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genome biology

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13 December 2024

Speaking the language of DNA

Right from the early days of DNA sequencing, EMBL’s scientists have been instrumental in helping the world understand, decode, archive, and manipulate genomes at scale and across many branches of the evolutionary tree, a task they continue to excel at today.

SCIENCE & TECHNOLOGY

2024

science-technology

25 July 2023 Ensembl logo in white circle on blue and green background

Ensembl Bacteria releases new annotation for all its genomes

Ensembl 110 and Ensembl Genomes 57 have introduced in-house prokaryotic gene annotation across genomes available in Ensembl Bacteria.  Since its inception, Ensembl Bacteria has imported user-submitted annotations from the International Nucleotide Sequence Database Collaboration (INSDC) for…

2023

updates-from-data-resources

22 March 2023 Artistic representation that features a long, winding helix joining together a doughnut-figure to a small shaggy ball to indicate the connections long-read sequencing can make about DNA mutations.

The ‘long read’ for cancer

Using Oxford Nanopore long-read sequencing, EMBL scientists sequenced a primary childhood brain tumour known as a medulloblastoma, uncovering a novel complex mutation pattern.

2023

science

4 August 2022 An illustration provides representation of fingers hovering over a cell phone

Zooming in to get the full picture

EMBL and UW researchers plus additional collaborators have constructed a complete map of fruit fly embryonic development using machine learning. This research is foundational to better understanding overall embryo development in other species, including humans.

SCIENCE & TECHNOLOGY

2022

sciencescience-technology

25 February 2022 Three colourful overlapping circles arranged in a row, a fruit-fly embryo being visible within each. Small circles within the embryos represent cell lineages.

Converging lenses on embryo development

Researchers from the Furlong group at EMBL have come up with a way to observe the development of fruit-fly embryos simultaneously at the genetic and cellular levels, generating a high-resolution and integrated view of how different cell lineages form.

SCIENCE & TECHNOLOGY

2022

sciencescience-technology

21 January 2022 The cross-section of a cell expressing a green fluorescently tagged protein and illuminated by a blue laser is visible in the foreground, surrounded by a vortex of cells

Cell sorting enters a new dimension

EMBL researchers, in collaboration with BD Biosciences, have demonstrated a new technology that allows rapid image-based sorting of cells. The new technology represents a major upgrade to flow cytometry and has applications in diverse life science fields.

SCIENCE & TECHNOLOGY

2022

sciencescience-technology

25 November 2021 Female scientist in front of a background of green plants

Welcome: Maria Zimmermann-Kogadeeva

Maria Zimmermann-Kogadeeva is one of EMBL’s newest group leaders and a computational biologist whose research group applies computational modelling to better understand the metabolism of gut bacteria and their potential to have far-reaching impacts on other organs.

LAB MATTERSPEOPLE & PERSPECTIVES

2021

lab-matterspeople-perspectives

13 October 2021 Illustration of a community of bacteria. Pills represent an antibiotic that can be used to treat an infection, and a second drug that could protect many gut bacteria from antibiotics.

Tackling the collateral damage from antibiotics

Researchers from EMBL’s Typas group and collaborators have analysed the effects of 144 antibiotics on the wellbeing of gut microbes. The study improves our understanding of antibiotics’ side effects and suggests a new approach to mitigating the adverse effects of antibiotics therapy on gut…

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

26 February 2021 Woman with long brown hair stands in front of snow scene with arms crossed in front of her.

Welcome: Sinem Saka

As one of EMBL’s newest group leaders, Sinem Saka will combine multiple technologies, such as microscopy and single-cell omics, to solve biological puzzles.

LAB MATTERSPEOPLE & PERSPECTIVES

2021

lab-matterspeople-perspectives

16 February 2021 Microscopy images of coronavirus-infected cells in blue and red, arranged on a clockface. Illustrations of virus particles.

Finding coronavirus’s helper proteins

A team of EMBL scientists and colleagues have analysed how the novel coronavirus affects proteins in human cells. They identified several human proteins as potential drug targets to prevent viral replication.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

1 June 2020 An illustration of single-cell RNA sequencing (scRNA-seq)

Enabling functional genomics studies in individual cells

Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

23 April 2020 Key visual for the EMBO | EMBL symposium ‘The Four-Dimensional Genome’

EMBL hosts its first virtual conference

The virtual EMBO | EMBL symposium ‘The Four-Dimensional Genome’ brought together 470 participants. Here, Jürgen Deka, Head of External Scientific Training, discusses how he and his team overcame the organisational challenges.

LAB MATTERS

2020

eventslab-matters

2 February 2011

The human genome’s breaking points

A detailed analysis of data from 185 human genomes sequenced in the course of the 1000 Genomes Project, by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, in collaboration with researchers at the Wellcome Trust Sanger Institute in Cambridge, UK, as well as the…

SCIENCE & TECHNOLOGY

2011

sciencescience-technology

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