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cell division

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21 August 2024 Three images of the cell at different stages of mitosis. In the left: round navy shape and irregular thick magenta line within it. In the middle: the same round shape with two irregular magenta shapes. On the right: Two round navy shapes connected with each other. Each of them holds shiny magenta-yellow clusters.

Three images of the cell at different stages of mitosis. In the left: round navy shape and irregular thick magenta line within it. In the middle: the same round shape with two irregular magenta shapes. On the right: Two round navy shapes connected with each other. Each of them holds shiny magenta-yellow clusters.

The forces behind chromosome repulsion and attraction during cell division

EMBL Heidelberg researchers discovered how a protein switches between repelling and gluing chromosomes during cell division. This helps the mother cell to divide the genome equally into two daughter cells and cluster chromosomes inside the daughter nuclei, ensuring a successful cell division.

SCIENCE & TECHNOLOGY

2024

science-technology

8 August 2024

We are EMBL: Jana Helsen on the Bridging Excellence fellowship, chromosomal evolution, and art

EMBL-Stanford Life Science Alliance fellow Jana Helsen shares how she balanced her life between two laboratories and countries, her latest research paper, and her passion for cover art.

PEOPLE & PERSPECTIVES

2024

people-perspectives

22 May 2024 A sphere with two separated halves; the left half is blue and depicts chromosomes separating along spindles inside multiple nuclei, while the right half is orange, depicting a single set of chromosomes and a spindle with no nuclear envelope visible.

A sphere with two separated halves; the left half is blue and depicts chromosomes separating along spindles inside multiple nuclei, while the right half is orange, depicting a single set of chromosomes and a spindle with no nuclear envelope visible.

Exploring diversity in cell division

New research by EMBL scientists shows how different modes of cell division used by animals and fungi might have evolved to support diverse life cycles.

SCIENCE & TECHNOLOGY

2024

science-technology

23 November 2023 Photographs of two scientists on a decorative background

Photographs of two scientists on a decorative background

ERC Consolidator Grants awarded to two EMBL researchers

Alba Diz-Muñoz and Arnaud Krebs from EMBL Heidelberg have received grants to work on projects that aim, respectively, to understand the cellular mechanics that control cell division and investigate the regulatory networks that govern transcription factor function.

EMBL ANNOUNCEMENTS LAB MATTERS

2023

embl-announcementslab-matters

21 November 2019

From cell to mouse – how tissues differentiate

Shedding light on the mechanisms that control the fate of embryonic cells

SCIENCE & TECHNOLOGY

2019

sciencescience-technology

2 July 2019

Cell duplication

What looks like a pair of scary alien eyes is actually the final stage in the duplication of a cell. Cell duplication is preceded by a process called mitosis, in which the replicated chromosomes are separated into two new nuclei. Mitosis is the prerequisite for a cell to divide into two identical…

SCIENCE & TECHNOLOGY

2019

picture-of-the-weekscience-technology

31 January 2019 Year 2018 standing on library shelf

Year 2018 standing on library shelf

Most popular articles of the year: 2018

A collection of the most read articles from the EMBL news website in 2018

LAB MATTERS

2019

lab-matters

10 September 2018 A dynamic protein atlas of a human cell. IMAGE: Aleksandra Krolik/EMBL

A dynamic protein atlas of a human cell. IMAGE: Aleksandra Krolik/EMBL

First interactive model of human cell division

Real-time tracking of proteins during mitosis is now possible using a 4D computer model

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

12 July 2018 Artistic 3D rendering of the dual spindle in the mammalian zygote. IMAGE: Cartasiova, Hossain, Reichmann, Ellenberg/EMBL

Artistic 3D rendering of the dual spindle in the mammalian zygote. IMAGE: Cartasiova, Hossain, Reichmann, Ellenberg/EMBL

Parental chromosomes kept apart during first division

Mammalian life begins differently than we thought

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

7 December 2016

Cycle of life

Paul Nurse’s failed experiment inspired a career that would uncover key mechanisms of cell division

SCIENCE & TECHNOLOGY

2016

sciencescience-technology

21 March 2016 First complete, real-time recording of starfish egg cell eliminating centrioles shows it handles mature ‘mother’ centrioles (green) and immature ‘daughter’ centrioles (purple) differently.

First complete, real-time recording of starfish egg cell eliminating centrioles shows it handles mature ‘mother’ centrioles (green) and immature ‘daughter’ centrioles (purple) differently.

Mothers and daughters

1st real-time video of starfish egg cell eliminating crucial structures, to ensure embryo viability

SCIENCE & TECHNOLOGY

2016

sciencescience-technology

7 March 2016 During cell division, DNA (purple) must be correctly grouped and divided between daughter cells. IMAGE: Nasser Rusan, National Institutes of Health (NIH)

During cell division, DNA (purple) must be correctly grouped and divided between daughter cells. IMAGE: Nasser Rusan, National Institutes of Health (NIH)

A cohesive structure

Structural insights into how cohesin keeps DNA together during the cell cycle

SCIENCE & TECHNOLOGY

2016

sciencescience-technology

18 May 2014

First, catch your DNA

DNA-coralling protein complex in an unexpected bind

SCIENCE & TECHNOLOGY

2014

sciencescience-technology

18 August 2011 Circling chromosomes. Chromosomes (blue) form a ‘belt’ around the centre of the spindle (green), discovered by the EMBL scientists.

Circling chromosomes. Chromosomes (blue) form a ‘belt’ around the centre of the spindle (green), discovered by the EMBL scientists.

Fishing games gone wrong

When an egg cell is being formed, the cellular machinery which separates chromosomes is extremely imprecise at fishing them out of the cell’s interior, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have discovered. The unexpected degree of trial-and-error…

SCIENCE & TECHNOLOGY

2011

sciencescience-technology

17 June 2011 Condensin loops around several strands of DNA, keeping it coiled up and easier to transport. (Artistic impression) Image credits: EMBL/ P. Riedinger

Condensin loops around several strands of DNA, keeping it coiled up and easier to transport. (Artistic impression) Image credits: EMBL/ P. Riedinger

Keeping it together

As any rock-climber knows, trailing a long length of rope behind you is not easy. A dangling length of rope is unwieldy and hard to manoeuvre, and can get tangled up or stuck on an outcropping. Cells face the same problem when dragging chromosomes apart during cell division. The chromosomes are…

SCIENCE & TECHNOLOGY

2011

sciencescience-technology

5 August 2010

Constant overlap

During cell division, microtubules emanating from each of the spindle poles meet and overlap in the spindle’s midzone. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have uncovered the molecular mechanism that determines the extent of this overlap. In a…

SCIENCE & TECHNOLOGY

2010

sciencescience-technology

1 April 2010

Each of these large images of dividing cells is composed of several microscopy images of human cells in which different individual genes were silenced. The smaller images are placed according to genes’ effects: images for genes that affect chromosomes make up the chromosomes (red/pink), while the mitotic spindle (green) is composed of images for genes that affect it. IMAGE: Thomas Walter & Mayumi Isokane / EMBL

Movies for the human genome

Name a human gene, and you’ll find a movie online showing you what happens to cells when it is switched off. This is the resource that researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and their collaborators in the Mitocheck consortium are making freely…

SCIENCE & TECHNOLOGY

2010

sciencescience-technology

3 December 2008

Picture Release

Cell division is one of the most fundamental processes of life. It explains how one cell can give rise to an organism of several million cells, it determines the shape of different life forms and it underpins our body’s capacity to heal when injured. Often we only notice how important cell…

SCIENCE & TECHNOLOGY

2008

sciencescience-technology

10 June 2007

Researchers shed light on shrinking of chromosomes

A human cell contains an enormous 1.8 metres of DNA partitioned into 46 chromosomes. These have to be copied and distributed equally into two daughter cells at every division. Condensation, the shortening of chromosomes, allows the cell to handle such huge amounts of genetic material during cell…

SCIENCE & TECHNOLOGY

2007

sciencescience-technology

4 May 2007

A matter of force

When a cell divides, normally the result is two identical daughter cells. In some cases however, cell division leads to two cells with different properties. This is called asymmetric cell division and plays an important role in embryonic development and the self-renewal of stem cells. Researchers…

SCIENCE & TECHNOLOGY

2007

sciencescience-technology

25 August 2006

A switch between life and death

Cells in an embryo divide at an amazing rate to build a whole body, but this growth needs to be controlled. Otherwise the result may be defects in embryonic development or cancer in adults. Controlling growth requires that some cells divide while others die; their fates are determined by signals…

SCIENCE & TECHNOLOGY

2006

sciencescience-technology

31 October 2005

ENFIN! Computational systems biology comes to a lab bench near you

The Commission of the European Union has awarded EUR 9 million over five years for a new Network of Excellence that will make computational systems biology accessible to bench scientists throughout Europe and beyond. ENFIN, which stands for ‘Experimental Network for Functional…

LAB MATTERS SCIENCE & TECHNOLOGY

2005

lab-mattersscience-technology

4 September 2005

A new link between stem cells and tumors

Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Institute of Biomedical Research of the Parc Científic de Barcelona (IRB-PCB) have now added key evidence to claims that some types of cancer originate with defects in stem cells. The study, reported this week in…

SCIENCE & TECHNOLOGY

2005

sciencescience-technology

13 July 2005

Actin moves chromosomes

Microtubules need a helping hand to find chromosomes in dividing egg cells, scientists have discovered. Although it was generally accepted that microtubules act alone as the cellular ropes to pull chromosomes into place, a new study by researchers at the European Molecular Biology Laboratory (EMBL)…

SCIENCE & TECHNOLOGY

2005

sciencescience-technology

12 July 2005

Hunt for human genes involved in cell division under way

A systematic search through human genes has begun at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. Working within the MitoCheck consortium that includes 10 other institutes throughout Europe, the EMBL scientists will silence all human genes, one-by-one, to find those…

CONNECTIONS LAB MATTERS

2005

connectionslab-matters

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