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A study from the Hackett group at EMBL Rome led to the development of an epigenetic editing system that allows to precisely program chromatin modifications at any specific position in the genome, to understand their causal role in transcription regulation.
SCIENCE & TECHNOLOGY2024
science-technology
EMBL Rome group leader Jamie Hackett receives EUR 2 million for the ModLogic project, aimed at understanding how chromatin modifications impact gene activity.
EMBL ANNOUNCEMENTSLAB MATTERS2023
embl-announcementslab-matters
Scientists at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Researchers in EMBL’s Zaugg group have studied the causes of pulmonary arterial hypertension (PAH), a rare disease that causes high blood pressure in the arteries of the lungs. The study, carried out in collaboration with Stanford University School of Medicine, compared lung cells of patients…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
In human cells, the genetic material is packaged into 23 different DNA molecules, the chromosomes. Each chromosome is present in two copies, one inherited from the paternal sperm, and the other from the maternal egg. During most of the cell’s life, chromosomes take the shape of long,…
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
The software diffTF quantifies activity of transcription factors and predicts their mode of action
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Exploring the diverse routes by which EMBL scientists are driving forward neurobiology
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Scientists uncover effects of mutation that can cause autism and intellectual disability
SCIENCE & TECHNOLOGY2018
sciencescience-technology
EMBL’s next Director General reflects on the questions that drive her research
PEOPLE & PERSPECTIVES2018
people-perspectivesscience
EMBL scientists show how chromatin usage in individual cells reveals developmental trajectories
SCIENCE & TECHNOLOGY2018
sciencescience-technology
EMBL scientists unveil how 3D chromatin structure affects RNA splicing
SCIENCE & TECHNOLOGY2017
sciencescience-technology
New research reveals that two different mechanisms are responsible for chromosome folding
SCIENCE & TECHNOLOGY2017
sciencescience-technology
EMBL researchers and collaborators unravel how chromosomes form
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Researchers from the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and the EMBL-European Bioinformatics Institute (EMBL-EBI) in Hinxton, UK, have revealed new insights into how sex chromosomes are regulated. A chromatin modifying enzyme helps compensate for the fact that…
SCIENCE & TECHNOLOGY2008
sciencescience-technology
Epigenetic regulation – modifications to the structure of chromatin that influence which genes are expressed in a cell – is a key player in embryonic development and cancer formation. Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg now gained new insight…
SCIENCE & TECHNOLOGY2008
sciencescience-technology
The European Commission has awarded 3.7 Million Euro under the European Union Framework 6 Programme over the next four years to a new Marie Curie Research Training Network, coordinated by Dr. Andreas Ladurner at the European Molecular Biology Laboratory (EMBL). The long molecules of DNA that carry…
LAB MATTERS2007
lab-matters
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