Edit

EMBL Taxonomy:

Epigenetics and neurobiology

Year
22 November 2024

Celebrating 25 years of EMBL Rome

Lab Matters EMBL Rome celebrates its 25th anniversary this year – some impressions of the symposium and party organised for staff and alumni to mark this special occasion.

2024

lab-matters

9 May 2024

An epigenome editing toolkit to dissect the mechanisms of gene regulation

Science & Technology A study from the Hackett group at EMBL Rome led to the development of an epigenetic editing system that allows to precisely program chromatin modifications at any specific position in the genome, to understand their causal role in transcription regulation.

2024

science-technology

1 May 2024 Alt Text: An artistic representation of gut microbes and sperm cells

Father’s gut microbes affect the next generation

Science & Technology Scientists from EMBL Rome and EMBL Heidelberg found that disrupting the gut microbiome of male mice increases the risk of disease in their offspring. Their findings suggest that a father’s pre-conception environment can have lifelong effects on offspring.

2024

science-technology

16 November 2023

New evidence on retinal function

Science & Technology A new study from the Asari group at EMBL Rome shows a different retinal function in awake mice compared to isolated retinal samples. These new insights could help to develop prosthetic devices that can act as a retina in the future.

2023

sciencescience-technology

9 October 2023

A night to share the wonders of science 

Lab Matters EMBL Rome celebrated the European Researchers’ Night by participating in an event organised at the CNR Campus in Montelibretti.

2023

lab-matters

30 March 2023 Profile picture of Cornelius Gross, interim head of EMBL Rome

ERC Advanced Grant awarded to EMBL Rome researcher

EMBL AnnouncementsLab Matters Interim head of EMBL Rome Cornelius Gross has been awarded an Advanced grant from the European Research Council (ERC) for his project TERRITORY, aimed at investigating the neural basis of territorial aggression and fear.

2023

embl-announcementslab-matters

8 April 2022 a metaphor for the process of epigenetic inheritance

A metaphor for epigenetic inheritance

Science & Technology Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration

2022

sciencescience-technology

28 October 2020 A brain hovers over a chess board, lines flow from the hypothalamus to the pieces, symbolising control over reactions to an aggressor and territory.

Should I run, or should I not? The neural basis of aggression and flight

Science & Technology Researchers in the Gross group at EMBL Rome have investigated the mechanism behind defensive behaviour in mice. They have identified a specific area of the brain that encodes both spatial and threat cues to drive location-specific defensive responses.

2020

sciencescience-technology

19 January 2012 Artist's impression of a chromosome exploding

Rigged to explode?

Science & Technology An inherited mutation in a gene known as the guardian of the genome is likely the link between exploding chromosomes and some particularly aggressive types of cancer, scientists at the European Molecular Biology Laboratory (EMBL), the German Cancer Research Centre (DKFZ) and the University…

2012

sciencescience-technology

10 December 2009 These microscopy images demonstrate the effects of Notch signalling on the hearts of newborn mice (top) and of adult mice after a heart attack (bottom). In a normal neonatal heart (top left), the two major heart chambers (ventricles) are clearly separated by tissue (septum). But when Notch signalling was inactivated in an embryo’s heart muscle cells, the septum between the ventricles of the newborn mouse’s heart was incomplete (asterisk). The same defect commonly occurs in humans with congenital heart disease, often leading to circulatory distress. In the images of adult hearts (bottom), healthy tissue is shown in red and damaged tissue in blue. Normally (bottom left), a heart attack causes extensive tissue damage to the left ventricle (right-hand cavity), but mice in which Notch was re-activated after the heart attack had reduced tissue damage (bottom right) and improved cardiac function. Image credit: EMBL

From fruit fly wings to heart failure. Why Not(ch)?

Science & Technology Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role in the recovery from heart attacks. In a study published today in Circulation Research, scientists at the European Molecular Biology Laboratory (EMBL)…

2009

sciencescience-technology

21 September 2009 This microscopy image, taken ten days after injury, shows that the muscle fibres of normal mice (left) had re-grown, while in mice which couldn’t boost C/EBPβ production (right) there were still many fibres that had not regenerated (arrowheads), and the tissue had a number of scars (arrows).

To regenerate muscle, cellular garbage men must become builders

Science & Technology For scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, what seemed like a disappointing result turned out to be an important discovery. Their findings, published online this week in the journal Proceedings of the National Academy of Sciences (PNAS), provide…

2009

sciencescience-technology

13 September 2009 In normal skin (left), the stem cells at the base, shown in green, differentiate into skin cells, shown in red. In mice whose skin has neither C/EBPα nor C/EBPβ (middle), this differentiation is blocked: green-labeled stem cells appear in upper layers of skin, and there are no differentiated skin cells (no red staining). This also happens at the initial stages of basal cell carcinomas. In skin where C/EBPα is present but has lost its capacity to interact with E2F, a molecule that regulates the cell cycle (right), skin cells start differentiating abnormally, before they have properly exited the stem cell ‘program’ (yellow/orange). This is similar to what is observed in the initial stages of squamous cell carcinomas, a more aggressive and invasive skin tumour.

How stem cells make skin

Science & Technology Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both mice and humans, a layer of cells at the base of the skin contains stem cells that can develop into the specialised cells in the layers above.…

2009

sciencescience-technology

22 June 2009 EMBL Rome

European centre of excellence for mouse biology celebrates its 10th anniversary

Lab Matters Mice are one of biology’s most important model organisms, because 98% of their genes and many of their traits and diseases are similar to ours. Researchers at the Mouse Biology Unit of the European Molecular Biology Laboratory (EMBL) take advantage of these similarities and use mice to study…

2009

lab-matters

EMBLetc.

Looking for past print editions of EMBLetc.? Browse our archive, going back 20 years.

EMBLetc. archive

Newsletter archive

Read past editions of our e-newsletter

For press

Contact the Press Office
Edit