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11 March 2024 Casting new light on gene regulation in development

Casting new light on gene regulation in development

Science & Technology New research from EMBL Heidelberg shows how cells in developing embryos undergo a major shift in the way they regulate gene expression as they mature and differentiate.

2024

sciencescience-technology

4 August 2022 An illustration provides representation of fingers hovering over a cell phone

Zooming in to get the full picture

Science & Technology EMBL and UW researchers plus additional collaborators have constructed a complete map of fruit fly embryonic development using machine learning. This research is foundational to better understanding overall embryo development in other species, including humans.

2022

sciencescience-technology

10 May 2022

Royal Society honour for Eileen Furlong

EMBL AnnouncementsLab Matters EMBL’s Head of Genome Biology announced as Fellow of the Royal Society for her exceptional contributions to science.

2022

embl-announcementslab-matters

25 February 2022 Three colourful overlapping circles arranged in a row, a fruit-fly embryo being visible within each. Small circles within the embryos represent cell lineages.

Converging lenses on embryo development

Science & Technology Researchers from the Furlong group at EMBL have come up with a way to observe the development of fruit-fly embryos simultaneously at the genetic and cellular levels, generating a high-resolution and integrated view of how different cell lineages form.

2022

sciencescience-technology

9 December 2021 Portrait photo of Eileen Furlong against blue-green background.

Eileen Furlong honoured with Leibniz Prize

EMBL AnnouncementsLab Matters EMBL Senior Scientist and Head of the Genome Biology Unit is among the researchers honoured for outstanding work by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG).

2021

embl-announcementslab-matters

19 August 2020 An embryo of the fruit fly Drosophila.

Predicting how gene expression varies

Science & Technology Discoveries at EMBL will help researchers to interpret one of the most common types of experiments in genomics and medical studies.

2020

sciencescience-technology

15 July 2019 The pyramids represent chromatin domains in the wild-type situation. The reflection in the water below represents the rearrangements in the mutant fruit fly chromosomes. At first glance the (regulatory) landscapes look very similar, but there are lots of changes to the topology, and yet these have little impact on the nature of the landscape (gene expression). IMAGE: Beata Edyta Mierzwa in collaboration with EMBL.

Rearranging chromosomes

Science & Technology Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.

2019

sciencescience-technology

13 March 2017

Futures: Genome regulation

Science & Technology ERC grantee Eileen Furlong shares her vision for the next ten years

2017

sciencescience-technology

13 February 2017

Genetic switches can change shape

Science & Technology EMBL scientists discovered that common mutations can change the shape of gene promoters

2017

sciencescience-technology

2 February 2012 Fruit fly embryo showing the cells that will become the gut and heart

Collective action

Science & Technology If you wanted to draw your family tree, you could start by searching for people who share your surname. Cells, of course, don’t have surnames, but scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found that genetic switches called enhancers, and the…

2012

sciencescience-technology

8 January 2012 Diagram of chromatin enhancers

Tracking genes’ remote controls

Science & Technology As an embryo develops, different genes are turned on in different cells, to form muscles, neurons and other bodily parts. Inside each cell’s nucleus, genetic sequences known as enhancers act like remote controls, switching genes on and off. Scientists at the European Molecular Biology Laboratory…

2012

sciencescience-technology

4 November 2009 fluorescence microscopy images of fruit fly embryos

Deciphering the regulatory code

Science & Technology Embryonic development is like a well-organised building project, with the embryo’s DNA serving as the blueprint from which all construction details are derived. Cells carry out different functions according to a developmental plan, by expressing, i.e. turning on, different combinations of genes.…

2009

sciencescience-technology

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