Researchers uncover that DNA changes that cause cancer drug resistance can be grouped into four categories, and identify possible new therapeutic targets.
2024
announcements
Science & Technology Scientists at EMBL Heidelberg and University of Virginia revealed a new cellular response to starvation: ribosomes attach to the mitochondrial outer membrane in a very unusual way, via their small subunit. The finding made in yeast might provide insights into how cancer cells survive the harsh…
2024
science-technology
Science & Technology An AI-enhanced advanced microscopy approach offers promise in better understanding glioblastomas, one of the deadliest brain cancers.
2024
science-technology
Science & Technology Study shows that gut bacteria can metabolise carcinogens and cause them to accumulate in distant organs, leading to tumour development.
2024
science-technology
Science & Technology EMBL Hamburg scientists and collaborators discovered a new molecular mechanism in which an unstructured protein disables one of the main cancer-promoting proteins by gluing them into an elongated stack. Data from human patient samples support the role of this mechanism in prostate cancer…
2024
science-technology
Science & Technology Large-scale study uses data from Danish health registries to predict individual risks of developing cancer
2024
research-highlightsscience-technology
Science & Technology An international team of researchers aim to combine social determinants of health with genomics, immune profiling, and exposomics data to tackle cancer inequities at an unprecedented scale.
2024
announcementssciencescience-technology
Science & Technology A new study from the Bhogaraju Group at EMBL Grenoble reveals how the cancer-promoting MAGE family of proteins bind to their targets, aiding the development of anti-cancer drugs that target these proteins.
2024
sciencescience-technology
Science & Technology Approximately 300 scientists met up at EMBL Heidelberg to unravel the centuries-old puzzle of cancer through the modern lens of genomics.
2024
eventsscience-technology
Science & Technology A new organoid model mimics the behaviour of neuroendocrine tumours (NETs), providing a novel and invaluable tool to study the disease in the lab.
2023
sciencescience-technology
Leading charities Children with Cancer UK and Cancer Research UK will co-fund a major £5.5 million research programme to advance precision medicine for relapsed childhood cancers.
2023
announcements
EMBLetc Baubak Bajoghli, Director of Austrian Bioimaging/CMI, discusses his passion for imaging and his work straddling basic and applied research in biology.
2023
Science & Technology New research improves understanding of the molecular mechanisms behind why some cancers respond to immunotherapy and others don't.
2023
research-highlightssciencescience-technology
Science & Technology SComatic enables researchers to link genotype to phenotype using only single-cell profiling data
2023
research-highlightssciencescience-technology
Science & Technology EMBL-EBI data resources are being used to deliver thousands of genetic diagnostics to patients every month.
2023
perspectivessciencescience-technology
Connections The PLAST-CELL project aims to understanding cancer progression by quantifying a cancer cell’s ability to respond to environmental stress that threatens its survival
2023
connectionstechnology-and-innovation
Lab MattersPeople & Perspectives Postdoctoral researcher Carolin Sauer is leveraging long-read sequencing to develop new detection methods for various cancers.
2023
lab-matterspeople-perspectivesresearch-highlights
Science & Technology Understanding chromothripsis offers insights into how cancer develops.
2023
research-highlightsscience-technology
Using Oxford Nanopore long-read sequencing, EMBL scientists sequenced a primary childhood brain tumour known as a medulloblastoma, uncovering a novel complex mutation pattern.
2023
science
Genomic sequencing and big data analysis are two novel technologies driving researchers’ understanding of the complexities of cancer.
2023
perspectivesscience
Aggregating clinical, genomic and functional data from patient-derived xenografts, organoids and cell lines
2023
updates-from-data-resources
Lab MattersPeople & Perspectives The new group leader in Barcelona aims to understand how cells behave in health and in disease, and approaches her favourite hobby, cooking, very similarly to her work in the lab.
2022
lab-matterspeople-perspectives
Researchers have created a tool that maps in previously unseen detail how breast cancer develops and spreads.
2022
research-highlightsscience
Science & Technology Researchers have come up with a way to test the efficacy of hundreds of anticancer drug combinations – simultaneously, rapidly, and accurately.
2022
sciencescience-technology
EMBL Announcements Two former EMBL staff members have been recognised for their outstanding contributions to research in the fields of brain evolution and cancer.
2022
alumniembl-announcements
Science & Technology Researchers discover how DNA mutations change blood cell production and how this relates to ageing and cancer development.
2022
research-highlightssciencescience-technology
EMBL AnnouncementsLab Matters Judith Zaugg, Group Leader at EMBL Heidelberg, has been awarded an ERC Consolidator Grant of €2 million funded under the European Union’s Horizon Europe research and innovation programme. Over the next five years, the grant will enable her group to study cellular interactions in the human bone…
2022
embl-announcementslab-matters
ConnectionsLab Matters The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB) a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.
2021
connectionslab-matters
Science & Technology New structural biology research provides fundamental information critical to understanding enzyme mutations connected to rare diseases and cancers.
2021
sciencescience-technology
ConnectionsLab Matters EMBL and Helmholtz Association have signed a memorandum of understanding. The expanded collaboration of both institutions will focus on research related to health.
2021
connectionslab-matters
People & Perspectives EMBL alumnus Pawel Masiewicz has transferred skills and experience gained at EMBL to oversee starting materials for mRNA vaccine development.
2021
alumnipeople-perspectives
Science & Technology A new method has the potential to boost international research efforts to find drugs that eradicate cancer at its source.
2021
sciencescience-technology
Science & Technology New EMBL research shows where & to what degree a component of cellular machinery known as RNA Pol III is mutated and becomes problematic.
2021
sciencescience-technology
Science & Technology Studying cancers means also knowing what healthy cells look like. In this case, mesenchymal stromal cells (MSCs) from healthy bone marrow are a bit ‘loopy’.
2020
picture-of-the-weekscience-technology
Science & Technology Members of an EMBL-led research group with collaborators in Estonia and Russia have built and trained a deep learning model to better understand how cells grow and divide.
2020
sciencescience-technology
Science & Technology The Gerstung Group at EMBL-EBI and collaborators have developed a statistical model that analyses genomic data to predict whether a patient has a high or low risk of developing oesophageal cancer.
2020
sciencescience-technology
Science & Technology Despite their ghostly appearance, these are very real cell nuclei infected with Influenza A virus – the only influenza virus known to cause pandemics.
2020
picture-of-the-weekscience-technology
Science & Technology Researchers have developed an artificial intelligence algorithm that uses computer vision to analyse tissue samples from cancer patients. The algorithm can distinguish between healthy and cancerous tissues, and can also identify patterns DNA and RNA changes in tumours.
2020
sciencescience-technology
Science & Technology EMBL scientists have created a new, realistic 3D testbed that could help achieve the goal of stopping cancers before they start by studying cancer cells as they first form.
2020
sciencescience-technology
Science & Technology Scientists discovered that antihypertensive agent alters the tissue characteristics of colon cancer metastases. This "stiffness" of metastases has an effect on the therapeutic success.
2020
sciencescience-technology
Science & Technology DNA mutations are caused by a combination of DNA damage and repair, shows study by EMBL-EBI and collaborators.
2020
sciencescience-technology
Science & Technology The causes of 40 percent of all cases of certain medulloblastoma – dangerous brain tumours affecting children – are hereditary. These are the findings of a recent genetic analysis carried out by scientists from EMBL and numerous colleagues around the world.
2020
sciencescience-technology
Science & Technology EMBL co-leads most comprehensive study of genetic causes of cancer
2020
sciencescience-technology
Science & Technology Cloud computing offers unprecedented opportunities for global-scale research collaborations. It also presents a unique set of challenges in terms of data protection and the ethics of data sharing.
2020
sciencescience-technology
Science & Technology The largest and most comprehensive catalogue of cancer-specific RNA alterations reveals new insights into the cancer genome.
2020
sciencescience-technology
Science & Technology Researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI) and the Francis Crick Institute have analysed the whole genomes of over 2600 tumours from 38 different cancer types to determine the chronology of genomic changes during cancer development.
2020
sciencescience-technology
Science & Technology Using the dataset from the Pan-Cancer project, scientists has developed methods to group, classify, and describe large rearrangements of the genome that are a key driver of cancer.
2020
sciencescience-technology
Science & Technology Researchers at Harvard Medical School and EMBL-EBI have carried out the largest analysis across cancer types of the newly discovered mutational phenomenon chromothripsis.
2020
sciencescience-technology
Science & Technology Using the data from the Pan-Cancer project EMBL scientists describe how our genetic background influences cancer development.
2020
sciencescience-technology
Science & Technology Breast cancer is the second leading cause of cancer-related deaths in women. It is so deadly because tumours often return after successful cancer treatment. This recurrence is caused by individual dormant cancer cells remaining inside the breast. These cells can develop into active cancer cells…
2019
picture-of-the-weekscience-technology
Science & Technology Researchers have developed a cheaper and faster method to check for genetic differences in individual cells
2019
sciencescience-technology
Science & Technology Immunotherapy: the role of B cells
2019
sciencescience-technology
People & Perspectives Exploring the cancer genomics labyrinth
2019
people-perspectivesscience
Science & Technology The increasing importance of code in the biological sciences
2019
sciencescience-technology
Science & Technology This image – resembling a network of rivers and canals – actually shows the tracheal tip cell of a fruit fly. Fruit flies are heavily used in research and they are a common model organism in developmental biology. Researchers at EMBL use the larvae of fruit flies to study tracheal cell…
2019
picture-of-the-weekscience-technology
Science & Technology Large CRISPR screen prioritises hundreds of promising genes for personalised cancer treatment
2019
sciencescience-technology
Science & Technology Colorectal cancer characterised by consistent changes in gut bacteria across continents, cultures and diets
2019
sciencescience-technology
People & Perspectives Scientists honoured for contributions in cancer immunotherapy and structural biology
2019
alumnipeople-perspectives
Science & Technology Cancer researchers have developed a computer model to predict the course of disease for prostate cancer
2018
sciencescience-technology
Science & Technology Large-scale systematic analysis explores how inherited genome affects drug response of cancer cells
2018
sciencescience-technology
Science & Technology Acute myloid leukaemia risk could be detected years before diagnosis
2018
sciencescience-technology
Science & Technology Combinations of cancer drugs can be quickly and cheaply tested using a novel microfluidic device
2018
sciencescience-technology
Science & Technology New computational method uses multi-omics analysis for personalised medicine
2018
sciencescience-technology
People & Perspectives More than 80 attendees gathered at the EMBL in Italy event at the FIRC Institute of Molecular Oncology (IFOM) in Milan
2018
alumnipeople-perspectives
Science & Technology EMBL group leader Jan Korbel reflects on his scientific origins and current research
2018
sciencescience-technology
Science & Technology What worms can tell us about cancer
2018
sciencescience-technology
Science & Technology Launch of the first free global online catalogue of PDX models
2018
sciencescience-technology
Science & Technology Thanos Halazonetis discusses the EMBO/EMBL Symposium: DNA Replication: From Basic Biology to Disease
2018
eventsscience-technology
Science & Technology How patient-derived computational models can help researchers understand cancer
2017
sciencescience-technology
Science & Technology EMBL-EBI and IMPC characterised over 3000 mouse genes, revealing new gene associations with disease
2017
sciencescience-technology
Science & Technology Hallmarks of residual breat cancer cells suggest new approaches for preventing relapse
2017
sciencescience-technology
Science & Technology ERC grantee Maja Köhn shares her vision for the next ten years
2017
sciencescience-technology
Lab MattersScience & Technology EMBL study finds that rearranging how DNA packs the nucleus can activate cancer genes
2016
lab-mattersscience-technology
Science & Technology Detailed structure paves the way for more effective cancer therapies
2016
sciencescience-technology
Science & Technology New method enables scientists to use light to direct where cancer cells go
2016
sciencescience-technology
Science & Technology Largest-ever study of breast cancer genomes reveals new genes and mutations
2016
sciencescience-technology
Science & Technology “It’s a bit like drawing a picture of an intricate object just by looking at its shadow on the wall."
2016
sciencescience-technology
Science & Technology New computational method to study biological signalling networks in healthy and cancer cells.
2015
sciencescience-technology
Science & Technology Jan Korbel and colleagues publish commentary on risks and rewards of genome cloud computing.
2015
sciencescience-technology
Lab MattersScience & Technology Academic community clouds take cancer research towards a brighter future.
2015
lab-mattersscience-technology
Science & Technology Kidney cancer linked to exposure to aristolochic acid, an ingredient in some herbal remedies.
2014
sciencescience-technology
Science & Technology Enabling neighbours: intact genes can cause cancer when placed near "enhancing" regions of DNA
2014
sciencescience-technology
Science & Technology Migrating cells, it seems, cover their tracks not for fear of being followed, but to keep moving forward. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have now shown that cells in a zebrafish embryo determine which direction they move in by effectively…
2013
sciencescience-technology
Science & Technology Like a fireman who becomes an arsonist, a protein that prevents cells becoming cancerous can also cause tumours, scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have discovered. The finding, published today in Nature Structural and Molecular Biology, stems…
2013
sciencescience-technology
Science & Technology An inherited mutation in a gene known as the guardian of the genome is likely the link between exploding chromosomes and some particularly aggressive types of cancer, scientists at the European Molecular Biology Laboratory (EMBL), the German Cancer Research Centre (DKFZ) and the University…
2012
sciencescience-technology
Science & Technology A team of geneticists and computational biologists at the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI), the Wellcome Trust Sanger Institute and Cancer Research UK reveal how an ancient mechanism is involved in gene control and continues to drive genome…
2012
sciencescience-technology
Science & Technology Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both mice and humans, a layer of cells at the base of the skin contains stem cells that can develop into the specialised cells in the layers above.…
2009
sciencescience-technology
Science & Technology Leukaemia – cancer of blood or bone marrow – is caused by mutations that allow defective blood cells to accumulate and displace healthy blood. To devise effective therapies it is crucial to know which mutations cause leukaemia and which cell type gives rise to leukaemic cells. Researchers from…
2008
sciencescience-technology
Science & Technology New insights into the cellular signal chain through which pheromones stimulate mating in yeast have been gained by scientists at the European Molecular Biology Laboratory [EMBL]. Similar signal chains are found in humans, where they are involved in many important processes such as the…
2007
sciencescience-technology
Science & Technology Scientists from the European Molecular Biology Laboratory (EMBL) have developed a new method to prepare and image biological samples in three dimensions with laser light-sheet based fluorescence microscopy. The technological advance, which is published in the current online issue of Nature…
2007
sciencescience-technology
Science & Technology Liver cancer is one of the deadliest cancers worldwide; every year sees more than 400,000 new cases, and most of the victims die in less than one year. Despite extensive research, the underlying molecular mechanisms of the disease are poorly understood. A new study by researchers from the Mouse…
2007
sciencescience-technology
Science & Technology Blood cells have limited lifespans, which means that they must be continually replaced by calling up reserves and turning these into the blood cell types needed by the body. Claus Nerlov and his colleagues at the European Molecular Biology Laboratory (EMBL) unit in Monterotondo, Italy, in…
2006
sciencescience-technology
Science & Technology Cells in an embryo divide at an amazing rate to build a whole body, but this growth needs to be controlled. Otherwise the result may be defects in embryonic development or cancer in adults. Controlling growth requires that some cells divide while others die; their fates are determined by signals…
2006
sciencescience-technology
Lab MattersScience & Technology Today EMBL scientists, EMBL’s commercial affiliate, EMBL Enterprise Management Technology Transfer GmbH (EMBLEM) and EMBL’s venture vehicle, EMBL Ventures GmbH, announce the foundation of Elara Pharmaceuticals GmbH, a start-up company that will translate basic research findings into new…
2006
lab-mattersscience-technology
Science & Technology Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Institute of Biomedical Research of the Parc Científic de Barcelona (IRB-PCB) have now added key evidence to claims that some types of cancer originate with defects in stem cells. The study, reported this week in…
2005
sciencescience-technology
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