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biochemistry

Year
23 October 2024

BioChemGraph: Unifying structural and bioactivity data to accelerate drug discovery

In the era of data-driven biology, integrating information from different resources is essential yet often challenging. The BioChemGraph project addresses this challenge by creating infrastructure that consolidates structural, functional, and biochemical annotations for small molecules and their…

2024

updates-from-data-resources

15 November 2023 Female scientist

Advocating for a generalist approach to science and life

EMBLetc Sara Fahs, who did her PhD from EMBL Heidelberg and is one of the newest members of the EMBL alumni association board, writes about key insights from her journey in science and her work on medicinal chemistry, during a career spanning academia and industry.

2023

5 February 2021 Artistic representation of the structure of the three proteins forming Integrator’s catalytic core.

At the core of the Integrator complex

Science & Technology A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.

2021

sciencescience-technology

29 September 2020 A metal rack holding glass test tubes with yellow and red solutions in them.

Colourful test tubes

Science & Technology To study the effect of commonly used drugs on bacterial envelopes, EMBL scientists applied a biochemical assay using a colour reaction. The deeper the red, the stronger the disruptive effect of the drug.

2020

picture-of-the-weekscience-technology

18 September 2020 Composite image of mouse cells and human cells showing different levels of luminescence, indicated as different colours.

Human and mouse cells run at different speeds

Science & Technology The internal clock that governs the development of embryos ticks slower for humans than for mice. Differences in the speed of biochemical reactions underlie the differences between species in the tempo of development.

2020

sciencescience-technology

10 August 2016 Paris at night. IMAGE: NASA (M. Justin Wilkinson, Texas State University, Jacobs Contract at NASA-JSC)

Life in the periphery

Science & Technology Storage of pre-made nuclear pores allows for rapid cell division in fruit fly embryos

2016

sciencescience-technology

28 July 2016 Landline vs. smartphone: the RNA-binding domain lets proteins do more than just talk to other proteins

Discovering protein smartphones

Science & Technology New technique reveals uncharted docking sites in RNA-binding proteins

2016

sciencescience-technology

9 October 2015 The ultrafast and yet selective binding allows the receptor (gold) to rapidly travel through the pore filled with disordered proteins (blue) into the nucleus, while any unwanted molecules are kept outside. IMAGE: Mercadante /HITS

Floppy but fast

Science & Technology Spaghetti-like proteins are surprisingly effective 'keys'

2015

sciencescience-technology

20 August 2015

First, find your membrane

Science & Technology Collaboration between scientists reveals collaboration between lipids.

2015

sciencescience-technology

20 October 2014

Breaking boundaries

How Nobel-winning work by alumnus Stefan Hell shapes and inspires current EMBL scientists' research.

2014

science

6 August 2014

Clarity in the cold

How fruit flies beat the cold, plus the value of precisely controlled experiments and detailed analysis

2014

science

4 August 2014 Explosion on gene motif

On editing the genetic code

Edward Lemke edits special issue of ChemBioChem on boom of technology for genetic code expansion

2014

science

1 July 2014 Matthias Wilmanns receives his membership certificate

Awards & Honours

Lab Matters EMBL scientists regularly receive prestigious awards - meet the latest honourees

2014

lab-matters

17 June 2011 Condensin loops around several strands of DNA, keeping it coiled up and easier to transport. (Artistic impression) Image credits: EMBL/ P. Riedinger

Keeping it together

As any rock-climber knows, trailing a long length of rope behind you is not easy. A dangling length of rope is unwieldy and hard to manoeuvre, and can get tangled up or stuck on an outcropping. Cells face the same problem when dragging chromosomes apart during cell division. The chromosomes are…

2011

science

6 December 2005

Setting the standard for computer models of life

Lab Matters In the December 6 issue of Nature Biotechnology, scientists from 14 different organizations around the world, including the EMBL-European Bioinformatics Institute, propose a new quality standard for biochemical models. MIRIAM [for Minimum information requested in the annotation of biochemical…

2005

lab-matters

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