Systems (epi)genetics to study the basis of complex traits and diseases
Great collaboration with Kasper Rasmussen and Christian Helin! Check it out here: https://genome.cshlp.org/content/29/4/564 TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells The epigenetic regulator TET2 is frequently mutated in hematological diseases.…
Check it out here: Quantification of differential transcription factor activity and multiomic-based classification into activators and repressors: diffTF
Check out our new paper on how CTCF loops can affect alternative exon usage: Ruiz-Velasco et al. (Cell Systems 2017). You can download the pdf here. Light summary and some background was covered in the EMBL News here.
Have a look here: Structure meets function: How chromatin organisation conveys functionality
Our SNPhood paper is out! Congratulations to Christian and Pooja! You can read the paper here: SNPhood: Investigate, quantify and visualise the epigenomic neighbourhood of SNPs using NGS data The corresponding Bioconductor package is here: SNPhood package
Genetic Control of Chromatin States in Humans Involves Local and Distal Chromosomal Interactions: http://www.sciencedirect.com/science/article/pii/S0092867415009642 Also check out the highlight in Cell: http://www.sciencedirect.com/science/article/pii/S0092867415010351 and Nature…