Researchers uncover what drives aggressive bone cancer
Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes.
SCIENCE & TECHNOLOGY2025
research-highlightsscience-technology
DECIPHER v11.29 released
The v11.29 DECIPHER release is out now. Find out about the new features and improvements.
2025
updates-from-data-resources
Sharing scientific expertise to empower European partners
EMBL and its partners have received funding from the European Commission for two new Twinning Projects, which will build expertise and research capacity in its member states.
CONNECTIONS2024
connections
Speaking the language of DNA
Right from the early days of DNA sequencing, EMBL’s scientists have been instrumental in helping the world understand, decode, archive, and manipulate genomes at scale and across many branches of the evolutionary tree, a task they continue to excel at today.
SCIENCE & TECHNOLOGY2024
science-technology
Human immune system is ‘ready to go’ long before birth
The most comprehensive map of the developing human thymus sheds light on how immune responses are built and maintained during early life
2024
announcements
Cancer drug resistance causes and categories identified
Researchers uncover that DNA changes that cause cancer drug resistance can be grouped into four categories, and identify possible new therapeutic targets.
2024
announcements
Funding awarded to develop a global Pathogen Data Network
EMBL-EBI and colleagues from other 11 institutes commit to pathogen data sharing project.
2024
announcements
Polygenic Score (PGS) Catalog increases diversity and usability of genetic data
Addition of data from more diverse populations to the Polygenic Score (PGS) Catalog and a new software tool for PGS calculation could help produce more equitable disease risk predictions.
SCIENCE & TECHNOLOGY2024
science-technologytechnology-and-innovation
EMBL-EBI’s open data resources for biodiversity and climate research
EMBL-EBI data resources help advance biodiversity and climate change research by enabling scientists to study species interactions, evolutionary processes, ecosystem health, and more.
SCIENCE & TECHNOLOGY2024
science-technologytechnology-and-innovation
Why clinical trials stop: the role of genetics
Using machine learning to analyse the genetic factors behind early clinical trial termination, researchers find a link between genetic evidence and trial outcome.
SCIENCE & TECHNOLOGY2024
research-highlightsscience-technology
DECIPHER v11.27 release
The v11.27 DECIPHER release is out now. Find out about the new features and improvements.
2024
updates-from-data-resources
The EMBL evolution: Ewan Birney on open data and the ethos of excellence
Ewan Birney reflects on his time at EMBL and the development of the organisation through a commitment to open data and nurturing scientific talent.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Welcome: Mallory Freeberg
The new Team Leader for Human Genomics at EMBL-EBI shares how curiosity and maths shaped her career and what it takes to be a community builder.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Ancient environmental DNA provides solutions for global food security challenges
Researchers explore genetic diversity found in ancient environmental DNA to help modern agricultural practices.
EMBL ANNOUNCEMENTS2024
announcementsembl-announcements
Genetic mosaicism more common than thought
Blood stem cells from healthy people carry major chromosomal alterations, a study in Nature Genetics by researchers at the Max Delbrück Center and the European Molecular Biology Laboratory (EMBL) finds. The discovery suggests that we are all genetic mosaics, which may contribute to ageing-related…
SCIENCE & TECHNOLOGY2024
science-technology
DECIPHER v11.26 release
The latest DECIPHER release includes AlphaMissense scores, links to the Open Targets Platform and more.
2024
updates-from-data-resources
Predicting cancer risk on the basis of national health data
Large-scale study uses data from Danish health registries to predict individual risks of developing cancer
SCIENCE & TECHNOLOGY2024
research-highlightsscience-technology
AlphaMissense data integrated into Ensembl, UniProt, DECIPHER and AlphaFold DB
The integration enables researchers to easily access AI-generated scores estimating how likely genetic variants are to be pathogenic
2024
technology-and-innovation
Ensembl 112 has been released
Ensembl 112 and the corresponding release of Ensembl Genomes 59 has released. This includes exciting new fish species, many more drosophila species and new VEP updates.
2024
updates-from-data-resources
MSD joins the Open Targets consortium
MSD joins as the latest partner in the Open Targets consortium, enhancing the initiative’s collaborative efforts in drug discovery.
EMBL ANNOUNCEMENTS2024
announcementsembl-announcements
Researchers aim to use quantum computing to assemble and analyse pangenomes
Experts in quantum computing and genomics to develop new methods and algorithms to process biological data.
SCIENCE & TECHNOLOGY2024
announcementsscience-technology
‘Exhausted’ immune cells in healthy women could be target for breast cancer prevention
New study uncovers the potential of immunotherapy in preventing breast cancer and creates the openly available Human Breast Cell Atlas.
SCIENCE & TECHNOLOGY2024
research-highlightssciencescience-technology
Using Data Hubs to analyse SARS-CoV-2 and other pathogen sequences
The SARS-CoV-2 Data Hubs are a set of tools coupled with infrastructure that support four components: the submission, analysis, presentation and visualisation of SARS-CoV-2 raw read data, and its resulting analyses. What makes Data Hubs attractive is a unique set of features: A new publication in…
2024
updates-from-data-resources
The malaria parasite generates genetic diversity using an evolutionary ‘copy-paste’ tactic
Plasmodium falciparum, a malaria parasite, uses gene conversion to produce genetic diversity in two surface protein genes targeted by the human immune system.
SCIENCE & TECHNOLOGY2024
announcementssciencescience-technology
Team SAMBAI: addressing cancer disparities in recent African heritage populations
An international team of researchers aim to combine social determinants of health with genomics, immune profiling, and exposomics data to tackle cancer inequities at an unprecedented scale.
SCIENCE & TECHNOLOGY2024
announcementssciencescience-technology
First datasets available in the Federated EGA Network
The Federated European Genome-phenome Archive (FEGA) marks a significant milestone with the release of its first datasets.
2024
announcements
DECIPHER v11.24 Released
Version 11.24 of DECIPHER introduces a new ACMG/AMP pathogenicity interface for sequence variant predictions, displays ClinGen Variant Curation Expert Panel recommendations on gene pages, and updates ACMG secondary finding information to v3.2.
2024
updates-from-data-resources
We are EMBL: Jacqueline Toussaint on strange bacteria and bioinformatics
Jacqueline shares her experience of EMBL's international PhD programme.
LAB MATTERSPEOPLE & PERSPECTIVES2024
lab-matterspeople-perspectives
Ensembl 111 has been released
The Ensembl 111 features a range of new Ensembl VEP plugins and updated agricultural, fish, plant and metazoa species.
2024
updates-from-data-resources
The Biodiversity Cell Atlas: charting cellular diversity on Earth
A $3.8 million grant from the Gordon and Betty Moore Foundation will help researchers lay groundwork for the Biodiversity Cell Atlas.
2024
announcements
Six takeaways from the EMBL conference Cancer Genomics 2023
Approximately 300 scientists met up at EMBL Heidelberg to unravel the centuries-old puzzle of cancer through the modern lens of genomics.
SCIENCE & TECHNOLOGY2024
eventsscience-technology
Unravelling the role of immune cells in early lung development
Researchers reveal that healthy lung development hinges on immune-epithelial crosstalk, with implications for respiratory diseases.
SCIENCE & TECHNOLOGY2023
research-highlightsscience-technology
The Global Biodiversity Portal: enabling biodiversity research worldwide
The new initiative brings together genomic data from various biodiversity projects to aid conservation and biodiversity efforts.
SCIENCE & TECHNOLOGY2023
announcementssciencescience-technology
Extending the network of infectious disease data portals: developments in Sweden and The Netherlands
Two new data portals are set to support infectious disease monitoring and research across Europe; the Swedish Pathogens Data Portal and the Netherlands COVID-19 Data Portal.
2023
updates-from-data-resources
EMBL-EBI co-leads on research programme to help treat relapsed childhood cancers
Leading charities Children with Cancer UK and Cancer Research UK will co-fund a major £5.5 million research programme to advance precision medicine for relapsed childhood cancers.
2023
announcements
Starting is easy, sustaining is hard
Where to start when thinking about the sustainability of informatics projects
2023
perspectives
Deciphering the data deluge: how large language models are transforming scientific data curation
Large language models are changing the way we carry out scientific data curation, annotation, and research, setting the stage for a more efficient understanding of scientific literature
EMBLetc2023
Embracing the genome sequencing revolution
EMBL’s Genomics Core Facility provides end-to-end support to researchers across Europe and beyond and stands at the forefront of scientific breakthroughs.
EMBLetc2023
Genes, cells, and embryos in development and evolution: Pere Alberch, 25 years on
Scientists from the MELIS department at UPF and EMBL Barcelona have organised a symposium to discuss the work of the visionary Catalan scientist Pere Alberch, who passed away 25 years ago.
CONNECTIONS2023
connectionsevents
ggCaller: The next step in scaling up bacterial genome annotation
The Lees group develops a tool that can scale up bacterial genome annotation.
2023
research-highlights
We are EMBL: Valentina Lorenzi on human reproductive development
PhD student Valentina Lorenzi is using single-cell sequencing data to create a map of the developing human reproductive system.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesperspectives
Understanding the mechanisms of enzyme catalysis
Enzymes constitute a large fraction of genomes – 20% in humans – which makes them a very important part of life. Despite decades of studies and a rich literature dedicated to understanding the reaction mechanisms of enzymes, the rules of enzyme catalysis are still not fully clear. A new…
SCIENCE & TECHNOLOGY2023
science-technologytechnology-and-innovation
Welcome: David Hulcoop
David Hulcoop discusses how his experience bridging organisational cultures will help address critical challenges in drug discovery and target selection at Open Targets.
LAB MATTERSPEOPLE & PERSPECTIVES2023
announcementslab-matterspeople-perspectives
Uncovering the mechanisms underlying lack of response to immunotherapy
New research improves understanding of the molecular mechanisms behind why some cancers respond to immunotherapy and others don't.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Novel algorithm able to detect mutations in single-cell sequencing data sets
SComatic enables researchers to link genotype to phenotype using only single-cell profiling data
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Filling the skills gap to advance genomic medicine: an interview with Emily Perry
By upskilling researchers on bioinformatics skills and tools, EMBL alumna Emily Perry is helping to make genomic medicine more accessible.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesperspectives
refget v2.0 links the hidden dictionaries of DNA
The GA4GH standard refget quietly helps decipher millions of genomes sequenced worldwide, and it just got better.
2023
technology-and-innovation
Ensembl 110 has been released
Ensembl 100 release brings exciting updates, such as the addition of regulation data to 5 animal genomes studied extensively in agriculture.
2023
updates-from-data-resources
EMBL-EBI’s new building set to support data growth and innovative partnerships
Construction begins on EMBL-EBI's new building named after Janet Thornton.
EMBL ANNOUNCEMENTSLAB MATTERS2023
announcementsembl-announcementslab-matters
DECIPHER database for rare diseases joins EMBL-EBI
Closer collaborations with EMBL-EBI data resources set to further develop and grow this unique rare disease platform.
EMBL ANNOUNCEMENTS2023
announcementsembl-announcementsscience
Pathogens Portal: The new gateway to public pathogen data
Enabling researchers worldwide to share and analyse pathogen data generated across the world
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
Supporting the development of hologenomic approaches for more sustainable animal feeds
HoloFood, the first consistent collection of multiomic data about chicken and salmon gut microbiomes, set to enable the development of better animal feeds.
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
Genomic medicine: ushering in a new era in healthcare
EMBL-EBI data resources are being used to deliver thousands of genetic diagnostics to patients every month.
SCIENCE & TECHNOLOGY2023
perspectivessciencescience-technology
ProtVar: understanding missense variation in humans
A new tool for the interpretation of missense variation in humans – ProtVar – will help enable drug discovery.
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
We are EMBL: Carolin Sauer on supporting cancer research
Postdoctoral researcher Carolin Sauer is leveraging long-read sequencing to develop new detection methods for various cancers.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesresearch-highlights
Managing a bioinformatics core facility
BioImage Archive Team Leader Matthew Hartley shares his experience and tips for people interested in managing a bioinformatics core facility.
2023
technology-and-innovation
The story of Clustal: democratising sequence alignments
Desmond Higgins, 2023 Lennart Philipson Award winner, discusses his time at EMBL and his research developing sequence alignment tools.
EMBLetc2023
What happens when chromosomes shatter
Understanding chromothripsis offers insights into how cancer develops.
SCIENCE & TECHNOLOGY2023
research-highlightsscience-technology
A more diverse human reference genome
The human pangenome – one of the most complete collections of genome sequences released so far – captures rich human diversity.
SCIENCE & TECHNOLOGY2023
announcementssciencescience-technology
Bioinformatics powers international effort to map gene function
EMBL-EBI is making a key contribution to a historic effort to understand the function of every human gene
LAB MATTERSSCIENCE & TECHNOLOGY2023
announcementslab-mattersscience-technology
The Human Genome Project at 20: interview with Ewan Birney
On the 20th anniversary of the Human Genome Project, we look back at its history, wonder and potential.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesperspectives
WormBase ParaSite 18 released
WormBase ParaSite release 18 adds largest number of new genomes and annotations since launch, as well as full integration with AlphaFold.
SCIENCE & TECHNOLOGY2023
science-technologyupdates-from-data-resources
Human genome editing: regulations, risks, and ethical considerations
Scientists have the technology to edit the human genome. But when should they, and who contributes to these decisions?
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesperspectives
MAPLE: a phylogenetic tool for pandemic-scale genome data
EMBL-EBI researchers have developed a new tool capable of performing state-of-the-art phylogenetic inference on larger datasets than previously thought possible.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Building a bioinformatics community at the nf-core hackathon
Darwin Tree of Life project improves bioinformatics tools for biodiversity data analysis
CONNECTIONS2023
connectionstechnology-and-innovation
The ‘long read’ for cancer
Using Oxford Nanopore long-read sequencing, EMBL scientists sequenced a primary childhood brain tumour known as a medulloblastoma, uncovering a novel complex mutation pattern.
2023
science
Genomic science to support conservation efforts: an interview with Lara Urban
Using long-read sequencing and machine learning approaches, EMBL alumna Lara Urban is making a difference in the field of One Health.
2023
perspectives
Large-scale study enables new insights into rare eye disorders
EMBL-EBI researchers use UK Biobank data to uncover new information about rare diseases of the eye.
2023
research-highlightsscience
Open data for biodiversity: an EMBL-EBI 2022 round-up
As major biodiversity projects ramp up, EMBL-EBI enables genomic data sharing for all species.
2023
perspectivesscience
New Job Dispatcher website launched
EMBL-EBI’s Software Development and Operations team is delighted to announce the launch of a brand-new Job Dispatcher website, currently in development. The updated website provides a landing page for the Job Dispatcher services, making it easier for users to find and navigate services…
2023
updates-from-data-resources
Molecules to Ecosystems: Jo McEntyre on data services
Jo McEntyre talks about data services, open data and a new era for research assessment.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesperspectives
Welcome: Hanh Vu
Group Leader Hanh Vu studies ‘immortal’ flatworms that can grow and de-grow to understand better factors that determine organisms’ sizes.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
Ensembl 109 has been released
Latest Ensembl and Ensembl Genomes releases bring updates to donkey and horse assemblies, and lots of new plants and metazoa.
2023
updates-from-data-resources
Leveraging long-read sequencing for cancer genomics
Genomic sequencing and big data analysis are two novel technologies driving researchers’ understanding of the complexities of cancer.
2023
perspectivesscience
Machine learning to identify and prioritise drug targets
Open Targets is using artificial intelligence and machine learning to identify and prioritise drug targets.
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
Darwin Tree of Life: first 500 genome assemblies released as project creates a buzz
We look back through some of the 2022 highlights from the Darwin Tree of Life project.
SCIENCE & TECHNOLOGY2023
perspectivessciencescience-technology
Molecules to Ecosystems: Rob Finn on the Microbial Ecosystems transversal theme
Rob Finn, one of the co-chairs of the Microbial Ecosystems theme, discusses his work, the challenges of multidisciplinary research, and how the theme is already helping to promote the exchange of scientific ideas.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
BOSS-RUNS: streamlining dynamic nanopore sequencing
A new method developed by EMBL-EBI researchers helps to streamline nanopore sequencing in real-time.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Genomic Data Infrastructure – integrating genomics into healthcare
EMBL-EBI supports new European Commission project set to support the use of genomics in research and healthcare.
2022
announcementsscience
Unleashing the biotechnology potential of euglenoids
An ambitious project to sequence the genomes of all known species of euglenoids will drive research on biofuels and sustainable foods.
2022
announcements
Open Targets consortium welcomes Genentech as newest member
Open Targets announces that Genentech will become the seventh partner in the drug discovery and validation consortium.
2022
announcementsscience
Open science for climate justice
Our experts discuss the importance of open science for food security and preserving global biodiversity.
2022
perspectivesscience
New molecular microscopy uncovers how breast cancer spreads
Researchers have created a tool that maps in previously unseen detail how breast cancer develops and spreads.
2022
research-highlightsscience
Ensembl 108 has been released
We are pleased to announce the release of Ensembl 108, and the corresponding release of Ensembl Genomes 55 featuring changes in the human default tracks, new genomes in Ensembl Plants and Ensembl Metazoa, and the addition of mitochondrial annotation for Tasmanian devil. Genome assemblies and…
2022
updates-from-data-resources
ArrayExpress interface now retired
Data continues to be available in BioStudies.
2022
updates-from-data-resources
Biodiversity Genomics Europe: addressing biodiversity loss through genomics
European experts gather to launch a project that aims to characterise and conserve life on Earth using DNA data.
2022
announcementsscience
European institutes commit to data access across borders
The Federated EGA is set to improve access to sensitive human data in a safe and secure way.
CONNECTIONS2022
announcementsconnectionsscience
Life Science Alliance starts new chapter
Dieter Schwarz Foundation renews 3-year funding to EMBL for the EMBL | Stanford Life Science Alliance, a unique international collaboration bringing together researchers from the two leading institutions to develop transformative technologies and accelerate biomedical research.
CONNECTIONSLAB MATTERS2022
connectionslab-matters
CNest: a new method for copy number variation analysis
A new method for the robust analysis of copy number variation and used UK Biobank data to identify links between genome and disease.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
New antibiotic resistance genes identified in tuberculosis
International consortium analyses the genetic sequences and antibiotic susceptibility of 10,000 global Mycobacterium tuberculosis isolates.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
Uncharted territories in the human genome
Scientists identify previously unexplored gene segments to be added to human genome databases.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
Ensembl 107 has been released
The Ensembl 107 release contains updates to regulatory annotations and updated vertebrate and metazoan species.
2022
updates-from-data-resources
Interactive data visualisation for Single Cell Expression Atlas
Using powerful data visualisation and interactive search results across datasets allows users to explore hypotheses across a range of metadata, and discover new insights backed by expertly curated, consistently reanalysed single cell sequencing data. Searching for metadata, allows a powerful…
2022
updates-from-data-resources
Darwin Tree of Life at the Royal Society Summer Science Exhibition
A closer look at how genome sequencing is helping us protect biodiversity and our latest public engagement activities
2022
announcements
Supporting the African BioGenome Project to build bioinformatics capacity
The African BioGenome Project and EMBL have signed a Memorandum of Understanding to support each other in building genomics and bioinformatics capacity across Africa
CONNECTIONSLAB MATTERS2022
announcementsconnectionslab-matters
Impact of DNA mutations on blood cell production uncovered
Researchers discover how DNA mutations change blood cell production and how this relates to ageing and cancer development.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
A machine learning approach for allocating gene function
Researchers in the Ensembl team are making the most of machine learning methods to speed up genome annotation pipelines
SCIENCE & TECHNOLOGY2022
sciencescience-technologytechnology-and-innovation
Fergal Martin – Eukaryotic Annotation Team Leader
Fergal Martin discusses the importance of open access data and his work in different biodiversity initiatives
LAB MATTERSPEOPLE & PERSPECTIVES2022
lab-matterspeople-perspectives
Organisations should embrace open science faster – interview with Prof. Dame Janet Thornton
Janet Thornton, the inaugural winner of the FEBS Journal Open Science Award, explains the importance and impact of open science.
LAB MATTERSPEOPLE & PERSPECTIVES2022
lab-matterspeople-perspectivesperspectives
Peter Harrison – Genome Analysis Team Leader
Peter Harrison discusses the importance of data accessibility and his passion for biodiversity and agricultural genomics.
LAB MATTERSPEOPLE & PERSPECTIVES2022
lab-matterspeople-perspectives
Greater than the sum of our genes: DNA does not define us
Ewan Birney discusses the input of both genetics and our environment in making us who we are
LAB MATTERS2022
lab-mattersperspectives
The MANE collaboration: working together to support genome science
Researchers from the MANE collaboration bring you the most comprehensive human genome annotation dataset to date.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
Welcome: John Lees
John Lees joins EMBL-EBI as a Group Leader in Pathogen informatics and modelling.
LAB MATTERSPEOPLE & PERSPECTIVES2022
lab-matterspeople-perspectives
Pathogen data sharing – key to pandemic preparedness
Researchers lay out a set of principles for open genomic data sharing or pathogens
SCIENCE & TECHNOLOGY2022
perspectivesscience-technology
Genomic sequencing aids the global Tuberculosis fight
Zamin Iqbal and his team are working with researchers all over the globe to help put a stop to Tuberculosis
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
New genetic data policy must promote biodiversity conservation
Scientists urge the adoption of a sensible international policy for digital sequence information.
SCIENCE & TECHNOLOGY2022
announcementssciencescience-technology
Pfizer joins the Open Targets consortium
Open Targets, a consortium focused on drug target identification, prioritisation, and validation, announced today that Pfizer has joined as a partner.
CONNECTIONS2022
announcementsconnectionsscience
Genomic data for biodiversity – a global challenge
An exploration of where in the world genomics methods are applied and where the data are used.
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
Can data help feed a hungry world?
How genomics, open data, and multidisciplinary science can improve food security.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Genomic sequencing to strengthen biodiversity
The Darwin Tree of Life project is an unprecedented initiative sequencing 70,000 species
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Genomic tracking of the COVID-19 pandemic in England
Largest in-depth analysis of genomic data tracks the spread of SARS-CoV-2 lineages in England.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Charting a multi-omic universe
A research collaboration used machine learning to map tumour molecular make-up, potentially paving way to more customised cancer treatment.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Common medications accumulate in gut bacteria
A new collaborative study led by EMBL group leaders Kiran Patil, Nassos Typas, and Peer Bork has found that common medications accumulate in human gut bacteria. This process reduces drug effectiveness and affects the metabolism of common gut microbes, thereby altering the gut microbiome.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Welcome: Sarah Dyer
EMBL welcomes Sarah Dyer, the new Non-Vertebrate Genomics Team Leader at EMBL-EBI.
LAB MATTERSPEOPLE & PERSPECTIVES2021
lab-matterspeople-perspectives
Joining forces to solve global challenges
EMBL and the Swedish Science for Life Laboratory sign agreement to advance science together.
CONNECTIONSLAB MATTERS2021
connectionslab-matters
Genomic surveillance of SARS-CoV-2 in England
The largest in-depth analysis of genomic surveillance data mapping out the dynamics of 62 lineages of the SARS-CoV-2 virus.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Piecing together the best reference genome
Researchers reveal the best technology for assembling reference genomes.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Genome sequencing accelerates cancer detection
The Gerstung Group at EMBL-EBI and collaborators have developed a statistical model that analyses genomic data to predict whether a patient has a high or low risk of developing oesophageal cancer.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
New clues to a 500-year old mystery about the human heart
An international team of scientists involving Ewan Birney's group has investigated the function of a complex mesh of muscle fibres that line the inner surface of the heart.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
The curious genome of the tuatara, an ancient reptile in peril
A global team of researchers including the Flicek Team at EMBL-EBI has partnered up with the Māori tribe Ngātiwai to sequence the genome of the tuatara, a rare reptile endemic to New Zealand.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Unparalleled inventory of the human gut ecosystem
An international team of scientists has collated all known bacterial genomes from the human gut microbiome into a single large database. Their work will allow researchers to explore the links between bacterial genes and proteins, and their effects on human health.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Two EMBL scientists become EMBO Members
This year, EMBO elected 63 new members, including Alexander Aulehla, Group Leader and Senior Scientist at EMBL Heidelberg, and Paul Flicek, Associate Director of EMBL-EBI Services, Senior Scientist, Group and Team Leader at EMBL-EBI.
EMBL ANNOUNCEMENTSLAB MATTERS2020
embl-announcementslab-matters
Welcome: Ellie McDonagh
Open Targets welcomes new Informatics Science Director
LAB MATTERSPEOPLE & PERSPECTIVES2020
lab-matterspeople-perspectives
Five things you probably didn’t know about the Human Genome Project
Today we celebrate the 20th anniversary of the first draft of the entire human genome.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Unpicking the complexity of DNA mutations
DNA damage caused by chemical mutagens is not repaired immediately and can create more genetic diversity in tumours.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Distinguishing coronavirus genome mutations from inadvertent errors
EMBL scientists have performed a large-scale analysis of over 4700 SARS-CoV-2 genome sequences. They found that many of the most interesting changes in the SARS-CoV-2 genome that have been reported so far are likely to be technical artefacts, rather than biological mutations.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Understanding the role of our genes in SARS-CoV-2 infections
EMBL scientists will contribute to the new German COVID-19 OMICS Initiative to study the biological mechanisms contributing to coronavirus infections. EMBL group leaders Jan Korbel and Oliver Stegle, who is also affiliated with the DKFZ Heidelberg, will coordinate the set-up of IT infrastructures…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
DNA damage and faulty repair jointly cause mutations
DNA mutations are caused by a combination of DNA damage and repair, shows study by EMBL-EBI and collaborators.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Welcome: Isidro Cortés-Ciriano
Exploring the cancer genomics labyrinth
PEOPLE & PERSPECTIVES2019
people-perspectivesscience
Understanding molecular mechanisms of ageing
Understanding how ageing works at a molecular level
SCIENCE & TECHNOLOGY2019
sciencescience-technology
How coding opens up scientific data
The increasing importance of code in the biological sciences
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Life with the endangered kākāpō
Using genomics to help endangered species
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Welcome: Jessica Vamathevan
Building bonds between academia and industry
LAB MATTERS2019
lab-matters
Funding for bioinformatics technical infrastructure
Enhancing the world's bioinformatics infrastructure
LAB MATTERS2019
lab-matters
Facilitating transcontinental human data exchange
Federated data sharing will now be possible on an unprecedented scale
SCIENCE & TECHNOLOGY2019
sciencescience-technology
An in silico hope for biology: machine learning
How EMBL scientists are using machine learning to advance biology
LAB MATTERSSCIENCE & TECHNOLOGY2018
lab-mattersscience-technology
Sanofi joins Open Targets
Pharmaceutical company Sanofi strengthens drug targets discovery collaboration Open Targets
CONNECTIONSLAB MATTERS2018
connectionslab-matters
Deleting genes to study how germ cells are born
How embryonic stem cells develop into the germ line
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Looking for life using geobiology
Meet the organisers of EMBO’s first course on molecular geobiology
SCIENCE & TECHNOLOGY2018
eventsscience-technology
Leukaemia roots detectable years before diagnosis
Acute myloid leukaemia risk could be detected years before diagnosis
SCIENCE & TECHNOLOGY2018
sciencescience-technology
New insights into the origins of cancer
What worms can tell us about cancer
SCIENCE & TECHNOLOGY2018
sciencescience-technology
The genetic risk factors for depression
Is depression in your genes?
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Loops in DNA affect which proteins are coded
EMBL scientists unveil how 3D chromatin structure affects RNA splicing
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Research highlights
A summary of recent research highlights from EMBL
SCIENCE & TECHNOLOGY2017
sciencescience-technology
UK pupils and scientists explore parasite problem
EMBL-EBI and collaborators engage schools in a large-scale genome decoding project
LAB MATTERS2017
eventslab-matters
UK Biobank partners with the EGA
Genetic data from a major cohort now distributed via EMBL-EBI
CONNECTIONS2017
connectionsscience
Futures: Genome regulation
ERC grantee Eileen Furlong shares her vision for the next ten years
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Building bioinformatics capacity in Africa
EMBL alumna Nicola Mulder reflects on her pan-African bioinformatics project and its impact
PEOPLE & PERSPECTIVES2017
alumnipeople-perspectives
Genetic switches can change shape
EMBL scientists discovered that common mutations can change the shape of gene promoters
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Buffering mechanism protects embryonic development
New mechanism revealed
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Collaboration is beautiful
Where design meets bioinformatics, new scientific perspectives abound.
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Mapping early development
“Like getting hold of a microscope for the first time”
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Scientific twins
Collaborations shorten distance between EMBL Heidelberg, Germany, and CEITEC in Brno, Czech Republic
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Microbiomes: Our humble overlords
What's a microbiome? How on Earth do they work?
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Unexpected link in protein production
From shared interests at a conference to a surprising discovery
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Towards personalised breast cancer treatment
Largest-ever study of breast cancer genomes reveals new genes and mutations
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Foetus, or placenta?
Subtle genetic differences destine cells to placenta or animal, very early in embryo development
SCIENCE & TECHNOLOGY2016
sciencescience-technology
![A new tool for single-cell genomics helps us better understand differences between T cell populations. [Illustration: Spencer Phillips, EMBL-EBI]](https://www.embl.org/news/wp-content/uploads/2016/03/TCell_news_EMBL-e1457443531496-300x205.jpg)
Immunology meets single-cell sequencing
TraCeR: new method for studying T cells opens up opportunities to explore immune responses
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Mapping malaria
First detailed atlas of start points for genes expression in malaria-causing parasite
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Drugging bacteria
Commonly used diabetes drug metformin impacts gut bacteria more than disease itself
SCIENCE & TECHNOLOGY2015
sciencescience-technology
BioBeat15: Translating genomics into biobusiness
Connecting entrepreneurs and world leaders in genomics to address opportunities and challenges.
CONNECTIONS2015
connectionsevents
What makes us human? Or not…
From jumping genes to organ transplants, the non-human features that make us human.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Awards & Honours
EMBL scientists regularly receive prestigious awards – meet the latest honourees.
EMBL ANNOUNCEMENTSLAB MATTERS2015
embl-announcementslab-matters
Unpacking embryonic pluripotency
Embryology, genomics and bioinformatics combine to identify factors regulating mammalian pluripotency.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Mini DNA sequencer tests true
Evaluation of MinION™ sequencer finds performance and reliability consistently good.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
A snapshot of stem cell expression
Study of mouse embryonic stem cells reveals new genes involved in the stem-cell regulatory network.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
A lasting legacy
1000 Genomes Project pushed technologies and knowledge forward to understand what is 'normal' human genetic variation
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Marine mysteries
From the role of diatoms to how life evolved - scientists' pressing questions about life in the sea.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Finding links and missing genes
Missing a gene may not be a big deal – a conclusion from global catalogue of genetic changes.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Symposium sails sea of knowledge
Insights from organisers of upcoming EMBO|EMBL Aquatic Microeukaryotes symposium.
CONNECTIONS2015
connectionsevents
Ages apart
Multifaceted approach reveals how brain and liver age, helps explain why ageing brain loses plasticity.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Awards & Honours
EMBL scientists regularly receive prestigious awards – meet the latest honourees.
EMBL ANNOUNCEMENTSLAB MATTERS2015
embl-announcementslab-matters
Decoding disease
Behind the scenes of start-up Miroculus, developing a non-invasive test for early-stage disease.
SCIENCE & TECHNOLOGY2015
alumniscience-technology
An ocean odyssey
A journalist who spent six weeks aboard Tara reflects on the expedition’s extraordinary outcomes.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
The French connection
EMBL Core Facilities collaborate with French research programme Signalife to revive training visit.
CONNECTIONSLAB MATTERS2015
connectionslab-matters
Make it personal
Leading scientists will gather in Heidelberg this November to discuss the potential of personalised health.
CONNECTIONS2015
connectionsevents
From patients to the lab (and back)
Multidisciplinary research provides clues to new treatments for deadly form of leukaemia in children
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Know your cells
How T-cells are trained on what not to kill
SCIENCE & TECHNOLOGY2015
sciencescience-technology
DNA protection, inch by inch
European team identify mechanism for producing piRNAs that silence jumping genes in germline cells.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Decaying RNA molecules tell a story
Decaying RNA molecules tell a story that could add more chapters to the study of ribosomes.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Are protein domains indivisible?
New research shows that some proteins domains can function even with big parts missing.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
When microbes feed each other
Cooperate or compete? Microbes show us that getting along is the better choice for communities.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Inside industry: Part I
Career insights from Riccardo Cortese, whose start-up is developing an Ebola vaccine candidate.
LAB MATTERS2015
alumnilab-matters
Element of surprise
Radiocarbon studies are helping researchers shine light on how neurons stay stable yet adaptable.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Curiosity created the ‘Bubome
Exploring the science and magic of Lil Bub – alumna launches project to sequence the ‘Lilbubome’.
LAB MATTERS2015
alumnilab-matters
Towards an expression atlas for an entire brain
New single-cell genomics techniques bring ‘omics to evolution and development research.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Team spirit in the genome
Go Team Genome! New method reveals genetic teamwork in drosophila genome.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Why is a dolphin not a cat?
How repurposing non-coding elements in the genome gave rise to the great ‘mammalian radiation’.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Awards & Honours
EMBL scientists regularly receive prestigious awards – meet the latest honourees.
LAB MATTERS2015
lab-matters
Christian Boulin Fellowship
New Christian Boulin Fellowship: 15 awards of up to €1500 for visitors to EMBL’s Core Facilities.
LAB MATTERS2015
lab-matters
Alumni awards
Announcing winners of the John Kendrew Young Scientist Award, and inaugural Lennart Philipson Award.
LAB MATTERS2014
alumnilab-matters
Luxembourg collaboration
Third round of calls for joint research projects between EMBL and Luxembourg in 2015
LAB MATTERS2014
lab-matters
Record parasitic worm dataset
Largest collection of helminth genomic data ever assembled, in new open-access WormBase ParaSite.
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Welcome: Kyung-Min Noh
The important thing is forming good biological questions, says new group leader in Genome Biology.
PEOPLE & PERSPECTIVES2014
people-perspectivesscience
Welcome: Judith Zaugg
Whether it’s information or people, the art of connecting is key to new group leader Judith Zaugg
PEOPLE & PERSPECTIVES2014
people-perspectivesscience
Next generation training
First series of training courses jointly organised by EMBL and Illumina is a resounding success.
2014
events
11th EMBL Transcription and Chromatin conference
Experts from multiple fields come together to understand how the instructions in genes are read
2014
events
Genotype to phenotype mapping course
EMBL-EBI hosts successful first EMBO Practical Course in Genotype to Phenotype Mapping.
2014
events
Gibbon genome joins Ensembl
Gibbon genome gives insights into evolution of this singing, swinging, tree-dwelling ape.
SCIENCE & TECHNOLOGY2014
sciencescience-technology
How do animals become domesticated?
Bronwen Aken discusses what research into the rabbit genome reveals about animal domestication.
SCIENCE & TECHNOLOGY2014
sciencescience-technology
From students to mentors
PhD students reap rewards and rave reviews as Summer School of Science organisers
CONNECTIONS2014
connectionsevents
New, improved human genome
Ensembl has incorporated a vast amount of knowledge into a fully annotated reference human genome
SCIENCE & TECHNOLOGY2014
sciencescience-technology
New genomics API
New genomics API allows researchers to share anonymised genetic data seamlessly across platforms.
LAB MATTERS2014
lab-matters
Shedding light on chimeral twins
Marmoset genome provides insights into chimerism: data available in Ensembl genome explorer
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Back to school
School ambassadors show next generation that scientists are more ‘role model’ than ‘mad professor’
LAB MATTERS2014
lab-matters
Five for the future
Scientists from EMBL's five sites reflect on the opportunities and challenges that might lie ahead
LAB MATTERS2014
lab-matters
Taken out of context
Enabling neighbours: intact genes can cause cancer when placed near "enhancing" regions of DNA
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Capturing marine biodiversity
Data from first ever worldwide Ocean Sampling Day will be shared via EMBL-EBI resources this autumn.
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Sheep genome provides rich resource for agricultural research
Reference sheep genome, published by International Sheep Genomics Consortium, available in Ensembl
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Tsetse fly genome sequenced
Tsetse fly genome sequenced; scientists hope to find new ways to control sleeping sickness.
SCIENCE & TECHNOLOGY2014
sciencescience-technology
A new tree of life allows a closer look at the origin of species
In 1870 the German scientist Ernst Haeckel mapped the evolutionary relationships of plants and animals in the first ‘tree of life’. Since then scientists have continuously redrawn and expanded the tree adding microorganisms and using modern molecular data, yet, many parts of the tree…
SCIENCE & TECHNOLOGY2006
sciencescience-technology
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