New datasets The release has 381 single-cell RNA-Seq experiments, consisting of more than 13.5 million cells from 21 different species to explore in the Single Cell Expression Atlas (SCEA). The resource now includes an entirely new class of data – externally analysed data, marked with an…
2024
updates-from-data-resources
People & Perspectives EMBL-EBI alumnus Alvis Brazma reflects on how mathematics and mountaineering have shaped his life and why keeping things simple in bioinformatics is key.
2024
people-perspectivesperspectives
Science & Technology A new research paper published in Nature Communications lays the groundwork for the development of new drugs specific to genetic mutations or alterations responsible for the onset of tumours or genetic diseases.
2024
science-technology
The latest Expression Atlas 40 release is now live, containing new RNA-seq datasets, including a featured experiment resulting from a collaboration with Genotype Tissue Expression (GTEx) project as well as new proteomics data derived from our collaboration with PRIDE. In total, this release…
2024
updates-from-data-resources
Science & Technology New study from the Galej group provides deeper structural insight into the assembly of a critical molecular machine, that removes non-coding information from genes during their expression.
2024
science-technology
Science & Technology New research from EMBL Heidelberg shows how cells in developing embryos undergo a major shift in the way they regulate gene expression as they mature and differentiate.
2024
sciencescience-technology
EMBL AnnouncementsLab Matters Alba Diz-Muñoz and Arnaud Krebs from EMBL Heidelberg have received grants to work on projects that aim, respectively, to understand the cellular mechanics that control cell division and investigate the regulatory networks that govern transcription factor function.
2023
embl-announcementslab-matters
Science & Technology EMBL researchers have made new strides into understanding and reversing genetic defects that underlie familial heart disease.
2023
sciencescience-technology
The latest Expression Atlas release is now live and contains a wider range of RNA-seq and proteomics datasets.
2023
updates-from-data-resources
Science & Technology EMBL researchers use a new cell sorting technology to gain new insights into cellular function in health and disease, as well as for other innovative applications.
2023
sciencescience-technology
Science & Technology A new tool for the interpretation of missense variation in humans – ProtVar – will help enable drug discovery.
2023
sciencescience-technologytechnology-and-innovation
EMBL Grenoble scientists provide new insights into the function of an essential RNA editing enzyme.
2023
science
Data continues to be available in BioStudies.
2022
updates-from-data-resources
Science & Technology EMBL and UW researchers plus additional collaborators have constructed a complete map of fruit fly embryonic development using machine learning. This research is foundational to better understanding overall embryo development in other species, including humans.
2022
sciencescience-technology
Science & Technology Genomes are made up of thousands of individual pieces – genes – which are expressed at different levels. Researchers at EMBL have shed light on how the placement of a gene affects its expression, as well as that of its neighbours.
2022
sciencescience-technology
Science & Technology Researchers from the Furlong group at EMBL have come up with a way to observe the development of fruit-fly embryos simultaneously at the genetic and cellular levels, generating a high-resolution and integrated view of how different cell lineages form.
2022
sciencescience-technology
New Expression Atlas release features differential-proteomics and baseline-proteomics experiments in collaboration with the PRIDE team at EMBL-EBI. This also includes new baseline DIA proteomics experiments as well as new differential proteomics datasets. To improve reproducibility,…
2022
updates-from-data-resources
Science & Technology EMBL researchers, in collaboration with BD Biosciences, have demonstrated a new technology that allows rapid image-based sorting of cells. The new technology represents a major upgrade to flow cytometry and has applications in diverse life science fields.
2022
sciencescience-technology
Science & Technology The Galej group at EMBL Grenoble has recently obtained high resolution snapshots of a crucial step in RNA splicing involving the U2 snRNP complex, a crucial component of the human spliceosome.
2022
sciencescience-technology
Science & Technology How genomics, open data, and multidisciplinary science can improve food security.
2021
sciencescience-technology
Science & Technology EMBL scientists and colleagues have developed an interactive atlas of the entire marine worm Platynereis dumerilii in its larval stage. The PlatyBrowser resource combines high-resolution gene expression data with volume electron microscopy images.
2021
sciencescience-technology
Science & Technology Scientists in the Stegle group and colleagues have studied induced pluripotent stem cells from around 1,000 donors to identify correlations between individual genetic variants and altered gene expression. They linked more than 4,000 of the genetic variants responsible for altered expression…
2021
sciencescience-technology
Science & Technology A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.
2021
sciencescience-technology
Science & Technology Discoveries at EMBL will help researchers to interpret one of the most common types of experiments in genomics and medical studies.
2020
sciencescience-technology
Science & Technology The image shows a larva of Platynereis dumerilii, a marine worm. The image here was produced by Constantin Pape, a visiting predoctoral fellow in the Kreshuk group at EMBL Heidelberg.
2020
picture-of-the-weekscience-technology
Science & Technology Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…
2020
sciencescience-technology
Science & Technology EMBL researchers in the Heard group at EMBL Heidelberg explore the interaction between DNA organisation and gene expression in the early embryo
2020
sciencescience-technology
Science & Technology EMBL scientists examine the molecular causes of a rare hereditary disease of the spine and ribs
2020
sciencescience-technology
Science & Technology EMBL researchers investigate the role of a histone protein in regulating gene expression
2020
sciencescience-technology
Science & Technology Enhancers in Drosophila embryos gather together to preserve phenotypes under stressful conditions
2019
sciencescience-technology
Science & Technology Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.
2019
sciencescience-technology
People & Perspectives EMBL’s next Director General reflects on the questions that drive her research
2018
people-perspectivesscience
People & Perspectives EMBL’s new group leader studies how gene expression is controlled
2018
people-perspectivesscience
Science & Technology EMBL scientists show that some promoters can act as enhancers and vice versa
2018
sciencescience-technology
Science & Technology Tim Richmond looks back on the work that revealed the high-resolution structure of the nucleosome
2017
eventsscience-technology
Science & Technology EMBL researchers complete a molecular atlas showing gene expression in all cells in an entire animal
2017
sciencescience-technology
Science & Technology Two EMBL researchers are exploring new ways to filter out noise and get to the data they need
2017
sciencescience-technology
Science & Technology ERC grantee Eileen Furlong shares her vision for the next ten years
2017
sciencescience-technology
Science & Technology Healing and anxiety are influenced by the genetics of one’s social partners
2017
sciencescience-technology
People & Perspectives New group leader Wojciech Galej investigates RNA-protein complexes involved in gene expression
2017
people-perspectivesscience
People & Perspectives EMBL alumnus Jop Kind reflects on the questions that led him to this year’s John Kendrew Award
2016
alumnipeople-perspectives
Science & Technology Embryology, genomics and bioinformatics combine to identify factors regulating mammalian pluripotency.
2015
sciencescience-technology
Science & Technology Study of mouse embryonic stem cells reveals new genes involved in the stem-cell regulatory network.
2015
sciencescience-technology
New single-cell genomics techniques bring ‘omics to evolution and development research.
2015
science
Science & Technology As an embryo develops, different genes are turned on in different cells, to form muscles, neurons and other bodily parts. Inside each cell’s nucleus, genetic sequences known as enhancers act like remote controls, switching genes on and off. Scientists at the European Molecular Biology Laboratory…
2012
sciencescience-technology
Science & Technology Embryonic development is like a well-organised building project, with the embryo’s DNA serving as the blueprint from which all construction details are derived. Cells carry out different functions according to a developmental plan, by expressing, i.e. turning on, different combinations of genes.…
2009
sciencescience-technology
Science & Technology Proteins are the executive agents that carry out all processes in a cell. Their activity is controlled and modified with the help of small chemical tags that can be dynamically added to and removed from the protein. 25 years after its first discovery, researchers at the European Molecular Biology…
2009
sciencescience-technology
Science & Technology Epigenetic regulation – modifications to the structure of chromatin that influence which genes are expressed in a cell – is a key player in embryonic development and cancer formation. Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg now gained new insight…
2008
sciencescience-technology
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