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drosophila

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11 March 2024 Casting new light on gene regulation in development

Casting new light on gene regulation in development

Science & Technology New research from EMBL Heidelberg shows how cells in developing embryos undergo a major shift in the way they regulate gene expression as they mature and differentiate.

2024

sciencescience-technology

31 August 2023 Part of a fruit fly embryo imaged against a dark background, with nuclei stained with DAPI (white), and a cluster of pole cells, marked by Vasa protein (yellow)

Spotlight: Off to the pole

Science & Technology For a fruit fly embryo to develop correctly, key factors need to get to the right place at the right time – a journey that starts in the developing egg, as seen in this image from the Ephrussi Group at EMBL Heidelberg

2023

picture-of-the-weeksciencescience-technology

4 August 2022 An illustration provides representation of fingers hovering over a cell phone

Zooming in to get the full picture

Science & Technology EMBL and UW researchers plus additional collaborators have constructed a complete map of fruit fly embryonic development using machine learning. This research is foundational to better understanding overall embryo development in other species, including humans.

2022

sciencescience-technology

23 March 2022 Two Drosophila embryos stained with fluorescent dye on a purple background that indicates either solid or liquid state

From liquid to solid to drive development

Science & Technology Condensates are membraneless organelles that control specific functions within a cell. Scientists at EMBL Heidelberg have shown how the physical state of condensates can influence biological function.

2022

sciencescience-technology

25 February 2022 Three colourful overlapping circles arranged in a row, a fruit-fly embryo being visible within each. Small circles within the embryos represent cell lineages.

Converging lenses on embryo development

Science & Technology Researchers from the Furlong group at EMBL have come up with a way to observe the development of fruit-fly embryos simultaneously at the genetic and cellular levels, generating a high-resolution and integrated view of how different cell lineages form.

2022

sciencescience-technology

19 August 2020 An embryo of the fruit fly Drosophila.

Predicting how gene expression varies

Science & Technology Discoveries at EMBL will help researchers to interpret one of the most common types of experiments in genomics and medical studies.

2020

sciencescience-technology

11 August 2020 Different parts of a fruit fly arranged into an artificial green eye.

The eye of science

Science & Technology This image is a composite of lateral pentascolopidial organs, a wing imaginal disc pouch, and an epithelial wound in a Drosophila larva. The organs are arranged here like eyelashes. Cells surrounding an epidermal wound appear as the iris and pupil of this artistic eye.

2020

picture-of-the-weekscience-technology

16 June 2020 Composite image of fly larvae organs making up a flower

From fly to flower

Science & Technology In this composite image, visual artist Mona Kakanj assembled three different biological structures in fly larvae into a flower. The original images were taken as part of a research project by Parisa Kakanj in Maria Leptin’s group.

2020

picture-of-the-weekscience-technology

14 April 2020

Gazing at healing wounds

Science & Technology What may look like a branch of a tree with the first flower buds emerging after winter are, in fact, tracheal cells of a fruit fly larva and their nuclei.

2020

picture-of-the-weekscience-technology

11 February 2020

Breathe in, breathe out

Science & Technology This image shows the tracheal system of a live fruit fly larva. Daniel Rios from the Leptin Group and Dimitri Kromm from the Hufnagel Group used this advanced microscope to investigate the dynamics of tracheal cells during development.

2020

picture-of-the-weekscience-technology

29 October 2019

Inside out, and grub becomes fly

Science & Technology The three bluish blobs shown in the top right corner of this image may not resemble the sphere of noodles that is the human brain, but they are still essential – at least for the fruit fly. This Picture of the Week shows the brain lobes of Drosophila. It’s an insect so tiny and so […]

2019

picture-of-the-weekscience-technology

25 September 2019

A giant called dumpy

Science & Technology Fruit flies have something that we don’t have: they produce a protein called dumpy. This protein is the largest created by insects, and is comparable in size to the largest human protein – titin. While titin is vital for our muscle function, dumpy connects the soft cells of the insect’s…

2019

picture-of-the-weekscience-technology

9 July 2019 A model of CRISPR/Cas9

Wielding the genetic scissors

Science & Technology What CRISPR may bring for the future of biology, and how it is used at EMBL

2019

sciencescience-technology

1 July 2019 The dynamic process of cell division.

Drawing knowledge

People & Perspectives A conversation about art-science collaborations and the importance of drawing in biology.

2019

people-perspectivesscience

5 December 2017 Lab manager Anna Cyrklaff takes a tray of fly specimens to be transferred into new vials

Behind the scenes in the Fly Room

Lab MattersPeople & Perspectives Curious about what goes on in EMBL’s Fly Room? Prepare to be a fly on the wall

2017

lab-matterspeople-perspectives

23 February 2017

Building labs with flies

People & Perspectives Flies can do a lot for science, inside and outside the lab. EMBL alumna Isabel Palacios explains how

2017

alumnipeople-perspectives

19 November 2015 When illuminated with a laser, individual cells (bright yellow) within the fruit fly embryo cannot contract. This novel optogenetic approach helped to get insights into how tissues bend.

Lighting up development

Science & Technology Using lasers to shed light on how tissues get into shape

2015

sciencescience-technology

8 May 2014 Microscopy image

Remodelling the cell

Science & Technology The balance behind membrane changes that turn one cell into 6000 as a fruit fly embryo develops

2014

sciencescience-technology

2 February 2012 Fruit fly embryo showing the cells that will become the gut and heart

Collective action

Science & Technology If you wanted to draw your family tree, you could start by searching for people who share your surname. Cells, of course, don’t have surnames, but scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found that genetic switches called enhancers, and the…

2012

sciencescience-technology

24 June 2010 These microscopy images show that a protein from the NSL complex (green) and MOF (red) both bind to all chromosomes in male (right) and female (left) fruit flies - overlap is shown in purple. On the male X chromosome, MOF binds not only to promoter regions but also to the body of the genes, generating a brighter signal (pink). Image credits: Akhtar/EMBL.

A life-changing partnership

Science & Technology Researchers from the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and the Max-Planck Institute of Immunobiology Freiburg have identified a novel protein complex that regulates around 4000 genes in the fruit fly Drosophila and likely plays an important role in mammals, too.…

2010

sciencescience-technology

2 May 2010 These microscopy images show the region of the embryo larva that will develop into the adult fruit fly’s wing. In cells genetically manipulated so that PR-DUB cannot remove the gene-silencing tag (left), a gene which would normally be silenced becomes turned on (red) - a situation which is corrected when PR-DUB’s activity is restored (right). Image credits: J.Mueller/EMBL.

Tags on, tags off

Science & Technology During embryonic development, proteins called Polycomb group complexes turn genes off when and where their activity must not be present, preventing specialised tissues and organs from forming in the wrong places. They also play an important role in processes like stem cell differentiation and…

2010

sciencescience-technology

4 November 2009 fluorescence microscopy images of fruit fly embryos

Deciphering the regulatory code

Science & Technology Embryonic development is like a well-organised building project, with the embryo’s DNA serving as the blueprint from which all construction details are derived. Cells carry out different functions according to a developmental plan, by expressing, i.e. turning on, different combinations of genes.…

2009

sciencescience-technology

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