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drug

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15 November 2023 Illustration showing a doorknob with a lock and many protein-marked keys floating towards it.

The secret of molecular promiscuity

EMBLetc Promiscuity is critical for nourishment. How? This question lies at the focus of research by the Löw Group at EMBL Hamburg. Using structural biology methods, they explore how specialised molecules located in the cell membrane allow cells absorb nutrients from their environment.

2023

17 October 2023 Pill icons representing different antibiotic classes are seen exerting their effects on a bacterium, whose cell wall, membrane, and protein synthesis machinery (two different classes) can be seen as potential targets. Curved lines connect the pills to each other, representing synergies in drug interactions. More bacteria can be seen in the background.

Fighting antimicrobial resistance with new drug combinations

Science & Technology In an extensive investigation, EMBL researchers have tested over 10,000 drug combinations against some of the leading pathogenic bacteria carrying antimicrobial resistance and causing mortality. 

2023

sciencescience-technology

8 December 2021 An illustration of the human gut, with coloured shapes representing bacteria. Three different drugs and drug combinations are shown affecting the bacteria, represented by changes in colour

The impact of drugs on gut microbes is greater than we thought

Science & Technology Researchers studying a massive cohort of European patients have found that commonly prescribed drugs for cardiometabolic disorders can have long-term effects on the gut microbiome. Such effects can complicate the understanding of how disease affects the microbiome and must be taken into…

2021

sciencescience-technology

8 September 2021 Illustration of two halves of a pill, which releases chemical molecules that are taken up by gut bacteria in the vicinity.

Common medications accumulate in gut bacteria

Science & Technology A new collaborative study led by EMBL group leaders Kiran Patil, Nassos Typas, and Peer Bork has found that common medications accumulate in human gut bacteria. This process reduces drug effectiveness and affects the metabolism of common gut microbes, thereby altering the gut microbiome.

2021

sciencescience-technology

9 February 2021 An artistic representation of how bioinformatics allows study of the SARS-CoV-2 infection process. On the left, coronaviruses are approaching a human face contour. On the right, protein structures and a network of connections represent bioinformatic analysis.

Protein sequences provide clues to how SARS-CoV-2 infects cells

Science & Technology Researchers at EMBL Heidelberg have identified sequences in human proteins that might be used by SARS-CoV-2 to infect cells. They have discovered that the virus might hijack certain cellular processes, and they discuss potentially relevant drugs for treating COVID-19.

2021

sciencescience-technology

29 September 2020 A metal rack holding glass test tubes with yellow and red solutions in them.

Colourful test tubes

Science & Technology To study the effect of commonly used drugs on bacterial envelopes, EMBL scientists applied a biochemical assay using a colour reaction. The deeper the red, the stronger the disruptive effect of the drug.

2020

picture-of-the-weekscience-technology

8 September 2020

Fighting cardiovascular disease with acne drug

Science & Technology Researchers have found the cause of dilated cardiomyopathy – a leading cause of heart failure – and identified a potential treatment for it: a drug already used to treat acne.

2020

sciencescience-technology

1 July 2020 New Informatics Science Director at Open Targets, Ellie McDonagh

Welcome: Ellie McDonagh

Lab MattersPeople & Perspectives Open Targets welcomes new Informatics Science Director

2020

lab-matterspeople-perspectives

22 January 2020

Antibody engineering for therapy and diagnosis

Lab MattersScience & Technology The new EMBL spinoff company Araxa Biosciences GmbH aims to set new standards for the development of antibody-based therapeutics and diagnostics

2020

lab-mattersscience-technology

11 March 2019 A visualisation of a membraneless organelle in the green-yellow style of the data presented in the Nature Communications paper

ATP affects proteome-wide solubility

Science & Technology Scientists develop technology to measure how ATP concentration affects protein solubility in cells

2019

sciencescience-technology

19 March 2018 Commonly used drugs affect our gut bacteria.

Commonly used drugs affect our gut bacteria

Science & Technology One in four drugs with human targets inhibit the growth of bacteria in the human gut, and may promote antibiotic resistance, EMBL researchers report in Nature

2018

sciencescience-technology

11 August 2013

From fireman to arsonist

Science & Technology Like a fireman who becomes an arsonist, a protein that prevents cells becoming cancerous can also cause tumours, scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have discovered. The finding, published today in Nature Structural and Molecular Biology, stems…

2013

sciencescience-technology

21 June 2012

Flu fighters

Science & Technology Savira pharmaceuticals GmbH, a spin-off of the European Molecular Biology Laboratory (EMBL) based in Vienna, Austria, has signed a collaboration and license agreement with Roche, thus further strengthening the links between fundamental research and major pharmaceutical development companies. This…

2012

sciencescience-technology

11 July 2008

Teaching old drugs new tricks

Science & Technology Researchers from the European Molecular Biology Laboratory (EMBL) discovered a new way to make use of drugs’ unwanted side effects. They developed a computational method that compares how similar the side effects of different drugs are and predicts how likely the drugs act on the same target…

2008

sciencescience-technology

11 February 2007

Putting an old drug to a new use

Science & Technology We all know that iron deficiencies are dangerous, but also too much iron is bad for our health. Our body stores excess iron in various tissues, where it can lead to organ failure and even death if not treated before irreversible damage has occurred. Researchers from the Innsbruck Medical…

2007

sciencescience-technology

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