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Marius Bruer

13 October 2021 Illustration of a community of bacteria. Pills represent an antibiotic that can be used to treat an infection, and a second drug that could protect many gut bacteria from antibiotics.

Tackling the collateral damage from antibiotics

Science & Technology Researchers from EMBL’s Typas group and collaborators have analysed the effects of 144 antibiotics on the wellbeing of gut microbes. The study improves our understanding of antibiotics’ side effects and suggests a new approach to mitigating the adverse effects of antibiotics therapy on gut…

2021

sciencescience-technology

5 October 2021 Illustration of a globe with colourful shapes and symbols superimposed.

A cellular atlas of an entire worm

Science & Technology EMBL scientists and colleagues have developed an interactive atlas of the entire marine worm Platynereis dumerilii in its larval stage. The PlatyBrowser resource combines high-resolution gene expression data with volume electron microscopy images.

2021

sciencescience-technology

29 September 2021 Female scientist working at a biosafety cabinet, wearing a yellow protective gown and black gloves.

Transferable skills

Lab MattersPeople & Perspectives In the lab, Diënty Hazenbrink works with microbes that live in our guts. In her free time, she enjoys wildlife photography. A shared set of skills facilitates both activities.

2021

lab-matterspeople-perspectives

3 June 2021 Illustration of a rocky coastline with sailing boat, mountains, underwater organisms, bridge and factory in the background.

Living laboratories

Science & Technology Under the innovative Planetary Biology research theme, EMBL scientists aim to understand life in the context of its environment.

2021

sciencescience-technology

27 April 2021 Microscope image of liver cells, highlighted in various colours.

Painting liver cells

Science & Technology A page from a biologist’s colouring book? EMBL’s new interior wall design? Not quite – a bunch of liver cells, grown in the lab so that scientists can learn about fatty liver disease, or steatosis.

2021

picture-of-the-weekscience-technology

20 April 2021 Black-and-white sphere with coronavirus spike protein structures and a two-layered ring of virus membrane superimposed.

Variations on a spike

Science & Technology What does coronavirus’s spike protein look like in 3D? EMBL scientists and colleagues used cryo-electron tomography and molecular dynamics simulations to find out.

2021

picture-of-the-weekscience-technology

16 February 2021 Microscopy images of coronavirus-infected cells in blue and red, arranged on a clockface. Illustrations of virus particles.

Finding coronavirus’s helper proteins

Science & Technology A team of EMBL scientists and colleagues have analysed how the novel coronavirus affects proteins in human cells. They identified several human proteins as potential drug targets to prevent viral replication.

2021

sciencescience-technology

20 November 2020 The Reichstag building (left) and Paul-Löbe-Haus (right) in Berlin, as seen in daylight from across the Spree river.

Sharing our vision for the future

ConnectionsLab Matters EMBL Director General Edith Heard introduced EMBL’s future plans during a parliamentary event at the Paul-Löbe-Haus of the German Bundestag in Berlin. She shared examples of EMBL’s research and outlined how EMBL’s activities will develop.

2020

connectionslab-matters

29 September 2020 A metal rack holding glass test tubes with yellow and red solutions in them.

Colourful test tubes

Science & Technology To study the effect of commonly used drugs on bacterial envelopes, EMBL scientists applied a biochemical assay using a colour reaction. The deeper the red, the stronger the disruptive effect of the drug.

2020

picture-of-the-weekscience-technology

4 September 2020 Portrait picture of Erin Tranfield, member of the EMBL Alumni Association Board, against a blue-green background.

Supporting the alumni community

People & Perspectives Erin Tranfield recently joined the EMBL Alumni Association Board as one of 15 newly elected members. Here, she talks about her new role on the board and reflects on how a life-changing event made her refocus her perspective on work and life.

2020

alumnipeople-perspectives

25 August 2020

Training the next generation of molecular biologists

EMBL AnnouncementsLab Matters The EMBL International PhD Programme is one of EMBL’s flagship training programmes. It forms part of our efforts to train and inspire talented scientists to become skilled and creative future leaders. Submission of applications for the current PhD student recruitment round is now possible.

2020

embl-announcementslab-matters

8 July 2020 Artwort illustrating various aspects of infection research. The centre of the image shows a cartoon representation of a coronavirus. The spheric shape has been overlaid with a map of the world to illustrate the global spread of viruses. The edges of the artwork feature images of potential virus hosts (bats, poultry, dromedary), a group of humans, a microscope, pills, a syringe and vaccine vial, protein structures, and an illustration of a human lung. The background is set in yellow and red colour.

What COVID-19 is teaching us

Science & Technology The virtual EMBL Conference ‘SARS-CoV-2: Towards a New Era in Infection Research’ explored the importance of fundamental research, collaboration, and data science in containing the SARS-CoV-2 pandemic, and discussed opportunities to improve our response to pandemics in the future.

2020

eventsscience-technology

6 July 2020 EMBL Director General Edith Heard standing at a laboratory work bench, facing the camera. Edith Heard on the left side, lab bench with pipettes and equipment on the right. Photo taken by érôme Brébion at Institut Curie, Paris.

Edith Heard elected senator of the Max Planck Society

EMBL AnnouncementsLab Matters EMBL Director General Edith Heard has been elected a senator of the Max Planck Society, one of Germany’s leading scientific research organisations. She joins the Senate along with Nobel Laureates and EMBL alumni Christiane Nüsslein-Volhard and Stefan W. Hell, as well as nine additional new…

2020

embl-announcementslab-matters

26 June 2020 Key visual for ‘Life Science Across the Globe’

Sharing our passion for science with the world

Lab Matters EMBL is joining the virtual seminar series ‘Life Science Across the Globe’ – a timely initiative to foster international scientific exchange across countries and continents, starting on 1 July.

2020

lab-matters

18 June 2020 Illustration of gender balances in academia

Closing the gender gap

EMBL Announcements To explore the origins of gender imbalances in academia and possible ways of overcoming them, international experts will meet for the virtual EMBL | EMBO | HHMI conference ‘Gender Roles and their Impact in Academia’ from 13–15 Oct 2020. The conference’s outcomes will be integrated into a…

2020

embl-announcementsevents

16 June 2020 Composite image of fly larvae organs making up a flower

From fly to flower

Science & Technology In this composite image, visual artist Mona Kakanj assembled three different biological structures in fly larvae into a flower. The original images were taken as part of a research project by Parisa Kakanj in Maria Leptin’s group.

2020

picture-of-the-weekscience-technology

15 June 2020 Key visual for the virtual EMBL conference ‘SARS-CoV-2: Towards a New Era in Infection Research’. Credits: Aleksandra Krolik/EMBL

Improving our response to emerging pandemics

EMBL Announcements The emergence of previously unknown pathogens, such as the novel coronavirus SARS-CoV-2, raises many questions. To explore these questions in an international scientific forum, EMBL will host the virtual conference ‘SARS-CoV-2: Towards a New Era in Infection Research’ on 3 July. Invited…

2020

embl-announcementsevents

9 June 2020 This image shows the structure of a bacterial group II intron

Genetic cut and paste at atomic resolution

Science & Technology Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…

2020

sciencescience-technology

9 June 2020 Mouse embryonic fibroblasts and their cell skeletons

Glow-in-the-dark cell skeletons

Science & Technology This image shows mouse embryonic fibroblasts (MEFs), their cell skeletons (green) and nuclei (blue) under a confocal microscope, photographed by Julia Hansen in the lab of Matthieu Boulard at EMBL Rome.

2020

picture-of-the-weekscience-technology

8 June 2020 Microscopic image showing a macrophage that has been infected with Salmonella (green), causing cellular cathepsins (red) to locate to the nucels (blue).

Re-trafficking proteins to fight Salmonella infections

Science & Technology Scientists including members of EMBL’s Typas group have investigated how immune cells called macrophages respond to infection by the intracellular pathogen Salmonella enterica. They discovered that Salmonella causes newly produced cathepsins to accumulate in the nuclei of infected cells to…

2020

sciencescience-technology

1 June 2020 An illustration of single-cell RNA sequencing (scRNA-seq)

Enabling functional genomics studies in individual cells

Science & Technology Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…

2020

sciencescience-technology

27 May 2020 Automated sample changer and diffractometer at the ID30B X-ray crystallography beamline at ESRF Grenoble.

Facilitating COVID-19 structural biology research

Connections EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…

2020

connectionsscience

26 May 2020 Bioinformatic analysis of over 4700 SARS-CoV-2 genomes revealed that many of the most interesting changes in the SARS-CoV-2 genome that have been reported so far are likely to be technical artefacts, rather than biological mutations.

Distinguishing coronavirus genome mutations from inadvertent errors

Science & Technology EMBL scientists have performed a large-scale analysis of over 4700 SARS-CoV-2 genome sequences. They found that many of the most interesting changes in the SARS-CoV-2 genome that have been reported so far are likely to be technical artefacts, rather than biological mutations.

2020

sciencescience-technology

13 May 2020 Close-up photograph of servers at EMBL Heidelberg's data centre.

Understanding the role of our genes in SARS-CoV-2 infections

Science & Technology EMBL scientists will contribute to the new German COVID-19 OMICS Initiative to study the biological mechanisms contributing to coronavirus infections. EMBL group leaders Jan Korbel and Oliver Stegle, who is also affiliated with the DKFZ Heidelberg, will coordinate the set-up of IT infrastructures…

2020

sciencescience-technology

28 April 2020 Close-up view of the interior of a protein analytics system

Exploring synthetic antibodies to stop coronavirus

Science & Technology Scientists at EMBL Hamburg and Karolinska Institutet Stockholm aim to find synthetic antibodies – known as nanobodies – that bind a surface protein of the novel SARS-CoV-2 coronavirus. Nanobodies could prevent the virus from entering human cells and causing COVID-19.

2020

sciencescience-technology

27 April 2020 Artistic rendering of an RNA-binding protein interacting with an RNA molecule.

Helping researchers identify host proteins used by coronavirus

Science & Technology EMBL scientists working in the groups of Matthias Hentze and Wolfgang Huber have created RBPbase – a database of RNA-binding proteins – to assist the identification of proteins that interact with the SARS-CoV-2 RNA genome.

2020

sciencescience-technology

23 April 2020 Key visual for the EMBO | EMBL symposium ‘The Four-Dimensional Genome’

EMBL hosts its first virtual conference

Lab Matters The virtual EMBO | EMBL symposium ‘The Four-Dimensional Genome’ brought together 470 participants. Here, Jürgen Deka, Head of External Scientific Training, discusses how he and his team overcame the organisational challenges.

2020

eventslab-matters

22 April 2020 Portrait photo of Brendan Rouse, EMBL's Environmental Officer

Welcome: Brendan Rouse

Lab MattersPeople & Perspectives Brendan Rouse came to Heidelberg in March as EMBL’s Environmental Officer, tasked with monitoring the organisation’s environmental impact and promoting sustainable practices. Here, he discusses his plans for the new role.

2020

lab-matterspeople-perspectives

16 April 2020 Micropipette tips in a liquid-handling robot

Helping to scale up coronavirus testing

Science & Technology Scientists at EMBL Heidelberg are contributing their expertise in a community effort to develop large-scale testing methods for coronavirus. Their goal is to increase the capacity and speed of testing, which is crucial for containing the pandemic.

2020

sciencescience-technology

15 April 2020 Purified proteins on an SDS-polyacrylamide gel

Producing proteins for coronavirus research

Science & Technology The Protein Expression and Purification Core Facility at EMBL Heidelberg will produce proteins for several coronavirus-related research projects, to assist the development of new strategies to fight the virus.

2020

sciencescience-technology

2 April 2020 Map showing institutes involved with EMBL in Twinning projects

EMBL shares expertise with four European institutes

ConnectionsLab Matters Three international teams involving EMBL Heidelberg have been granted funding from the European Commission for three Twinning projects with institutes in Portugal and the Czech Republic.

2020

connectionslab-matters

31 March 2020 Portrait of Bastian Drees, Head of Library

Welcome: Bastian Drees

Lab MattersPeople & Perspectives Bastian Drees is a biophysicist turned librarian, who joined EMBL in January as the new Head of Library. Here, he discusses the changing role of libraries and how they can help scientists organise and share their results.

2020

lab-matterspeople-perspectives

20 February 2020 lucia-von-bredow

Welcome: Lucia von Bredow

Lab MattersPeople & Perspectives EMBL’s new Science and Society Manager shares her plans for fostering multidisciplinary dialogue

2020

lab-matterspeople-perspectives

19 February 2020 Claire Deo

Welcome: Claire Deo

People & Perspectives New group leader at EMBL Heidelberg employs synthetic chemistry to develop novel tools for biology

2020

people-perspectivesscience

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