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EMBL Grenoble

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26 November 2024

Diving into the world of science

Lab Matters EMBL Grenoble took part in a series of activities during the French Science Week, highlighting EMBL’s research and the TREC scientific expedition.

2024

lab-matters

12 November 2024 Picture of Nicolas Foos fixing a piece of technological equipment.

Making in situ serial crystallography more accessible

Science & Technology Nicolas Foos, a postdoctoral fellow at EMBL Grenoble, talks about the implementation of a new method for in situ serial crystallography developed during his ARISE fellowship.

2024

science-technology

10 October 2024 A multi-coloured donut representing the structure of an NPC.

“Structurally” sound

Science & Technology The function of biological molecules is intimately linked to their structure. In the 50 years since EMBL was established, its researchers and engineers have constantly provided leadership in structural biology research and services, resulting in many scientific breakthroughs and novel insights.

2024

science-technology

8 October 2024

Machine learning discoveries honoured with 2024 Nobel Prize for Physics

Science & Technology The prize was awarded to John J. Hopfield, Princeton University, USA, and Geoffrey Hinton, University of Toronto, Canada, for their seminal contributions to the foundational methods that enabled the development of machine learning.

2024

science-technology

2 July 2024

IIT-EMBL: New molecules to modulate gene expression

Science & Technology A new research paper published in Nature Communications lays the groundwork for the development of new drugs specific to genetic mutations or alterations responsible for the onset of tumours or genetic diseases.

2024

science-technology

25 June 2024 In the front, a 3D model of three molecules bound together: METTL6 in (orange), serine tRNA synthetase in (shades of lilac) and serine tRNA (black). In the background an illustration of a construction site. Two trucks with ‘UGA’ and ‘AGA’ written on them are visible at the bottom.

An enzyme with a smart friend

Science & Technology EMBL Grenoble’s Kowalinski Group analysed the structure of an enzyme responsible for modifying tRNA molecules to fine-tune protein production. They discovered that to distinguish almost identical, yet different, tRNA molecules, the enzyme uses help from another enzyme – a type of cooperation…

2024

science-technology

12 June 2024

AI approaches in structural biology and drug discovery

Connections EMBL Grenoble and the ESRF hosted a workshop bringing together representatives from research and industry to discuss the ever-growing role of artificial intelligence in the field of structural biology.

2024

connections

24 May 2024

Stephen Cusack: what I’ve learned

People & Perspectives Stephen Cusack, world-renowned structural biologist and former Head of EMBL Grenoble, reflects on his early influences, his achievements, and the lessons he’s learned as he embarks on his next adventure

2024

people-perspectives

4 April 2024

Building the cell’s splicing machine

Science & Technology New study from the Galej group provides deeper structural insight into the assembly of a critical molecular machine, that removes non-coding information from genes during their expression.

2024

science-technology

6 March 2024 The background shows a render of a suspension of tumour cells, while an inset shows the structures of two proteins – MAGEA4 and RAD18 – marked in green and blue respectively

Studying the relationship between cancer-promoting proteins

Science & Technology A new study from the Bhogaraju Group at EMBL Grenoble reveals how the cancer-promoting MAGE family of proteins bind to their targets, aiding the development of anti-cancer drugs that target these proteins.

2024

sciencescience-technology

15 November 2023 Group picture with mountain in the background

Looking back on 20 years of structural biology collaboration in Grenoble

ConnectionsLab Matters On this date (15 November), 21 years ago, the EMBL, ESRF, ILL, and IBS directors signed a memorandum of understanding to create the Partnership for Structural Biology (PSB) on the European Photon and Neutron (EPN) science campus in Grenoble.

2023

connectionslab-matters

7 November 2023

Enjoying a science day in Grenoble

ConnectionsLab Matters EMBL Grenoble was once again present for the science outreach event ‘Parvis des Sciences’ on Saturday 14 October 2023.

2023

connectionslab-matters

26 October 2023

A promising target to fight inflammatory bowel diseases

Science & Technology Researchers from the Cusack group at EMBL Grenoble provide structural insights on the XIAP/RIPK2 complex, a promising drug target to fight inflammatory bowel diseases.

2023

sciencescience-technology

15 September 2023 Group of scientists attending symposium staring upward to the photographer.

Celebrating Stephen Cusack’s contributions to science

People & Perspectives Researchers from across the globe have gathered in Grenoble to celebrate the remarkable lifelong scientific achievements of Stephen Cusack, the former head of EMBL Grenoble.

2023

eventspeople-perspectives

15 September 2023

Switching off the cytokine storm

Science & Technology EMBL Grenoble and University of Geneva researchers shed light on the molecular activation of the MAP kinase p38α, the final ‘switch’ triggering the inflammatory response.

2023

sciencescience-technology

10 July 2023 Green parasites on black background

Spotlight: Shedding light on deadly parasites

Lab MattersScience & Technology This single-celled organism the size of a dust particle is capable of causing deadly tropical diseases in both humans and livestock –Trypanosoma brucei, in an image by Luciano Dolce from EMBL.

2023

lab-matterspicture-of-the-weekscience-technology

7 July 2023 Cartoon of a molecule, formed by sticks and spheres.

Facilitating drug discovery against COVID-19

Science & Technology A collaboration between EMBL Grenoble and EBRIS scientists led to the characterisation of a new compound with promising activity against SARS-CoV-2 variants.

2023

sciencescience-technology

20 April 2023 White woman with short red hair standing in garden in front of a tree. Picture of Angelika Thomasson. Credits: Marcos Lopez-Marrero/EMBL

We are EMBL: Angelika Thomasson on administrative support to EMBL staff

Lab MattersPeople & Perspectives Angelika Thomasson, administrative assistant at EMBL Grenoble, talks about her role in supporting her colleagues in organising events and travels, what she enjoys about EMBL, and which famous female scientist she would like to have coffee with.

2023

lab-matterspeople-perspectives

20 March 2023 Team leader Gergely Papp.

Welcome: Gergely Papp

Lab MattersPeople & Perspectives Together with his team, Gergely Papp pushes the frontiers of technology development in the field of structural biology.

2023

lab-matterspeople-perspectives

16 February 2023

New EU-funded Project: Fragment-Screen

Lab MattersScience & Technology EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.

2023

lab-mattersscience-technology

9 January 2023

New molecular insights on medical cannabis

Science & Technology EMBL Grenoble researchers have investigated the interaction between THC and some proteins it might bind to. In a recent study, they showed in vitro that THC inhibits an important human enzyme called autotaxin.

2023

sciencescience-technology

12 December 2022 A mother and her child looking through a microscope

Celebrating science in Grenoble

ConnectionsLab Matters In October 2022, EMBL Grenoble participated in the annual science outreach event Parvis des Sciences, organised by the GIANT campus under the umbrella of the French science week – La Fête de la science.

2022

connectionslab-matters

1 December 2022

Getting closer to stopping toxoplasmosis infection

Science & Technology Recent studies supported by EMBL Grenoble’s expertise in structural biology research and scientific services have identified Altiratinib as a potential drug to stop toxoplasmosis infection and opened up treatment options against malaria.

2022

sciencescience-technology

3 November 2022 View from above of a small room with several tools, cables and pieces of technology. A rectangular box, a robotic arm and a device are highlighted in green.

Two in one: combining MASSIF-1 and CrystalDirect

Lab MattersScience & Technology Researchers and engineers have integrated a CrystalDirect harvester into the fully automated beamline MASSIF-1, a unique combination of structural biology technologies that is now open to external academic users.

2022

lab-mattersscience-technology

20 October 2022 Two EMBL staff members looking at a piece of equipment

Teaming up to drive forward time-resolved crystallography

Lab MattersScience & Technology The recent construction of the new ID29 beamline in Grenoble is pioneering a new way of doing experiments in time-resolved crystallography and opening up technology transfer possibilities

2022

lab-mattersscience-technology

27 April 2022 Portrait of Kristina Djinović-Carugo

Next Head of EMBL Grenoble appointed

EMBL AnnouncementsLab Matters Professor Kristina Djinović-Carugo has been appointed as the next head of EMBL Grenoble. She will join EMBL in July from the Max Perutz Laboratories at the University of Vienna, where she is currently Head of the Department of Structural and Computational Biology and full Professor of Structural…

2022

embl-announcementslab-matters

27 April 2022 Kristina Djinović-Carugo sitting at her desk.

Meet the next Head of EMBL Grenoble

Lab MattersPeople & Perspectives Slovenian structural biologist Kristina Djinović-Carugo will join EMBL in July as the new Head of EMBL Grenoble. We spoke to her about her background, research interests, and plans for EMBL Grenoble.

2022

lab-matterspeople-perspectives

18 January 2022 Science illustration composed by a photographic film highlighting three-dimensional structures of a protein complex involved in splicing.

Capturing ‘snapshots’ of a crucial step in RNA splicing

Science & Technology The Galej group at EMBL Grenoble has recently obtained high resolution snapshots of a crucial step in RNA splicing involving the U2 snRNP complex, a crucial component of the human spliceosome.

2022

sciencescience-technology

22 December 2021 Scientific illustrations of MEG3, a very large RNA involved in cell proliferation. IAB and EMBL logos are located in the center of the illustration.

EMBL-IAB collaboration on the rise

ConnectionsLab Matters The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB) a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.

2021

connectionslab-matters

20 December 2021 A detailed structure map shows two proteins interacting in the foreground, each shown in a different colour. The background shows small green dots marking bacteria

Solving molecular puzzles to find the perfect fit

Science & Technology Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.

2021

sciencescience-technology

9 December 2021 Logos of CNRS and EMBL with text “memorandum of understanding”

Strengthening collaborations in France

ConnectionsLab Matters EMBL and the French National Centre for Scientific Research (CNRS) signed a memorandum of understanding.

2021

connectionslab-matters

8 October 2021 Logos of Ifremer and EMBL with text: “memorandum of understanding”. Illustrations of marine animals and numbers in the background.

EMBL and Ifremer cooperate to advance ocean sciences

ConnectionsLab Matters The two organisations have signed a memorandum of understanding to support scientific cooperation in the exploration of coastal and oceanic ecosystems.

2021

connectionslab-matters

7 October 2021 SARS-CoV-2 and planet Earth are merged together in this illustration

Six Ways to Protect the Planet Against Pandemics*

Science & Technology EMBL will host a conference to look at the state of the pandemic, lessons learned, and ways to improve pandemic preparedness. Here’s a sneak peek into what promises to be another interesting and informative EMBL conference.

2021

eventsscience-technology

10 August 2021 Scientist working on an instrument of the MASSIF-1 beamline

MASSIF-1 beamline in Grenoble supports COVID-19 drug discovery

Lab MattersScience & Technology MASSIF-1, run jointly by EMBL Grenoble and the ESRF, is a beamline for macromolecular crystallography. It is used by the research community to study the 3D structure of proteins, which is important for drug development.

2021

lab-mattersscience-technology

8 July 2021 Two men stand outside in front of a building, holding a document and looking at it.

A hidden medal

People & Perspectives We all like a story about rediscovering treasures, right? Well, that’s just what happened recently at EMBL Grenoble!

2021

alumnipeople-perspectives

10 May 2021 The image shows Inserm and EMBL logos and illustrates the memorandum of understanding signed between both institutions.

EMBL and Inserm to join forces

ConnectionsLab Matters A memorandum of understanding has been signed between EMBL and Inserm to strengthen their scientific cooperation.

2021

connectionslab-matters

13 April 2021 Picture showing MD3, the micro-diffractometer developed by the Instrumentation team, installed at one of the EMBL Hamburg's beamline. Credits: Kinga Lubowiecka/EMBL

Structural biology at EMBL: driving technology development

Lab MattersScience & Technology Florent Cipriani, who recently retired as Head of the Instrumentation Team after a long career at EMBL Grenoble, is one of the pioneers of instrumentation development in this field.

2021

lab-mattersscience-technology

9 March 2021 This photo shows the European Photon and Neutron (EPN) science campus on the peninsula at the confluence of the Isère and Drac rivers, where EMBL Grenoble is located.

Touch of springtime in Grenoble

Lab Matters This photo shows the European Photon and Neutron (EPN) science campus where EMBL Grenoble is located. A delightful spring breeze in the air melts the last remaining patches of snow in the mountains.

2021

lab-matterspicture-of-the-week

9 February 2021 Crystal cubes seen through a microscope

Purity, beauty, and perfection

Science & Technology The regular structures of crystals are a source of inspiration and fascination to us humans. While the crystals in this picture were not grown in nature, but instead by Petra Drncova from EMBL Grenoble, they share the same attributes as those found in nature.

2021

picture-of-the-weekscience-technology

5 February 2021 Artistic representation of the structure of the three proteins forming Integrator’s catalytic core.

At the core of the Integrator complex

Science & Technology A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.

2021

sciencescience-technology

12 January 2021 Three images showing close-ups of different EMBL facilitites.

EMBL becomes newest Instruct Centre

ConnectionsLab Matters EMBL’s sites in Grenoble, Hamburg, and Heidelberg form the newest Instruct Centre. The new centre offers users access to a broad range of state-of-the-art facilities.

2021

connectionslab-matters

15 December 2020 Snowy mountains behind functional buildings. The Moon is up in the sky.

First powder over EMBL Grenoble

Lab Matters The first snowflakes have fallen on the Vercors Mountains, right behind the EMBL Grenoble building, and an almost full moon is showing up during a sunny morning.

2020

lab-matterspicture-of-the-week

19 October 2020 Green background with white sphere bearing the logos of the two MoU signors, EMBL and CIML

EMBL forms new collaborations in France

ConnectionsLab Matters EMBL and CIML have signed a memorandum of understanding that will open up new scientific opportunities.

2020

connectionslab-matters

25 August 2020 Circular beamline building, surrounded by illuminated Grenoble city in the evening and the alps in the background.

Upgraded beamlines at EMBL Grenoble unveiled

EMBL Announcements The beamlines run jointly by EMBL Grenoble and the ESRF reopen today, unveiling significant upgrades that exploit the brand new fourth generation ESRF synchrotron source.

2020

embl-announcementsscience

8 July 2020 The Logo of the ALPX company.

ALPX – smart crystallography

Lab Matters The CrystalDirect® technology, combined with the web-based CRIMS software enable a fully automated, remote-controlled protein-to-structure pipeline.

2020

lab-matters

17 June 2020 Crystal selection for X-ray diffraction experiments.

Investigating the structure and mechanisms of coronavirus biomolecules

Science & Technology While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…

2020

sciencescience-technology

9 June 2020 This image shows the structure of a bacterial group II intron

Genetic cut and paste at atomic resolution

Science & Technology Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…

2020

sciencescience-technology

27 May 2020 Automated sample changer and diffractometer at the ID30B X-ray crystallography beamline at ESRF Grenoble.

Facilitating COVID-19 structural biology research

Connections EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…

2020

connectionsscience

5 May 2020 Liquid handling robot transfering protein crystalisation solutions

Responding to health threats posed by coronaviruses

Science & Technology By re-opening the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble, EMBL is supporting structural biology projects to respond to the health threats posed by coronaviruses.

2020

sciencescience-technology

10 March 2020

It’s Lab Ski Day!

Lab Matters This image, taken by Raphaël Cohen-Aberdam from the Cipriani team, shows that the weather for the Grenoble Lab Ski Day 2020 was just perfect!

2020

lab-matterspicture-of-the-week

17 September 2019

The end of a productive day

Lab Matters It’s evening and the Sun is setting over the mountains surrounding the city of Grenoble – home to one of EMBL’s six sites – bathing the mountaintops in fiery red light. The Picture of the Week, taken by Zuzanna Kaczmarska shows the lab she worked in after a long and busy day. Bottles…

2019

lab-matterspicture-of-the-week

23 February 2012

New distributed research infrastructure for structural biology

Science & Technology Breakthroughs in biomedical science are a step closer today, with the launch of a new distributed research infrastructure for the science of structural biology: Instruct. The launch of Instruct will give academic and commercial scientists across Europe access to a full portfolio of integrated…

2012

sciencescience-technology

12 December 2010 This cryo-electron microscopy image shows the 3D structure of the ribosome (yellow/blue) bound to the signal recognition particle (SRP) and the SRP receptor (both in red). Below it is an atomic model of SRP (green-yellow/orange) and its receptor (pink). Image credits: EMBL/Schaffitzel.

How cells export and embed proteins in the membrane

Science & Technology Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure…

2010

sciencescience-technology

16 November 2010

One-touch make-up – for our cells

Science & Technology The cells in the different parts of this video are always the same (grey), but, like actors using make-up to highlight different facial features, they have fluorescent labels that mark different cellular components in different colours: blue shows the nucleus, yellow shows tubulin (a component of…

2010

sciencescience-technology

30 September 2009 In the centre, a structural model determined by X-ray crystallography shows how the two tags (attached to a short section of the histone protein – all in cyan) fit neatly into the Brdt pocket (purple). In the background image, hypercompaction by Brdt causes relatively diffuse chromatin (stained blue inside the nuclei of two cells on the top left) to compact and clump together (two on the bottom right).

Putting the squeeze on sperm DNA

Science & Technology In the quest for speed, olympic swimmers shave themselves or squeeze into high-tech super-suits. In the body, sperm are the only cells that swim and, as speed is crucial to fertility, have developed their own ways to become exceptionally streamlined. Scientists at the European Molecular Biology…

2009

sciencescience-technology

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