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bork

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13 November 2024 Illustration showing a human gut floating over a scale resting on a microchip labelled ‘AI’. The two sides of the scale show a varying number of bacteria, shown against a backdrop of 0s and 1s.

Microbial load can influence disease associations

Science & Technology Scientists have developed a new machine-learning model to predict microbial load — the density of microbes in our guts — and used it to demonstrate how microbial load plays an important role in disease-microbiome associations.

2024

science-technology

24 September 2024 Illustration showing several drugs being broken down when reaching a community of gut bacteria. This community has different types of bacteria.

Better together: gut microbiome communities’ resilience to drugs

Science & Technology EMBL Heidelberg researchers compared the effect of drugs on isolated bacteria versus those growing in communities. This is the first study showing that bacteria are more resilient when in community due to cross-protection strategies. This could help researchers design more efficient therapies.

2024

science-technology

4 April 2023 A mobile lab on a road, with the TREC logo on the side.

TREC is underway!

EMBL Announcements EMBL’s planetary biology flagship TREC expedition has officially started. The new project applies EMBL's expertise and technologies in molecular and cellular biology to current environmental challenges, and connects with a wide range of research disciplines.

2023

embl-announcementseventsscience

15 September 2022 The foreground shows two yellow pipes representing the human gastrointestinal tract coming together, representing the confluence of donor and recipient gut ecosystems. Bacteria can be seen as green shapes inside the pipes and various kinds of interactions between them are shown symbolically as a mixing of colours.

When microbiomes collide

Science & Technology EMBL researchers used data from over 300 human faecal microbiota transplants to gain an ecological understanding of what happens when two gut microbiomes clash.

2022

sciencescience-technology

15 December 2021 An outline of Earth, covered with depictions of bacteria. The image of Earth is within a the frame of a computer window. There is an “Upload file” button on the bottom left, and a mouse cursor on the right.

Connecting the dots between bacterial genes around the world

Science & Technology Bork Group at EMBL Heidelberg analysed a new global gene database to study how genes emerge and spread across various habitats on our planet. In the future, the group will expand the database and use it for studying microbial gene evolution and dispersal at a finer-grained scale.

2021

sciencescience-technology

8 December 2021 An illustration of the human gut, with coloured shapes representing bacteria. Three different drugs and drug combinations are shown affecting the bacteria, represented by changes in colour

The impact of drugs on gut microbes is greater than we thought

Science & Technology Researchers studying a massive cohort of European patients have found that commonly prescribed drugs for cardiometabolic disorders can have long-term effects on the gut microbiome. Such effects can complicate the understanding of how disease affects the microbiome and must be taken into…

2021

sciencescience-technology

8 September 2021 Illustration of two halves of a pill, which releases chemical molecules that are taken up by gut bacteria in the vicinity.

Common medications accumulate in gut bacteria

Science & Technology A new collaborative study led by EMBL group leaders Kiran Patil, Nassos Typas, and Peer Bork has found that common medications accumulate in human gut bacteria. This process reduces drug effectiveness and affects the metabolism of common gut microbes, thereby altering the gut microbiome.

2021

sciencescience-technology

16 June 2021 Microscopy images of bacteria against a backdrop of a crowd of humans.

How our gut microbiome changes over time

Science & Technology Researchers investigate how external factors can influence the persistence of microbe species in the human gut

2021

sciencescience-technology

3 June 2021 Illustration of a rocky coastline with sailing boat, mountains, underwater organisms, bridge and factory in the background.

Living laboratories

Science & Technology Under the innovative Planetary Biology research theme, EMBL scientists aim to understand life in the context of its environment.

2021

sciencescience-technology

25 April 2019 The proteotype of an individual is substantially affected by both its sex and its diet.

Sex and diet affect proteotype

Science & Technology EMBL scientists have discovered that the proteome is substantially affected by both sex and diet

2019

sciencescience-technology

19 March 2018 Commonly used drugs affect our gut bacteria.

Commonly used drugs affect our gut bacteria

Science & Technology One in four drugs with human targets inhibit the growth of bacteria in the human gut, and may promote antibiotic resistance, EMBL researchers report in Nature

2018

sciencescience-technology

20 October 2016

Diving into Autumn

Connections Participants learn about EMBL’s ocean biodiversity research at the Fall Gala

2016

connectionsevents

29 August 2016

Awards & Honours

EMBL AnnouncementsLab Matters EMBL scientists regularly receive prestigious awards – meet the latest honourees.

2016

embl-announcementslab-matters

24 June 2016

Bork lab peers gather

Lab Matters 27 former Bork lab members joined Peer for a full-day get-together this summer

2016

alumnilab-matters

20 August 2015

First, find your membrane

Science & Technology Collaboration between scientists reveals collaboration between lipids.

2015

sciencescience-technology

21 July 2011 Model of the inner ring (green) of the nuclear pore, showing its components.

A hot species for cool structures

Science & Technology A fungus that lives at extremely high temperatures could help understand structures within our own cells. Scientists at the European Molecular Biology Laboratory (EMBL) and Heidelberg University, both in Heidelberg, Germany, were the first to sequence and analyse the genome of a heat-loving fungus,…

2011

sciencescience-technology

20 April 2011 Artistic impression of the 3 human gut types.

What’s your gut type?

Science & Technology In the future, when you walk into a doctor’s surgery or hospital, you could be asked not just about your allergies and blood group, but also about your gut type. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and collaborators in the international MetaHIT…

2011

sciencescience-technology

4 March 2010

Bacterial balance that keeps us healthy

Science & Technology The thousands of bacteria, fungi and other microbes that live in our gut are essential contributors to our good health. They break down toxins, manufacture some vitamins and essential amino acids, and form a barrier against invaders. A study published today in Nature shows that, at 3.3 million,…

2010

sciencescience-technology

31 January 2010

MicroRNA: a glimpse into the past

Science & Technology The last ancestor we shared with worms, which roamed the seas around 600 million years ago, may already have had a sophisticated brain that released hormones into the blood and was connected to various sensory organs. The evidence comes not from a newly found fossil but from the study of microRNAs…

2010

sciencescience-technology

26 November 2009 This image represents the integration of genomic, metabolic, proteomic, structural and cellular information about Mycoplasma pneumoniae in this project: one layer of an Electron Tomography scan of a bottle-shaped M. pneumoniae cell (grey) is overlaid with a schematic representation of this bacterium’s metabolism, where blue indicates interactions between proteins encoded in genes from the same functional unit. Apart from these expected interactions, the scientists found that, surprisingly, many proteins are multifunctional. For instance, there were various unexpected physical interactions (yellow lines) between proteins and the subunits that form the ribosome, which is depicted as an Electron microscopy image (yellow). Image credit: Takuji Yamada / EMBL

First-ever blueprint of a minimal cell is more complex than expected

Science & Technology What are the bare essentials of life, the indispensable ingredients required to produce a cell that can survive on its own? Can we describe the molecular anatomy of a cell, and understand how an entire organism functions as a system? These are just some of the questions that scientists in a…

2009

sciencescience-technology

3 February 2005

Biology in four dimensions

Science & Technology Most things that happen in the cell are the work of ‘molecular machines’ – complexes of proteins that carry out important cellular functions. Until now, scientists didn’t have a clear idea of when proteins form these machines – are these complexes pre-fabricated or put…

2005

sciencescience-technology

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