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drug discovery

Year
1 August 2024 Open Targets logo

Why clinical trials stop: the role of genetics

Science & Technology Using machine learning to analyse the genetic factors behind early clinical trial termination, researchers find a link between genetic evidence and trial outcome.

2024

research-highlightsscience-technology

2 July 2024

IIT-EMBL: New molecules to modulate gene expression

Science & Technology A new research paper published in Nature Communications lays the groundwork for the development of new drugs specific to genetic mutations or alterations responsible for the onset of tumours or genetic diseases.

2024

science-technology

12 June 2024

AI approaches in structural biology and drug discovery

Connections EMBL Grenoble and the ESRF hosted a workshop bringing together representatives from research and industry to discuss the ever-growing role of artificial intelligence in the field of structural biology.

2024

connections

30 April 2024 Open Targets logo

MSD joins the Open Targets consortium

EMBL Announcements MSD joins as the latest partner in the Open Targets consortium, enhancing the initiative’s collaborative efforts in drug discovery.

2024

announcementsembl-announcements

21 September 2023

Understanding the mechanisms of enzyme catalysis

Science & Technology Enzymes constitute a large fraction of genomes – 20% in humans – which makes them a very important part of life. Despite decades of studies and a rich literature dedicated to understanding the reaction mechanisms of enzymes, the rules of enzyme catalysis are still not fully clear. A new…

2023

science-technologytechnology-and-innovation

21 September 2023 Man standing outside

Welcome: David Hulcoop

Lab MattersPeople & Perspectives David Hulcoop discusses how his experience bridging organisational cultures will help address critical challenges in drug discovery and target selection at Open Targets.

2023

announcementslab-matterspeople-perspectives

5 July 2023 Man standing in corridor

David Hulcoop appointed as Open Targets Director

EMBL Announcements Coming from a pharmaceutical industry background, David Hulcoop is set to take over as Executive Director of the public-private partnership Open Targets.

2023

announcementsembl-announcements

16 February 2023

New EU-funded Project: Fragment-Screen

Lab MattersScience & Technology EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.

2023

lab-mattersscience-technology

10 February 2022 Pfizer logo with pipette tips in the background

Pfizer joins the Open Targets consortium

Connections Open Targets, a consortium focused on drug target identification, prioritisation, and validation, announced today that Pfizer has joined as a partner.

2022

announcementsconnectionsscience

7 October 2021 SARS-CoV-2 and planet Earth are merged together in this illustration

Six Ways to Protect the Planet Against Pandemics*

Science & Technology EMBL will host a conference to look at the state of the pandemic, lessons learned, and ways to improve pandemic preparedness. Here’s a sneak peek into what promises to be another interesting and informative EMBL conference.

2021

eventsscience-technology

15 October 2020 Four blue circular objects are surrounded with green structures, and the central blue circle with pink structures. The blue circles are human cell nuclei, and pink and green structures are proteins.

Repurposing drugs for a pan-coronavirus treatment

Science & Technology Scientists from the Beltrao Group at EMBL-EBI and collaborators identified drug targets common to SARS-CoV-2, SARS-CoV-1, and MERS-CoV, three pathogenic coronaviruses. They also found potential drugs that could be repurposed as COVID-19 treatments, and against emerging coronavirus strains in the…

2020

sciencescience-technology

8 July 2020 Artwort illustrating various aspects of infection research. The centre of the image shows a cartoon representation of a coronavirus. The spheric shape has been overlaid with a map of the world to illustrate the global spread of viruses. The edges of the artwork feature images of potential virus hosts (bats, poultry, dromedary), a group of humans, a microscope, pills, a syringe and vaccine vial, protein structures, and an illustration of a human lung. The background is set in yellow and red colour.

What COVID-19 is teaching us

Science & Technology The virtual EMBL Conference ‘SARS-CoV-2: Towards a New Era in Infection Research’ explored the importance of fundamental research, collaboration, and data science in containing the SARS-CoV-2 pandemic, and discussed opportunities to improve our response to pandemics in the future.

2020

eventsscience-technology

1 July 2020 New Informatics Science Director at Open Targets, Ellie McDonagh

Welcome: Ellie McDonagh

Lab MattersPeople & Perspectives Open Targets welcomes new Informatics Science Director

2020

lab-matterspeople-perspectives

29 April 2020 The Influenza virus

Understanding the influenza virus

Science & Technology The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…

2020

sciencescience-technology

17 June 2019 A photo of the Hamburg harbour at dusk

EMBL and Tara: Hamburg

EMBL Announcements EMBL Hamburg and Tara raise awareness of the risks of microplastic pollution and global infection

2019

embl-announcementsevents

30 October 2018 Sanofi logo on blue background

Sanofi joins Open Targets

ConnectionsLab Matters Pharmaceutical company Sanofi strengthens drug targets discovery collaboration Open Targets

2018

connectionslab-matters

4 May 2018 Celgene logo on white background

Celgene joins Open Targets

ConnectionsLab Matters New partner strengthens drug discovery collaboration

2018

connectionslab-matters

20 December 2017 In this representation of influenza polymerase, a molecule (white) that strongly inhibits the enzyme’s activity is shown bound to the region of the enzyme (red) that usually binds the cap section of mRNA. IMAGE: EMBL/Cusack Group

Futures: Unravelling influenza

Science & Technology ERC grantee Stephen Cusack shares his vision for the next ten years

2017

sciencescience-technology

29 September 2017 Photo of Andrew Leach, Head of Chemical Biology data services at EMBL-EBI

Welcome, Andrew Leach

People & Perspectives Q&A with EMBL-EBI's Head of Chemical Biology data services

2017

people-perspectivesscience

3 May 2017

Futures: Phosphatases

Science & Technology ERC grantee Maja Köhn shares her vision for the next ten years

2017

sciencescience-technology

8 February 2016 Biogen joins the CTTV

Biogen joins CTTV

ConnectionsLab Matters Pioneering target validation collaboration expands to accelerate drug discovery research.

2016

connectionslab-matters

4 February 2013

Learning from the linker

Science & Technology Mature cells can be reprogrammed to pluripotency and thus regain the ability to divide and differentiate into specialized cell types. Although these so-called induced pluripotent stem cells (iPS cells) represent a milestone in stem cell research, many of the biochemical processes that underlie…

2013

sciencescience-technology

18 January 2010

Open access drug discovery database launches with half a million compounds

Science & Technology ChEMBLdb, a vast online database of information on the properties and activities of drugs and drug-like small molecules and their targets, launches today with information on over half a million compounds. The data lie at the heart of translating information from the human genome into successful new…

2010

sciencescience-technology

23 July 2008

Open access to large-scale drug discovery data

Lab Matters The Wellcome Trust has awarded £4.7 million (€5.8 million) to EMBL’s European Bioinformatics Institute (EMBL-EBI) to support the transfer of a large collection of information on the properties and activities of drugs and a large set of drug-like small molecules from the publicly listed…

2008

lab-matters

9 August 2006

EMBL scientists found start-up company to develop anti-cancer drugs

Lab MattersScience & Technology Today EMBL scientists, EMBL’s commercial affiliate, EMBL Enterprise Management Technology Transfer GmbH (EMBLEM) and EMBL’s venture vehicle, EMBL Ventures GmbH, announce the foundation of Elara Pharmaceuticals GmbH, a start-up company that will translate basic research findings into new…

2006

lab-mattersscience-technology

29 May 2006

New potential drug target in tuberculosis

Science & Technology Tuberculosis remains one of the deadliest threats to public health. Every year two million people die of the disease, which is caused by the microorganism Mycobacterium tuberculosis. Roughly one third of the world’s population is infected and more and more bacterial strains have developed…

2006

sciencescience-technology

16 February 2006

Waking a sleeping virus

Science & Technology A detailed structural picture of a molecule that plays a key role in activating the Epstein Barr Virus in human cells has now been obtained by researchers at the European Molecular Biology Laboratory (EMBL) and the Institut de Virologie Moléculaire et Structurale (IVMS), associated with the…

2006

sciencescience-technology

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