Edit

enhancer

Year

20 February 2023 DNA is shown as green strands wrapped around histones represented as green spheres. Transcription factors (lilac spheres) are shown binding to DNA locations with our without methyl groups (white spheres). The background contains a heat map from the paper.

DNA is shown as green strands wrapped around histones represented as green spheres. Transcription factors (lilac spheres) are shown binding to DNA locations with our without methyl groups (white spheres). The background contains a heat map from the paper.

Studying epigenetic regulation at the single-molecule level

In a first-of-its-kind study, EMBL researchers have shown how DNA methylation across the genome contributes to the precise regulation of gene expression.

2023

science

8 February 2023 The inset shows a fruit fly perched upon a surface. In the background, the photograph of a lab smoothly transitions to the photograph of a garden with fruits fallen on the ground.

The inset shows a fruit fly perched upon a surface. In the background, the photograph of a lab smoothly transitions to the photograph of a garden with fruits fallen on the ground.

New evolutionary insights from stepping outside the lab

EMBL researchers are stepping outside the lab and thinking outside the box to understand the basic principles that underlie the development and evolution of organismal characteristics.

2023

science

14 October 2020

Seeing evolution happening before your eyes

Science & Technology Researchers from EMBL Heidelberg have established an automated pipeline to create mutations in genomic enhancers, letting them watch evolution unfold before their eyes.

2020

sciencescience-technology

15 July 2019

The pyramids represent chromatin domains in the wild-type situation. The reflection in the water below represents the rearrangements in the mutant fruit fly chromosomes. At first glance the (regulatory) landscapes look very similar, but there are lots of changes to the topology, and yet these have little impact on the nature of the landscape (gene expression). IMAGE: Beata Edyta Mierzwa in collaboration with EMBL.

Rearranging chromosomes

Science & Technology Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.

2019

sciencescience-technology

30 January 2018 Enhancer activity (green) and promoter activity (purple) in the same regulatory element. IMAGE: EMBL / Eileen Furlong