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embryonic development

Year
18 June 2024 A progression of three images against a blue/purple background. Each image shows a simulated mouse embryo inner cell mass with two types of cells marked in pink and green respectively. From the first to the third image, the pink cells slowly move from the outer edge to the inside of the mass.

Minecraft-ing our way into studying cell sorting

Science & Technology A theoretical model involving tiny Minecraft-like cubes can help us understand dynamic biological processes, such as cell sorting in embryos.

2024

science-technology

1 May 2024 Alt Text: An artistic representation of gut microbes and sperm cells

Father’s gut microbes affect the next generation

Science & Technology Scientists from EMBL Rome and EMBL Heidelberg found that disrupting the gut microbiome of male mice increases the risk of disease in their offspring. Their findings suggest that a father’s pre-conception environment can have lifelong effects on offspring.

2024

science-technology

11 March 2024 Casting new light on gene regulation in development

Casting new light on gene regulation in development

Science & Technology New research from EMBL Heidelberg shows how cells in developing embryos undergo a major shift in the way they regulate gene expression as they mature and differentiate.

2024

sciencescience-technology

15 November 2023

Why time is of the essence in development

EMBLetc EMBL developmental biologists – with help from other disciplines – pursue the significance of time, timing, and transitions in organisms during their development

2023

4 August 2022 An illustration provides representation of fingers hovering over a cell phone

Zooming in to get the full picture

Science & Technology EMBL and UW researchers plus additional collaborators have constructed a complete map of fruit fly embryonic development using machine learning. This research is foundational to better understanding overall embryo development in other species, including humans.

2022

sciencescience-technology

28 April 2022 Microsocopy image of Pair of somites. Blue is a nuclear marker (DAPI) and red is an apical marker (ZO-1).

Unravelling the origins of the human spine

Science & Technology Scientists at EMBL Barcelona have created for the first time a 3D in vitro model that recapitulates the periodic formation of human somites – structures that give rise to the spinal column.

2022

sciencescience-technology

8 April 2022 a metaphor for the process of epigenetic inheritance

A metaphor for epigenetic inheritance

Science & Technology Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration

2022

sciencescience-technology

4 March 2022 A gloved hand holds a slide with visible wells containing Matrigel immersed in culture medium. A magnified close-up shows a mouse embryo developing over the course of 48 hours

A 3D culture model to study embryo growth

Science & Technology A recent study by EMBL researchers proposes a new method to grow early embryos in the laboratory. With a 3D culture set-up, scientists can closely monitor the changes embryos undergo around the time of implantation.

2022

sciencescience-technology

25 February 2022 Three colourful overlapping circles arranged in a row, a fruit-fly embryo being visible within each. Small circles within the embryos represent cell lineages.

Converging lenses on embryo development

Science & Technology Researchers from the Furlong group at EMBL have come up with a way to observe the development of fruit-fly embryos simultaneously at the genetic and cellular levels, generating a high-resolution and integrated view of how different cell lineages form.

2022

sciencescience-technology

23 February 2022 A male scientist in a white shirt stands at a walkway railing.

Welcome: Michael Dorrity

Lab MattersPeople & Perspectives Michael Dorrity, one of EMBL’s newest group leaders, is studying how the environment influences early life stages in zebrafish.

2022

lab-matterspeople-perspectives

6 September 2021 Cells organised according to their transcript data changing to the seqFISH mouse embryo map.

The Spatial Mouse Atlas: new insights into cell fate

Science & Technology Researchers have combined spatial gene expression information with single-cell genomics data to create a high-resolution atlas of mouse organogenesis.

2021

sciencescience-technology

30 March 2021 Ana Boskovic sitting in her office

Welcome: Ana Boskovic

Lab MattersPeople & Perspectives The new group leader at EMBL Rome will study how embryos can inherit non-genetic information from their parents that causes stable and heritable effects

2021

lab-matterspeople-perspectives

27 January 2021 Nicoletta Petridou looks towards the camera smiling, whilst standing in a science laboratory

Welcome: Nicoletta Petridou

Lab MattersPeople & Perspectives New group leader Nicoletta Petridou explains her fascination with the complexity of early embryo development, and how the interdisciplinary nature of EMBL will aid her research.

2021

lab-matterspeople-perspectives

18 September 2020 Composite image of mouse cells and human cells showing different levels of luminescence, indicated as different colours.

Human and mouse cells run at different speeds

Science & Technology The internal clock that governs the development of embryos ticks slower for humans than for mice. Differences in the speed of biochemical reactions underlie the differences between species in the tempo of development.

2020

sciencescience-technology

20 April 2020 A 4D visualisation of single-cell expression patterns. Credit: Hanna Sladitschek/EMBL

Unprecedented single-cell studies in virtual embryo

Science & Technology Researchers from EMBL Heidelberg have created a complete description of early embryo development, accounting for every single cell in the embryo.

2020

sciencescience-technology

9 April 2020 3D reconstruction of parental chromosomes in the mouse embryo

How chromosome structure influences development

Science & Technology EMBL researchers in the Heard group at EMBL Heidelberg explore the interaction between DNA organisation and gene expression in the early embryo

2020

sciencescience-technology

25 February 2020

Accidental beauty

Science & Technology In the Trivedi Group at EMBL Barcelona, Krisztina Arató and Jia Le Lim study the early development of zebrafish embryos.

2020

picture-of-the-weekscience-technology

15 November 2018 Top view picture of modified and natural invagination in a tissue

Controlling organ growth with light

Science & Technology The De Renzis group investigated invagination, the first step of organ development in embryos.

2018

sciencescience-technology

20 March 2018 A heatmap graph displaying high (red) or low (blue) levels of gene expressions in different cells.

From blood vessels to blood stem cells

Science & Technology EMBL scientists discover how blood vessel cells become blood stem cells during embryonic development

2018

sciencescience-technology

28 February 2013

DNA’s twisted communication

Science & Technology During embryo development, genes are dynamically, and very precisely, switched on and off to confer different properties to different cells and build a well-proportioned and healthy animal. Fgf8 is one of the key genes in this process, controlling in particular the growth of the limbs and…

2013

sciencescience-technology

2 February 2012 Fruit fly embryo showing the cells that will become the gut and heart

Collective action

Science & Technology If you wanted to draw your family tree, you could start by searching for people who share your surname. Cells, of course, don’t have surnames, but scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found that genetic switches called enhancers, and the…

2012

sciencescience-technology

25 June 2009 The microscope image of the dorsal closure of a fly embryo shows alternating stripes of epithelial cells with aligned microtubule bundles (green) and epithelial cells treated with a microtubule-destroying drug (blue). Labelled in red is the protein actin that lines the border of cells, particularly the amnioserosa cells occupying the eye-shaped opening.

Uncovering how cells cover gaps

Science & Technology Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, came a step closer to understanding how cells close gaps not only during embryonic development but also during wound healing. Their study, published this week in the journal Cell, uncovers a fundamental…

2009

sciencescience-technology

15 September 2007

A molecule that protects from neuronal disorders

Science & Technology Many neuronal disorders, including epilepsy, schizophrenia and lissencephaly ─ a form of mental retardation ─ result from abnormal migration of nerve cells during the development of the brain. Researchers from the Mouse Biology Unit of the European Molecular Biology Laboratory (EMBL) in Italy,…

2007

sciencescience-technology

25 August 2006

A wandering eye

Science & Technology Eyes are among the earliest recognisable structures in an embryo; they start off as bulges on the sides of tube-shaped tissue that will eventually become the brain. Researchers from the European Molecular Biology Laboratory (EMBL) in Heidelberg have now discovered that cells are programmed to make…

2006

sciencescience-technology

25 August 2006

A switch between life and death

Science & Technology Cells in an embryo divide at an amazing rate to build a whole body, but this growth needs to be controlled. Otherwise the result may be defects in embryonic development or cancer in adults. Controlling growth requires that some cells divide while others die; their fates are determined by signals…

2006

sciencescience-technology

25 January 2005

How do cells travel through our bodies?

Science & Technology One of the most basic yet least understood processes in our bodies is how cells crawl along tissues. This behavior is essential to the formation of an embryo and other processes, but it must be tightly controlled. A disturbance can lead to the spread of cancer cells or diseases like Spina…

2005

sciencescience-technology

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