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Tag:

genome

Year
9 May 2024

An epigenome editing toolkit to dissect the mechanisms of gene regulation

Science & Technology A study from the Hackett group at EMBL Rome led to the development of an epigenetic editing system that allows to precisely program chromatin modifications at any specific position in the genome, to understand their causal role in transcription regulation.

2024

science-technology

25 July 2023 Ensembl logo in white circle on blue and green background

Ensembl Bacteria releases new annotation for all its genomes

Ensembl 110 and Ensembl Genomes 57 have introduced in-house prokaryotic gene annotation across genomes available in Ensembl Bacteria.  Since its inception, Ensembl Bacteria has imported user-submitted annotations from the International Nucleotide Sequence Database Collaboration (INSDC) for…

2023

updates-from-data-resources

21 March 2023 Male scientist in blue shirt standing in front of a building with glass doors.

Welcome: Thomas Quail

Lab MattersPeople & Perspectives New group leader Thomas Quail studies the fundamental processes that determine how proteins organise the genome inside a cell.

2023

lab-matterspeople-perspectives

13 July 2022 Decorative image showing a double helix DNA road and with what look like road signs.

Uncharted territories in the human genome

Science & Technology Scientists identify previously unexplored gene segments to be added to human genome databases.

2022

research-highlightssciencescience-technology

10 May 2022

Royal Society honour for Eileen Furlong

EMBL AnnouncementsLab Matters EMBL’s Head of Genome Biology announced as Fellow of the Royal Society for her exceptional contributions to science.

2022

embl-announcementslab-matters

6 May 2022 Drawing of two chromosomes in which a highlighted area is switched around.

Flip-flop genome

Science & Technology Researchers at EMBL Heidelberg found that inversions in the human genome are more common than previously thought, which impacts our understanding of certain genetic diseases.

2022

sciencescience-technology

4 March 2022 Science art expressing the concept of transcriptional neighbourhoods regulating transcript isoform lengths and expression levels.

Understanding genomes, piece by piece

Science & Technology Genomes are made up of thousands of individual pieces – genes – which are expressed at different levels. Researchers at EMBL have shed light on how the placement of a gene affects its expression, as well as that of its neighbours.

2022

sciencescience-technology

5 August 2020 The tuatara, an iguana-like reptile with a crest of spikes, sits on a forest floor.

The curious genome of the tuatara, an ancient reptile in peril

Science & Technology A global team of researchers including the Flicek Team at EMBL-EBI has partnered up with the Māori tribe Ngātiwai to sequence the genome of the tuatara, a rare reptile endemic to New Zealand.

2020

sciencescience-technology

3 August 2020 A woman with glasses holds a book. The book cover says "Gene naming rules". Thought bubbles float around her head and display gene symbols like BRCA1.

Bagpipe and Pokemon, or how not to name a human gene

Science & Technology The human genome harbours about 19 000 protein-coding genes, many of which still have no known function. As scientists unveil the secrets of our DNA, they come across novel genes that they need to refer to using a unique name. The Human Genome Organisation’s Gene Nomenclature Committee (HGNC) at…

2020

sciencescience-technology

30 June 2020

EMBL boosts national and international sharing of genomic data

ConnectionsLab Matters A national consortium including EMBL and the DKFZ is set to launch the German Human Genome–Phenome Archive, creating an invaluable bridge between fundamental biomedical research and applied healthcare.

2020

connectionslab-matters

5 February 2020

The Pan-Cancer project

Science & Technology EMBL co-leads most comprehensive study of genetic causes of cancer

2020

sciencescience-technology

5 February 2020

Protecting data in the cloud

Science & Technology Cloud computing offers unprecedented opportunities for global-scale research collaborations. It also presents a unique set of challenges in terms of data protection and the ethics of data sharing.

2020

sciencescience-technology

5 February 2020

Characterising RNA alterations in cancer

Science & Technology The largest and most comprehensive catalogue of cancer-specific RNA alterations reveals new insights into the cancer genome.

2020

sciencescience-technology

5 February 2020

Cancer mutations occur decades before diagnosis

Science & Technology Researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI) and the Francis Crick Institute have analysed the whole genomes of over 2600 tumours from 38 different cancer types to determine the chronology of genomic changes during cancer development.

2020

sciencescience-technology

5 February 2020

Studying DNA rearrangement to understand cancer

Science & Technology Using the dataset from the Pan-Cancer project, scientists has developed methods to group, classify, and describe large rearrangements of the genome that are a key driver of cancer.

2020

sciencescience-technology

5 February 2020

Chromothripsis in human cancer

Science & Technology Researchers at Harvard Medical School and EMBL-EBI have carried out the largest analysis across cancer types of the newly discovered mutational phenomenon chromothripsis.

2020

sciencescience-technology

5 February 2020

Finding genetic cancer risks

Science & Technology Using the data from the Pan-Cancer project EMBL scientists describe how our genetic background influences cancer development.

2020

sciencescience-technology

6 June 2019 Photo of University of Cambridge professor Tim Lewens

Editing the ethical code

Lab Matters Professor Tim Lewens challenges the human genome’s unique place in bioethics

2019

eventslab-matters

11 March 2013

Havoc in biology’s most-used human cell line

Science & Technology HeLa cells are the world’s most commonly used human cell lines, and have served as a standard for understanding many fundamental biological processes. In a study published today in G3: Genes, Genomes and Genetics online, scientists at the European Molecular Biology Laboratory in…

2013

sciencescience-technology

31 January 2013

The mutation police

Science & Technology Scientists at the EMBL-European Bioinformatics Institute (EMBL-EBI) and the MRC Laboratory of Molecular Biology in the UK have discovered how our genome keeps the effects of mutations in check. The discovery, published in the journal Cell, will help in the study of diseases such as cancer and…

2013

sciencescience-technology

31 October 2012

Spot the difference

Science & Technology In a nutshell: 1st map combining human genetic variation at different scales – from single letters to large chunks Based on genomes of 1092 healthy people from Europe, the Americas and East Asia Could help identify genetic causes of disease, rather than just links Data made freely available in…

2012

sciencescience-technology

22 April 2012 Abstract image showing DNA code

A matter of priorities

Science & Technology Just as banks store away only the most valuable possessions in the most secure safes, cells prioritise which genes they guard most closely, researchers at the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI) have found. The study, published online today…

2012

sciencescience-technology

21 July 2011 Model of the inner ring (green) of the nuclear pore, showing its components.

A hot species for cool structures

A fungus that lives at extremely high temperatures could help understand structures within our own cells. Scientists at the European Molecular Biology Laboratory (EMBL) and Heidelberg University, both in Heidelberg, Germany, were the first to sequence and analyse the genome of a heat-loving fungus,…

2011

science

2 February 2011

The human genome’s breaking points

A detailed analysis of data from 185 human genomes sequenced in the course of the 1000 Genomes Project, by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, in collaboration with researchers at the Wellcome Trust Sanger Institute in Cambridge, UK, as well as the…

2011

science

1 April 2010 Each of these large images of dividing cells is composed of several microscopy images of human cells in which different individual genes were silenced. The smaller images are placed according to genes’ effects: images for genes that affect chromosomes make up the chromosomes (red/pink), while the mitotic spindle (green) is composed of images for genes that affect it. IMAGE: Thomas Walter & Mayumi Isokane / EMBL

Movies for the human genome

Name a human gene, and you’ll find a movie online showing you what happens to cells when it is switched off. This is the resource that researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and their collaborators in the Mitocheck consortium are making freely…

2010

science

13 August 2009

Raising the alarm when DNA goes bad

Our genome is constantly under attack from things like UV light and toxins, which can damage or even break DNA strands and ultimately lead to cancer and other diseases. Scientists have known for a long time that when DNA is damaged, a key enzyme sets off a cellular ‘alarm bell’ to alert the…

2009

science

16 October 2008

Researchers establish international human microbiome consortium

Lab Matters Today at a meeting organised by the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, scientists from around the globe announced the formation of the International Human Microbiome Consortium (IHMC), an effort that will enable researchers to characterise the relationship of the…

2008

lab-matters

23 July 2008

Open access to large-scale drug discovery data

Lab Matters The Wellcome Trust has awarded £4.7 million (€5.8 million) to EMBL’s European Bioinformatics Institute (EMBL-EBI) to support the transfer of a large collection of information on the properties and activities of drugs and a large set of drug-like small molecules from the publicly listed…

2008

lab-matters

7 May 2008

Platypus genome sequence published

UK-based researchers at the Medical Research Council Functional Genomics Unit in Oxford and the European Molecular Biology Laboratory’s European Bioinformatics Institute in Cambridge have revealed the genetic makeup of the one of the world’s strangest mammals. They have analysed the DNA…

2008

science

22 January 2008

International consortium announces the 1000 Genomes Project

Lab Matters Drawing on the expertise of multi-disciplinary research teams, the map developed by the 1000 Genomes Project will provide a view of biomedically relevant DNA variations at a resolution unmatched by current resources. The European Bioinformatics Institute (EBI), working with long-term collaborator…

2008

lab-matters

14 June 2007

New findings challenge established views about human genome

The ENCyclopedia Of DNA Elements (ENCODE), an international research consortium organised by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), today published the results of its exhaustive, four-year effort to build a “parts list” of…

2007

science

22 January 2006

The closest look ever at the cell’s machines

Today researchers in Germany announce they have finished the first complete analysis of the “molecular machines” in one of biology’s most important model organisms: S. cerevisiae (baker’s yeast). The study from the biotechnology company Cellzome, in collaboration with the…

2006

science

22 August 2005

Public collections of DNA and RNA sequence reach 100 gigabases

Lab Matters The world’s three leading public repositories for DNA and RNA sequence information have reached 100 gigabases (100,000,000,000 bases; the ‘letters’ of the genetic code) of sequence. Thanks to their data exchange policy, which has paved the way for the global exchange of many types…

2005

lab-matters

12 July 2005

Hunt for human genes involved in cell division under way

Lab Matters A systematic search through human genes has begun at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. Working within the MitoCheck consortium that includes 10 other institutes throughout Europe, the EMBL scientists will silence all human genes, one-by-one, to find those…

2005

lab-matters

21 April 2005

Whale bones and farm soil: Sequencing biodiversity

Instead of sequencing the genome of one organism, why not sequence a drop of sea water, a gram of farm soil or even a sunken whale skeleton? Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg and their US collaborators have done just that, and the result is a new…

2005

science

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