Systems (epi)genetics to study the basis of complex traits and diseases
Check out here how we combine high-throughput genomics data and statistical learning to gain mechanistic insights and functional consequences of cooperative transcription factor binding: Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions…
Interested in quantifying differential TF activity and classifying TFs into activators and repressors? Then you should check out our recent manuscript and associated tool diffTF: Quantification of Differential Transcription Factor Activity and Multiomics-Based Classification into Activators and…
This is a great collaboration with our MMPU partner lab headed by Caroline Pabst. Check it out here: http://www.bloodjournal.org/content/early/2019/05/10/blood.2018862383?sso-checked=true Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated…
Great collaboration with Kasper Rasmussen and Christian Helin! Check it out here: https://genome.cshlp.org/content/29/4/564 TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells The epigenetic regulator TET2 is frequently mutated in hematological diseases.…
Multiomics to Mechanisms – Challenges in Data Integration The repeat of our successful EMBL|EMBO symposium on Multiomics data integration is happening again Sept 11-13 2019. Check-out our excellent speaker line-up: here This conference will provide a platform for bringing together…
The first PhD of the Zaugg lab, well done Mariana!
Thanks everyone involved for making this a success! The next Attacking Open Chromatin with ATAC-Sequencing course will happen again next year in September 2019. Make sure to write a good motivation letter, the course was heavily oversubscribed this year.
Check it out here: Quantification of differential transcription factor activity and multiomic-based classification into activators and repressors: diffTF
The Molecular Medicine Partnership Unit is a program to connect basic science (at EMBL) with clinical research (at the University hospital Heidelberg). Our MMPU group will be focusing on investigating the stem cell interactions within the bone marrow niche. Check out our MMPU website: Stem…
Check out our new paper on how CTCF loops can affect alternative exon usage: Ruiz-Velasco et al. (Cell Systems 2017). You can download the pdf here. Light summary and some background was covered in the EMBL News here.