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cryo-em

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4 April 2024

Building the cell’s splicing machine

Science & Technology New study from the Galej group provides deeper structural insight into the assembly of a critical molecular machine, that removes non-coding information from genes during their expression.

2024

science-technology

14 November 2023 Blue thumbprint-sized ovals cluster together on a black background with white and pink dots sporadically situated on the blue ovals.

Five takeaways from ‘Seeing is believing’ in 2023

Science & Technology A recent EMBO | EMBL symposium brought together leading developers of imaging methods with cutting-edge applications that illustrate how imaging can answer biological questions.

2023

eventsscience-technology

21 July 2023 Three-dimensional cartoon of the hexasome with a chromatin remodeler on DNA.

A glimpse into the hexasome: 40 years on

Science & Technology Research from the Eustermann group at EMBL Heidelberg reveals how the packaging of DNA into hexasomes impacts the function of enzymes involved in gene regulation.

2023

sciencescience-technology

16 February 2023

New EU-funded Project: Fragment-Screen

Lab MattersScience & Technology EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.

2023

lab-mattersscience-technology

3 June 2022 he internal structure of a mitotic chromosome is shown with colourful threads representing DNA, one of which is shown being packaged into loops by the condensin protein complex. The background shows mitotic chromosomes in the cellular space

Shaping up the genome for cell division

Science & Technology Researchers have discovered the mechanism by which a family of DNA motor proteins packages loosely arranged strands of DNA into compact individual chromosomes during cell division.

2022

sciencescience-technology

18 January 2022 Science illustration composed by a photographic film highlighting three-dimensional structures of a protein complex involved in splicing.

Capturing ‘snapshots’ of a crucial step in RNA splicing

Science & Technology The Galej group at EMBL Grenoble has recently obtained high resolution snapshots of a crucial step in RNA splicing involving the U2 snRNP complex, a crucial component of the human spliceosome.

2022

sciencescience-technology

20 December 2021 A detailed structure map shows two proteins interacting in the foreground, each shown in a different colour. The background shows small green dots marking bacteria

Solving molecular puzzles to find the perfect fit

Science & Technology Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.

2021

sciencescience-technology

9 December 2021 Colourful interwoven coils are displayed against a grid of small black and white photographic images.

A gallery of human RNA polymerases

Science & Technology New structural biology research provides fundamental information critical to understanding enzyme mutations connected to rare diseases and cancers.

2021

sciencescience-technology

28 October 2021 female scientist sits in front of building

Welcome: Svetlana Dodonova

Lab MattersPeople & Perspectives Svetlana Dodonova is one of EMBL's newest group leaders, leading a team of researchers who will study how genetic material is organised inside cells using structural biology approaches.

2021

lab-matterspeople-perspectives

7 April 2021 Man standing next to painting

Welcome: Matthew Hartley

Lab MattersPeople & Perspectives The challenges and opportunities when setting up a global archive for bioimages

2021

lab-matterspeople-perspectives

23 February 2021 Greyscale image of a cell with its internal components visible

Seeing through a cell

Science & Technology Liang Xue used cryo-electron tomography to capture this detailed image of a Mycoplasma pneumoniae cell.

2021

picture-of-the-weekscience-technology

5 February 2021 Artistic representation of the structure of the three proteins forming Integrator’s catalytic core.

At the core of the Integrator complex

Science & Technology A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.

2021

sciencescience-technology

18 January 2021 man wearing sweater and glasses stands in front of snow and glassy building

Welcome: Timo Zimmermann

Lab MattersPeople & Perspectives The EMBL Imaging Centre is scheduled to open in 2021 with Timo Zimmermann as Team Leader for advanced light microscopy technology development and service provision.

2021

lab-matterspeople-perspectives

24 August 2020 Simone Mattei, the new team leader in electron microscopy service and technology development

Welcome: Simone Mattei

Lab MattersPeople & Perspectives The new team leader offering services in electron microscopy discusses his hopes and plans for the forthcoming EMBL Imaging Centre

2020

lab-matterspeople-perspectives

28 July 2020 Atomic model of the entire condensin complex

Understanding chromosome organisation

Science & Technology EMBL scientists and collaborators help reveal the process by which enormous quantities of DNA are folded into cells.

2020

sciencescience-technology

17 June 2020 Crystal selection for X-ray diffraction experiments.

Investigating the structure and mechanisms of coronavirus biomolecules

Science & Technology While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…

2020

sciencescience-technology

29 April 2020 The Influenza virus

Understanding the influenza virus

Science & Technology The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…

2020

sciencescience-technology

19 December 2019 Before a biological sample reaches the beamline, a lot of work is put into its preparation. Scientists can use the wide range of services and resources at EMBL to prepare their biological samples for structural studies at the X-ray beamlines in Grenoble and Hamburg. Photo: Marietta Schupp/EMBL

Empowering European structural biology

EMBL AnnouncementsLab Matters EU funding for iNEXT-Discovery consortium unlocks key technologies for structural biology

2019

embl-announcementslab-matters

11 July 2019 Structure of the Elongator complex

A tRNA modifier at work

Science & Technology Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.

2019

sciencescience-technology

12 December 2010 This cryo-electron microscopy image shows the 3D structure of the ribosome (yellow/blue) bound to the signal recognition particle (SRP) and the SRP receptor (both in red). Below it is an atomic model of SRP (green-yellow/orange) and its receptor (pink). Image credits: EMBL/Schaffitzel.

How cells export and embed proteins in the membrane

Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure…

2010

science

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