applied crystallography, 2018

doi:10.1107/S1600576718010956.

ID30B - a versatile beamline for macromolecular crystallography experiments at the ESRF.

McCarthy AA, Barrett R, Beteva A, Caserotto H, Dobias F, Felisaz F, Giraud T, Guijarro M, Janocha R, Khadrouche A, Lentini M, Leonard GA, Lopez Marrero M, Malbet-Monaco S, McSweeney S, Papp G, Nurizzo D, Sinoir J, Rossi C, Surr J, Sorez C, Zander U, Svensson O, Theveneau P, Cipriani F, Mueller-Dieckmann C

Journal of synchrotron radiation, 2018

doi:10.1107/S1600577518007166.

Robo1 Forms a Compact Dimer-of-Dimers Assembly.

Aleksandrova N, Gutsche I, Kandiah E, Avilov SV, Petoukhov MV, Seiradake E, McCarthy AA

Structure (London, England : 1993), 2018

doi:10.1016/j.str.2017.12.003.

A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model

Skubak P, Arac D, Bowler MW, Correia A, Hoelz A, Larsen S, Leonard G, McCarthy A, McSweeney S, Mueller-Dieckmann C, Otten H, Salzman G, Pannu N

IUCrJ, 2018

doi:10.1107/S2052252517017961.

Towards a compact and precise sample holder for macromolecular crystallography.

Papp G, Rossi C, Janocha R, Sorez C, Lopez-Marrero M, Astruc A, McCarthy A, Belrhali H, Bowler MW, Cipriani F

Acta crystallographica. Section D, Structural biology, 2017

doi:10.1107/S2059798317013742.

Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites

Simon B, Huart A, Temmerman K, Vahokoski J, Mertens H, Komadina D, Hoffmann J, Yumerefendi H, Svergun D, Kursula P, Schultz C, McCarthy A, Hart D, Wilmanns M

Structure, 2016

doi:10.1016/j.str.2016.03.020.

PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway.

Yang Z, Chen KM, Pandey RR, Homolka D, Reuter M, Janeiro BK, Sachidanandam R, Fauvarque MO, McCarthy AA, Pillai RS

Molecular cell, 2015

doi:10.1016/j.molcel.2015.11.009.

Asymmetric ring structure of Vps4 required for ESCRT-III disassembly.

Caillat C, Macheboeuf P, Wu Y, McCarthy AA, Boeri-Erba E, Effantin G, Göttlinger HG, Weissenhorn W, Renesto P

Nature communications, 2015

doi:10.1038/ncomms9781.

Crystallization and X-ray diffraction studies of a complete bacterial fatty-acid synthase type I.

Enderle M, McCarthy A, Paithankar KS, Grininger M

Acta crystallographica. Section F, Structural biology communications, 2015

doi:10.1107/s2053230x15018336.

MeshAndCollect: an automated multi-crystal data-collection workflow for synchrotron macromolecular crystallography beamlines.

Zander U, Bourenkov G, Popov AN, de Sanctis D, Svensson O, McCarthy AA, Round E, Gordeliy V, Mueller-Dieckmann C, Leonard GA

Acta crystallographica. Section D, Biological crystallography, 2015

doi:10.1107/s1399004715017927.

Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists.

Chen KM, Campbell E, Pandey RR, Yang Z, McCarthy AA, Pillai RS

2015

doi:10.1261/rna.049437.114.

The status of the macromolecular crystallography beamlines at the European Synchrotron Radiation Facility

Mueller-Dieckmann C, Bowler MW, Carpentier P, Flot D, McCarthy AA, Nanao MH, Nurizzo D, Pernot P, Popov A, Round A, Royant A, de Sanctis D, von Stetten D, Leonard GA

EUROPEAN PHYSICAL JOURNAL PLUS, 2015

doi:10.1140/epjp/i2015-15070-0.

Mammalian translation elongation factor eEF1A2: X-ray structure and new features of GDP/GTP exchange mechanism in higher eukaryotes.

Crepin T, Shalak VF, Yaremchuk AD, Vlasenko DO, McCarthy A, Negrutskii BS, Tukalo MA, El'skaya AV

Nucleic acids research, 2014

doi:10.1093/nar/gku974.

Protein assembly mediated by sulfonatocalix[4]arene.

McGovern RE, McCarthy AA, Crowley PB

Chemical communications (Cambridge, England), 2014

doi:10.1039/c4cc04897k.

The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs

Cora E, Pandey RR, Xiol J, Taylor J, Sachidanandam R, McCarthy AA, Pillai RS

RNA (New York, N.Y.), 2014

doi:10.1261/rna.044701.114.

The use of a mini-κ goniometer head in macromolecular crystallography diffraction experiments

Brockhauser S, Ravelli RB, McCarthy AA

Acta crystallographica. Section D, Biological crystallography, 2013

doi:10.1107/s0907444913003880.

Automatic processing of macromolecular crystallography X-ray diffraction data at the ESRF

Monaco S, Gordon E, Bowler MW, Delagenière S, Guijarro M, Spruce D, Svensson O, McSweeney SM, McCarthy AA, Leonard G, Nanao MH

Journal of applied crystallography, 2013

doi:10.1107/s0021889813006195.

A structural basis for the biosynthesis of the major chlorogenic acids found in coffee

Lallemand LA, Zubieta C, Lee SG, Wang Y, Acajjaoui S, Timmins J, McSweeney S, Jez JM, McCarthy JG, McCarthy AA

Plant physiology, 2012

doi:10.1104/pp.112.202051.

The use of workflows in the design and implementation of complex experiments in macromolecular crystallography

Brockhauser S, Svensson O, Bowler MW, Nanao M, Gordon E, Leal RM, Popov A, Gerring M, McCarthy AA, Gotz A

Acta crystallographica. Section D, Biological crystallography, 2012

doi:10.1107/s090744491201863x.

Purification, crystallization and preliminary X-ray diffraction analysis of a hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyltransferase (HCT) from Coffea canephora involved in chlorogenic acid biosynthesis

Lallemand LA, McCarthy JG, McSweeney S, McCarthy AA

Acta crystallographica. Section F, Structural biology and crystallization communications, 2012

doi:10.1107/s1744309112019082.

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, Grigorov B, Gerlier D, Cusack S

Cell, 2011

doi:10.1016/j.cell.2011.09.039.

Translation calibration of inverse-kappa goniometers in macromolecular crystallography

Brockhauser S, White KI, McCarthy AA, Ravelli RB

Acta crystallographica. Section A, Foundations of crystallography, 2011

doi:10.1107/s0108767311004831.

Inducing phase transitions in protein crystals by controlled crystal dehydration.

Silvia R, Babu M, McCarthy A, Cipriani F, Hassan B

2011

doi:10.1107/S010876731107944X.

Visualizing the metal-binding versatility of copper trafficking sites

Badarau A, Firbank SJ, McCarthy AA, Banfield MJ, Dennison C

Biochemistry, 2010

doi:10.1021/bi101064w.

MxCuBE: a synchrotron beamline control environment customized for macromolecular crystallography experiments

Gabadinho J, Beteva A, Guijarro M, Rey-Bakaikoa V, Spruce D, Bowler MW, Brockhauser S, Flot D, Gordon EJ, Hall DR, Lavault B, McCarthy AA, McCarthy J, Mitchell E, Monaco S, Mueller-Dieckmann C, Nurizzo D, Ravelli RB, Thibault X, Walsh MA, Leonard GA, McSweeney SM

Journal of synchrotron radiation, 2010

doi:10.1107/s0909049510020005.

Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain

Hinz A, Miguet N, Natrajan G, Usami Y, Yamanaka H, Renesto P, Hartlieb B, McCarthy AA, Simorre JP, Göttlinger H, Weissenhorn W

Cell host & microbe, 2010

doi:10.1016/j.chom.2010.03.005.

A decade of user operation on the macromolecular crystallography MAD beamline ID14-4 at the ESRF

McCarthy AA, Brockhauser S, Nurizzo D, Theveneau P, Mairs T, Spruce D, Guijarro M, Lesourd M, Ravelli RB, McSweeney S

Journal of synchrotron radiation, 2009

doi:10.1107/s0909049509035377.

Structure and functional relevance of the Slit2 homodimerization domain

Seiradake E, von Philipsborn AC, Henry M, Fritz M, Lortat-Jacob H, Jamin M, Hemrika W, Bastmeyer M, Cusack S, McCarthy AA

EMBO reports, 2009

doi:10.1038/embor.2009.95.

Structure of SRP14 from the Schizosaccharomyces pombe signal recognition particle

Brooks MA, Ravelli RB, McCarthy AA, Strub K, Cusack S

Acta crystallographica. Section D, Biological crystallography, 2009

doi:10.1107/s0907444909005484.

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Dias A, Bouvier D, Crépin T, McCarthy AA, Hart DJ, Baudin F, Cusack S, Ruigrok RW

Nature, 2009

doi:10.1038/nature07745.

X-ray tomographic reconstruction of macromolecular samples

Brockhauser S, Di Michiel M, McGeehan JE, McCarthy AA, Ravelli RBG

Journal of applied crystallography, 2008

doi:10.1107/S002188980802935X.

Capturing the Shape of Macromolecular Crystals in 3D

Leal RMF, Teixeira SCM, Rey V, Forsyth VT, Mitchel EP, Brockhauser S, Di Michiel M, McGeehan JE, McCarthy A, Ravelli RBG

2008

doi:.

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3

Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA

Acta crystallographica. Section D, Biological crystallography, 2007

doi:10.1107/s0907444907035470.

Structural insights into the Slit-Robo complex

Morlot C, Thielens NM, Ravelli RB, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA

Proceedings of the National Academy of Sciences of the United States of America, 2007

doi:10.1073/pnas.0705310104.

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggström JZ, Nordlund P

Nature, 2007

doi:10.1038/nature06009.

Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human roundabout 1 (Robo1)

Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA

Acta crystallographica. Section F, Structural biology and crystallization communications, 2007

doi:10.1107/S1744309107033027.

The structure of two N-methyltransferases from the caffeine biosynthetic pathway

McCarthy AA, McCarthy JG

Plant physiology, 2007

doi:10.1104/pp.106.094854.

Cloning, expression, crystallization and preliminary X-ray analysis of the XMT and DXMT N-methyltransferases from Coffea canephora (robusta)

McCarthy AA, Biget L, Lin C, Petiard V, Tanksley SD, McCarthy JG

Acta crystallographica. Section F, Structural biology and crystallization communications, 2007

doi:10.1107/S1744309107009268.

Structure of dimeric SecA, the Escherichia coli preprotein translocase motor

Papanikolau Y, Papadovasilaki M, Ravelli RB, McCarthy AA, Cusack S, Economou A, Petratos K

Journal of molecular biology, 2007

doi:10.1016/j.jmb.2006.12.049.

Plastic-embedded protein crystals

Ravelli RB, Haselmann-Weiss U, McGeehan JE, McCarthy AA, Marquez JA, Antony C, Frangakis AS, Stranzl G

Journal of synchrotron radiation, 2007

doi:10.1107/s0909049506043111.

Structure of C3b reveals conformational changes that underlie complement activity

Janssen BJ, Christodoulidou A, McCarthy A, Lambris JD, Gros P

Nature, 2006

doi:10.1038/nature05172.

High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput gene-to-structure pipeline

Beteva A, Cipriani F, Cusack S, Delageniere S, Gabadinho J, Gordon EJ, Guijarro M, Hall DR, Larsen S, Launer L, Lavault CB, Leonard GA, Mairs T, McCarthy A, McCarthy J, Meyer J, Mitchell E, Monaco S, Nurizzo D, Pernot P, Pieritz R, Ravelli RG, Rey V, Shepard W, Spruce D, Stuart DI, Svensson O, Theveneau P, Thibault X, Turkenburg J, Walsh M, McSweeney SM

Acta crystallographica. Section D, Biological crystallography, 2006

doi:10.1107/s0907444906032859.

The care and nurture of undulator data sets

Flot D, Gordon EJ, Hall DR, Leonard GA, McCarthy A, McCarthy J, McSweeney S, Mitchell E, Nurizzo D, Ravelli RG, Shepard W

Acta crystallographica. Section D, Biological crystallography, 2006

doi:10.1107/s0907444905032646.

Automation of macromolecular crystallography beamlines

Arzt S, Beteva A, Cipriani F, Delageniere S, Felisaz F, Förstner G, Gordon E, Launer L, Lavault B, Leonard G, Mairs T, McCarthy A, McCarthy J, McSweeney S, Meyer J, Mitchell E, Monaco S, Nurizzo D, Ravelli R, Rey V, Shepard W, Spruce D, Svensson O, Theveneau P

Progress in biophysics and molecular biology, 2005

doi:10.1016/j.pbiomolbio.2004.09.003.

Structure and function of the C-terminal domain of the polymerase cofactor of rabies virus

Mavrakis M, McCarthy AA, Roche S, Blondel D, Ruigrok RW

Journal of molecular biology, 2004

doi:10.1016/j.jmb.2004.08.071.

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS

Nature structural & molecular biology, 2004

doi:10.1038/nsmb767.

Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis

McCarthy AA, Peterson NA, Knijff R, Baker EN

Journal of molecular biology, 2004

doi:10.1016/j.jmb.2003.11.034.