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chromosome dynamics

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24 March 2025 Illustration showing four stages of cell division placed along a blue 'road’ on a green background. On top of each cell division stage, there is a coloured chromosomal trace showing how its structure grows more compact as cell division proceeds.

Illustration showing four stages of cell division placed along a blue 'road’ on a green background. On top of each cell division stage, there is a coloured chromosomal trace showing how its structure grows more compact as cell division proceeds.

How chromosomes shape up for cell division

EMBL scientists have shown how overlapping loops of DNA stack upon each other in dividing cells to give rise to rod-shaped chromosomes.

SCIENCE & TECHNOLOGY

2025

science-technology

3 June 2022 he internal structure of a mitotic chromosome is shown with colourful threads representing DNA, one of which is shown being packaged into loops by the condensin protein complex. The background shows mitotic chromosomes in the cellular space

he internal structure of a mitotic chromosome is shown with colourful threads representing DNA, one of which is shown being packaged into loops by the condensin protein complex. The background shows mitotic chromosomes in the cellular space

Shaping up the genome for cell division

Researchers have discovered the mechanism by which a family of DNA motor proteins packages loosely arranged strands of DNA into compact individual chromosomes during cell division.

SCIENCE & TECHNOLOGY

2022

sciencescience-technology

28 April 2020

Dancing chromosomes

In human cells, the genetic material is packaged into 23 different DNA molecules, the chromosomes. Each chromosome is present in two copies, one inherited from the paternal sperm, and the other from the maternal egg. During most of the cell’s life, chromosomes take the shape of long,…

SCIENCE & TECHNOLOGY

2020

picture-of-the-weekscience-technology

20 June 2019 Structural biology image of the condensin complex.

Intact chromosomes during cell division

The mystery of how condensin maintains the integrity of the genome during cell division.

SCIENCE & TECHNOLOGY

2019

sciencescience-technology

25 May 2018 Melina Schuh has received an EMBO Gold Medal for outstanding contributions to the life sciences in Europe.

Melina Schuh receives EMBO Gold Medal

EMBL alumna Melina Schuh recognised for excellence in science

PEOPLE & PERSPECTIVES

2018

alumnipeople-perspectives

23 May 2018 As a cell prepares to divide, the chromosomes (shown here in pink) condense, becoming more tightly coiled and easier to observe under the microscope. The faint structure in the centre is a cell nucleus in which the chromosomes are in their usual decondensed state.