Welcome: Christina Ernst
EMBL-EBI's new Functional Genomics Team Leader will develop standards for new data types and integrate AI into workflows.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Sea anemone study shows how animals stay ‘in shape’
Scientists have shown how regenerating sea anemones restore their shape following a major injury, uncovering novel cellular and molecular mechanisms.
SCIENCE & TECHNOLOGY2024
science-technology
Single Cell Expression Atlas 21 released
New datasets The release has 381 single-cell RNA-Seq experiments, consisting of more than 13.5 million cells from 21 different species to explore in the Single Cell Expression Atlas (SCEA). The resource now includes an entirely new class of data – externally analysed data, marked with an…
2024
updates-from-data-resources
Alvis Brazma: What I’ve learned
EMBL-EBI alumnus Alvis Brazma reflects on how mathematics and mountaineering have shaped his life and why keeping things simple in bioinformatics is key.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
IIT-EMBL: New molecules to modulate gene expression
A new research paper published in Nature Communications lays the groundwork for the development of new drugs specific to genetic mutations or alterations responsible for the onset of tumours or genetic diseases.
SCIENCE & TECHNOLOGY2024
science-technology
Expression Atlas 40 released
The latest Expression Atlas 40 release is now live, containing new RNA-seq datasets, including a featured experiment resulting from a collaboration with Genotype Tissue Expression (GTEx) project as well as new proteomics data derived from our collaboration with PRIDE. In total, this release…
2024
updates-from-data-resources
Building the cell’s splicing machine
New study from the Galej group provides deeper structural insight into the assembly of a critical molecular machine, that removes non-coding information from genes during their expression.
SCIENCE & TECHNOLOGY2024
science-technology
Casting new light on gene regulation in development
New research from EMBL Heidelberg shows how cells in developing embryos undergo a major shift in the way they regulate gene expression as they mature and differentiate.
SCIENCE & TECHNOLOGY2024
sciencescience-technology
ERC Consolidator Grants awarded to two EMBL researchers
Alba Diz-Muñoz and Arnaud Krebs from EMBL Heidelberg have received grants to work on projects that aim, respectively, to understand the cellular mechanics that control cell division and investigate the regulatory networks that govern transcription factor function.
EMBL ANNOUNCEMENTSLAB MATTERS2023
embl-announcementslab-matters
New therapies to improve cardiovascular health
EMBL researchers have made new strides into understanding and reversing genetic defects that underlie familial heart disease.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Latest release of the Expression Atlas
The latest Expression Atlas release is now live and contains a wider range of RNA-seq and proteomics datasets.
2023
updates-from-data-resources
The power of cell sorting: understanding heart disease, phase separation, plankton, and more
EMBL researchers use a new cell sorting technology to gain new insights into cellular function in health and disease, as well as for other innovative applications.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
ProtVar: understanding missense variation in humans
A new tool for the interpretation of missense variation in humans – ProtVar – will help enable drug discovery.
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
Solving the structure of a critical molecular editor
EMBL Grenoble scientists provide new insights into the function of an essential RNA editing enzyme.
2023
science
ArrayExpress interface now retired
Data continues to be available in BioStudies.
2022
updates-from-data-resources
Zooming in to get the full picture
EMBL and UW researchers plus additional collaborators have constructed a complete map of fruit fly embryonic development using machine learning. This research is foundational to better understanding overall embryo development in other species, including humans.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Understanding genomes, piece by piece
Genomes are made up of thousands of individual pieces – genes – which are expressed at different levels. Researchers at EMBL have shed light on how the placement of a gene affects its expression, as well as that of its neighbours.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Converging lenses on embryo development
Researchers from the Furlong group at EMBL have come up with a way to observe the development of fruit-fly embryos simultaneously at the genetic and cellular levels, generating a high-resolution and integrated view of how different cell lineages form.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
New Expression Atlas release in collaboration with PRIDE
New Expression Atlas release features differential-proteomics and baseline-proteomics experiments in collaboration with the PRIDE team at EMBL-EBI. This also includes new baseline DIA proteomics experiments as well as new differential proteomics datasets. To improve reproducibility,…
2022
updates-from-data-resources
Cell sorting enters a new dimension
EMBL researchers, in collaboration with BD Biosciences, have demonstrated a new technology that allows rapid image-based sorting of cells. The new technology represents a major upgrade to flow cytometry and has applications in diverse life science fields.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Capturing ‘snapshots’ of a crucial step in RNA splicing
The Galej group at EMBL Grenoble has recently obtained high resolution snapshots of a crucial step in RNA splicing involving the U2 snRNP complex, a crucial component of the human spliceosome.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Can data help feed a hungry world?
How genomics, open data, and multidisciplinary science can improve food security.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
A cellular atlas of an entire worm
EMBL scientists and colleagues have developed an interactive atlas of the entire marine worm Platynereis dumerilii in its larval stage. The PlatyBrowser resource combines high-resolution gene expression data with volume electron microscopy images.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Induced pluripotent stem cells reveal causes of disease
Scientists in the Stegle group and colleagues have studied induced pluripotent stem cells from around 1,000 donors to identify correlations between individual genetic variants and altered gene expression. They linked more than 4,000 of the genetic variants responsible for altered expression…
SCIENCE & TECHNOLOGY2021
sciencescience-technology
At the core of the Integrator complex
A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Predicting how gene expression varies
Discoveries at EMBL will help researchers to interpret one of the most common types of experiments in genomics and medical studies.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Muscular worm larva
The image shows a larva of Platynereis dumerilii, a marine worm. The image here was produced by Constantin Pape, a visiting predoctoral fellow in the Kreshuk group at EMBL Heidelberg.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Enabling functional genomics studies in individual cells
Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
How chromosome structure influences development
EMBL researchers in the Heard group at EMBL Heidelberg explore the interaction between DNA organisation and gene expression in the early embryo
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Tissue dynamics provide clues to human disease
EMBL scientists examine the molecular causes of a rare hereditary disease of the spine and ribs
SCIENCE & TECHNOLOGY2020
sciencescience-technology
New insights into gene regulation
EMBL researchers investigate the role of a histone protein in regulating gene expression
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Transcriptional hubs confer phenotypic robustness
Enhancers in Drosophila embryos gather together to preserve phenotypes under stressful conditions
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Rearranging chromosomes
Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
The scientific origins of Edith Heard
EMBL’s next Director General reflects on the questions that drive her research
PEOPLE & PERSPECTIVES2018
people-perspectivesscience
Welcome: Arnaud Krebs
EMBL’s new group leader studies how gene expression is controlled
PEOPLE & PERSPECTIVES2018
people-perspectivesscience
Multipurpose enhancers and promoters in embryonic development
EMBL scientists show that some promoters can act as enhancers and vice versa
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Solving the nucleosome: twenty years on
Tim Richmond looks back on the work that revealed the high-resolution structure of the nucleosome
SCIENCE & TECHNOLOGY2017
eventsscience-technology
Mapping gene expression, cell by cell
EMBL researchers complete a molecular atlas showing gene expression in all cells in an entire animal
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Senses: Silencing noise
Two EMBL researchers are exploring new ways to filter out noise and get to the data they need
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Futures: Genome regulation
ERC grantee Eileen Furlong shares her vision for the next ten years
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Genetics of ‘room-mate’ influences health
Healing and anxiety are influenced by the genetics of one’s social partners
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Welcome: Wojciech Galej
New group leader Wojciech Galej investigates RNA-protein complexes involved in gene expression
PEOPLE & PERSPECTIVES2017
people-perspectivesscience
Chromatin cartographer
EMBL alumnus Jop Kind reflects on the questions that led him to this year’s John Kendrew Award
PEOPLE & PERSPECTIVES2016
alumnipeople-perspectives
Unpacking embryonic pluripotency
Embryology, genomics and bioinformatics combine to identify factors regulating mammalian pluripotency.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
A snapshot of stem cell expression
Study of mouse embryonic stem cells reveals new genes involved in the stem-cell regulatory network.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Towards an expression atlas for an entire brain
New single-cell genomics techniques bring ‘omics to evolution and development research.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Tracking genes’ remote controls
As an embryo develops, different genes are turned on in different cells, to form muscles, neurons and other bodily parts. Inside each cell’s nucleus, genetic sequences known as enhancers act like remote controls, switching genes on and off. Scientists at the European Molecular Biology Laboratory…
SCIENCE & TECHNOLOGY2012
sciencescience-technology
Deciphering the regulatory code
Embryonic development is like a well-organised building project, with the embryo’s DNA serving as the blueprint from which all construction details are derived. Cells carry out different functions according to a developmental plan, by expressing, i.e. turning on, different combinations of genes.…
SCIENCE & TECHNOLOGY2009
sciencescience-technology
Sugarcoating fruit fly development
Proteins are the executive agents that carry out all processes in a cell. Their activity is controlled and modified with the help of small chemical tags that can be dynamically added to and removed from the protein. 25 years after its first discovery, researchers at the European Molecular Biology…
SCIENCE & TECHNOLOGY2009
sciencescience-technology
New revelations in epigenetic control shed light on breast cancer
Epigenetic regulation – modifications to the structure of chromatin that influence which genes are expressed in a cell – is a key player in embryonic development and cancer formation. Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg now gained new insight…
SCIENCE & TECHNOLOGY2008
sciencescience-technology
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