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26 November 2024

Diving into the world of science

EMBL Grenoble took part in a series of activities during the French Science Week, highlighting EMBL’s research and the TREC scientific expedition.

LAB MATTERS

2024

lab-matters

10 October 2024 A multi-coloured donut representing the structure of an NPC.

“Structurally” sound

The function of biological molecules is intimately linked to their structure. In the 50 years since EMBL was established, its researchers and engineers have constantly provided leadership in structural biology research and services, resulting in many scientific breakthroughs and novel insights.

SCIENCE & TECHNOLOGY

2024

science-technology

25 June 2024 In the front, a 3D model of three molecules bound together: METTL6 in (orange), serine tRNA synthetase in (shades of lilac) and serine tRNA (black). In the background an illustration of a construction site. Two trucks with ‘UGA’ and ‘AGA’ written on them are visible at the bottom.

An enzyme with a smart friend

EMBL Grenoble’s Kowalinski Group analysed the structure of an enzyme responsible for modifying tRNA molecules to fine-tune protein production. They discovered that to distinguish almost identical, yet different, tRNA molecules, the enzyme uses help from another enzyme – a type of cooperation…

SCIENCE & TECHNOLOGY

2024

science-technology

24 May 2024

Stephen Cusack: what I’ve learned

Stephen Cusack, world-renowned structural biologist and former Head of EMBL Grenoble, reflects on his early influences, his achievements, and the lessons he’s learned as he embarks on his next adventure

PEOPLE & PERSPECTIVES

2024

people-perspectives

15 September 2023

Switching off the cytokine storm

EMBL Grenoble and University of Geneva researchers shed light on the molecular activation of the MAP kinase p38α, the final ‘switch’ triggering the inflammatory response.

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

15 May 2023 Two scientists in a laboratory

Behind the scenes of innovation

EMBL Grenoble technology teams provide a sneak peek into their latest collaborative project in structural biology services: the complete automation of an integral step in X-ray crystallography.

EMBLetc

2023

1 March 2023 Moisés Bueno is standing next to the transfer robot. The robot has a form of a yellow robotic arm on a stand. Behind is the CrystalDirect™ Harvester, which is a white cuboid with two transparent dimmed windows for laser protection.

Biology meets engineering

Physicists, engineers and robotics experts work together in EMBL Hamburg’s Instrumentation Team to design instruments that support structural biology research. The team has finished a transfer robot that facilitates automated handling of protein crystals with care and precision. This will help…

LAB MATTERSSCIENCE & TECHNOLOGY

2023

lab-mattersscience-technology

9 January 2023

New molecular insights on medical cannabis

EMBL Grenoble researchers have investigated the interaction between THC and some proteins it might bind to. In a recent study, they showed in vitro that THC inhibits an important human enzyme called autotaxin.

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

12 December 2022 A mother and her child looking through a microscope

Celebrating science in Grenoble

In October 2022, EMBL Grenoble participated in the annual science outreach event Parvis des Sciences, organised by the GIANT campus under the umbrella of the French science week – La Fête de la science.

CONNECTIONSLAB MATTERS

2022

connectionslab-matters

1 December 2022

Getting closer to stopping toxoplasmosis infection

Recent studies supported by EMBL Grenoble’s expertise in structural biology research and scientific services have identified Altiratinib as a potential drug to stop toxoplasmosis infection and opened up treatment options against malaria.

SCIENCE & TECHNOLOGY

2022

sciencescience-technology

27 April 2022 Portrait of Kristina Djinović-Carugo

Next Head of EMBL Grenoble appointed

Professor Kristina Djinović-Carugo has been appointed as the next head of EMBL Grenoble. She will join EMBL in July from the Max Perutz Laboratories at the University of Vienna, where she is currently Head of the Department of Structural and Computational Biology and full Professor of Structural…

EMBL ANNOUNCEMENTSLAB MATTERS

2022

embl-announcementslab-matters

22 December 2021 Scientific illustrations of MEG3, a very large RNA involved in cell proliferation. IAB and EMBL logos are located in the center of the illustration.

EMBL-IAB collaboration on the rise

The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB) a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.

CONNECTIONSLAB MATTERS

2021

connectionslab-matters

20 December 2021 A detailed structure map shows two proteins interacting in the foreground, each shown in a different colour. The background shows small green dots marking bacteria

Solving molecular puzzles to find the perfect fit

Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

8 July 2021 Two men stand outside in front of a building, holding a document and looking at it.

A hidden medal

We all like a story about rediscovering treasures, right? Well, that’s just what happened recently at EMBL Grenoble!

PEOPLE & PERSPECTIVES

2021

alumnipeople-perspectives

8 June 2021 Two scientists in lab coats working on an instrument in the lab.

EMBL external research community survey

EMBL is conducting an Impact Assessment of our experimental services to understand the value these services have for our external user community. If you have accessed EMBL experimental services at one or more of our facilities to support the conduct of your research, we would like to hear from you.

LAB MATTERS

2021

lab-matters

9 March 2021 This photo shows the European Photon and Neutron (EPN) science campus on the peninsula at the confluence of the Isère and Drac rivers, where EMBL Grenoble is located.

Touch of springtime in Grenoble

This photo shows the European Photon and Neutron (EPN) science campus where EMBL Grenoble is located. A delightful spring breeze in the air melts the last remaining patches of snow in the mountains.

LAB MATTERS

2021

lab-matterspicture-of-the-week

9 February 2021 Crystal cubes seen through a microscope

Purity, beauty, and perfection

The regular structures of crystals are a source of inspiration and fascination to us humans. While the crystals in this picture were not grown in nature, but instead by Petra Drncova from EMBL Grenoble, they share the same attributes as those found in nature.

SCIENCE & TECHNOLOGY

2021

picture-of-the-weekscience-technology

15 December 2020 Snowy mountains behind functional buildings. The Moon is up in the sky.

First powder over EMBL Grenoble

The first snowflakes have fallen on the Vercors Mountains, right behind the EMBL Grenoble building, and an almost full moon is showing up during a sunny morning.

LAB MATTERS

2020

lab-matterspicture-of-the-week

8 July 2020 The Logo of the ALPX company.

ALPX – smart crystallography

The CrystalDirect® technology, combined with the web-based CRIMS software enable a fully automated, remote-controlled protein-to-structure pipeline.

LAB MATTERS

2020

lab-matters

9 June 2020 This image shows the structure of a bacterial group II intron

Genetic cut and paste at atomic resolution

Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

27 May 2020 Automated sample changer and diffractometer at the ID30B X-ray crystallography beamline at ESRF Grenoble.

Facilitating COVID-19 structural biology research

EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…

CONNECTIONS

2020

connectionsscience

29 April 2020 The Influenza virus

Understanding the influenza virus

The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

10 March 2020

It’s Lab Ski Day!

This image, taken by Raphaël Cohen-Aberdam from the Cipriani team, shows that the weather for the Grenoble Lab Ski Day 2020 was just perfect!

LAB MATTERS

2020

lab-matterspicture-of-the-week

17 September 2019

The end of a productive day

It’s evening and the Sun is setting over the mountains surrounding the city of Grenoble – home to one of EMBL’s six sites – bathing the mountaintops in fiery red light. The Picture of the Week, taken by Zuzanna Kaczmarska shows the lab she worked in after a long and busy day. Bottles…

LAB MATTERS

2019

lab-matterspicture-of-the-week

31 May 2019 EMBL scientists in a bar for the event Pint of Science

A thirst for science

EMBL got together with the global science festival Pint of Science to explain and celebrate science.

LAB MATTERS

2019

eventslab-matters

30 August 2016

Atomic proportions

EMBL and ESRF scientists and mechanics work together on upgrade for one of Europe’s big X-ray sources

CONNECTIONS

2016

connectionsscience

18 June 2015

From mountains to molecules

Staff, alumni, partners and more meet at EMBL Grenoble to celebrate Outstation's 40th anniversary.

2015

events

27 January 2015 Building blocks TAF8 (blue), TAF10 (green) and TAF2 (not shown) form a module in the cytoplasm before entering the nucleus to form TFIID. IMAGE: EMBL/I.BERGER

Come together

First experimental proof that a key cellular machine forms by uniting pre-assembled modules.

SCIENCE & TECHNOLOGY

2015

sciencescience-technology

4 November 2014

Zombies and crystals

Open Day in Grenoble celebrates crystallography for the Fête de la Science.

2014

events

1 July 2014 Illustration: Aad Goudappel, Rotterdam

Five for the future

Scientists from EMBL's five sites reflect on the opportunities and challenges that might lie ahead

LAB MATTERS

2014

lab-matters

25 June 2014

Chain reactions

Scientists determine the structure of auxin response factors: daisy-chains that regulate gene expression

SCIENCE & TECHNOLOGY

2014

sciencescience-technology

13 October 2013

Choreographed origami

An important step in building ribosomes – the cell’s protein factories – is like a strictly choreographed dance, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have discovered. To build these factories, other ‘machines’ inside the cell have to…

SCIENCE & TECHNOLOGY

2013

sciencescience-technology

6 January 2013

Protein production: going viral

A research team of scientists from EMBL Grenoble and the IGBMC in Strasbourg, France, have, for the first time, described in molecular detail the architecture of the central scaffold of TFIID: the human protein complex essential for transcription from DNA to mRNA. The study, published today…

SCIENCE & TECHNOLOGY

2013

sciencescience-technology

2 August 2012 Different inhibitors (yellow, grey) fill the cave-like active site of the cap-snatching protein (the endonuclease, in green) differently, even though they all bind to the active site’s two metal ions (magenta).

Catching the cap-snatcher

Researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have determined the detailed 3-dimensional structure of part of the flu virus’ RNA polymerase, an enzyme that is crucial for influenza virus replication. This important finding is published today in PLoS…

SCIENCE & TECHNOLOGY

2012

sciencescience-technology

21 June 2012

Flu fighters

Savira pharmaceuticals GmbH, a spin-off of the European Molecular Biology Laboratory (EMBL) based in Vienna, Austria, has signed a collaboration and license agreement with Roche, thus further strengthening the links between fundamental research and major pharmaceutical development companies. This…

SCIENCE & TECHNOLOGY

2012

sciencescience-technology

23 February 2012

New distributed research infrastructure for structural biology

Breakthroughs in biomedical science are a step closer today, with the launch of a new distributed research infrastructure for the science of structural biology: Instruct. The launch of Instruct will give academic and commercial scientists across Europe access to a full portfolio of integrated…

SCIENCE & TECHNOLOGY

2012

sciencescience-technology

13 October 2011 In the absence of viral RNA (top), the part of RIG-I that senses viral RNA is exposed (orange), whilst the domains responsible for signalling (blue and pink) are out of reach of the signalling machinery. When RIG-I detects viral RNA, it changes shape (bottom), and the signalling domains become accessible to sound the alarm.

Intruder detected: raise the alarm!

When a thief breaks into a bank vault, sensors are activated and the alarm is raised. Cells have their own early-warning system for intruders, and scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have discovered how a particular protein sounds that alarm when it…

SCIENCE & TECHNOLOGY

2011

sciencescience-technology

12 December 2010 This cryo-electron microscopy image shows the 3D structure of the ribosome (yellow/blue) bound to the signal recognition particle (SRP) and the SRP receptor (both in red). Below it is an atomic model of SRP (green-yellow/orange) and its receptor (pink). Image credits: EMBL/Schaffitzel.

How cells export and embed proteins in the membrane

Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure…

SCIENCE & TECHNOLOGY

2010

sciencescience-technology

26 January 2010 This image shows the three-dimensional structure of Death-Associated Protein Kinase (green and yellow) when bound to calmodulin (violet and blue). It was obtained by X-ray crystallography. Image credit: Mathias Wilmanns / EMBL

How to shoot the messenger

Cells rely on a range of signalling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of…

SCIENCE & TECHNOLOGY

2010

sciencescience-technology

8 November 2009

Drought resistance explained

Much as adrenaline coursing through our veins drives our body’s reactions to stress, the plant hormone abscisic acid (ABA) is behind plants’ responses to stressful situations such as drought, but how it does so has been a mystery for years. Scientists at the European Molecular Biology…

SCIENCE & TECHNOLOGY

2009

sciencescience-technology

30 September 2009 In the centre, a structural model determined by X-ray crystallography shows how the two tags (attached to a short section of the histone protein – all in cyan) fit neatly into the Brdt pocket (purple). In the background image, hypercompaction by Brdt causes relatively diffuse chromatin (stained blue inside the nuclei of two cells on the top left) to compact and clump together (two on the bottom right).

Putting the squeeze on sperm DNA

In the quest for speed, olympic swimmers shave themselves or squeeze into high-tech super-suits. In the body, sperm are the only cells that swim and, as speed is crucial to fertility, have developed their own ways to become exceptionally streamlined. Scientists at the European Molecular Biology…

SCIENCE & TECHNOLOGY

2009

sciencescience-technology

4 February 2009 High resolution image of the key domain of the influenza virus polymerase. The active site responsible for RNA cleavage is shown in red. Its activity is crucial for the virus to multiply in human cells

New findings reveal how influenza virus hijacks human cells

Influenza is and remains a disease to reckon with. Seasonal epidemics around the world kill several hundred thousand people every year. In the light of looming pandemics if bird flu strains develop the ability to infect humans easily, new drugs and vaccines are desperately sought. Researchers at…

SCIENCE & TECHNOLOGY

2009

sciencescience-technology

4 May 2008

Getting wise to the influenza virus’ tricks

Influenza is currently a grave concern for governments and health organisations around the world. Now one of the tactics used by influenza virus to take over the machinery of infected cells has been laid bare by structural biologists at the EMBL, the joint Unit of Virus Host-Cell Interaction of…

SCIENCE & TECHNOLOGY

2008

sciencescience-technology

25 February 2007

A first glimpse of the influenza replication machine

In 1918, 50 million people died during a worldwide influenza pandemic caused by mutation of a bird-specific strain of the influenza virus. Recently H5N1, another highly infectious avian strain has caused outbreaks of bird flu around the world. There is great concern that this virus might also…

SCIENCE & TECHNOLOGY

2007

sciencescience-technology

16 June 2006

Cracking a virus protection shield

Ebola, measles and rabies are serious threats to public health in developing countries. Despite different symptoms all of the diseases are caused by the same class of viruses that unlike most other living beings carry their genetic information on a single RNA molecule instead of a double strand of…

SCIENCE & TECHNOLOGY

2006

sciencescience-technology

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