Researchers uncover what drives aggressive bone cancer
Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes.
SCIENCE & TECHNOLOGY2025
research-highlightsscience-technology
DECIPHER v11.29 released
The v11.29 DECIPHER release is out now. Find out about the new features and improvements.
2025
updates-from-data-resources
Welcome: Christina Ernst
EMBL-EBI's new Functional Genomics Team Leader will develop standards for new data types and integrate AI into workflows.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Human immune system is ‘ready to go’ long before birth
The most comprehensive map of the developing human thymus sheds light on how immune responses are built and maintained during early life
2024
announcements
We are EMBL: Briony Jackson on community-focused public engagement
Public Engagement Officer Briony Jackson is building lasting relationships with local communities to make science accessible and engaging for all.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Cancer drug resistance causes and categories identified
Researchers uncover that DNA changes that cause cancer drug resistance can be grouped into four categories, and identify possible new therapeutic targets.
2024
announcements
Polygenic Score (PGS) Catalog increases diversity and usability of genetic data
Addition of data from more diverse populations to the Polygenic Score (PGS) Catalog and a new software tool for PGS calculation could help produce more equitable disease risk predictions.
SCIENCE & TECHNOLOGY2024
science-technologytechnology-and-innovation
EMBL-EBI’s open data resources for biodiversity and climate research
EMBL-EBI data resources help advance biodiversity and climate change research by enabling scientists to study species interactions, evolutionary processes, ecosystem health, and more.
SCIENCE & TECHNOLOGY2024
science-technologytechnology-and-innovation
Welcome: David Ocaña
EMBL-EBI’s new Head of Applications will use his expertise in cloud infrastructure and security to support the institute’s open data resources.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
We are EMBL: Kim Gurwitz on working with global partners to support bioinformatics training
Kim Gurwitz talks about her role as Scientific Training Lead at EMBL-EBI and how collaborative projects for bioinformatics training support researchers and service providers in making the most of publicly available data.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Ancient environmental DNA provides solutions for global food security challenges
Researchers explore genetic diversity found in ancient environmental DNA to help modern agricultural practices.
EMBL ANNOUNCEMENTS2024
announcementsembl-announcements
Exploring cellular complexity with EMPIAR’s new cryo-electron tomography prototype browser
Data obtained through cryogenic sample electron tomography (cryo-ET) are openly available in the new Electron Microscopy Public Image Archive (EMPIAR) cryo-ET tomography browser.
EMBL ANNOUNCEMENTS2024
announcementsembl-announcements
‘Exhausted’ immune cells in healthy women could be target for breast cancer prevention
New study uncovers the potential of immunotherapy in preventing breast cancer and creates the openly available Human Breast Cell Atlas.
SCIENCE & TECHNOLOGY2024
research-highlightssciencescience-technology
AI annotations increase patent data in SureCheMBL
AI annotations added to the SureChEMBL database increase the depth of data made available to users.
2024
sciencetechnology-and-innovation
The malaria parasite generates genetic diversity using an evolutionary ‘copy-paste’ tactic
Plasmodium falciparum, a malaria parasite, uses gene conversion to produce genetic diversity in two surface protein genes targeted by the human immune system.
SCIENCE & TECHNOLOGY2024
announcementssciencescience-technology
Team SAMBAI: addressing cancer disparities in recent African heritage populations
An international team of researchers aim to combine social determinants of health with genomics, immune profiling, and exposomics data to tackle cancer inequities at an unprecedented scale.
SCIENCE & TECHNOLOGY2024
announcementssciencescience-technology
Welcome: Kyle Morris
Kyle Morris joins EMBL-EBI as Electron Microscopy Data Bank (EMDB) Team Leader.
LAB MATTERSPEOPLE & PERSPECTIVES2024
lab-matterspeople-perspectives
ProteomicsML: empowering proteomics research with machine learning
Streamlining proteomics data access for machine learning applications.
2024
sciencetechnology-and-innovation
The Biodiversity Cell Atlas: charting cellular diversity on Earth
A $3.8 million grant from the Gordon and Betty Moore Foundation will help researchers lay groundwork for the Biodiversity Cell Atlas.
2024
announcements
Unravelling the role of immune cells in early lung development
Researchers reveal that healthy lung development hinges on immune-epithelial crosstalk, with implications for respiratory diseases.
SCIENCE & TECHNOLOGY2023
research-highlightsscience-technology
The Global Biodiversity Portal: enabling biodiversity research worldwide
The new initiative brings together genomic data from various biodiversity projects to aid conservation and biodiversity efforts.
SCIENCE & TECHNOLOGY2023
announcementssciencescience-technology
EMBL-EBI co-leads on research programme to help treat relapsed childhood cancers
Leading charities Children with Cancer UK and Cancer Research UK will co-fund a major £5.5 million research programme to advance precision medicine for relapsed childhood cancers.
2023
announcements
Deciphering the data deluge: how large language models are transforming scientific data curation
Large language models are changing the way we carry out scientific data curation, annotation, and research, setting the stage for a more efficient understanding of scientific literature
2023
technology-and-innovation
Deciphering the data deluge: how large language models are transforming scientific data curation
Large language models are changing the way we carry out scientific data curation, annotation, and research, setting the stage for a more efficient understanding of scientific literature
EMBLetc2023
We are EMBL: Valentina Lorenzi on human reproductive development
PhD student Valentina Lorenzi is using single-cell sequencing data to create a map of the developing human reproductive system.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesperspectives
Welcome: David Hulcoop
David Hulcoop discusses how his experience bridging organisational cultures will help address critical challenges in drug discovery and target selection at Open Targets.
LAB MATTERSPEOPLE & PERSPECTIVES2023
announcementslab-matterspeople-perspectives
Uncovering the mechanisms underlying lack of response to immunotherapy
New research improves understanding of the molecular mechanisms behind why some cancers respond to immunotherapy and others don't.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Revealing the secrets of protein evolution using the AlphaFold database
Researchers use the AlphaFold database and Foldseek Cluster algorithm to analyse millions of predicted protein structures and offer new insights into protein evolution.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Nurturing computational excellence: the unique research culture at EMBL-EBI
EMBL-EBI’s Deputy Head of Research Virginie Uhlmann delves into the institute’s unique research landscape and the essential qualities for effective leadership in this field
2023
perspectives
From data management to AI: an interview with Laura Clarke
Experience in data management and coordination has enabled EMBL alumna Laura Clarke to pursue a career in AI development.
PEOPLE & PERSPECTIVES2023
people-perspectivesperspectivesscience
Filling the skills gap to advance genomic medicine: an interview with Emily Perry
By upskilling researchers on bioinformatics skills and tools, EMBL alumna Emily Perry is helping to make genomic medicine more accessible.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesperspectives
DECIPHER database for rare diseases joins EMBL-EBI
Closer collaborations with EMBL-EBI data resources set to further develop and grow this unique rare disease platform.
EMBL ANNOUNCEMENTS2023
announcementsembl-announcementsscience
Research assessment reform at EMBL: an interview with Wolfgang Huber
Wolfgang Huber discusses why research assessment needs reform and how this could make science more diverse, more inclusive, and better
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
Janet Thornton retires: a pioneer in structural bioinformatics
In recognition of Janet Thornton’s retirement, we look back at some of her biggest accomplishments shaping the field of bioinformatics.
LAB MATTERSPEOPLE & PERSPECTIVES2023
announcementslab-matterspeople-perspectives
Janet Thornton retires: a pioneer in structural bioinformatics
In recognition of Janet Thornton’s retirement, we look back at some of her biggest accomplishments in shaping the field of bioinformatics.
EMBLetc2023
A more diverse human reference genome
The human pangenome – one of the most complete collections of genome sequences released so far – captures rich human diversity.
SCIENCE & TECHNOLOGY2023
announcementssciencescience-technology
MAPLE: a phylogenetic tool for pandemic-scale genome data
EMBL-EBI researchers have developed a new tool capable of performing state-of-the-art phylogenetic inference on larger datasets than previously thought possible.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Genomic science to support conservation efforts: an interview with Lara Urban
Using long-read sequencing and machine learning approaches, EMBL alumna Lara Urban is making a difference in the field of One Health.
2023
perspectives
Large-scale study enables new insights into rare eye disorders
EMBL-EBI researchers use UK Biobank data to uncover new information about rare diseases of the eye.
2023
research-highlightsscience
Equality, diversity, and inclusion in science: individuals driving change
Meet some of our equality, diversity, and inclusion champions and find out how they’re making EMBL-EBI a better place to work
2023
announcements
Latest Release of the Single Cell Expression Atlas
The Single Cell Expression Atlas (SCEA) now includes more datasets and species.
2023
updates-from-data-resources
BlueRemediomics: harnessing marine microbes to promote a circular bioeconomy
Funding awarded for developing tools to harness marine microbiome data for biotechnological applications and ecosystem services.
2023
announcementsscience
Darwin Tree of Life: first 500 genome assemblies released as project creates a buzz
We look back through some of the 2022 highlights from the Darwin Tree of Life project.
SCIENCE & TECHNOLOGY2023
perspectivessciencescience-technology
Molecules to Ecosystems: Rob Finn on the Microbial Ecosystems transversal theme
Rob Finn, one of the co-chairs of the Microbial Ecosystems theme, discusses his work, the challenges of multidisciplinary research, and how the theme is already helping to promote the exchange of scientific ideas.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
BOSS-RUNS: streamlining dynamic nanopore sequencing
A new method developed by EMBL-EBI researchers helps to streamline nanopore sequencing in real-time.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
EMBL-EBI databases considered critical to life sciences
Open data resources that enable global research and development recognised by the Global Biodata Coalition.
2022
announcementsscience
Unleashing the biotechnology potential of euglenoids
An ambitious project to sequence the genomes of all known species of euglenoids will drive research on biofuels and sustainable foods.
2022
announcements
Open science for climate justice
Our experts discuss the importance of open science for food security and preserving global biodiversity.
2022
perspectivesscience
New molecular microscopy uncovers how breast cancer spreads
Researchers have created a tool that maps in previously unseen detail how breast cancer develops and spreads.
2022
research-highlightsscience
AI4LIFE: AI models for bioimaging
Researchers across EMBL are helping to make artificial intelligence (AI) models for bioimaging analysis interoperable and openly available to the scientific community.
2022
announcementsscience
Mapping the human brain: a global collaboration
NIH BRAIN Initiative to fund brain atlases, network coordination, and knowledge sharing to explore brain function research.
2022
announcementsscience
Natural language processing for rapid protein annotation
Over 40 million protein annotations have been added to the UniProt database using a Google Research natural language processing model.
2022
technology-and-innovation
Biodiversity Genomics Europe: addressing biodiversity loss through genomics
European experts gather to launch a project that aims to characterise and conserve life on Earth using DNA data.
2022
announcementsscience
Ardan Patwardhan receives Scientific Achievement Award
The Royal Microscopical Society recognises Ardan Patwardhan’s contributions to the field of electron microscopy.
2022
announcements
AlphaFold: where will the next AI breakthrough come from?
Ewan Birney, Deputy Director General of EMBL and Director of EMBL-EBI, reveals the key factors that enabled AlphaFold to change the world of biology.
PEOPLE & PERSPECTIVES2022
people-perspectivesperspectivesscience
CNest: a new method for copy number variation analysis
A new method for the robust analysis of copy number variation and used UK Biobank data to identify links between genome and disease.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
New releases: InterPro 90.0 and InterProScan 5.57-90.0
InterPro version 90.0 and InterProScan 5.57-90.0 are now available. InterPro now features hundreds of new methods integrated from partner databases, and InterProScan draws on over 40000 entries
2022
updates-from-data-resources
Darwin Tree of Life at the Royal Society Summer Science Exhibition
A closer look at how genome sequencing is helping us protect biodiversity and our latest public engagement activities
2022
announcements
ArrayExpress interface to close
On 30 September 2022 the ArrayExpress interface will close. All datasets have now been migrated from ArrayExpress into the BioStudies ArrayExpress collection
2022
updates-from-data-resources
Supporting the African BioGenome Project to build bioinformatics capacity
The African BioGenome Project and EMBL have signed a Memorandum of Understanding to support each other in building genomics and bioinformatics capacity across Africa
CONNECTIONSLAB MATTERS2022
announcementsconnectionslab-matters
A machine learning approach for allocating gene function
Researchers in the Ensembl team are making the most of machine learning methods to speed up genome annotation pipelines
SCIENCE & TECHNOLOGY2022
sciencescience-technologytechnology-and-innovation
Fergal Martin – Eukaryotic Annotation Team Leader
Fergal Martin discusses the importance of open access data and his work in different biodiversity initiatives
LAB MATTERSPEOPLE & PERSPECTIVES2022
lab-matterspeople-perspectives
Europe PMC: Harnessing the power of text mining to accelerate life sciences research
How text mining collaborations benefit our research, data resources, and the wider scientific community.
SCIENCE & TECHNOLOGY2022
sciencescience-technologytechnology-and-innovation
2.4 billion sequences now available in the latest MGnify protein database release
2.4 billion protein sequences are now available in the latest MGnify release including new annotations provided by Google AI
2022
updates-from-data-resources
Peter Harrison – Genome Analysis Team Leader
Peter Harrison discusses the importance of data accessibility and his passion for biodiversity and agricultural genomics.
LAB MATTERSPEOPLE & PERSPECTIVES2022
lab-matterspeople-perspectives
Greater than the sum of our genes: DNA does not define us
Ewan Birney discusses the input of both genetics and our environment in making us who we are
LAB MATTERS2022
lab-mattersperspectives
The MANE collaboration: working together to support genome science
Researchers from the MANE collaboration bring you the most comprehensive human genome annotation dataset to date.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
Welcome: John Lees
John Lees joins EMBL-EBI as a Group Leader in Pathogen informatics and modelling.
LAB MATTERSPEOPLE & PERSPECTIVES2022
lab-matterspeople-perspectives
Latest Release of the Single Cell Expression Atlas
The latest Single Cell Expression Atlas (SCEA) release is here and features collaborations with DiscovAIR and the Fly Cell Atlas
2022
updates-from-data-resources
Genomic sequencing aids the global Tuberculosis fight
Zamin Iqbal and his team are working with researchers all over the globe to help put a stop to Tuberculosis
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
Darwin Tree of Life at EMBL-EBI: reaching the first major milestone
Our researchers highlight their contributions to the Darwin Tree of Life project and how new genome annotations helps to further biodiversity research
SCIENCE & TECHNOLOGY2022
announcementssciencescience-technology
Safeguarding African biodiversity through genomics
The African BioGenome Project aims to safeguard biodiversity and build bioinformatics capacity across Africa
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
Deep learning models help predict protein function
Deep learning models can improve protein annotations and has helped expand the Pfam database.
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
The Earth Biogenome Project: on track and ready to ramp up
On track to reach an ambitious goal of 3,000 genomes sequenced by the end of 2022, what’s next for the Earth Biogenome Project?
SCIENCE & TECHNOLOGY2022
announcementssciencescience-technology
Welcome: Melissa Harrison
Melissa Harrison joins EMBL-EBI as the new Team Leader of Literature Services. We found out more about her plans for open access publishing and Europe PMC.
LAB MATTERSPEOPLE & PERSPECTIVES2022
lab-matterspeople-perspectives
New bacteria and viruses found on human skin
Researchers have identified hundreds of new bacterial species and viruses in the human skin microbiome.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Darwin Tree of Life in 2021: tireless fieldwork and the first beautiful genomes
A look back at some of the 2021 highlights from the Darwin Tree of Life partner institutes.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Open science at EMBL: a transparent way of working
EMBL announces the release of its new Open Science Policy, contributing to positive culture change across the life sciences.
LAB MATTERS2021
lab-matters
Welcome: Tudor Groza
Tudor Groza joins EMBL-EBI as our new Phenomics Team Lead. We found out from Tudor exactly what this new role will entail
LAB MATTERSPEOPLE & PERSPECTIVES2021
lab-matterspeople-perspectives
DUO: streamlining access to biomedical datasets
The GA4GH Data Use Ontology (DUO) supports a data authorisation and access framework to streamline consent to use biomedical data
SCIENCE & TECHNOLOGY2021
sciencescience-technology
BY-COVID – a new EU project for pandemic preparedness
The BY-COVID project aims to make infectious disease data, including COVID-19, openly available to everyone.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
CRyPTIC: cataloguing drug resistance mutations in M. tuberculosis
Profiling M. tuberculosis strains from 27 countries to reveal causes of drug resistance.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Characterising protein phosphosite function at scale
Researchers develop a new high-throughput approach to assess the functional significance of protein phosphosites.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Proteins, art and seeing the world through a new lens
Hundreds of school children explore the beauty of proteins through art
LAB MATTERS2021
lab-matters
3D-Beacons Network: protein structure data, all in one place
3D-Beacons Network acts as a one-stop shop for protein structures by combining and standardising data from several providers.
CONNECTIONS2021
connectionsscience
The Spatial Mouse Atlas: new insights into cell fate
Researchers have combined spatial gene expression information with single-cell genomics data to create a high-resolution atlas of mouse organogenesis.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
DeepMind and EMBL release the most complete database of predicted 3D structures of human proteins
Partners use AlphaFold, the AI system recognised last year as a solution to the protein structure prediction problem, to release more than 350,000 protein structure predictions including the entire human proteome to the scientific community.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Welcome: Sarah Dyer
EMBL welcomes Sarah Dyer, the new Non-Vertebrate Genomics Team Leader at EMBL-EBI.
LAB MATTERSPEOPLE & PERSPECTIVES2021
lab-matterspeople-perspectives
Visualising RNA structures using R2DT
New software enables scientists to visualise RNA secondary structures using the world’s largest RNA structure dataset.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
EMBL scientists elected as EMBO Members
John Marioni, Alex Bateman, and Takashi Hiiragi have been elected to EMBO Membership.
EMBL ANNOUNCEMENTSLAB MATTERS2021
embl-announcementslab-matters
Genomic surveillance of SARS-CoV-2 in England
The largest in-depth analysis of genomic surveillance data mapping out the dynamics of 62 lineages of the SARS-CoV-2 virus.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Piecing together the best reference genome
Researchers reveal the best technology for assembling reference genomes.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Using metagenomic techniques to explore lichens
Researchers have used a metagenomics approach to piece together the genomes of yeasts found in wild lichens.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
The value of open data for Latin American science
Scientists from the CABANA project explore how open data is benefiting global research efforts.
CONNECTIONS2021
connectionsscience
Repurposing drugs to manage COVID-19 progression
Researchers use large-scale human genetic studies to identify drug targets important for managing COVID-19 in its early stages
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Linking genetics and age-related diseases
Researchers have used human medical and genetic data from UK Biobank to investigate the genetics of age-related diseases
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Allyship and support: an interview with Janet Thornton
Professor Dame Janet Thornton discusses work–life balance, the support she has received during her career, and how organisations can help staff during the COVID-19 pandemic
LAB MATTERS2021
lab-matters
Insights into the new B.1.1.7 coronavirus lineage
A new lineage of coronavirus was first identified in the UK, but why is it spreading much more rapidly within the population?
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Darwin Tree of Life: looking back on 2020
Despite restrictions, 2020 has been a busy year for the Darwin Tree of Life Project. We take a look at some of this year’s achievements and highlights.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Open data sharing accelerates COVID-19 research
Open access data benefits millions of scientists around the world and is essential for a rapid response to the COVID-19 pandemic.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Repurposing drugs for a pan-coronavirus treatment
Scientists from the Beltrao Group at EMBL-EBI and collaborators identified drug targets common to SARS-CoV-2, SARS-CoV-1, and MERS-CoV, three pathogenic coronaviruses. They also found potential drugs that could be repurposed as COVID-19 treatments, and against emerging coronavirus strains in the…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
EMBL-EBI leads International collaboration to share COVID-19 research data
EMBL-EBI set to launch European COVID-19 Data Platform to help store, share, and analyse research data linked to the COVID-19 pandemic.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Characterising RNA alterations in cancer
The largest and most comprehensive catalogue of cancer-specific RNA alterations reveals new insights into the cancer genome.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Cancer mutations occur decades before diagnosis
Researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI) and the Francis Crick Institute have analysed the whole genomes of over 2600 tumours from 38 different cancer types to determine the chronology of genomic changes during cancer development.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Chromothripsis in human cancer
Researchers at Harvard Medical School and EMBL-EBI have carried out the largest analysis across cancer types of the newly discovered mutational phenomenon chromothripsis.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Pinpointing rare disease mutations
New resource that categorises genes essential for supporting life could be used to identify rare disease mutations
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Ageing and disease
Dame Janet Thornton presents the 2019 EMBL Insight Lecture: Ageing and disease – what is the link?
SCIENCE & TECHNOLOGY2020
eventsscience-technology
Machine learning finds critical phosphosites
Resource has implications for disease research
SCIENCE & TECHNOLOGY2019
sciencescience-technology
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