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10 October 2024 A multi-coloured donut representing the structure of an NPC.

“Structurally” sound

The function of biological molecules is intimately linked to their structure. In the 50 years since EMBL was established, its researchers and engineers have constantly provided leadership in structural biology research and services, resulting in many scientific breakthroughs and novel insights.

SCIENCE & TECHNOLOGY

2024

science-technology

19 June 2024 In the centre: green angular origami-like shapes stacked on top of each other. Small orange rectangles akin to adhesive tape are placed where the green shapes connect with each other. In the background: a circle in the middle and cancer cells on the left and right.

‘Invisible’ protein keeps cancer at bay

EMBL Hamburg scientists and collaborators discovered a new molecular mechanism in which an unstructured protein disables one of the main cancer-promoting proteins by gluing them into an elongated stack. Data from human patient samples support the role of this mechanism in prostate cancer…

SCIENCE & TECHNOLOGY

2024

science-technology

21 December 2023 On the left: image of a protein complex in a shape of a yellow doughnut with blue elements. Above it is a drawing of nucleic acid with arrows connecting nitrogenous bases to different points in the protein complex. On the right: a line with peaks indicating the peaks recorded in mass spectrometry. Above two peaks, there are smaller depictions of the doughnut-shaped complex, one with a blue element and one without.

RNA to rule them all

The Kosinski Group at EMBL Hamburg collaborated with other groups in Hamburg to reveal critical steps in Lassa virus ribonucleoparticle assembly and recruitment, and the crucial role played by RNA in in the Lassa virus life cycle.

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

19 December 2023 Cartoon showing nanoparticles on a conveyer belt passing through a machine. They are ordered by size and the smallest one pass through the machine before the bigger ones. A ray of light enters the machine, where a nanoparticle is being scanned, and leaves it on the other side. A monitor on top of the scanning machine shows an X-ray of a nanoparticle.

‘X-ray vision’ for investigation of mRNA nanomedicines

EMBL Hamburg, Johannes Gutenberg University Mainz, Postnova Analytics GmbH, and BioNTech SE have developed a new method to quantitatively investigate sizes of nanoparticles containing mRNA. It may become an important part of regular characterisation of mRNA nanomedicines in the future.

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

15 November 2023 Illustration showing a doorknob with a lock and many protein-marked keys floating towards it.

The secret of molecular promiscuity

Promiscuity is critical for nourishment. How? This question lies at the focus of research by the Löw Group at EMBL Hamburg. Using structural biology methods, they explore how specialised molecules located in the cell membrane allow cells absorb nutrients from their environment.

EMBLetc

2023

2 October 2023 Outline of a human, purple against red background. Red RNA strand in the background, electrocardiogram across the image. On the right, outline of a Nobel prize medal.

mRNA nanomedicines scoop Nobel Prize in Physiology or Medicine

Pioneers of the mRNA nanomedicines technology receive 2023 Nobel Prize in Physiology or medicine. EMBL is pleased to have supported the development of the application of the mRNA nanomedicine technology through our long-standing collaboration with BioNTech, Johannes Gutenberg University Mainz and…

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

6 September 2023 A drawing of swordfish and a bubble containing a drawing of a molecular model. Both on blue background representing water.

Swordfish sword under X-rays: SAXS explained

Learn how scientists use bio-SAXS, an experimental X-ray technique, to study the shape and dynamics of proteins and other biomolecules. SAXS can be even used to analyse the structure of mineral particles in the swordfish sword bone, which can help scientists better understand bone ageing.

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

8 August 2023 Clément Blanchet at the EMBL Hamburg’s P12 beamline’s experimental hutch.

Welcome: Clément Blanchet

Clément Blanchet has been appointed to lead the team working on small-angle X-ray scattering (SAXS) at EMBL Hamburg. In this interview, he talks his ambitions for the future work of the SAXS Team, his passion for science, and a memorable ‘aha’ moment he had in his early career.

LAB MATTERSPEOPLE & PERSPECTIVES

2023

lab-matterspeople-perspectives

3 July 2023 In the foreground: an intrinsically disordered protein, which has a form of a tangled, unstructured string. In the background: a set of parallel curved lines.

Bringing research on disordered proteins to order

A third of all known proteins are either completely or partially unstructured. EMBL scientists contributed to a new set of guidelines – Minimum Information About a Disorder Experiment (MIADE) – that will help researchers share data on unstructured proteins in a more useful way and will enable…

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

10 May 2023 Illustration showing a cute humanoid-shaped robot that spits pink droplets at a sheet.

Time-resolved crystallography for the masses

EMBL Hamburg scientists have contributed to the development of the Spitrobot, a ground-breaking experimental setup that will simplify creating molecular movies. The Spitrobot automates the sample preparation for time-resolved crystallography, which is used to create 3D snapshots of protein…

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

20 April 2023 Photo of a human hand introducing a small element into a machine at the SPC Facility.

EMBL Hamburg joins northern European life science consortium

EMBL Hamburg partners with the Hanseatic Life Science Research Infrastructure Consortium (HALRIC) to enhance life sciences research in Scandinavia and northern Germany. The consortium builds on the HALOS project to foster collaborations between industry, hospitals, and universities, leveraging…

CONNECTIONSLAB MATTERS

2023

connectionslab-matters

17 March 2023 Liz Duke standing on the left side of the photo, with EMBL Hamburg's P14 beamline and a big screen on the right.

Molecules to Ecosystems: Liz Duke on X-ray imaging

Biological X-ray imaging is an emerging technology that uses X-rays to image tissues or even entire organisms. It will play an important role in EMBL Hamburg’s future service portfolio, and will allow studying life on multiple scales. Team Leader Liz Duke discusses her plans to establish X-ray…

LAB MATTERSPEOPLE & PERSPECTIVES

2023

lab-matterspeople-perspectives

1 March 2023 Moisés Bueno is standing next to the transfer robot. The robot has a form of a yellow robotic arm on a stand. Behind is the CrystalDirect™ Harvester, which is a white cuboid with two transparent dimmed windows for laser protection.

Biology meets engineering

Physicists, engineers and robotics experts work together in EMBL Hamburg’s Instrumentation Team to design instruments that support structural biology research. The team has finished a transfer robot that facilitates automated handling of protein crystals with care and precision. This will help…

LAB MATTERSSCIENCE & TECHNOLOGY

2023

lab-mattersscience-technology

10 June 2022 A colourful structural model of the doughnut-shaped human nuclear pore complex seen from above.

Puzzling out the structure of a molecular giant

Scientists have solved several mysteries around the structure and function of a true molecular giant: the human nuclear pore complex. They created the most complete model of the complex thanks to combining the program AlphaFold2 with cryo-electron tomography, integrative modelling, molecular…

SCIENCE & TECHNOLOGY

2022

sciencescience-technology

18 May 2022 The visiting group from the Business Academy Aarhus during lunch at the EMBL Hamburg’s terrace

EMBL Hamburg is helping train lab techs of the future

Students from the Business Academy Aarhus visit EMBL Hamburg annually. Many of them return later as trainees to gain experience as lab technicians. EMBL Hamburg offers great opportunities to learn diverse techniques and work with various equipment. This experience helps them in their future jobs in…

LAB MATTERS

2022

lab-matters

1 February 2022 A photograph of the Amazonian lancehead snake Bothrops atrox

Decoding the secrets of snake venom

EMBL Hamburg’s Grzegorz Chojnowski from the Wilmanns Group developed software called findMySequence, which identifies proteins’ amino-acid sequences based on electron cryo-microscopy and X-ray crystallography data. It’s useful for identifying unknown proteins in samples from natural sources.

SCIENCE & TECHNOLOGY

2022

sciencescience-technology

21 December 2021 A model of the doughnut-shaped nuclear pore complex. Individual molecules are marked in various colours.

Observing the secret life of molecules inside the cell

EMBL Hamburg’s Kosinski Group, the Beck Laboratory at the Max Planck Institute of Biophysics, and colleagues at EMBL Heidelberg recorded the nuclear pore complex contracting in living cells. They visualised the movement with an unprecedented level of detail with help of new software called…

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

7 December 2021 A cartoon image showing a person's arm and a needle with a vaccine being injected into it. The text on the left reads: "EMBL research: How structural biologists at EMBL Hamburg help to develop and improve RNA vaccines"

How structural biology helps to make RNA vaccines

RNA vaccines, such as the ones for COVID-19, represent a new approach in vaccine technology. Cy Jeffries, faculty staff scientist at EMBL Hamburg, explains the clever technology behind RNA vaccines, and how structural biology contributes to its development. EMBL Hamburg collaborated on several…

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

5 November 2021 A headshot photo of Ken Holmes from July 2021

Ken Holmes

Ken Holmes, outstanding pioneer of structural biology and founder of EMBL´s Hamburg site, died on 2 November 2021 at the age of 87.

PEOPLE & PERSPECTIVES

2021

alumnipeople-perspectives

5 November 2021 Three-dimensional rendering of sponge neuroid cells (coloured orange) and sponge digestive cells (coloured green).

More than a gut reaction

What can sponges tell us about the evolution of the brain? Sponges have the genes involved in neuronal function in higher animals. But if sponges don’t have brains, what is the role of these? EMBL scientists imaged the sponge digestive chamber to find out.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

25 October 2021 A collage of the visuals representing each of the three modules of the eSPC platform.

Biophysics analysis made easy with an online tool

EMBL Hamburg’s Sample Preparation and Characterisation (SPC) Facility has released eSPC, an online platform for analysing data from biophysical experiments. The platform enables the scientific community to analyse data from different experiments without the need to travel.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

15 October 2021 In the middle, there are two molecules of pUL21. One is blurred, to represent the molecule’s flexibility. In the background are two neuronal scenes. The one on the left is healthy and has a smooth surface. The one on the right is infected, which is represented by several green viral particles.

How herpes seizes proteins’ means of production

The Graham and Crump groups at the University of Cambridge and the Svergun Group at EMBL Hamburg have discovered a mechanism by which the herpes simplex virus takes control of the molecular machinery of human cells. Their work reveals how a dedicated viral protein hijacks key host proteins, forcing…

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

13 July 2021 From right to left, Ilaria Piazza and Ken Holmes’ portraits are side by side in circles on a greenish background

EMBL Alumni Awards 2021

EMBL alumni Ilaria Piazza and Ken Holmes have been recognised for their outstanding contributions, and will receive their awards as part of the celebrations for EMBL World Alumni Day.

PEOPLE & PERSPECTIVES

2021

alumnipeople-perspectives

8 June 2021 Two scientists in lab coats working on an instrument in the lab.

EMBL external research community survey

EMBL is conducting an Impact Assessment of our experimental services to understand the value these services have for our external user community. If you have accessed EMBL experimental services at one or more of our facilities to support the conduct of your research, we would like to hear from you.

LAB MATTERS

2021

lab-matters

21 May 2021 Image of a mosquito on a clear surface

EMBL scientists support malaria research

EMBL scientists support research on malaria by providing freely available data resources and using innovative experimental approaches. Our Course and Conference Office facilitates the exchange of knowledge in the field by hosting the annual BioMalPar conference.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

30 March 2021 A close-up photo of a shiny droplet of liquid that has been placed into one of the wells of a crystallisation plate.

Droplet beauty

Scientists at EMBL Hamburg use droplets of protein solution to grow protein crystals. By exposing the crystals to X-rays, they are able to determine the protein’s molecular structure.

SCIENCE & TECHNOLOGY

2021

picture-of-the-weekscience-technology

22 February 2021 A scientist (only their hand is visible) inserting a 96-well plate into a sample dispensing device in the Sample Preparation and Characterisation Facility in Hamburg.

SPC Facility in Hamburg supports a new pan-European consortium

The Sample Preparation and Characterisation (SPC) Facility at EMBL Hamburg is one of the founding members of the Molecular-Scale Biophysics Research Infrastructure (MOSBRI). Within this new European initiative, the SPC Facility will offer services related to membrane proteins, protein complexes,…

CONNECTIONSLAB MATTERS

2021

connectionslab-matters

26 January 2021 Two X-ray mirrors installed in the macromolecular crystallography beamline P14 at EMBL Hamburg. The mirrors are visible in the photo as dark rectangular crystal blocks, with two metal holders supporting the crystals in a stress-free position. The mirrors are inserted into a vacuum-compatible stainless steel vessel.

Mirror, mirror

Scientists at EMBL Hamburg use specially designed mirrors to reflect and focus X-ray beams onto tiny crystals made of proteins or other biological molecules.

SCIENCE & TECHNOLOGY

2021

picture-of-the-weekscience-technology

14 January 2021 An electron microscopy photo shows two bacterial cells surrounded by several white fibrils of the amphibian peptide.

Toadlet peptide transforms into a deadly weapon against bacteria

Researchers at the Technion – Israel Institute of Technology and EMBL Hamburg, in collaboration with scientists in Israel and Spain, have discovered remarkable molecular properties of an antimicrobial peptide from the skin of the Australian toadlet. The discovery could inspire the development of…

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

12 January 2021 A metallic tool.

Homage to a vital tool

Structural biologists want to study proteins at the atomic level. The device shown in this Picture of the Week is essential for this.

SCIENCE & TECHNOLOGY

2021

picture-of-the-weekscience-technology

1 December 2020 Rainbow on a cloudy sky above technical buildings.

Rainbow over the Hanseatic city

Hamburg hosts one of EMBL’s six sites. The city is notorious for its windy and rainy weather. Lots of rain also means a high chance of beautiful rainbows!

LAB MATTERS

2020

lab-matterspicture-of-the-week

4 November 2020 SARS-CoV-2 is represented as a sphere with spike proteins poking out of its surface, which give it a corona-like appearance. The spike proteins resemble triangular ‘bushes’ with three tips at the top. In the background, a cell surface is visible with ACE2 proteins poking out of it in many places. The virus is about to attach to the cell surface. The sybodies, represented as tiny V-shaped structures, bind to the viral spike proteins at their tips.

Scientists identify synthetic mini-antibody to combat COVID-19

By screening hundreds of sybodies (synthetic mini-antibodies), scientists have identified one that might stop SARS-CoV-2 from infecting human cells. This work, which holds promise for treating COVID-19, was conducted by EMBL Hamburg and collaborators from the Centre for Structural Systems Biology…

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

3 September 2020 Left: Slice of a cell in grey. Right: Two 3D reconstructions of parts of the slice, showing the internal structure.

Nuclear pores in their natural context

Scientists from the Beck group have studied the 3D structure of nuclear pores in budding yeast. They show how the architecture of the nuclear pore complex differs inside cells compared to its form observed in vitro studies.

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

18 August 2020 Three cells, each looking like a face.

Three little ghosts

Despite their ghostly appearance, these are very real cell nuclei infected with Influenza A virus – the only influenza virus known to cause pandemics.

SCIENCE & TECHNOLOGY

2020

picture-of-the-weekscience-technology

9 June 2020 Beamline Hamburg

Shining high-brilliance beams on coronavirus structure

EMBL researchers are studying COVID-19-related molecules by exposing them to high-brilliance X-ray beams. The Svergun group at EMBL Hamburg is using biological small-angle X-ray scattering (SAXS) as part of a global effort by scientists to elucidate the structural organisation of SARS-CoV-2…

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

11 May 2020

EMBL SPC facility supports COVID-19 projects

The Sample Preparation and Characterisation Facility (SPC) at EMBL Hamburg reopens to support scientists working on Covid-19 research. The SPC Facility is one of the best equipped facilities in Europe is therefore in high demand from external users. Re-opening the facility also allows experts at…

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

28 April 2020 Close-up view of the interior of a protein analytics system

Exploring synthetic antibodies to stop coronavirus

Scientists at EMBL Hamburg and Karolinska Institutet Stockholm aim to find synthetic antibodies – known as nanobodies – that bind a surface protein of the novel SARS-CoV-2 coronavirus. Nanobodies could prevent the virus from entering human cells and causing COVID-19.

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

7 April 2020

Exciting science!

EMBL is all about exciting science, through which we aim to achieve a fundamental understanding of biological processes.

SCIENCE & TECHNOLOGY

2020

picture-of-the-weekscience-technology

31 May 2019 EMBL scientists in a bar for the event Pint of Science

A thirst for science

EMBL got together with the global science festival Pint of Science to explain and celebrate science.

LAB MATTERS

2019

eventslab-matters

6 July 2017

CSSB opens its doors

On 29 June, at a ceremony in front of 700 guests, the Centre for Structural Systems Biology (CSSB) in Hamburg, was officially opened. At the event on the Deutsches Elektronen-Synchrotron (DESY) Campus in Hamburg, Helmut Dosch, Chairman of the DESY Board of Directors, presented Head of EMBL Hamburg…

CONNECTIONSLAB MATTERS

2017

connectionslab-matters

24 November 2015 No coincidence: organisers of this year’s PhD Symposium gather at EMBL Heidelberg 22–24 October for Just by Chance? Randomness and variability shaping biology. PHOTO: EMBL Photolab/Marietta Shupp

EMBL in pictures

A snapshot of the many activities and events that took place in the world of EMBL this Autumn.

LAB MATTERS

2015

eventslab-matters

11 December 2014

Lighting the way

EMBL Hamburg celebrates four decades of vision, pioneering research and beamline services.

2014

events

18 November 2014

On a SAXS quest

Course attendees go hunting (protein) aliens in a quest for optimal SAXS data.

2014

events

3 November 2014

PEPC recipe for success

How to make good quality samples for good quality structural biology experiments.

2014

events

1 July 2014 Illustration: Aad Goudappel, Rotterdam

Five for the future

Scientists from EMBL's five sites reflect on the opportunities and challenges that might lie ahead

LAB MATTERS

2014

lab-matters

14 February 2011 3D structure of Mycobacterium tuberculosis’ enzyme PriA

Two in one

In a paper published online today in PNAS, scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, reveal new insights into the workings of enzymes from a group of bacteria including Mycobacterium tuberculosis, the bacterium that causes tuberculosis. The new findings…

SCIENCE & TECHNOLOGY

2011

sciencescience-technology

8 November 2010 Signing the declaration of accession to the EIROforum: Massimo Altarelli, Chairman of the XFEL Management Board (left) and Francesco Romanelli, Chairman of the EIROforum (right). In the back (left to right): Francesco Sette (ESRF), Felicitas Pauss (CERN), Iain Mattaj (EMBL), Richard Wagner (ILL), Rowena Sirey (ESO) and David Southwood (ESA)

European XFEL joins EIROforum

At the Autumn 2010Council meeting of the EIROforum, a partnership of seven European intergovernmental research organisations with large research infrastructures, the Directors General unanimously accepted the European X-Ray Free-Electron Laser Facility (European XFEL), based in Hamburg, Germany, to…

LAB MATTERS

2010

lab-matters

26 January 2010 This image shows the three-dimensional structure of Death-Associated Protein Kinase (green and yellow) when bound to calmodulin (violet and blue). It was obtained by X-ray crystallography. Image credit: Mathias Wilmanns / EMBL

How to shoot the messenger

Cells rely on a range of signalling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of…

SCIENCE & TECHNOLOGY

2010

sciencescience-technology

11 January 2006

The giant protein titin helps build muscles

Imagine grabbing two snakes by the tail so that they can’t wriggle off in opposite directions. Scientists at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and collaborators from King’s College in London have now discovered that something similar happens to a…

SCIENCE & TECHNOLOGY

2006

sciencescience-technology

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