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development

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11 March 2024 Casting new light on gene regulation in development

Casting new light on gene regulation in development

Science & Technology New research from EMBL Heidelberg shows how cells in developing embryos undergo a major shift in the way they regulate gene expression as they mature and differentiate.

2024

sciencescience-technology

15 November 2023

Why time is of the essence in development

EMBLetc EMBL developmental biologists – with help from other disciplines – pursue the significance of time, timing, and transitions in organisms during their development

2023

27 October 2023 The image shows a uerine environment made of a jelly-like and transparent material, with a cylindrical 3D structure.

Spotlight: Creating an artificial uterus

Science & Technology EMBL researchers have created an engineered uterus that allows a closer look at a mouse embryo’s development and its interactions with the uterine environment.

2023

picture-of-the-weeksciencescience-technology

13 October 2023 Scientific illustration showing various model organisms used to study developmental plasticity and a series of concentric circles representing adaptability of interactions.

Understanding developmental plasticity in time and space

Lab MattersScience & Technology A two-week practical course introduced participants to the intricacies of studying the dynamic interplay between organisms and their changing environment and how it impacts development and evolution.

2023

lab-mattersscience-technology

31 August 2023 Part of a fruit fly embryo imaged against a dark background, with nuclei stained with DAPI (white), and a cluster of pole cells, marked by Vasa protein (yellow)

Spotlight: Off to the pole

Science & Technology For a fruit fly embryo to develop correctly, key factors need to get to the right place at the right time – a journey that starts in the developing egg, as seen in this image from the Ephrussi Group at EMBL Heidelberg

2023

picture-of-the-weeksciencescience-technology

30 March 2023 Science illustration representing two embryos imaged using the Brillouin microscopy technique. The embryo in the front is a mouse embryo at 20h and the one in the back a Phallusia mammillata embryo. A laser beam crosses the samples to analyse tissue stiffness (here represented by acoustic waves).

Shining light on the mechanics of embryo development

Lab MattersScience & Technology A new microscope built by EMBL researchers, based on Brillouin scattering principles, allows scientists to observe the dynamics of mechanical properties inside developing embryos in real time.

2023

lab-matterssciencescience-technology

5 August 2022 A rod-like structure with green and magenta segments representing cellular markers.

Making patterns visible

Science & Technology How do gene expression patterns result in the generation of different cell types? Scientists at EMBL Heidelberg used the zebrafish notochord to find out.

2022

sciencescience-technology

4 August 2022 An illustration provides representation of fingers hovering over a cell phone

Zooming in to get the full picture

Science & Technology EMBL and UW researchers plus additional collaborators have constructed a complete map of fruit fly embryonic development using machine learning. This research is foundational to better understanding overall embryo development in other species, including humans.

2022

sciencescience-technology

23 March 2022 Two Drosophila embryos stained with fluorescent dye on a purple background that indicates either solid or liquid state

From liquid to solid to drive development

Science & Technology Condensates are membraneless organelles that control specific functions within a cell. Scientists at EMBL Heidelberg have shown how the physical state of condensates can influence biological function.

2022

sciencescience-technology

4 March 2022 A gloved hand holds a slide with visible wells containing Matrigel immersed in culture medium. A magnified close-up shows a mouse embryo developing over the course of 48 hours

A 3D culture model to study embryo growth

Science & Technology A recent study by EMBL researchers proposes a new method to grow early embryos in the laboratory. With a 3D culture set-up, scientists can closely monitor the changes embryos undergo around the time of implantation.

2022

sciencescience-technology

25 February 2022 Three colourful overlapping circles arranged in a row, a fruit-fly embryo being visible within each. Small circles within the embryos represent cell lineages.

Converging lenses on embryo development

Science & Technology Researchers from the Furlong group at EMBL have come up with a way to observe the development of fruit-fly embryos simultaneously at the genetic and cellular levels, generating a high-resolution and integrated view of how different cell lineages form.

2022

sciencescience-technology

9 December 2021 Portrait photo of Eileen Furlong against blue-green background.

Eileen Furlong honoured with Leibniz Prize

EMBL AnnouncementsLab Matters EMBL Senior Scientist and Head of the Genome Biology Unit is among the researchers honoured for outstanding work by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG).

2021

embl-announcementslab-matters

6 September 2021 Cells organised according to their transcript data changing to the seqFISH mouse embryo map.

The Spatial Mouse Atlas: new insights into cell fate

Science & Technology Researchers have combined spatial gene expression information with single-cell genomics data to create a high-resolution atlas of mouse organogenesis.

2021

sciencescience-technology

16 June 2020 Composite image of fly larvae organs making up a flower

From fly to flower

Science & Technology In this composite image, visual artist Mona Kakanj assembled three different biological structures in fly larvae into a flower. The original images were taken as part of a research project by Parisa Kakanj in Maria Leptin’s group.

2020

picture-of-the-weekscience-technology

15 May 2020 Cell division

Tracing the origins of cells

Science & Technology Researchers from the Sharpe group at EMBL Barcelona have published a method to track the developmental history of a cell using the gene editing tool CRISPR–Cas9, but without the need to create transgenic organisms.

2020

sciencescience-technology

9 April 2020 3D reconstruction of parental chromosomes in the mouse embryo

How chromosome structure influences development

Science & Technology EMBL researchers in the Heard group at EMBL Heidelberg explore the interaction between DNA organisation and gene expression in the early embryo

2020

sciencescience-technology

11 February 2020

Breathe in, breathe out

Science & Technology This image shows the tracheal system of a live fruit fly larva. Daniel Rios from the Leptin Group and Dimitri Kromm from the Hufnagel Group used this advanced microscope to investigate the dynamics of tracheal cells during development.

2020

picture-of-the-weekscience-technology

4 February 2020 Mouse genetic data identifies rare disease genes

Pinpointing rare disease mutations

Science & Technology New resource that categorises genes essential for supporting life could be used to identify rare disease mutations

2020

sciencescience-technology

29 November 2019 Choanocyte chamber of sponge, with neuroid cell

Neural pathways

Science & Technology Exploring the diverse routes by which EMBL scientists are driving forward neurobiology

2019

sciencescience-technology

1 July 2019 The dynamic process of cell division.

Drawing knowledge

People & Perspectives A conversation about art-science collaborations and the importance of drawing in biology.

2019

people-perspectivesscience

29 April 2019 This illustration, based on real data shows the heart of a Japanese rice fish. The green and blue laser beams demonstrate how the newly developed 3D imaging microscope is scanning the heart.

New 3D microscope

Science & Technology A newly developed 3D microscope visualises fast biological processes better than ever.

2019

sciencescience-technology

3 August 2018 Optical section of a ‘gastruloid’ – an embryonic organoid made from mouse embryonic stem cells and stained for E-Cadherin (red), marking cell outlines and nuclei (blue). IMAGE: Vikas Trivedi/EMBL

Welcome: Vikas Trivedi

People & Perspectives An engineer’s approach to understanding morphogenesis

2018

people-perspectivesscience

8 March 2018 Netrin-1 bound to Draxin

Axon guidance and bundling are linked

Science & Technology EMBL scientists discover how two guidance cues work together when neurons project axons across the midline

2018

sciencescience-technology

8 January 2018 A photo of new EMBL Heidelberg group leader Aissam Ikmi.

Welcome: Aissam Ikmi

People & Perspectives New group leader studies sea anemones to investigate why some animals regenerate better than others

2018

people-perspectivesscience

5 December 2017 Lab manager Anna Cyrklaff takes a tray of fly specimens to be transferred into new vials

Behind the scenes in the Fly Room

Lab MattersPeople & Perspectives Curious about what goes on in EMBL’s Fly Room? Prepare to be a fly on the wall

2017

lab-matterspeople-perspectives

21 November 2017 Fotis was EMBL's third Director-General. PHOTO: EMBL

Obituary: Fotis Kafatos

People & Perspectives Former EMBL Director General Fotis Kafatos passes away

2017

alumnipeople-perspectives

13 November 2017

Research highlights

Science & Technology A summary of recent research highlights from EMBL

2017

sciencescience-technology

21 September 2017

Fish on fire

Science & Technology New study by Paola Kuri and Maria Leptin shows how inflammation happens in zebrafish in real time

2017

sciencescience-technology

11 August 2017

Welcome: Justin Crocker

People & Perspectives Meet Justin Crocker, EMBL’s new group leader in gene regulation during evolution and development

2017

people-perspectivesscience

25 April 2017

Embryos use ancient viral DNA

Science & Technology EMBL scientists detect important function of genetic sequence our ancestors assimilated from a virus

2017

sciencescience-technology

13 March 2017

Futures: Brain evolution

Science & Technology ERC grantee Detlev Arendt shares his vision for the next ten years

2017

sciencescience-technology

13 March 2017

Futures: Genome regulation

Science & Technology ERC grantee Eileen Furlong shares her vision for the next ten years

2017

sciencescience-technology

2 March 2017

Metabolism matters

Science & Technology Differentiated and undifferentiated cells get energy in different ways, sensor made at EMBL shows

2017

sciencescience-technology

24 November 2016

What would it take to regrow an arm?

Science & Technology Exploring what it would take to regrow a lost limb, and what we might learn along the way

2016

sciencescience-technology

24 November 2016 SPIM image of Medaka juveniles. Photo: EMBL/Philipp Keller

Thinking in 3D

People & Perspectives Ernst Stelzer earns 2016 Lennart Philipson award for advances in light sheet microscopy

2016

alumnipeople-perspectives

24 November 2016

Chromatin cartographer

People & Perspectives EMBL alumnus Jop Kind reflects on the questions that led him to this year’s John Kendrew Award

2016

alumnipeople-perspectives

10 November 2016

Review: Lab Girl

Lab MattersPeople & Perspectives Hope Jahren’s autobiography educates and delights

2016

lab-matterspeople-perspectives

3 November 2016

Spiral growth

Science & Technology What happens when plant's leaf-placing feedback loop isn't quite right

2016

sciencescience-technology

20 October 2016

Diving into Autumn

Connections Participants learn about EMBL’s ocean biodiversity research at the Fall Gala

2016

connectionsevents

4 October 2016

In pursuit of flat growth in leaves

Science & Technology EMBL scientists investigate how leaves grow flat to efficiently capture sunlight

2016

sciencescience-technology

30 August 2016 Data by Natalia Wesolowska has been visualised in 3D stereoscopic view, as an anaglyph and a 3D lenticular poster by Stefan Günther & Gustavo de Medeiros at EMBL

See data in a new light

Science & Technology 3D printing, gaming, virtual reality and lenticular posters bring new perspectives to research

2016

sciencescience-technology

7 July 2016

Mapping early development

Science & Technology “Like getting hold of a microscope for the first time”

2016

sciencescience-technology

21 April 2016 EMBL scientists are discovering and understanding the waves and rhythms inside us. ILLUSTRATION: Aad Goudappel, Rotterdam

The rhythms in life

Science & Technology How EMBL scientists are discovering and understanding the waves and rhythms inside us

2016

sciencescience-technology

21 April 2016 Giorgia Guglielmi 's PhD project puts development in a new light. PHOTO: EMBL Photolab/Marietta Schupp

Light control

Science & Technology EMBL PhD project puts development in a new light

2016

sciencescience-technology

24 March 2016 Zernicka-Goetz lab, University of Cambridge

Foetus, or placenta?

Science & Technology Subtle genetic differences destine cells to placenta or animal, very early in embryo development

2016

sciencescience-technology

21 March 2016 First complete, real-time recording of starfish egg cell eliminating centrioles shows it handles mature ‘mother’ centrioles (green) and immature ‘daughter’ centrioles (purple) differently.

Mothers and daughters

Science & Technology 1st real-time video of starfish egg cell eliminating crucial structures, to ensure embryo viability

2016

sciencescience-technology

12 February 2016 Cells formed circles where blinking happened in a wave, rolling outwards from the centre. IMAGE: EMBL/C.Tsiairis

In sync

Science & Technology What do cells in an embryo have in common with schools of fish, swarms of fireflies, and applauding audiences?

2016

sciencescience-technology

11 February 2016 The 3D structure shows how two transcription factors influence one another’s binding to a specific stretch of DNA – an interaction that is crucial for a heart to develop healthily. IMAGE: EMBL/C.Müller

True Love

Science & Technology How transcription factors interact to create a heart

2016

sciencescience-technology

14 December 2015 Scientists can now view and track the first days of a mouse embryo’s life. IMAGE: EMBL/ Julius Hossain

Turning point of a lifetime

Science & Technology New microscope can record the first days of a mouse embryo’s life

2015

sciencescience-technology

19 November 2015 When illuminated with a laser, individual cells (bright yellow) within the fruit fly embryo cannot contract. This novel optogenetic approach helped to get insights into how tissues bend.

Lighting up development

Science & Technology Using lasers to shed light on how tissues get into shape

2015

sciencescience-technology

16 July 2015

Oskar’s structure revealed

Science & Technology 3D structure of Oskar protein gives first molecular insight into how it functions.

2015

sciencescience-technology

12 May 2015

Destined for the brain

Not all embryonic macrophages are the same, and only some are destined to become microglia.

2015

science

26 January 2015 ILLUSTRATION: AAD GOUDAPPEL

Cell control in a flash

From using light to control brain activity to illuminating fruit fly development and mice’s sense of touch

2015

science

15 December 2014

Luxembourg collaboration

Lab Matters Third round of calls for joint research projects between EMBL and Luxembourg in 2015

2014

lab-matters

23 October 2014

Chamber of secrets

Like sports teams, cells can huddle to communicate in secret and organise group behaviour

2014

science

17 October 2014 Five-armed starfish

Superstars of science

From anemones to starfish, sea creatures are helping understand development, evolution and more.

2014

science

25 September 2014 Marine ragworm brain

How plankton gets jet lagged

How plankton gets jet lagged: the same hormone governs our sleep patterns and a daily marine migration.

2014

science

6 August 2014

Clarity in the cold

How fruit flies beat the cold, plus the value of precisely controlled experiments and detailed analysis

2014

science

25 May 2014

Insights into genetics of cleft lip

Science & Technology How a DNA stretch influences face formation and contributes to common congenital malformations

2014

sciencescience-technology

8 May 2014 Microscopy image

Remodelling the cell

Science & Technology The balance behind membrane changes that turn one cell into 6000 as a fruit fly embryo develops

2014

sciencescience-technology

19 December 2012

Sync to grow

Science & Technology Gene expression wave in the lower part of the future vertebrae column of a mammalian embryo. As the wave goes forward, new pre-vertebrae are formed and the future vertebrae column elongates. (Image and video credit: Nature) In a nutshell: The size of pre-vertebrae in a mammalian embryo is…

2012

sciencescience-technology

10 December 2009 These microscopy images demonstrate the effects of Notch signalling on the hearts of newborn mice (top) and of adult mice after a heart attack (bottom). In a normal neonatal heart (top left), the two major heart chambers (ventricles) are clearly separated by tissue (septum). But when Notch signalling was inactivated in an embryo’s heart muscle cells, the septum between the ventricles of the newborn mouse’s heart was incomplete (asterisk). The same defect commonly occurs in humans with congenital heart disease, often leading to circulatory distress. In the images of adult hearts (bottom), healthy tissue is shown in red and damaged tissue in blue. Normally (bottom left), a heart attack causes extensive tissue damage to the left ventricle (right-hand cavity), but mice in which Notch was re-activated after the heart attack had reduced tissue damage (bottom right) and improved cardiac function. Image credit: EMBL

From fruit fly wings to heart failure. Why Not(ch)?

Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role in the recovery from heart attacks. In a study published today in Circulation Research, scientists at the European Molecular Biology Laboratory (EMBL)…

2009

science

3 September 2006

Lost in the labyrinth

Blood cells have limited lifespans, which means that they must be continually replaced by calling up reserves and turning these into the blood cell types needed by the body. Claus Nerlov and his colleagues at the European Molecular Biology Laboratory (EMBL) unit in Monterotondo, Italy, in…

2006

science

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