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Iris Kruijen

19 December 2019 Before a biological sample reaches the beamline, a lot of work is put into its preparation. Scientists can use the wide range of services and resources at EMBL to prepare their biological samples for structural studies at the X-ray beamlines in Grenoble and Hamburg. Photo: Marietta Schupp/EMBL

Before a biological sample reaches the beamline, a lot of work is put into its preparation. Scientists can use the wide range of services and resources at EMBL to prepare their biological samples for structural studies at the X-ray beamlines in Grenoble and Hamburg. Photo: Marietta Schupp/EMBL

Empowering European structural biology

EU funding for iNEXT-Discovery consortium unlocks key technologies for structural biology

EMBL ANNOUNCEMENTS LAB MATTERS

2019

embl-announcementslab-matters

13 December 2019

Graduation Ceremony 2019

Forty-seven PhD students from all of EMBL’s six sites were celebrated during EMBL’s 2019 Graduation Ceremony on Friday 13 December

LAB MATTERS

2019

lab-matters

23 July 2019 EMBL appoints new Directors and Associate Directors

EMBL appoints new Directors and Associate Directors

New Directors and Associate Directors

Promotions for Anne Ephrussi, Rainer Pepperkok, Paul Flicek and Jo McEntyre

EMBL ANNOUNCEMENTS LAB MATTERS

2019

embl-announcementslab-matters

15 July 2019

The pyramids represent chromatin domains in the wild-type situation. The reflection in the water below represents the rearrangements in the mutant fruit fly chromosomes. At first glance the (regulatory) landscapes look very similar, but there are lots of changes to the topology, and yet these have little impact on the nature of the landscape (gene expression). IMAGE: Beata Edyta Mierzwa in collaboration with EMBL.

Rearranging chromosomes

Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.

SCIENCE & TECHNOLOGY

2019

sciencescience-technology

21 June 2019 Tara in the harbour in Hamburg.

Tara in the harbour in Hamburg.

EMBL joins Tara stopovers in London and Hamburg

Tara schooner welcomes on board journalists, policymakers, funders and scientists

EMBL ANNOUNCEMENTS

2019

embl-announcementsevents

16 May 2019 map of tara stops near EMBL sites

map of tara stops near EMBL sites

The origins of plastic pollution at sea

Tara Ocean Foundation launches the exploration of 10 European rivers

SCIENCE & TECHNOLOGY

2019

sciencescience-technology

1 April 2019

Global microbial signatures for colorectal cancer

Colorectal cancer characterised by consistent changes in gut bacteria across continents, cultures and diets

SCIENCE & TECHNOLOGY

2019

sciencescience-technology

28 March 2019 Sketch of a building being constructed in a city landscape

Sketch of a building being constructed in a city landscape

Designer organelles bring new functionalities into cells

EMBL scientists create membraneless organelle to build proteins in living cell

SCIENCE & TECHNOLOGY

2019

sciencescience-technology

18 February 2019 Toxin-Antitoxin system in tuberculosis

Toxin-Antitoxin system in tuberculosis

Cell death trigger in tuberculosis bacteria

Suicide system in tuberculosis bacteria might hold key to treatment

SCIENCE & TECHNOLOGY

2019

sciencescience-technology

19 December 2018 The robots used during the experiments. The shape of this particular swarm is a hand-made illustration of the technique. PHOTO: reprinted with permission from AAAS

The robots used during the experiments. The shape of this particular swarm is a hand-made illustration of the technique. PHOTO: reprinted with permission from AAAS

Hundreds of tiny robots grow bio-inspired shapes

Scientists build self-organising features into robot swarms to study shape formation

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

17 December 2018 Mouse skin samples of the rare genetic skin disease amyloidosis, before light treatment (left) and after treatment (right). The arrows indicate aggregates of debris, which cause the skin to become rough and uncomfortable. Upon treatment these aggregates are reduced, allowing the skin to heal. IMAGES: Paul Heppenstall and Linda Nocchi / EMBL

Mouse skin samples of the rare genetic skin disease amyloidosis, before light treatment (left) and after treatment (right). The arrows indicate aggregates of debris, which cause the skin to become rough and uncomfortable. Upon treatment these aggregates are reduced, allowing the skin to heal. IMAGES: Paul Heppenstall and Linda Nocchi / EMBL

Using light to stop itch

EMBL researchers have found a way to stop itch with light in mice

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

24 October 2018 Insulin receptor structural biology. IMAGE: Felix Weis and Christoph Müller / EMBL

Insulin receptor structural biology. IMAGE: Felix Weis and Christoph Müller / EMBL

More effective insulin thanks to first 3D image

New study reveals how to make therapeutic insulins more effective than they currently are

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

1 October 2018 Studying the molecular features of ageing in human blood stem cells showed that as blood stem cells age, their sugar metabolism increases. IMAGE: Campbell Medical Illustration

Studying the molecular features of ageing in human blood stem cells showed that as blood stem cells age, their sugar metabolism increases. IMAGE: Campbell Medical Illustration

Ageing is visible in the way cells use glucose

Researchers from EMBL and Heidelberg University unveil the molecular mechanisms of ageing

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

13 September 2018 IMAGE: Manon Boschard

IMAGE: Manon Boschard

X-rays reveal surprising shape of scaffolding protein

X-ray experiments show that scaffolding protein PDZK1 has a L-shaped conformation

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

10 September 2018 A dynamic protein atlas of a human cell. IMAGE: Aleksandra Krolik/EMBL

A dynamic protein atlas of a human cell. IMAGE: Aleksandra Krolik/EMBL

First interactive model of human cell division

Real-time tracking of proteins during mitosis is now possible using a 4D computer model

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

1 August 2018 Global warfare between bacteria and fungi in soil. IMAGE: Hildebrand/Krolik in collaboration with Campbell Medical Illustration/EMBL

Global warfare between bacteria and fungi in soil. IMAGE: Hildebrand/Krolik in collaboration with Campbell Medical Illustration/EMBL

Understanding soil through its microbiome

First global survey of soil genomics reveals a war between fungi and bacteria

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

12 July 2018 Artistic 3D rendering of the dual spindle in the mammalian zygote. IMAGE: Cartasiova, Hossain, Reichmann, Ellenberg/EMBL

Artistic 3D rendering of the dual spindle in the mammalian zygote. IMAGE: Cartasiova, Hossain, Reichmann, Ellenberg/EMBL

Parental chromosomes kept apart during first division

Mammalian life begins differently than we thought

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

11 July 2018 IMAGE: Aleksandra Krolik, EMBL

IMAGE: Aleksandra Krolik, EMBL

Maternal bacteria persistent in newborns

Scientists show how bacteria and other microorganisms are passed on from mother to child

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

6 July 2018 E. coli bacteria colored in heat gradient. IMAGE: Aleksandra Krolik / EMBL

E. coli bacteria colored in heat gradient. IMAGE: Aleksandra Krolik / EMBL

Melting bacteria to decipher antibiotic resistance

EMBL scientists investigate how bacteria melt to study their reaction to drugs

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

26 June 2018 Mutations at the amino acid shown in orange (isoleucine 38) lead to reduced susceptibility to the drug. IMAGE - Stephen Cusack, EMBL

Mutations at the amino acid shown in orange (isoleucine 38) lead to reduced susceptibility to the drug. IMAGE - Stephen Cusack, EMBL

Flu’s response to new drug explored

EMBL scientists investigate how influenza virus responds to new drug treatment

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

18 June 2018 Three examples of the tissue shapes the team created. The black and white square, circle and triangle on the left correspond to the cells that were illuminated. On the right, three fruit fly embryos are shown in cyan, magenta and yellow, demonstrating how the illuminated cells folded inwards after the light-activation. IMAGE: Stefano De Renzis, EMBL

Three examples of the tissue shapes the team created. The black and white square, circle and triangle on the left correspond to the cells that were illuminated. On the right, three fruit fly embryos are shown in cyan, magenta and yellow, demonstrating how the illuminated cells folded inwards after the light-activation. IMAGE: Stefano De Renzis, EMBL

Constructing new tissue shapes with light

EMBL researchers guide the shape of cells and tissues with optogenetics

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

29 May 2018 Intermediate detection in capsid formation of the lumazine synthase enzyme. CREDIT: Aleksandra Krolik / EMBL

Intermediate detection in capsid formation of the lumazine synthase enzyme. CREDIT: Aleksandra Krolik / EMBL

Reconstructing 3D shapes from unmeasurable data

Scientists at EMBL Hamburg determine shapes of intermediate states in dynamic biological systems

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

10 May 2018 MRI image of a medulloblastoma

MRI image of a medulloblastoma

New risk factors for rare childhood cancer

Researchers identify genes that can cause brain tumours in children and other cancers later in life

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

7 May 2018

New Platform Transforms CRISPR Gene Editor Into Precision Tool. IMAGE: Irvine/NIST

CRISPR: from clipping scissors to word processor

New platform transforms CRISPR gene editor into precision tool

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

26 April 2018 Dividing cell colored in a heat gradient, highlighting the variation in proteins’ thermal stability within and between different cell cycle stages. IMAGE: Aleksandra Krolik / EMBL

Dividing cell colored in a heat gradient, highlighting the variation in proteins’ thermal stability within and between different cell cycle stages. IMAGE: Aleksandra Krolik / EMBL

Protein stability and solubility during cell cycle

EMBL scientists uncover large solubility and thermal stability changes of proteins during the cell cycle

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

24 April 2018

Managing chronic pain with light

Scientists at EMBL Rome develop new method that uses light to manage neuropathic pain in mice

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

19 April 2018

Dog microbiome closer to humans' than expected

Dog microbiome closer to humans’ than expected

Dog and human gut microbiomes have more similar genes and responses to diet than previously thought

PEOPLE & PERSPECTIVES

2018

people-perspectivesscience

26 March 2018 Multiple synapse heads send out filopodia (green) converging on one microglia (red), as seen by focused ion beam scanning electron microscopy (FIBSEM).

Multiple synapse heads send out filopodia (green) converging on one microglia (red), as seen by focused ion beam scanning electron microscopy (FIBSEM).

Captured: microglia nibbling on brain synapses

For the first time, EMBL Rome researchers have captured microglia nibbling on brain synapses on film.

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

19 March 2018

Commonly used drugs affect our gut bacteria.

Commonly used drugs affect our gut bacteria

One in four drugs with human targets inhibit the growth of bacteria in the human gut, and may promote antibiotic resistance, EMBL researchers report in Nature

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

19 March 2018

Molecular cuisine for gut bacteria. IMAGE: Aleksandra Krolik / EMBL

Molecular cuisine for gut bacteria

EMBL scientists show how to grow a wide range of gut bacteria in the lab

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

15 March 2018 Potential new way to limit antibiotic resistance spreading. IMAGE: Aleksandra Krolik / EMBL

Potential new way to limit antibiotic resistance spreading. IMAGE: Aleksandra Krolik / EMBL

Potential way to limit antibiotic resistance

EMBL scientists unravel the molecular basis of a major antibiotic resistance transfer mechanism

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

15 March 2018

How drugs affect the life and death of proteins. IMAGE: Cell

How drugs affect the life and death of proteins

Scientists at EMBL and Cellzome develop technology to monitor the effects of drug treatments on protein degradation and synthesis

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

14 March 2018 Information (arrows) emanating out of chromatin to give rise to different cell types. IMAGE: Campbell Medical Illustration

Information (arrows) emanating out of chromatin to give rise to different cell types. IMAGE: Campbell Medical Illustration

Chromatin usage reveals developmental trajectories

EMBL scientists show how chromatin usage in individual cells reveals developmental trajectories

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

7 March 2018 EMBL spinoff Velabs Therapeutics to help antibody discovery. IMAGE: Velabs Therapeutics

EMBL spinoff Velabs Therapeutics to help antibody discovery. IMAGE: Velabs Therapeutics

EMBL spinoff to help antibody discovery

New EMBL spinoff company Velabs Therapeutics aims to speed up discovery of therapeutic antibodies

LAB MATTERS SCIENCE & TECHNOLOGY

2018

lab-mattersscience-technology

22 February 2018 A condensin protein complex creates a loop in DNA. IMAGE: Cees Dekker Lab TU Delft/Scixel

A condensin protein complex creates a loop in DNA. IMAGE: Cees Dekker Lab TU Delft/Scixel

Loops, loops and loops: how DNA gets organised

Researchers from Delft University and EMBL crack the mystery of condensin’s neat DNA loop extrusion

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

22 February 2018

Synchronised waves control embryonic patterning

Synchronised waves control embryonic patterning

EMBL scientists show that the rhythm between Wnt and Notch waves enables patterning in embryos.

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

30 January 2018 Enhancer activity (green) and promoter activity (purple) in the same regulatory element. IMAGE: EMBL / Eileen Furlong

Enhancer activity (green) and promoter activity (purple) in the same regulatory element. IMAGE: EMBL / Eileen Furlong

Multipurpose enhancers and promoters in embryonic development

EMBL scientists show that some promoters can act as enhancers and vice versa

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

21 December 2017 The colour of the dots on this ATM keypad represents the amount of a molecule that was transferred from the person’s finger to the keypad.

The colour of the dots on this ATM keypad represents the amount of a molecule that was transferred from the person’s finger to the keypad.

Mapping molecules on people, fields and ATMs

Molecule mapping method raises interest in forensics, agriculture and microbiome studies

SCIENCE & TECHNOLOGY

2017

sciencescience-technology

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