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12 November 2024 Picture of Nicolas Foos fixing a piece of technological equipment.

Making in situ serial crystallography more accessible

Science & Technology Nicolas Foos, a postdoctoral fellow at EMBL Grenoble, talks about the implementation of a new method for in situ serial crystallography developed during his ARISE fellowship.

2024

science-technology

10 October 2024 A multi-coloured donut representing the structure of an NPC.

“Structurally” sound

Science & Technology The function of biological molecules is intimately linked to their structure. In the 50 years since EMBL was established, its researchers and engineers have constantly provided leadership in structural biology research and services, resulting in many scientific breakthroughs and novel insights.

2024

science-technology

2 July 2024

IIT-EMBL: New molecules to modulate gene expression

Science & Technology A new research paper published in Nature Communications lays the groundwork for the development of new drugs specific to genetic mutations or alterations responsible for the onset of tumours or genetic diseases.

2024

science-technology

25 June 2024 In the front, a 3D model of three molecules bound together: METTL6 in (orange), serine tRNA synthetase in (shades of lilac) and serine tRNA (black). In the background an illustration of a construction site. Two trucks with ‘UGA’ and ‘AGA’ written on them are visible at the bottom.

An enzyme with a smart friend

Science & Technology EMBL Grenoble’s Kowalinski Group analysed the structure of an enzyme responsible for modifying tRNA molecules to fine-tune protein production. They discovered that to distinguish almost identical, yet different, tRNA molecules, the enzyme uses help from another enzyme – a type of cooperation…

2024

science-technology

12 June 2024

AI approaches in structural biology and drug discovery

Connections EMBL Grenoble and the ESRF hosted a workshop bringing together representatives from research and industry to discuss the ever-growing role of artificial intelligence in the field of structural biology.

2024

connections

24 May 2024

Stephen Cusack: what I’ve learned

People & Perspectives Stephen Cusack, world-renowned structural biologist and former Head of EMBL Grenoble, reflects on his early influences, his achievements, and the lessons he’s learned as he embarks on his next adventure

2024

people-perspectives

4 April 2024

Building the cell’s splicing machine

Science & Technology New study from the Galej group provides deeper structural insight into the assembly of a critical molecular machine, that removes non-coding information from genes during their expression.

2024

science-technology

6 March 2024 The background shows a render of a suspension of tumour cells, while an inset shows the structures of two proteins – MAGEA4 and RAD18 – marked in green and blue respectively

Studying the relationship between cancer-promoting proteins

Science & Technology A new study from the Bhogaraju Group at EMBL Grenoble reveals how the cancer-promoting MAGE family of proteins bind to their targets, aiding the development of anti-cancer drugs that target these proteins.

2024

sciencescience-technology

15 November 2023 Group picture with mountain in the background

Looking back on 20 years of structural biology collaboration in Grenoble

ConnectionsLab Matters On this date (15 November), 21 years ago, the EMBL, ESRF, ILL, and IBS directors signed a memorandum of understanding to create the Partnership for Structural Biology (PSB) on the European Photon and Neutron (EPN) science campus in Grenoble.

2023

connectionslab-matters

7 November 2023

Enjoying a science day in Grenoble

ConnectionsLab Matters EMBL Grenoble was once again present for the science outreach event ‘Parvis des Sciences’ on Saturday 14 October 2023.

2023

connectionslab-matters

26 October 2023

A promising target to fight inflammatory bowel diseases

Science & Technology Researchers from the Cusack group at EMBL Grenoble provide structural insights on the XIAP/RIPK2 complex, a promising drug target to fight inflammatory bowel diseases.

2023

sciencescience-technology

15 September 2023 Group of scientists attending symposium staring upward to the photographer.

Celebrating Stephen Cusack’s contributions to science

People & Perspectives Researchers from across the globe have gathered in Grenoble to celebrate the remarkable lifelong scientific achievements of Stephen Cusack, the former head of EMBL Grenoble.

2023

eventspeople-perspectives

15 September 2023

Switching off the cytokine storm

Science & Technology EMBL Grenoble and University of Geneva researchers shed light on the molecular activation of the MAP kinase p38α, the final ‘switch’ triggering the inflammatory response.

2023

sciencescience-technology

10 July 2023 Green parasites on black background

Spotlight: Shedding light on deadly parasites

Lab MattersScience & Technology This single-celled organism the size of a dust particle is capable of causing deadly tropical diseases in both humans and livestock –Trypanosoma brucei, in an image by Luciano Dolce from EMBL.

2023

lab-matterspicture-of-the-weekscience-technology

7 July 2023 Cartoon of a molecule, formed by sticks and spheres.

Facilitating drug discovery against COVID-19

Science & Technology A collaboration between EMBL Grenoble and EBRIS scientists led to the characterisation of a new compound with promising activity against SARS-CoV-2 variants.

2023

sciencescience-technology

15 May 2023 Two scientists in a laboratory

Behind the scenes of innovation

EMBLetc EMBL Grenoble technology teams provide a sneak peek into their latest collaborative project in structural biology services: the complete automation of an integral step in X-ray crystallography.

2023

20 April 2023 White woman with short red hair standing in garden in front of a tree. Picture of Angelika Thomasson. Credits: Marcos Lopez-Marrero/EMBL

We are EMBL: Angelika Thomasson on administrative support to EMBL staff

Lab MattersPeople & Perspectives Angelika Thomasson, administrative assistant at EMBL Grenoble, talks about her role in supporting her colleagues in organising events and travels, what she enjoys about EMBL, and which famous female scientist she would like to have coffee with.

2023

lab-matterspeople-perspectives

20 March 2023 Team leader Gergely Papp.

Welcome: Gergely Papp

Lab MattersPeople & Perspectives Together with his team, Gergely Papp pushes the frontiers of technology development in the field of structural biology.

2023

lab-matterspeople-perspectives

1 March 2023 Moisés Bueno is standing next to the transfer robot. The robot has a form of a yellow robotic arm on a stand. Behind is the CrystalDirect™ Harvester, which is a white cuboid with two transparent dimmed windows for laser protection.

Biology meets engineering

Lab MattersScience & Technology Physicists, engineers and robotics experts work together in EMBL Hamburg’s Instrumentation Team to design instruments that support structural biology research. The team has finished a transfer robot that facilitates automated handling of protein crystals with care and precision. This will help…

2023

lab-mattersscience-technology

16 February 2023

New EU-funded Project: Fragment-Screen

Lab MattersScience & Technology EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.

2023

lab-mattersscience-technology

9 January 2023

New molecular insights on medical cannabis

Science & Technology EMBL Grenoble researchers have investigated the interaction between THC and some proteins it might bind to. In a recent study, they showed in vitro that THC inhibits an important human enzyme called autotaxin.

2023

sciencescience-technology

12 December 2022 A mother and her child looking through a microscope

Celebrating science in Grenoble

ConnectionsLab Matters In October 2022, EMBL Grenoble participated in the annual science outreach event Parvis des Sciences, organised by the GIANT campus under the umbrella of the French science week – La Fête de la science.

2022

connectionslab-matters

1 December 2022

Getting closer to stopping toxoplasmosis infection

Science & Technology Recent studies supported by EMBL Grenoble’s expertise in structural biology research and scientific services have identified Altiratinib as a potential drug to stop toxoplasmosis infection and opened up treatment options against malaria.

2022

sciencescience-technology

3 November 2022 View from above of a small room with several tools, cables and pieces of technology. A rectangular box, a robotic arm and a device are highlighted in green.

Two in one: combining MASSIF-1 and CrystalDirect

Lab MattersScience & Technology Researchers and engineers have integrated a CrystalDirect harvester into the fully automated beamline MASSIF-1, a unique combination of structural biology technologies that is now open to external academic users.

2022

lab-mattersscience-technology

20 October 2022 Two EMBL staff members looking at a piece of equipment

Teaming up to drive forward time-resolved crystallography

Lab MattersScience & Technology The recent construction of the new ID29 beamline in Grenoble is pioneering a new way of doing experiments in time-resolved crystallography and opening up technology transfer possibilities

2022

lab-mattersscience-technology

27 April 2022 Portrait of Kristina Djinović-Carugo

Next Head of EMBL Grenoble appointed

EMBL AnnouncementsLab Matters Professor Kristina Djinović-Carugo has been appointed as the next head of EMBL Grenoble. She will join EMBL in July from the Max Perutz Laboratories at the University of Vienna, where she is currently Head of the Department of Structural and Computational Biology and full Professor of Structural…

2022

embl-announcementslab-matters

27 April 2022 Kristina Djinović-Carugo sitting at her desk.

Meet the next Head of EMBL Grenoble

Lab MattersPeople & Perspectives Slovenian structural biologist Kristina Djinović-Carugo will join EMBL in July as the new Head of EMBL Grenoble. We spoke to her about her background, research interests, and plans for EMBL Grenoble.

2022

lab-matterspeople-perspectives

18 January 2022 Science illustration composed by a photographic film highlighting three-dimensional structures of a protein complex involved in splicing.

Capturing ‘snapshots’ of a crucial step in RNA splicing

Science & Technology The Galej group at EMBL Grenoble has recently obtained high resolution snapshots of a crucial step in RNA splicing involving the U2 snRNP complex, a crucial component of the human spliceosome.

2022

sciencescience-technology

22 December 2021 Scientific illustrations of MEG3, a very large RNA involved in cell proliferation. IAB and EMBL logos are located in the center of the illustration.

EMBL-IAB collaboration on the rise

ConnectionsLab Matters The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB) a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.

2021

connectionslab-matters

20 December 2021 A detailed structure map shows two proteins interacting in the foreground, each shown in a different colour. The background shows small green dots marking bacteria

Solving molecular puzzles to find the perfect fit

Science & Technology Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.

2021

sciencescience-technology

9 December 2021 Logos of CNRS and EMBL with text “memorandum of understanding”

Strengthening collaborations in France

ConnectionsLab Matters EMBL and the French National Centre for Scientific Research (CNRS) signed a memorandum of understanding.

2021

connectionslab-matters

8 October 2021 Logos of Ifremer and EMBL with text: “memorandum of understanding”. Illustrations of marine animals and numbers in the background.

EMBL and Ifremer cooperate to advance ocean sciences

ConnectionsLab Matters The two organisations have signed a memorandum of understanding to support scientific cooperation in the exploration of coastal and oceanic ecosystems.

2021

connectionslab-matters

7 October 2021 SARS-CoV-2 and planet Earth are merged together in this illustration

Six Ways to Protect the Planet Against Pandemics*

Science & Technology EMBL will host a conference to look at the state of the pandemic, lessons learned, and ways to improve pandemic preparedness. Here’s a sneak peek into what promises to be another interesting and informative EMBL conference.

2021

eventsscience-technology

10 August 2021 Scientist working on an instrument of the MASSIF-1 beamline

MASSIF-1 beamline in Grenoble supports COVID-19 drug discovery

Lab MattersScience & Technology MASSIF-1, run jointly by EMBL Grenoble and the ESRF, is a beamline for macromolecular crystallography. It is used by the research community to study the 3D structure of proteins, which is important for drug development.

2021

lab-mattersscience-technology

8 July 2021 Two men stand outside in front of a building, holding a document and looking at it.

A hidden medal

People & Perspectives We all like a story about rediscovering treasures, right? Well, that’s just what happened recently at EMBL Grenoble!

2021

alumnipeople-perspectives

8 June 2021 Two scientists in lab coats working on an instrument in the lab.

EMBL external research community survey

Lab Matters EMBL is conducting an Impact Assessment of our experimental services to understand the value these services have for our external user community. If you have accessed EMBL experimental services at one or more of our facilities to support the conduct of your research, we would like to hear from you.

2021

lab-matters

10 May 2021 The image shows Inserm and EMBL logos and illustrates the memorandum of understanding signed between both institutions.

EMBL and Inserm to join forces

ConnectionsLab Matters A memorandum of understanding has been signed between EMBL and Inserm to strengthen their scientific cooperation.

2021

connectionslab-matters

13 April 2021 Picture showing MD3, the micro-diffractometer developed by the Instrumentation team, installed at one of the EMBL Hamburg's beamline. Credits: Kinga Lubowiecka/EMBL

Structural biology at EMBL: driving technology development

Lab MattersScience & Technology Florent Cipriani, who recently retired as Head of the Instrumentation Team after a long career at EMBL Grenoble, is one of the pioneers of instrumentation development in this field.

2021

lab-mattersscience-technology

9 March 2021 This photo shows the European Photon and Neutron (EPN) science campus on the peninsula at the confluence of the Isère and Drac rivers, where EMBL Grenoble is located.

Touch of springtime in Grenoble

Lab Matters This photo shows the European Photon and Neutron (EPN) science campus where EMBL Grenoble is located. A delightful spring breeze in the air melts the last remaining patches of snow in the mountains.

2021

lab-matterspicture-of-the-week

9 February 2021 Crystal cubes seen through a microscope

Purity, beauty, and perfection

Science & Technology The regular structures of crystals are a source of inspiration and fascination to us humans. While the crystals in this picture were not grown in nature, but instead by Petra Drncova from EMBL Grenoble, they share the same attributes as those found in nature.

2021

picture-of-the-weekscience-technology

5 February 2021 Artistic representation of the structure of the three proteins forming Integrator’s catalytic core.

At the core of the Integrator complex

Science & Technology A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.

2021

sciencescience-technology

12 January 2021 Three images showing close-ups of different EMBL facilitites.

EMBL becomes newest Instruct Centre

ConnectionsLab Matters EMBL’s sites in Grenoble, Hamburg, and Heidelberg form the newest Instruct Centre. The new centre offers users access to a broad range of state-of-the-art facilities.

2021

connectionslab-matters

15 December 2020 Snowy mountains behind functional buildings. The Moon is up in the sky.

First powder over EMBL Grenoble

Lab Matters The first snowflakes have fallen on the Vercors Mountains, right behind the EMBL Grenoble building, and an almost full moon is showing up during a sunny morning.

2020

lab-matterspicture-of-the-week

2 December 2020 Curly-shaped trypanosomes, grey with bright specks of green fluorescent protein, against a grey background.

Tackling tropical diseases

Science & Technology Members of the EMBL community are working to improve our understanding of the parasites that cause malaria and sleeping sickness

2020

sciencescience-technology

19 October 2020 Green background with white sphere bearing the logos of the two MoU signors, EMBL and CIML

EMBL forms new collaborations in France

ConnectionsLab Matters EMBL and CIML have signed a memorandum of understanding that will open up new scientific opportunities.

2020

connectionslab-matters

25 August 2020 Circular beamline building, surrounded by illuminated Grenoble city in the evening and the alps in the background.

Upgraded beamlines at EMBL Grenoble unveiled

EMBL Announcements The beamlines run jointly by EMBL Grenoble and the ESRF reopen today, unveiling significant upgrades that exploit the brand new fourth generation ESRF synchrotron source.

2020

embl-announcementsscience

8 July 2020 The Logo of the ALPX company.

ALPX – smart crystallography

Lab Matters The CrystalDirect® technology, combined with the web-based CRIMS software enable a fully automated, remote-controlled protein-to-structure pipeline.

2020

lab-matters

17 June 2020 Crystal selection for X-ray diffraction experiments.

Investigating the structure and mechanisms of coronavirus biomolecules

Science & Technology While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…

2020

sciencescience-technology

9 June 2020 This image shows the structure of a bacterial group II intron

Genetic cut and paste at atomic resolution

Science & Technology Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…

2020

sciencescience-technology

27 May 2020 Automated sample changer and diffractometer at the ID30B X-ray crystallography beamline at ESRF Grenoble.

Facilitating COVID-19 structural biology research

Connections EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…

2020

connectionsscience

5 May 2020 Liquid handling robot transfering protein crystalisation solutions

Responding to health threats posed by coronaviruses

Science & Technology By re-opening the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble, EMBL is supporting structural biology projects to respond to the health threats posed by coronaviruses.

2020

sciencescience-technology

29 April 2020 The Influenza virus

Understanding the influenza virus

Science & Technology The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…

2020

sciencescience-technology

10 March 2020

It’s Lab Ski Day!

Lab Matters This image, taken by Raphaël Cohen-Aberdam from the Cipriani team, shows that the weather for the Grenoble Lab Ski Day 2020 was just perfect!

2020

lab-matterspicture-of-the-week

19 December 2019 Before a biological sample reaches the beamline, a lot of work is put into its preparation. Scientists can use the wide range of services and resources at EMBL to prepare their biological samples for structural studies at the X-ray beamlines in Grenoble and Hamburg. Photo: Marietta Schupp/EMBL

Empowering European structural biology

EMBL AnnouncementsLab Matters EU funding for iNEXT-Discovery consortium unlocks key technologies for structural biology

2019

embl-announcementslab-matters

29 November 2019 Choanocyte chamber of sponge, with neuroid cell

Neural pathways

Science & Technology Exploring the diverse routes by which EMBL scientists are driving forward neurobiology

2019

sciencescience-technology

26 September 2019 The Old Port of Marseille.

EMBL and Tara: Marseille

EMBL Announcements From 27–30 September, Tara will be docked in the port of Marseille, France’s second largest city.

2019

embl-announcementsevents

17 September 2019

The end of a productive day

Lab Matters It’s evening and the Sun is setting over the mountains surrounding the city of Grenoble – home to one of EMBL’s six sites – bathing the mountaintops in fiery red light. The Picture of the Week, taken by Zuzanna Kaczmarska shows the lab she worked in after a long and busy day. Bottles…

2019

lab-matterspicture-of-the-week

28 June 2019 EIPOD4 logo banner showing the 4 available tracks, research, industrial, clinical and academic.

EIPOD4: 2019 applications are open

EMBL AnnouncementsLab Matters EIPOD4 will prepare researchers for the increasing interdisciplinarity of scientific career paths

2019

embl-announcementslab-matters

31 May 2019 EMBL scientists in a bar for the event Pint of Science

A thirst for science

Lab Matters EMBL got together with the global science festival Pint of Science to explain and celebrate science.

2019

eventslab-matters

8 March 2019 Sagar Bhogaraju portrait photo

Welcome: Sagar Bhogaraju

Science & Technology New group leader at EMBL Grenoble is investigating the cellular role of melanoma antigens

2019

sciencescience-technology

29 August 2018 During cell division, cohesin directly engages DNA (purple) and holds the replicated chromosome together. IMAGE: Nasser Rusan/National Institutes of Health

Cohesin: a glue for DNA

Science & Technology EMBL scientists discover how a component of the cohesin ring binds DNA

2018

sciencescience-technology

2 August 2018 Humans of EMBL: Outreach

Humans of EMBL: Outreach

Lab MattersPeople & Perspectives Discover how EMBLers across all sites share their passion for science

2018

lab-matterspeople-perspectives

1 June 2018 EMBL researchers and collaborators enjoy their EMBL pints.

A pint of EMBL science

Lab Matters EMBL and Pint of Science join forces to entertain and educate

2018

eventslab-matters

23 February 2018 Meet some of the Humans of EMBL

Humans of EMBL: Past lives

Lab MattersPeople & Perspectives Discover the past lives and journeys that brought people to EMBL

2018

lab-matterspeople-perspectives

29 January 2018 General view of the ID23-2 sample environment showing the MD3-Up diffractometer and FlexHCD sample changer. PHOTO: EMBL/J. Sinoir

Beamline ID23-2 tools up for ESRF upgrade

Lab MattersScience & Technology EMBL instrumentation teams adapting tech to run biological experiments on the synchrotron after its upgrade

2018

lab-mattersscience-technology

4 January 2018 Schematic reconstruction of the Robo1 structure. IMAGE: Andrew McCarthy / Structure

One way crossing across the midline

Science & Technology EMBL researchers solve a decades-long debate on a key process for brain and embryo-development

2018

sciencescience-technology

21 December 2017

Your favourite reads of 2017

Lab Matters A look back at some of the most read stories on EMBL’s news website this year

2017

lab-matters

20 December 2017 In this representation of influenza polymerase, a molecule (white) that strongly inhibits the enzyme’s activity is shown bound to the region of the enzyme (red) that usually binds the cap section of mRNA. IMAGE: EMBL/Cusack Group

Futures: Unravelling influenza

Science & Technology ERC grantee Stephen Cusack shares his vision for the next ten years

2017

sciencescience-technology

4 December 2017 A photo of Eva Kowalinski

Welcome: Eva Kowalinski

People & Perspectives New group leader based in Grenoble aims to unveil the mechanisms of RNA editing

2017

people-perspectivesscience

29 November 2017 Collage of photos of some humans of EMBL discussed in this article

Humans of EMBL: Curiosity

Lab Matters EMBLers across all sites share how their curiosity about the world shapes their everyday life

2017

lab-matters

24 May 2017

Humans of EMBL: Senses

Lab MattersPeople & Perspectives People across EMBL’s sites reflect on the ways they perceive their world

2017

lab-matterspeople-perspectives

16 February 2017

Beamline 14’s legacy

Lab MattersScience & Technology Beamline BM14 in Grenoble shuts down, continues collaboration with India

2017

lab-mattersscience-technology

25 January 2017 Wojciech Galej, new group leader at EMBL

Welcome: Wojciech Galej

People & Perspectives New group leader Wojciech Galej investigates RNA-protein complexes involved in gene expression

2017

people-perspectivesscience

21 December 2016

How flu steals your RNA

Science & Technology Understanding how the flu virus steals host RNA offers hope of new drugs

2016

sciencescience-technology

14 December 2016

New Crystallography platform inaugurated

EMBL AnnouncementsLab Matters A new crystallography platform in Grenoble opens the door to new technological developments

2016

embl-announcementslab-matters

11 November 2016

Big data, cool servers

Lab Matters Upgraded server room is ready to take the heat at EMBL Grenoble

2016

lab-matters

13 September 2016

New drug candidate unleashed for TB

Science & Technology EMBL researchers help to design a lead compound active against four different pathogens

2016

sciencescience-technology

13 September 2016

Opinion: 2006, a year of champagne

Lab MattersPeople & Perspectives Stephen Cusack looks back on the early days of his collaboration with Anacor developing anti-infectives

2016

lab-matterspeople-perspectives

30 August 2016 Francesco Iorio, an EMBL-EBI/Sanger Interdisciplinary Postdoc and now a senior bioinformatician at EMBL-EBI, strives to be "a great dad, as well as a great researcher". PHOTO: Robert Slowley

Postdocs of EMBL

Lab MattersPeople & Perspectives Turning the spotlight on the diverse universe of EMBL’s 200-strong postdoc community

2016

lab-matterspeople-perspectives

30 August 2016

Atomic proportions

Connections EMBL and ESRF scientists and mechanics work together on upgrade for one of Europe’s big X-ray sources

2016

connectionsscience

16 June 2016 Emiko Uchikawa in her lab at EMBL in Grenoble. IMAGE: Isabelle Kling/EMBL

Found in translation

Science & Technology Studying at EMBL in Grenoble helps Japanese postdoc see her native country through different eyes

2016

sciencescience-technology

10 May 2016 A small loop (green) of the atomic structure of DAPK shown to be crucial for dimer formation and binding with its signaling partner Calmodulin. IMAGE: Petra Riedinger/EMBL

Enzyme with a dual-purpose loop

Science & Technology Unexpected results: structure of DAPK enzyme reveals dual-purpose loop

2016

sciencescience-technology

21 April 2016 Florent Cipriani (right) developed CrystalDirect™ together with Josan Marquez (left) PHOTO: EMBL

The man behind the machine

Science & Technology Florent Cipriani talks about his passion for developing beamline instrumentation

2016

sciencescience-technology

21 April 2016 CrystalDirect robot control software: signal from a video camera monitoring the laser working area within a microplate (centre), used to locate the aperture (green trace) and cutting shape (red line), and to select final position of pin tip relative to the crystal (red oval). IMAGE: Zander, U, et al.

Crystals in the beamlight

Science & Technology CrystalDirect, developed at EMBL, automates crystal preparation for X-ray analysis

2016

sciencescience-technology

7 March 2016 During cell division, DNA (purple) must be correctly grouped and divided between daughter cells. IMAGE: Nasser Rusan, National Institutes of Health (NIH)

A cohesive structure

Science & Technology Structural insights into how cohesin keeps DNA together during the cell cycle

2016

sciencescience-technology

28 January 2016 Bernard Jacrot in the late 1960s. IMAGE: ILL

Obituary: Bernard Jacrot

People & Perspectives Former Head of EMBL Grenoble passed away on 21 January 2016 at the age of 89

2016

alumnipeople-perspectives

17 December 2015

What’s on in 2016

Connections With 28 conferences and 57 courses, 2016 will be EMBL’s most eventful year to date.

2015

connectionsevents

25 November 2015

Humans of EMBL

Lab MattersPeople & Perspectives Compelling short stories that shine light on the life and work of EMBL staff.

2015

lab-matterspeople-perspectives

22 September 2015

MASSIFly efficient

Science & Technology MASSIF-1 processes its 10,000th crystal, less than one year after the beamline became operational.

2015

sciencescience-technology

24 August 2015

Molecular momentum

People & Perspectives Andrew Miller, first head of EMBL Grenoble, reflects on four decades at the Outstation.

2015

alumnipeople-perspectives

24 August 2015

EMBL Grenoble: Alumni stories

People & Perspectives Alumni Reuben Leberman, Jeremy Smith, Elena Seiradake, and Winfried Weissenhorn share their stories.

2015

alumnipeople-perspectives

13 July 2015

EIPOD goes cubic

EMBL AnnouncementsLab Matters EI3POD: flagship interdisciplinary postdoc programme opens its doors to academia and industry.

2015

embl-announcementslab-matters

9 July 2015

DNA protection, inch by inch

Science & Technology European team identify mechanism for producing piRNAs that silence jumping genes in germline cells.

2015

sciencescience-technology

18 June 2015

From mountains to molecules

Staff, alumni, partners and more meet at EMBL Grenoble to celebrate Outstation's 40th anniversary.

2015

events

21 May 2015

It runs in the family

Detailed structural study shows distantly related viruses share a common machinery for replication.

2015

science

27 January 2015 Building blocks TAF8 (blue), TAF10 (green) and TAF2 (not shown) form a module in the cytoplasm before entering the nucleus to form TFIID. IMAGE: EMBL/I.BERGER

Come together

First experimental proof that a key cellular machine forms by uniting pre-assembled modules.

2015

science

9 January 2015

Welcome: Marco Marcia

New group leader Marco Marcia aims to broaden horizons while mapping molecules.

2015

science

28 November 2014

MASSIF step forward

Science & Technology In two months, 2.3 million diffraction images collected on new, fully automated ESRF/EMBL beamline.

2014

sciencescience-technology

19 November 2014

20 years in the making

Science & Technology First complete picture of flu virus polymerase. A story of two decades of blood, sweat and sneezes.

2014

sciencescience-technology

4 November 2014

Zombies and crystals

Open Day in Grenoble celebrates crystallography for the Fête de la Science.

2014

events

17 October 2014

100 different stories

Lab Matters Drumming, drama, dancing and discovery in a diary of art and science event, Roche Continents.

2014

lab-matters

20 August 2014

Binding bracelet

Science & Technology Vasa protein preserves pieces of 'enemy' DNA to help protect the genes of future generations.

2014

sciencescience-technology

1 July 2014

The future’s bright

Science & Technology Surprising protein from a flu-like virus is 10 000th ESRF structure

2014

sciencescience-technology

1 July 2014 Illustration: Aad Goudappel, Rotterdam

Five for the future

Lab Matters Scientists from EMBL's five sites reflect on the opportunities and challenges that might lie ahead

2014

lab-matters

25 June 2014

Chain reactions

Science & Technology Scientists determine the structure of auxin response factors: daisy-chains that regulate gene expression

2014

sciencescience-technology

13 October 2013

Choreographed origami

Science & Technology An important step in building ribosomes – the cell’s protein factories – is like a strictly choreographed dance, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have discovered. To build these factories, other ‘machines’ inside the cell have to…

2013

sciencescience-technology

6 January 2013

Protein production: going viral

Science & Technology A research team of scientists from EMBL Grenoble and the IGBMC in Strasbourg, France, have, for the first time, described in molecular detail the architecture of the central scaffold of TFIID: the human protein complex essential for transcription from DNA to mRNA. The study, published today…

2013

sciencescience-technology

2 August 2012 Different inhibitors (yellow, grey) fill the cave-like active site of the cap-snatching protein (the endonuclease, in green) differently, even though they all bind to the active site’s two metal ions (magenta).

Catching the cap-snatcher

Science & Technology Researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have determined the detailed 3-dimensional structure of part of the flu virus’ RNA polymerase, an enzyme that is crucial for influenza virus replication. This important finding is published today in PLoS…

2012

sciencescience-technology

21 June 2012

Flu fighters

Science & Technology Savira pharmaceuticals GmbH, a spin-off of the European Molecular Biology Laboratory (EMBL) based in Vienna, Austria, has signed a collaboration and license agreement with Roche, thus further strengthening the links between fundamental research and major pharmaceutical development companies. This…

2012

sciencescience-technology

23 February 2012

New distributed research infrastructure for structural biology

Science & Technology Breakthroughs in biomedical science are a step closer today, with the launch of a new distributed research infrastructure for the science of structural biology: Instruct. The launch of Instruct will give academic and commercial scientists across Europe access to a full portfolio of integrated…

2012

sciencescience-technology

13 October 2011 In the absence of viral RNA (top), the part of RIG-I that senses viral RNA is exposed (orange), whilst the domains responsible for signalling (blue and pink) are out of reach of the signalling machinery. When RIG-I detects viral RNA, it changes shape (bottom), and the signalling domains become accessible to sound the alarm.

Intruder detected: raise the alarm!

Science & Technology When a thief breaks into a bank vault, sensors are activated and the alarm is raised. Cells have their own early-warning system for intruders, and scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have discovered how a particular protein sounds that alarm when it…

2011

sciencescience-technology

12 December 2010 This cryo-electron microscopy image shows the 3D structure of the ribosome (yellow/blue) bound to the signal recognition particle (SRP) and the SRP receptor (both in red). Below it is an atomic model of SRP (green-yellow/orange) and its receptor (pink). Image credits: EMBL/Schaffitzel.

How cells export and embed proteins in the membrane

Science & Technology Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure…

2010

sciencescience-technology

26 January 2010 This image shows the three-dimensional structure of Death-Associated Protein Kinase (green and yellow) when bound to calmodulin (violet and blue). It was obtained by X-ray crystallography. Image credit: Mathias Wilmanns / EMBL

How to shoot the messenger

Science & Technology Cells rely on a range of signalling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of…

2010

sciencescience-technology

8 November 2009

Drought resistance explained

Science & Technology Much as adrenaline coursing through our veins drives our body’s reactions to stress, the plant hormone abscisic acid (ABA) is behind plants’ responses to stressful situations such as drought, but how it does so has been a mystery for years. Scientists at the European Molecular Biology…

2009

sciencescience-technology

30 September 2009 In the centre, a structural model determined by X-ray crystallography shows how the two tags (attached to a short section of the histone protein – all in cyan) fit neatly into the Brdt pocket (purple). In the background image, hypercompaction by Brdt causes relatively diffuse chromatin (stained blue inside the nuclei of two cells on the top left) to compact and clump together (two on the bottom right).

Putting the squeeze on sperm DNA

Science & Technology In the quest for speed, olympic swimmers shave themselves or squeeze into high-tech super-suits. In the body, sperm are the only cells that swim and, as speed is crucial to fertility, have developed their own ways to become exceptionally streamlined. Scientists at the European Molecular Biology…

2009

sciencescience-technology

4 February 2009 High resolution image of the key domain of the influenza virus polymerase. The active site responsible for RNA cleavage is shown in red. Its activity is crucial for the virus to multiply in human cells

New findings reveal how influenza virus hijacks human cells

Science & Technology Influenza is and remains a disease to reckon with. Seasonal epidemics around the world kill several hundred thousand people every year. In the light of looming pandemics if bird flu strains develop the ability to infect humans easily, new drugs and vaccines are desperately sought. Researchers at…

2009

sciencescience-technology

4 May 2008

Getting wise to the influenza virus’ tricks

Science & Technology Influenza is currently a grave concern for governments and health organisations around the world. Now one of the tactics used by influenza virus to take over the machinery of infected cells has been laid bare by structural biologists at the EMBL, the joint Unit of Virus Host-Cell Interaction of…

2008

sciencescience-technology

25 February 2007

A first glimpse of the influenza replication machine

Science & Technology In 1918, 50 million people died during a worldwide influenza pandemic caused by mutation of a bird-specific strain of the influenza virus. Recently H5N1, another highly infectious avian strain has caused outbreaks of bird flu around the world. There is great concern that this virus might also…

2007

sciencescience-technology

16 June 2006

Cracking a virus protection shield

Science & Technology Ebola, measles and rabies are serious threats to public health in developing countries. Despite different symptoms all of the diseases are caused by the same class of viruses that unlike most other living beings carry their genetic information on a single RNA molecule instead of a double strand of…

2006

sciencescience-technology

10 January 2006

A major European Centre for Structural Biology inaugurated in Grenoble

Lab Matters On Friday, 13 January 2006, the new Carl-Ivar Brändén Building (CIBB) will be inaugurated on the Polygone Scientifique Campus in Grenoble, France. The CIBB will be operated as a collaboration between major international and national partners based in Grenoble and is a further step in the…

2006

lab-matters

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